LOCUS       NM_011193               1851 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus proline-serine-threonine phosphatase-interacting
            protein 1 (Pstpip1), transcript variant 1, mRNA.
ACCESSION   NM_011193
VERSION     NM_011193.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1851)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1851)
  AUTHORS   Sztacho,M., Segeletz,S., Sanchez-Fernandez,M.A., Czupalla,C.,
            Niehage,C. and Hoflack,B.
  TITLE     BAR Proteins PSTPIP1/2 Regulate Podosome Dynamics and the
            Resorption Activity of Osteoclasts
  JOURNAL   PLoS One 11 (10), e0164829 (2016)
   PUBMED   27760174
  REMARK    GeneRIF: a new PSTPIP1/PTPN6/SHIP1/2-dependent negative feedback
            mechanism that counterbalances Src and PI(3,4,5)P3 signalling to
            control osteoclast cell polarity and activity during bone
            resorption
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1851)
  AUTHORS   Wang,D., Hoing,S., Patterson,H.C., Ahmad,U.M., Rathinam,V.A.,
            Rajewsky,K., Fitzgerald,K.A. and Golenbock,D.T.
  TITLE     Inflammation in mice ectopically expressing human Pyogenic
            Arthritis, Pyoderma Gangrenosum, and Acne (PAPA)
            Syndrome-associated PSTPIP1 A230T mutant proteins
  JOURNAL   J Biol Chem 288 (7), 4594-4601 (2013)
   PUBMED   23293022
  REMARK    GeneRIF: analysis of inflammation in mice ectopically expressing
            human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA)
            Syndrome-associated PSTPIP1 A230T mutant proteins
REFERENCE   4  (bases 1 to 1851)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   5  (bases 1 to 1851)
  AUTHORS   Cooper,K.M., Bennin,D.A. and Huttenlocher,A.
  TITLE     The PCH family member proline-serine-threonine
            phosphatase-interacting protein 1 targets to the leukocyte uropod
            and regulates directed cell migration
  JOURNAL   Mol Biol Cell 19 (8), 3180-3191 (2008)
   PUBMED   18480402
  REMARK    GeneRIF: PSTPIP1 is a novel component of the leukocyte uropod that
            regulates endocytosis and cell migration
REFERENCE   6  (bases 1 to 1851)
  AUTHORS   Cong,F., Spencer,S., Cote,J.F., Wu,Y., Tremblay,M.L., Lasky,L.A.
            and Goff,S.P.
  TITLE     Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine
            phosphatase to the c-Abl kinase to mediate Abl dephosphorylation
  JOURNAL   Mol Cell 6 (6), 1413-1423 (2000)
   PUBMED   11163214
REFERENCE   7  (bases 1 to 1851)
  AUTHORS   Hotfilder,M., Baxendale,S., Cross,M.A. and Sablitzky,F.
  TITLE     Def-2, -3, -6 and -8, novel mouse genes differentially expressed in
            the haemopoietic system
  JOURNAL   Br J Haematol 106 (2), 335-344 (1999)
   PUBMED   10460589
REFERENCE   8  (bases 1 to 1851)
  AUTHORS   Wu,Y., Dowbenko,D. and Lasky,L.A.
  TITLE     PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated
            protein that binds a PEST-type protein-tyrosine phosphatase
  JOURNAL   J Biol Chem 273 (46), 30487-30496 (1998)
   PUBMED   9804817
REFERENCE   9  (bases 1 to 1851)
  AUTHORS   Wu,Y., Spencer,S.D. and Lasky,L.A.
  TITLE     Tyrosine phosphorylation regulates the SH3-mediated binding of the
            Wiskott-Aldrich syndrome protein to PSTPIP, a
            cytoskeletal-associated protein
  JOURNAL   J Biol Chem 273 (10), 5765-5770 (1998)
   PUBMED   9488710
REFERENCE   10 (bases 1 to 1851)
  AUTHORS   Spencer,S., Dowbenko,D., Cheng,J., Li,W., Brush,J., Utzig,S.,
            Simanis,V. and Lasky,L.A.
  TITLE     PSTPIP: a tyrosine phosphorylated cleavage furrow-associated
            protein that is a substrate for a PEST tyrosine phosphatase
  JOURNAL   J Cell Biol 138 (4), 845-860 (1997)
   PUBMED   9265651
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158999.2.
