LOCUS       NM_001077363            2872 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus polypyrimidine tract binding protein 1 (Ptbp1),
            transcript variant 1, mRNA.
ACCESSION   NM_001077363
VERSION     NM_001077363.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2872)
  AUTHORS   Shen,C.L., Tsai,Y.Y., Chou,S.J., Chang,Y.M. and Tarn,W.Y.
  TITLE     RBM4-mediated intron excision of Hsf1 induces BDNF for cerebellar
            foliation
  JOURNAL   Commun Biol 7 (1), 1712 (2024)
   PUBMED   39738787
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2872)
  AUTHORS   Wang,Y., Chembazhi,U.V., Yee,D., Chen,S., Ji,J., Wang,Y.,
            Nguyen,K.L., Lin,P., Ratti,A., Hess,R.A., Qiao,H., Ko,C., Yang,J.,
            Kalsotra,A. and Mei,W.
  TITLE     PTBP1 mediates Sertoli cell actin cytoskeleton organization by
            regulating alternative splicing of actin regulators
  JOURNAL   Nucleic Acids Res 52 (20), 12244-12261 (2024)
   PUBMED   39373517
REFERENCE   3  (bases 1 to 2872)
  AUTHORS   Fukui,Y., Morihara,R., Hu,X., Nakano,Y., Yunoki,T., Takemoto,M.,
            Abe,K. and Yamashita,T.
  TITLE     Suppression of PTBP1 in hippocampal astrocytes promotes
            neurogenesis and ameliorates recognition memory in mice with
            cerebral ischemia
  JOURNAL   Sci Rep 14 (1), 20521 (2024)
   PUBMED   39227632
  REMARK    GeneRIF: Suppression of PTBP1 in hippocampal astrocytes promotes
            neurogenesis and ameliorates recognition memory in mice with
            cerebral ischemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2872)
  AUTHORS   Tu,W., Zhu,S., Li,F., Xu,C., Tu,W. and Chen,Y.
  TITLE     A novel link between melatonin and circ_0005753/PTBP1/TXNIP
            regulatory network in the modulation of osteogenic potential in
            mesenchymal stem cells
  JOURNAL   Chem Biol Drug Des 103 (1), e14380 (2024)
   PUBMED   37890873
  REMARK    GeneRIF: A novel link between melatonin and
            circ_0005753/PTBP1/TXNIP regulatory network in the modulation of
            osteogenic potential in mesenchymal stem cells.
REFERENCE   5  (bases 1 to 2872)
  AUTHORS   Xuan,L., Xu,Z., Luo,J., Wang,Y., Yan,Y., Qu,C., Xie,Z.,
            Skonieczna,M., Zhou,P.K. and Huang,R.
  TITLE     Lactate exacerbates lung damage induced by nanomicroplastic through
            the gut microbiota-HIF1a/PTBP1 pathway
  JOURNAL   Exp Mol Med 55 (12), 2596-2607 (2023)
   PUBMED   38036735
REFERENCE   6  (bases 1 to 2872)
  AUTHORS   Polydorides,A.D., Okano,H.J., Yang,Y.Y., Stefani,G. and
            Darnell,R.B.
  TITLE     A brain-enriched polypyrimidine tract-binding protein antagonizes
            the ability of Nova to regulate neuron-specific alternative
            splicing
  JOURNAL   Proc Natl Acad Sci U S A 97 (12), 6350-6355 (2000)
   PUBMED   10829067
REFERENCE   7  (bases 1 to 2872)
  AUTHORS   Misawa,K., Nosaka,T., Morita,S., Kaneko,A., Nakahata,T., Asano,S.
            and Kitamura,T.
  TITLE     A method to identify cDNAs based on localization of green
            fluorescent protein fusion products
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3062-3066 (2000)
   PUBMED   10716735
REFERENCE   8  (bases 1 to 2872)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   9  (bases 1 to 2872)
  AUTHORS   Niepmann,M.
