LOCUS       NM_013831               3138 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus proline-serine-threonine phosphatase-interacting
            protein 2 (Pstpip2), mRNA.
ACCESSION   NM_013831 XM_357037
VERSION     NM_013831.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3138)
  AUTHORS   Pavliuchenko,N., Kuzmina,M., Danek,P., Spoutil,F., Prochazka,J.,
            Skopcova,T., Pokorna,J., Sedlacek,R., Alberich-Jorda,M. and
            Brdicka,T.
  TITLE     Genetic background affects neutrophil activity and determines the
            severity of autoinflammatory osteomyelitis in mice
  JOURNAL   J Leukoc Biol 117 (1) (2024)
   PUBMED   39120532
REFERENCE   2  (bases 1 to 3138)
  AUTHORS   Xu,C., Wang,Q., Du,C., Chen,L., Zhou,Z., Zhang,Z., Cai,N., Li,J.,
            Huang,C. and Ma,T.
  TITLE     Histone deacetylase-mediated silencing of PSTPIP2 expression
            contributes to aristolochic acid nephropathy-induced PANoptosis
  JOURNAL   Br J Pharmacol 181 (9), 1452-1473 (2024)
   PUBMED   38073114
  REMARK    GeneRIF: Histone deacetylase-mediated silencing of PSTPIP2
            expression contributes to aristolochic acid nephropathy-induced
            PANoptosis.
REFERENCE   3  (bases 1 to 3138)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3138)
  AUTHORS   Burocziova,M., Grusanovic,S., Vanickova,K., Kosanovic,S. and
            Alberich-Jorda,M.
  TITLE     Chronic inflammation promotes cancer progression as a second hit
  JOURNAL   Exp Hematol 128, 30-37 (2023)
   PUBMED   37709251
REFERENCE   5  (bases 1 to 3138)
  AUTHORS   Xu,J. and Lv,H.
  TITLE     PSTPIP2 alleviates obesity associated adipose tissue inflammation
            and insulin resistance in diabetes mice through promoting M2
            macrophage polarization via activation of PPARgamma
  JOURNAL   J Diabetes Complications 37 (6), 108479 (2023)
   PUBMED   37150118
  REMARK    GeneRIF: PSTPIP2 alleviates obesity associated adipose tissue
            inflammation and insulin resistance in diabetes mice through
            promoting M2 macrophage polarization via activation of PPARgamma.
REFERENCE   6  (bases 1 to 3138)
  AUTHORS   Rogers,M.S., Rohan,R.M., Birsner,A.E. and D'Amato,R.J.
  TITLE     Genetic loci that control the angiogenic response to basic
            fibroblast growth factor
  JOURNAL   FASEB J 18 (10), 1050-1059 (2004)
   PUBMED   15226265
  REMARK    Erratum:[FASEB J. 2015 Jan;29(1):354-5]
REFERENCE   7  (bases 1 to 3138)
  AUTHORS   Hentunen,T.A., Choi,S.J., Boyce,B.F., Dallas,M.R., Dallas,S.L.,
            Shen-Ong,G.L. and Roodman,G.D.
  TITLE     A murine model of inflammatory bone disease
  JOURNAL   Bone 26 (2), 183-188 (2000)
   PUBMED   10678414
REFERENCE   8  (bases 1 to 3138)
  AUTHORS   Yeung,Y.G., Soldera,S. and Stanley,E.R.
  TITLE     A novel macrophage actin-associated protein (MAYP) is
            tyrosine-phosphorylated following colony stimulating factor-1
            stimulation
  JOURNAL   J Biol Chem 273 (46), 30638-30642 (1998)
   PUBMED   9804836
REFERENCE   9  (bases 1 to 3138)
  AUTHORS   Wu,Y., Dowbenko,D. and Lasky,L.A.
  TITLE     PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated
            protein that binds a PEST-type protein-tyrosine phosphatase
  JOURNAL   J Biol Chem 273 (46), 30487-30496 (1998)
   PUBMED   9804817
REFERENCE   10 (bases 1 to 3138)
  AUTHORS   Byrd,L., Grossmann,M., Potter,M. and Shen-Ong,G.L.
  TITLE     Chronic multifocal osteomyelitis, a new recessive mutation on
            chromosome 18 of the mouse
  JOURNAL   Genomics 11 (4), 794-798 (1991)
   PUBMED   1686018
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY194204.1, AK157994.1, AC157649.4 and AK132418.1.
