LOCUS       NM_001081211            3660 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus platelet-activating factor receptor (Ptafr), mRNA.
ACCESSION   NM_001081211 XM_357441
VERSION     NM_001081211.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3660)
  AUTHORS   Dalmaso,B., Liber,A.M.P., Ventura,D.F., Jancar,S. and Del
            Debbio,C.B.
  TITLE     Platelet-activating factor receptor (PAFR) regulates neuronal
            maturation and synaptic transmission during postnatal retinal
            development
  JOURNAL   Front Cell Neurosci 18, 1343745 (2024)
   PUBMED   38572071
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3660)
  AUTHORS   Costa,K.A., Lacerda,D.R., Silveira,A.L.M., Martins,L.B.,
            Oliveira,M.C., Rezende,B.M., Menezes-Garcia,Z., Mugge,F.L.B.,
            Silva,A.M., Teixeira,M.M., Rouault,C., Pinho,V., Marcelin,G.,
            Clement,K. and Ferreira,A.V.M.
  TITLE     PAF signaling plays a role in obesity-induced adipose tissue
            remodeling
  JOURNAL   Int J Obes (Lond) 46 (1), 68-76 (2022)
   PUBMED   34493775
REFERENCE   3  (bases 1 to 3660)
  AUTHORS   Tian,Z., Chu,T., Shields,L.B.E., Zhu,Q., Zhang,Y.P., Kong,M.,
            Barnes,G.N., Wang,Y., Shields,C.B. and Cai,J.
  TITLE     Platelet-Activating Factor Deteriorates
            Lysophosphatidylcholine-Induced Demyelination Via Its
            Receptor-Dependent and -Independent Effects
  JOURNAL   Mol Neurobiol 57 (10), 4069-4081 (2020)
   PUBMED   32661728
  REMARK    GeneRIF: Platelet-Activating Factor Deteriorates
            Lysophosphatidylcholine-Induced Demyelination Via Its
            Receptor-Dependent and -Independent Effects.
REFERENCE   4  (bases 1 to 3660)
  AUTHORS   Liu,L., Fahy,K.E., Awoyemi,A.A., Thapa,P., Kelly,L.E., Chen,J.,
            Bihl,J.C., Cool,D.R., Chen,Y., Rapp,C.M., Johnson,R.M. and
            Travers,J.B.
  TITLE     Thermal Burn Injury Generates Bioactive Microvesicles: Evidence for
            a Novel Transport Mechanism for the Lipid Mediator
            Platelet-Activating Factor (PAF) That Involves Subcellular
            Particles and the PAF Receptor
  JOURNAL   J Immunol 205 (1), 193-201 (2020)
   PUBMED   32434939
  REMARK    GeneRIF: Thermal Burn Injury Generates Bioactive Microvesicles:
            Evidence for a Novel Transport Mechanism for the Lipid Mediator
            Platelet-Activating Factor (PAF) That Involves Subcellular
            Particles and the PAF Receptor.
REFERENCE   5  (bases 1 to 3660)
  AUTHORS   Karhausen,J., Choi,H.W., Maddipati,K.R., Mathew,J.P., Ma,Q.,
            Boulaftali,Y., Lee,R.H., Bergmeier,W. and Abraham,S.N.
  TITLE     Platelets trigger perivascular mast cell degranulation to cause
            inflammatory responses and tissue injury
  JOURNAL   Sci Adv 6 (12), eaay6314 (2020)
   PUBMED   32206714
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3660)
  AUTHORS   Ishii,S., Kuwaki,T., Nagase,T., Maki,K., Tashiro,F., Sunaga,S.,
            Cao,W.H., Kume,K., Fukuchi,Y., Ikuta,K., Miyazaki,J., Kumada,M. and
            Shimizu,T.
  TITLE     Impaired anaphylactic responses with intact sensitivity to
            endotoxin in mice lacking a platelet-activating factor receptor
  JOURNAL   J Exp Med 187 (11), 1779-1788 (1998)
   PUBMED   9607919
REFERENCE   7  (bases 1 to 3660)
  AUTHORS   Roudebush,W.E., LaMarche,M.D., Levine,A.S., Jiang,H. and
            Butler,W.J.