  TITLE     Porcine polypyrimidine tract-binding protein stimulates translation
            initiation at the internal ribosome entry site of
            foot-and-mouth-disease virus
  JOURNAL   FEBS Lett 388 (1), 39-42 (1996)
   PUBMED   8654585
REFERENCE   10 (bases 1 to 2872)
  AUTHORS   Bothwell,A.L., Ballard,D.W., Philbrick,W.M., Lindwall,G.,
            Maher,S.E., Bridgett,M.M., Jamison,S.F. and Garcia-Blanco,M.A.
  TITLE     Murine polypyrimidine tract binding protein. Purification, cloning,
            and mapping of the RNA binding domain
  JOURNAL   J Biol Chem 266 (36), 24657-24663 (1991)
   PUBMED   1722210
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151846.3.
            
            On Jun 2, 2022 this sequence version replaced NM_001077363.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053926.1, AK088483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AC151846.3         145278-145331       c
            55-85               AC151846.3         143465-143495       c
            86-158              AC151846.3         141175-141247       c
            159-478             AC151846.3         140728-141047       c
            479-649             AC151846.3         140477-140647       c
            650-760             AC151846.3         140287-140397       c
            761-935             AC151846.3         140044-140218       c
            936-1013            AC151846.3         139805-139882       c
            1014-1159           AC151846.3         139030-139175       c
            1160-1193           AC151846.3         137952-137985       c
            1194-1286           AC151846.3         137458-137550       c
            1287-1503           AC151846.3         137130-137346       c
            1504-1581           AC151846.3         136944-137021       c
            1582-2872           AC151846.3         135564-136854       c
FEATURES             Location/Qualifiers
     source          1..2872
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2872
                     /gene="Ptbp1"
                     /gene_synonym="HNRPI; pPTB; Ptb; PTB-1; PTB2; PTB3; PTB4"
                     /note="polypyrimidine tract binding protein 1"
                     /db_xref="GeneID:19205"
                     /db_xref="MGI:MGI:97791"
     exon            1..54
                     /gene="Ptbp1"
                     /gene_synonym="HNRPI; pPTB; Ptb; PTB-1; PTB2; PTB3; PTB4"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1714
                     /gene="Ptbp1"
                     /gene_synonym="HNRPI; pPTB; Ptb; PTB-1; PTB2; PTB3; PTB4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     heterogeneous nuclear ribonucleoprotein I; hnRNP I"
                     /codon_start=1
                     /product="polypyrimidine tract-binding protein 1 isoform
                     1"
                     /protein_id="NP_001070831.1"
                     /db_xref="CCDS:CCDS35969.1"
                     /db_xref="GeneID:19205"
                     /db_xref="MGI:MGI:97791"
                     /translation="MDGIVPDIAVGTKRGSDELFSTCVSNGPFIMSSSASAANGNDSK
                     KFKGDNRSAGVPSRVIHVRKLPSDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNT
                     EEAANTMVNYYTSVAPVLRGQPIYIQFSNHKELKTDSSPNQARAQAALQAVNSVQSGN
                     LALAASAAAVDAGMAMAGQSPVLRIIVENLFYPVTLDVLHQIFSKFGTVLKIITFTKN
                     NQFQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDYTR
                     PDLPSGDSQPSLDQTMAAAFGAPGIMSASPYAGAGFPPTFAIPQAAGLSVPNVHGALA