            
            On Jan 6, 2017 this sequence version replaced NM_011193.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096761.1, U87814.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-469               AC158999.2         102357-102825       c
            470-570             AC158999.2         78471-78571         c
            571-645             AC158999.2         77664-77738         c
            646-680             AC158999.2         72466-72500         c
            681-787             AC158999.2         72148-72254         c
            788-850             AC158999.2         69980-70042         c
            851-949             AC158999.2         69441-69539         c
            950-995             AC158999.2         69008-69053         c
            996-1075            AC158999.2         68128-68207         c
            1076-1174           AC158999.2         67579-67677         c
            1175-1271           AC158999.2         66778-66874         c
            1272-1362           AC158999.2         66129-66219         c
            1363-1415           AC158999.2         65264-65316         c
            1416-1549           AC158999.2         64941-65074         c
            1550-1851           AC158999.2         63911-64212         c
FEATURES             Location/Qualifiers
     source          1..1851
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 30.13 cM"
     gene            1..1851
                     /gene="Pstpip1"
                     /gene_synonym="CD2BP1; def-2"
                     /note="proline-serine-threonine phosphatase-interacting
                     protein 1"
                     /db_xref="GeneID:19200"
                     /db_xref="MGI:MGI:1321396"
     exon            1..469
                     /gene="Pstpip1"
                     /gene_synonym="CD2BP1; def-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             434..1681
                     /gene="Pstpip1"
                     /gene_synonym="CD2BP1; def-2"
                     /note="isoform 1 is encoded by transcript variant 1; PEST
                     phosphatase-interacting protein 1"
                     /codon_start=1
                     /product="proline-serine-threonine phosphatase-interacting
                     protein 1 isoform 1"
                     /protein_id="NP_035323.2"
                     /db_xref="CCDS:CCDS40645.1"
                     /db_xref="GeneID:19200"
                     /db_xref="MGI:MGI:1321396"
                     /translation="MMAQLQFRDAFWCRDFTAHTGYEVLLQRLLDGRKMCKDVEELLR
                     QRAQAEERYGKELVQIARKAGGQTEMNSLRTSFDSLKQQTENVGSAHIQLALALREEL
                     RSLEEFRERQKEQRKKYEAIMDRVQKSKLSLYKKTMESKKAYDQKCRDADDAEQAFER
                     VSANGHQKQVEKSQNKAKQCKESATEAERVYRQNIEQLERARTEWEQEHRTTCEAFQL
                     QEFDRLTILRNALWVHCNQLSMQCVKDDELYEEVRLTLEGCDVEGDINGFIQSKSTGR
                     EPPAPVPYQNYYDREVTPLIGSPSVQPSCGVIKRFSGLLHGSPKTTPSAPAASTETLT
                     PTPERNELVYASIEVQATQGNLNSSAQDYRALYDYTAQNSDELDISAGDILAVILEGE
                     DGWWTVERNGQRGFVPGSYLEKL"
     exon            470..570
                     /gene="Pstpip1"
                     /gene_synonym="CD2BP1; def-2"
                     /inference="alignment:Splign:2.1.0"
     exon            571..645
                     /gene="Pstpip1"
                     /gene_synonym="CD2BP1; def-2"
                     /inference="alignment:Splign:2.1.0"
     exon            646..680
                     /gene="Pstpip1"
                     /gene_synonym="CD2BP1; def-2"
                     /inference="alignment:Splign:2.1.0"
     exon            681..787
                     /gene="Pstpip1"
                     /gene_synonym="CD2BP1; def-2"
                     /inference="alignment:Splign:2.1.0"
     exon            788..850
                     /gene="Pstpip1"
                     /gene_synonym="CD2BP1; def-2"
                     /inference="alignment:Splign:2.1.0"
     exon            851..949