  TITLE     Evidence for the presence of the platelet-activating factor
            receptor in the CFW mouse preimplantation two-cell-stage embryo
  JOURNAL   Biol Reprod 57 (3), 575-579 (1997)
   PUBMED   9282993
REFERENCE   8  (bases 1 to 3660)
  AUTHORS   Shinji,H., Akagawa,K.S., Tsuji,M., Maeda,M., Yamada,R.,
            Matsuura,K., Yamamoto,S. and Yoshida,T.
  TITLE     Lipopolysaccharide-induced biphasic inositol 1,4,5-trisphosphate
            response and tyrosine phosphorylation of 140-kilodalton protein in
            mouse peritoneal macrophages
  JOURNAL   J Immunol 158 (3), 1370-1376 (1997)
   PUBMED   9013981
REFERENCE   9  (bases 1 to 3660)
  AUTHORS   Ishii,S., Nagase,T., Tashiro,F., Ikuta,K., Sato,S., Waga,I.,
            Kume,K., Miyazaki,J. and Shimizu,T.
  TITLE     Bronchial hyperreactivity, increased endotoxin lethality and
            melanocytic tumorigenesis in transgenic mice overexpressing
            platelet-activating factor receptor
  JOURNAL   EMBO J 16 (1), 133-142 (1997)
   PUBMED   9009274
REFERENCE   10 (bases 1 to 3660)
  AUTHORS   Ishii,S., Matsuda,Y., Nakamura,M., Waga,I., Kume,K., Izumi,T. and
            Shimizu,T.
  TITLE     A murine platelet-activating factor receptor gene: cloning,
            chromosomal localization and up-regulation of expression by
            lipopolysaccharide in peritoneal resident macrophages
  JOURNAL   Biochem J 314 (Pt 2) (Pt 2), 671-678 (1996)
   PUBMED   8670084
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY194666.1, AK032547.1,
            BY203963.1, CR931794.3 and AA960103.1.
            
            [WARNING] On Apr 26, 2024 this sequence was replaced by
            NM_001081211.3.
            
            On Aug 19, 2015 this sequence version replaced NM_001081211.1.
            
            Summary: This gene encodes a member of the G-protein coupled
            receptor 1 family of proteins. Binding of the encoded protein to
            its phospholipid ligand, platelet-activating factor (PAF), may
            regulate the inflammatory response and the perception of pain.
            Homozygous knockout mice for this gene exhibit impaired
            anaphylactic response, resistance to bacterial infection, and
            reduced pain-related behavior. [provided by RefSeq, Aug 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032547.1, BY194666.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               BY194666.1         2-157
            157-271             AK032547.1         1-115
            272-272             BY203963.1         129-129
            273-751             AK032547.1         117-595
            752-799             CR931794.3         13646-13693
            800-1530            AK032547.1         644-1374
            1531-3219           CR931794.3         14425-16113
            3220-3660           AA960103.1         1-441               c
FEATURES             Location/Qualifiers
     source          1..3660
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 65.56 cM"
     gene            1..3660
                     /gene="Ptafr"
                     /gene_synonym="PAFR"
                     /note="platelet-activating factor receptor"