                     PLAIPSAAAAAAASRIAIPGLAGAGNSVLLVSNLNPERVTPQSLFILFGVYGDVQRVK
                     ILFNKKENALVQMADGSQAQLAMSHLNGHKLHGKSVRITLSKHQSVQLPREGQEDQGL
                     TKDYGSSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVSEDDLKSLFSSNGGVVKGF
                     KFFQKDRKMALIQMGSVEEAVQALIELHNHDLGENHHLRVSFSKSTI"
     exon            55..85
                     /gene="Ptbp1"
                     /gene_synonym="HNRPI; pPTB; Ptb; PTB-1; PTB2; PTB3; PTB4"
                     /inference="alignment:Splign:2.1.0"
     exon            86..158
                     /gene="Ptbp1"
                     /gene_synonym="HNRPI; pPTB; Ptb; PTB-1; PTB2; PTB3; PTB4"
                     /inference="alignment:Splign:2.1.0"
     exon            159..478
                     /gene="Ptbp1"
                     /gene_synonym="HNRPI; pPTB; Ptb; PTB-1; PTB2; PTB3; PTB4"
                     /inference="alignment:Splign:2.1.0"
     exon            479..649
                     /gene="Ptbp1"
                     /gene_synonym="HNRPI; pPTB; Ptb; PTB-1; PTB2; PTB3; PTB4"
                     /inference="alignment:Splign:2.1.0"
     exon            650..760
                     /gene="Ptbp1"
                     /gene_synonym="HNRPI; pPTB; Ptb; PTB-1; PTB2; PTB3; PTB4"
                     /inference="alignment:Splign:2.1.0"
     exon            761..935
                     /gene="Ptbp1"
                     /gene_synonym="HNRPI; pPTB; Ptb; PTB-1; PTB2; PTB3; PTB4"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1013
                     /gene="Ptbp1"
                     /gene_synonym="HNRPI; pPTB; Ptb; PTB-1; PTB2; PTB3; PTB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1159
                     /gene="Ptbp1"
                     /gene_synonym="HNRPI; pPTB; Ptb; PTB-1; PTB2; PTB3; PTB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1193
                     /gene="Ptbp1"
                     /gene_synonym="HNRPI; pPTB; Ptb; PTB-1; PTB2; PTB3; PTB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1286
                     /gene="Ptbp1"
                     /gene_synonym="HNRPI; pPTB; Ptb; PTB-1; PTB2; PTB3; PTB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1503
                     /gene="Ptbp1"
                     /gene_synonym="HNRPI; pPTB; Ptb; PTB-1; PTB2; PTB3; PTB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1581
                     /gene="Ptbp1"
                     /gene_synonym="HNRPI; pPTB; Ptb; PTB-1; PTB2; PTB3; PTB4"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..2872
                     /gene="Ptbp1"
                     /gene_synonym="HNRPI; pPTB; Ptb; PTB-1; PTB2; PTB3; PTB4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2777..2782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptbp1"
                     /gene_synonym="HNRPI; pPTB; Ptb; PTB-1; PTB2; PTB3; PTB4"
                     /note="hexamer: ATTAAA"
     polyA_site      2798
                     /gene="Ptbp1"
                     /gene_synonym="HNRPI; pPTB; Ptb; PTB-1; PTB2; PTB3; PTB4"
                     /note="major polyA site"
     regulatory      2852..2857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptbp1"
                     /gene_synonym="HNRPI; pPTB; Ptb; PTB-1; PTB2; PTB3; PTB4"
                     /note="hexamer: AATAAA"
     polyA_site      2872
                     /gene="Ptbp1"
                     /gene_synonym="HNRPI; pPTB; Ptb; PTB-1; PTB2; PTB3; PTB4"
                     /note="major polyA site"
ORIGIN      
        1 attcctgcgc ctccgctccg ttccccgcgg gtctcttccg tgtgccatgg acggcatcgt