            
            On Mar 2, 2007 this sequence version replaced NM_013831.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132418.1, AK154724.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               BY194204.1         7-207
            202-1311            AK157994.1         186-1295
            1312-1817           AC157649.4         35941-36446
            1818-3138           AK132418.1         1800-3120
FEATURES             Location/Qualifiers
     source          1..3138
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 52.38 cM"
     gene            1..3138
                     /gene="Pstpip2"
                     /gene_synonym="cmo; MAYP"
                     /note="proline-serine-threonine phosphatase-interacting
                     protein 2"
                     /db_xref="GeneID:19201"
                     /db_xref="MGI:MGI:1335088"
     exon            1..201
                     /gene="Pstpip2"
                     /gene_synonym="cmo; MAYP"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1173
                     /gene="Pstpip2"
                     /gene_synonym="cmo; MAYP"
                     /note="pp37; PEST phosphatase-interacting protein 2;
                     macrophage actin-associated tyrosine-phosphorylated
                     protein"
                     /codon_start=1
                     /product="proline-serine-threonine phosphatase-interacting
                     protein 2"
                     /protein_id="NP_038859.3"
                     /db_xref="CCDS:CCDS37868.1"
                     /db_xref="GeneID:19201"
                     /db_xref="MGI:MGI:1335088"
                     /translation="MTGSLFKGNFWSTDILSTIGYDSIIQHLNNGRKNCKEFEDFLKE
                     RASIEEKYGKDLLNLSRKKPCGQSEINTLKRALEVFKQQVDNVAQCHIQLAQTLREEA
                     RKMEEFREKQKLQRKKTETIMDAAHKQRNAQFKKAMDAKKNYEQKCRDKDEAEQAVHR
                     SANVANQRQQEKLFVKLATSKTAVEDSDKAYMLHINMLEKVREDWQSEHIKACEVFEA
                     QECERINFFRNALWLHLNQLSQQCVANDEMYEQVRKSLETCSIEKDIQYFVNQRKTGQ
                     TPPAPIMYENFYSPQRNAAPPGKTTGPNPARRGPLPVPKRIPDDPDYSVVEDYSLLYQ
                     "
     exon            202..302
                     /gene="Pstpip2"
                     /gene_synonym="cmo; MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            303..380
                     /gene="Pstpip2"
                     /gene_synonym="cmo; MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            381..415
                     /gene="Pstpip2"
                     /gene_synonym="cmo; MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            416..522
                     /gene="Pstpip2"
                     /gene_synonym="cmo; MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            523..585
                     /gene="Pstpip2"
                     /gene_synonym="cmo; MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            586..684
                     /gene="Pstpip2"
                     /gene_synonym="cmo; MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            685..730
                     /gene="Pstpip2"
                     /gene_synonym="cmo; MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            731..810
                     /gene="Pstpip2"
                     /gene_synonym="cmo; MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            811..909
                     /gene="Pstpip2"
                     /gene_synonym="cmo; MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1006
                     /gene="Pstpip2"
                     /gene_synonym="cmo; MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1088
                     /gene="Pstpip2"
                     /gene_synonym="cmo; MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1123
                     /gene="Pstpip2"
                     /gene_synonym="cmo; MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1184
                     /gene="Pstpip2"
                     /gene_synonym="cmo; MAYP"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..3138
                     /gene="Pstpip2"
                     /gene_synonym="cmo; MAYP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2114..2119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pstpip2"
                     /gene_synonym="cmo; MAYP"
                     /note="hexamer: AATAAA"
     polyA_site      2134