                     /db_xref="GeneID:19204"
                     /db_xref="MGI:MGI:106066"
     exon            1..208
                     /gene="Ptafr"
                     /gene_synonym="PAFR"
                     /inference="alignment:Splign:2.1.0"
     exon            209..3637
                     /gene="Ptafr"
                     /gene_synonym="PAFR"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1280
                     /gene="Ptafr"
                     /gene_synonym="PAFR"
                     /note="PAF receptor"
                     /codon_start=1
                     /product="platelet-activating factor receptor"
                     /protein_id="NP_001074680.1"
                     /db_xref="CCDS:CCDS38899.1"
                     /db_xref="GeneID:19204"
                     /db_xref="MGI:MGI:106066"
                     /translation="MEHNGSFRVDSEFRYTLFPIVYSVIFILGVVANGYVLWVFANLY
                     PSKKLNEIKIFMVNLTMADLLFLITLPLWIVYYYNEGDWILPNFLCNVAGCLFFINTY
                     CSVAFLGVITYNRYQAVAYPIKTAQATTRKRGISLSLIIWVSIVATASYFLATDSTNL
                     VPNKDGSGNITRCFEHYEPYSVPILVVHVFIAFCFFLVFFLIFYCNLVIIHTLLTQPM
                     RQQRKAGVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQI
                     TLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVIVPANQT
                     PIVSLKN"
     regulatory      3616..3621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ptafr"
                     /gene_synonym="PAFR"
                     /note="hexamer: AATAAA"
     polyA_site      3637
                     /gene="Ptafr"
                     /gene_synonym="PAFR"
                     /note="major polyA site"
ORIGIN      
        1 agtactgagt ctggctggct cagtccgtgt ggaggttcct gtggcatctg gtggaggggc
       61 cctgggtcac tgtgtttcct cccaggggtg acttggcagt gctttgctct gtttcctcac
      121 ttctgcaatt gccaggccac aacacagagg ctcgagctga ggcttggacc aggagggagc
      181 agagcctacg gctgagctcc tcctacaggc atattcagcg ctccatgacc aggtgaccct
      241 tcctgcccag agcaatggag cacaatggct cctttcgtgt ggattctgag tttcgataca
      301 cgctctttcc gattgtttac agtgtcatct ttatactggg ggtggttgcc aacggctatg
      361 tgctatgggt ctttgctaac ttgtaccctt ccaagaaact aaatgagata aagatcttta
      421 tggtgaatct cactatggct gacctgctct tcctgatcac cctcccactg tggattgtct
      481 actactacaa cgagggcgac tggattctac ccaacttcct gtgcaacgtg gctggctgcc
      541 tcttcttcat caatacctac tgcagtgtgg cctttttggg tgtcatcact tataaccgct
      601 accaggcagt agcctatccc atcaagactg cacaggccac cacccgcaag cgtggcatct
      661 ctttgtccct gatcatttgg gtatccattg tggctactgc atcctatttc ctggccacag
      721 actccaccaa cctagtgccc aataaggatg gctcaggcaa catcacccgc tgctttgagc
      781 attatgagcc atacagtgtg cccatccttg ttgttcatgt cttcatcgcc ttctgcttct
      841 tcctcgtctt cttccttatc ttctactgca acttggtcat catccacacg ctgctcacgc
      901 agcccatgag gcagcagcgc aaagcggggg tgaagcggag ggcgctgtgg atggtctgca
      961 cggtcttggc ggtattcatc atctgttttg tgccccatca cgtggtccag ctgccctgga
     1021 ccctagcaga gttgggctac cagaccaact tccatcaggc tattaatgat gcccatcaaa
     1081 tcaccctctg cctcctcagc accaactgtg tcttagatcc cgttatctat tgctttctta