       61 cccagacata gcagtcggta caaagcgggg atccgacgag ctcttctcca cgtgtgtcag
      121 caacggcccc ttcatcatga gcagctctgc ctcagcagcc aatggaaacg atagcaagaa
      181 gttcaaaggt gacaacagga gcgcaggagt cccttccaga gtcatccatg tcagaaagct
      241 gcccagcgat gtcactgagg gcgaggtcat ctccctaggg ctgccctttg gaaaggttac
      301 caaccttctc atgctgaagg ggaagaacca ggccttcatt gagatgaaca cagaggaggc
      361 tgccaacact atggttaact actatacatc ggtggcgcca gtgcttcgtg gacagcccat
      421 ctacatccag ttctccaacc acaaagagct caagaccgac agctcgccca accaggcacg
      481 tgcccaggca gccctgcagg ctgtaaactc cgtccagtct ggaaacctgg ccttggcagc
      541 gtccgctgct gccgtggatg caggaatggc aatggcaggg cagagcccag tgctcaggat
      601 cattgtggaa aaccttttct acccagtgac cctggacgtg ctgcaccaga tcttctctaa
      661 gtttggcacc gtcctgaaga tcatcacgtt caccaagaac aaccagttcc aggcgctgct
      721 gcagtatgct gaccctgtga gcgcccagca tgccaagctg tccctggatg gccagaacat
      781 ctacaacgcc tgctgcacgc tgcgcatcga cttctccaag ctcaccagtc tcaatgtcaa
      841 gtacaacaat gataagagca gagactacac tcgacctgac ctgccctctg gagacagcca
      901 gccttcacta gaccagacca tggcagcagc ctttggtgcg cccggcataa tgtcagcctc
      961 tccgtatgca ggagccgggt tccctcccac ctttgccatc cctcaggccg caggcctctc
     1021 tgtccctaat gtccatggag ccttggcccc cctggccatc ccgtctgctg ctgctgctgc
     1081 tgcggccagc cgcattgcca tcccagggtt ggcaggtgct gggaattctg tccttttggt
     1141 cagcaatctg aaccctgaga gagtcacacc ccaaagcctc tttattctct tcggcgtcta
     1201 cggtgatgtg cagcgggtga agatcctgtt caataagaag gagaacgcac ttgtgcagat
     1261 ggcagacggc agccaggccc agctggccat gagccacctg aacgggcaca agctgcacgg
     1321 gaagtcagtg cgcattacac tgtccaagca tcagagtgtg cagctgcctc gggagggtca
     1381 ggaggaccag ggcctgacca aggactatgg cagctccccg ctgcaccgct tcaagaaacc
     1441 aggctccaag aacttccaga acatctttcc accctcagct accctgcacc tctccaacat
     1501 cccgccctct gtgtcagagg acgacctcaa gagcctcttc tccagcaacg gtggtgtggt
     1561 caaaggcttc aagttcttcc agaaggaccg caagatggca ctgatccaga tgggctctgt
     1621 ggaggaggct gtgcaggcgc tgattgaact gcacaaccat gacctgggcg agaaccacca
     1681 cctgcgagtg tccttttcca agtccaccat ctaggtgcct gtgggcctgc atcagcttcc
     1741 accattccag aaaagccact ttaaaaagca gctgaagtga ccttacagac cagagatttt
     1801 atttttttaa agagagatca gtttacctgt ttttaaaaaa attaaatcta gcccactctg
     1861 cagtggcagg aaatggcttg gaccacagag gcccagtcaa tcccagcacc atgccttgag
     1921 gggctcaggc gtgaggccac agcggtgccc caaacatagc cgctttctgt gccttacaaa
     1981 ccagcgtgcc tcatggccgt acacccaccc tctaaggcca ccagttgtct ctagacctgc
     2041 aggtgagcca ggtggcctat acataggctc cccaatgctg tgcaagagct ggggccactc
     2101 ccctacaccc ttataatcaa gtgacatgat tctcccatgt ccctggccag cccggagggt
     2161 ccaggccatc ctcagctgcc gagcctcatt gtgacctttg tattctattc cgtgtggtca
     2221 cagacacctg tgcctagcaa tatttccact tgaccaaata cccgaatctt ttccatttat
     2281 atgcaagaga tatagtttta agtaactttt tatagcaatg atacaattgt atgtgtgtat
     2341 tctgagcttc tatgtcccct gagctccttc cagtgaccaa cttgcaggtg ggcccaggcc
     2401 agggctggag aaaaagctct gagacttgtg ggtttctacc ttcaaaattt tggaccaaag
     2461 tttagctttc tgcccgcctc tgactgtgcc cagttgaggg gctgacctct aggccttaat
     2521 gtcctcctgc acagccacct ctatcctagc ctgttcctgt gggaggggtt ccctgcaccc
     2581 tggttctgtg gaaggcgtgg aagagtgtaa atatttatga ttttatacct gtggggctga
     2641 ggcggtgcag cagtttttta tggtgacaga tgtatatttt ggtaacgact acaggctcag
     2701 tattgtcctg gggccagccc tggccacatc taccccatcc cagatggtgt attggggaag
     2761 gggggggggg ctttccatta aagcagtttt ataacctctg tcttccctga gcccttcatt
     2821 ctgagctgta ggccaggctg ggcctggatt caataaacac ctgtgtctta ca
//