                     /gene="Pstpip2"
                     /gene_synonym="cmo; MAYP"
                     /note="major polyA site"
     regulatory      2172..2177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pstpip2"
                     /gene_synonym="cmo; MAYP"
                     /note="hexamer: AATAAA"
     polyA_site      2199
                     /gene="Pstpip2"
                     /gene_synonym="cmo; MAYP"
ORIGIN      
        1 ggcttcccgg ggtgacagtg gaactccaaa gttgcgctgg accttggccc tgacagtctg
       61 agctctcggc gcgatccggc cgtcctcccg ctgtcctccc gctgtccgcc gtcctcagcc
      121 gccttccgtc ctccgctccc agccctgcgc tcacaaccca gcgccggcat gacgggctcg
      181 ctgttcaagg ggaacttctg gagcacggac attctcagca ccattggcta cgacagcatt
      241 atccagcacc tgaacaatgg ccgtaagaac tgcaaggagt ttgaagactt tttgaaagaa
      301 agagcatcaa ttgaagagaa atatggcaaa gacctgctga acctctccag gaagaagccg
      361 tgtggacagt ctgagatcaa taccttgaag agagcccttg aggtcttcaa gcagcaagta
      421 gacaacgtgg ctcaatgtca cattcagctt gcgcagactc taagagaaga ggccaggaag
      481 atggaagaat tccgggaaaa gcagaagctg cagcggaaaa agacagaaac aataatggat
      541 gctgcccaca agcaaaggaa cgcacagttc aagaaagcca tggatgccaa gaagaattat
      601 gagcaaaagt gccgggacaa ggatgaggca gagcaagctg tccaccgcag cgccaatgtg
      661 gccaaccaac ggcaacaaga aaagcttttt gtgaaactgg ccacttcaaa gactgcagta
      721 gaggattcag acaaagcgta catgttgcac atcaacatgc tggagaaggt tcgagaagac
      781 tggcagagtg aacacattaa ggcctgcgag gtgttcgagg ctcaggaatg tgaacgaatc
      841 aacttcttcc ggaatgcact gtggttgcat ctgaatcagc tgtcacaaca atgtgtcgca
      901 aatgacgaga tgtatgagca agtccgtaag agtttagaaa catgcagcat tgagaaggac
      961 atccagtatt ttgtgaacca gcggaaaact ggacagactc ccccagcacc catcatgtat
     1021 gagaacttct actctcctca gcggaatgct gccccaccag gaaagactac agggcccaat
     1081 ccagcaagga gaggacctct ccctgtccct aagcggatac cagatgatcc tgattactct
     1141 gtggttgaag attacagttt gctctatcag tgacgtcaga ggtgaaaaga aagctttcct
     1201 cagctactgc ttctgtgaca tgatgtgaga tccagagagc agcagtccat aaccaaatcg
     1261 cgtcgatcat gaagactttg atgtgaatcc ttgttgaaaa attgtttttt ttgatatttt
     1321 aaatttatag tatacatttg actcaaccta gtcgagtaga gttctgcaga gtcccccttt
     1381 tttccccctc agagagttta catactgctc cagaaggaag aattattatt ttctggctag
     1441 ctactaaggt tgtgagtgtt gtttcctgtc ggggaagcag agccactctg gatcctaagc
     1501 gttggcttga gcagagctgc ggaggtggct ccagtttcca aagatgctcc gtgggctgtg
     1561 ggaaggaggc ccgggggaac gggcaccctc tctcagtggt gcagcgttta aaactacctt
     1621 tgttcttagc tggaagctgt agaagcatct gattggactt gctcattttc acagatggga
     1681 aagtgagacc cagcagggtg agatcagttt ccttacaatt ctgatggcca atgagaggca
     1741 gaaccagagc tagagcacaa ctttctggca cagggctgtt ctagccgttt gtgtggctgc
     1801 catgctcctg tgggctgaat gagggtgtaa agattctgtg caagcctgat ggcccgtgtt
     1861 ccatccctgg gacccacaca tgtgtggggt tcctctggcc tccacacatg tgcatagcag
     1921 tgactgacac atgcacaggc agacagacac acagacatac acagacacac acatacacca
     1981 tgcacacata gagaccacac cacaaacaca cacacagaca cacacacaca tacagacaca
     2041 catacacaca cacatacaca cacatacaaa cacacattta aaaaggatat ttggctaaca
     2101 ttttttttca gtgaataaaa tgactggaat ttaagtgtca gaattatttt tacaaaaaat
     2161 gcaatgttct gaataaacca caaaggagag agatcttaat ctgtgaggcc ctggattgta
     2221 aagtacactc ttgtttgtat ctaggaagat atgatgggag ctgccgacta agttgtggca
     2281 gtctgtagat ggccaactcc atttgattct gagacaggaa agttgaaaaa aaaattagat
     2341 tcaaagagat atgttatttt aatgattcct caaaaggatt taggattttt taaagcccat
     2401 attcaatctc aaatctttac agaaagtctc cttctgctgt gctctggaac ctttaaaggg
     2461 tcatgttcac ggcagggaaa tcatgcacta tgtacccggt gttttacacc caagaaattg
     2521 gacattgtag ttaggacaaa gtctgtggca agacttctga ttggcatgtt gtaaatgtct
     2581 gtgccacttc aaaggacaat cacattcttt tcctctgtgc tatagctttt ccaggacttt
     2641 ggacaaattg attaaaataa gattgaaacc ctgtgcatgg gagtgcctgc ccgtaatgcc
     2701 agcatgctgg aggctgagac agggggattg tgagtctgag actggcctgg atacatagtg
     2761 agaagccatc tcaacccctt ccctacccaa agatcagcta tttcccctct ttcaatgtag
     2821 gacgcacccg gccgtggcag cctcgtggcc accttgtggc atgacaggaa atttgcacca
     2881 gctgggcatc cttttaagaa actcaggttt gcaaaggtcc atggacttcc ccaaactgga
     2941 gagcctcagg aaattgtcta ttggacatag aacattctct ttctaagtat attatttatt
     3001 gttggtcttc aatgatttct gttttctatc aatcagcata gctgatgtaa acgtgtttta
     3061 tgagtgtaaa ataatattaa ttttatggct ttttttcctg cttgacatga agtaaaataa
     3121 aagtttgtga tgatttgg
//