                     /gene="Pstpip1"
                     /gene_synonym="CD2BP1; def-2"
                     /inference="alignment:Splign:2.1.0"
     exon            950..995
                     /gene="Pstpip1"
                     /gene_synonym="CD2BP1; def-2"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1075
                     /gene="Pstpip1"
                     /gene_synonym="CD2BP1; def-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1174
                     /gene="Pstpip1"
                     /gene_synonym="CD2BP1; def-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1271
                     /gene="Pstpip1"
                     /gene_synonym="CD2BP1; def-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1362
                     /gene="Pstpip1"
                     /gene_synonym="CD2BP1; def-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1415
                     /gene="Pstpip1"
                     /gene_synonym="CD2BP1; def-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1549
                     /gene="Pstpip1"
                     /gene_synonym="CD2BP1; def-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1851
                     /gene="Pstpip1"
                     /gene_synonym="CD2BP1; def-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1818..1823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pstpip1"
                     /gene_synonym="CD2BP1; def-2"
                     /note="hexamer: AATAAA"
     polyA_site      1847
                     /gene="Pstpip1"
                     /gene_synonym="CD2BP1; def-2"
                     /note="major polyA site"
ORIGIN      
        1 aaaccttcct gtgccggcct caggctgcct gcctgcctgc ctggcctgtg cacatccttc
       61 ctctctccca gcctctgcct gccacctggg ctgcctgccc tgggcctcag cctgcgtcct
      121 cctccatcag tggggctggc gagagcctag gctggaaatc gtggcccacc cttccatcac
      181 tgggcagggc tccttcctca tttcgctgct gattctagcc ccaaacaaaa caggttgagc
      241 ctttttcctc ctccggcagt tgcctctggc ttgtggctgc cttctgagcg tttcagacgg
      301 cgccggctgg gagtgggagg gagggcctgg gctagccgcg ctgggactgg gacgtgctcc
      361 tggctcctgg cccatgttca gccctgcttg aagcaggagt gctagcattt gacacaacag
      421 acgcccttgg aggatgatgg cccagctgca gttccgagat gccttctggt gcagggactt
      481 cacggcccac acagggtatg aggtgctact gcagaggctg ctggacggca ggaagatgtg
      541 caaggatgtg gaggagctgc tcagacagag ggcccaggcg gaggagaggt acgggaagga
      601 gctggtgcag attgcacgca aggctggtgg ccagacagag atgaattccc tgaggacctc
      661 ctttgactcc ctgaagcagc aaacagagaa tgtgggcagt gcacacatcc agctggccct
      721 ggccctgcgt gaggagctgc ggagcctgga ggagttccga gagagacaga aagagcagcg
      781 gaagaagtat gaggccatca tggaccgtgt ccagaagagc aagttgtcgc tctacaagaa
      841 gaccatggag tccaagaagg catatgacca gaagtgcagg gatgcagatg atgctgagca
      901 ggccttcgag cgtgtgagtg ccaatggcca ccagaagcaa gtagaaaaga gccagaacaa
      961 agccaagcag tgcaaggagt cagccacaga ggcagaaaga gtgtacaggc aaaatatcga
     1021 acaactggag agagcgagga ccgagtggga gcaggagcac cggactacct gtgaggcctt
     1081 ccagttgcag gagtttgacc ggctcaccat cctccgcaat gccctgtggg tgcactgtaa
     1141 ccagctctcc atgcagtgtg tcaaggatga tgagctctat gaggaagtgc ggctgaccct
     1201 tgagggctgt gatgtggaag gtgacatcaa tggcttcatc cagtccaaga gcactggcag
     1261 agagccccca gctccggtgc cttatcagaa ctactatgac agggaggtga ccccactgat
     1321 tggcagccct agcgtccagc cctcctgtgg tgtgataaag aggttctctg ggctgctaca
     1381 tggaagtccc aagaccacac cttctgctcc tgctgcttcc acagagactc tgactcccac
     1441 ccctgagcgg aatgagttgg tctacgcatc catcgaagtg caggcgaccc agggaaacct
     1501 taactcatca gcccaggact accgggcact ctacgactac accgcacaga attctgatga
     1561 gctggacatt tccgcgggag acatcctggc ggtcatcctg gaaggggagg atggctggtg
     1621 gactgtggag cggaacggac aacgtggctt tgtccctggg tcgtacttgg agaagctctg
     1681 aggaaaggct agcagtctcc acatacctcc gccctgactg tgaggtcagg actgtttctt
     1741 tccatcaccg cccaggcctc acggggccag aaccaagccc ggtggtgctg ggaatgggct
     1801 gggtgctggc tactctcaat aaatgtctcc cagaaggagt aaagcggcac a
//