     1141 ccaagaagtt ccgaaagcac ctcagtgaga agttttacag catgcgcagt agccggaagt
     1201 gctccagagc cacgagtgac acgtgcaccg aggtgatagt gccagccaac cagactccta
     1261 ttgtgtcgct gaaaaattaa tctctgctta ttaaagccag atccagagcc ttctcttcaa
     1321 tggacctcac agacggagct aggaggtgga ctgaccctgg tggactcaag tgcggcagtt
     1381 acttcctcgc agagagccgg ttgctggaag atacagaacc tggatgctcc ttttcactag
     1441 tctttgggtc aacgctagag gactgtggct gatggactca cccagagctt cagattgtga
     1501 catccagcta gggtcagacc ttggggagaa acgctaagca gctcagttca tccaactggg
     1561 gcatcaactt aaggtttggt cagtgacttc caggggctac aggaagaggg gagatgggtt
     1621 gtggggattc atcactgatt gtgtggaaga tttttgggga agcaattaag tttcagatgg
     1681 tgccttcctt ggtccatcta taggtacaag gtccttgtga cccttcctag aggaagtggt
     1741 ttggtggtat ctcttgactg acccaagtac ctggcctcaa atgtaaccag aggaataaac
     1801 acagaagttg accagaagct aggatgtgag cgtgtttgct tgaggcagct gagttttgcc
     1861 caggcctgaa tgagtgctga aggaatggaa gagagatggc tacctcaggg cactgcactt
     1921 tccacttccg gcaggcagct tcttatcgag gtcttctggc cacatggtag tgattttttg
     1981 gcaagtgtct cagtcccatc tcactcactg tacccagcct ccctgtcaga aacaactcaa
     2041 ggagggagag atttattttg gctcacagtt tagaagacct cggtccctca tggcaaggaa
     2101 ggcacggtag ggcagctccg actctggtgg tgggaacagg agatggggtg ttcatgtgac
     2161 agtgggccag gaaccaaaga ctgcacctta acccggggat gcgataaaac ccacccccag
     2221 ccaccaactt ctacagccag gacctacctc ctgaaggttc catagtctcc caacacagag
     2281 agcagggcac ggggccagtg agatggtagt gcaaggtagc gagcacttgc agctaacact
     2341 gctgatcagt gtttaatccc aggagccaca tggtacaaag agagaacaga caggccagtc
     2401 gtccttctac ctttactttc ataccatggc acacacatgc cccgcctccc catatacata
     2461 tacatacaaa gttaataaga taaagcaaaa caaatgtgac cccatgaaat atcaggttta
     2521 ttcaaattat gtctgctatt tcgtttacat gagatgccct cttgccctct gagaagtacc
     2581 cagaagctgt agactcagca ctcagaggac cttttcctgt tttcctgagc cttgtgcttt
     2641 tttttttttt tttttttttc tttccctgag acagggtttc tctgtgtagc cctggctgtc
     2701 ctggaactca actttgtaga ccaggctggc ctcgaactca gaaatccacc tgcctctgcc
     2761 tcccgagtgc tgggattaaa ggcgtgcgcc accactgcct ggcgcctttt tcttttcttt
     2821 aaaaagaaaa aacaaagtcc ttccttccag caagtgtctc cttgaagttg ggtcagttga
     2881 tgcctgtctg caagacaggc ataggcttgt tccaataggg caggaatctg cttggattgg
     2941 tgtcatggca gtattgtgga cctggctgaa ggggactaag tagttaagac aacatgcttg
     3001 aactgtgaca tcttacaaag tcaggttcaa gtcttgcctg tgctaaatgc tgttcaggac
     3061 gtgggaattt cattttctac ctcgtagtgt cattagctgg gaggttcaac ctacctcacg
     3121 ggacttctga gcaggcatgt tcagctgaaa tctgggtgac taatcccgaa cctcccctcc
     3181 ctcggccctt tgataggaac tgaagagggg ccagggttgg acatctggat ttgggatgca
     3241 cctctcaggg agctgtggcc gtgtctacat gtgaagtggg ttgggtggcc acctaggtga
     3301 ctggcagaca agtggctttt caaagaaagc agatgtgtta ggctaagcag aggttggaga
     3361 gaaacaagaa cttggcgaga agacacagct tccaaggggc cagagggacc aagtgctttc
     3421 tcctgagtcc tgggaggttc tcttgtcagg attccttctc tttccttcct taagctcatt
     3481 ggaatgggtg tctagtgctc tcaatgaaat aacattctct gtttctatgt taatatggta
     3541 tattctgaat ttcatcatat gcatatctcc cttgccattg gtttgcaata tccatgtacc
     3601 atagtatgtt tacttaataa acatttttct cttctaaaaa aaaaaaaaaa aaaaaaaaaa
//
