LOCUS       NM_001039534            1130 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus phosphoseryl-tRNA kinase (Pstk), transcript variant 1,
            mRNA.
ACCESSION   NM_001039534
VERSION     NM_001039534.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1130)
  AUTHORS   Zheng,D., Zhao,Y., Liu,L., Sun,X., Xia,Y., Sun,L. and Xie,K.
  TITLE     Differential expression profile analysis of PSTK-regulated mRNAs in
            podocytes
  JOURNAL   J Cell Biochem 120 (6), 8935-8948 (2019)
   PUBMED   28419530
  REMARK    GeneRIF: Study identified a set of candidate genes that are
            putatively regulated by PSTK in podocytes.
REFERENCE   2  (bases 1 to 1130)
  AUTHORS   Ye,J., Beetz,N., O'Keeffe,S., Tapia,J.C., Macpherson,L., Chen,W.V.,
            Bassel-Duby,R., Olson,E.N. and Maniatis,T.
  TITLE     hnRNP U protein is required for normal pre-mRNA splicing and
            postnatal heart development and function
  JOURNAL   Proc Natl Acad Sci U S A 112 (23), E3020-E3029 (2015)
   PUBMED   26039991
REFERENCE   3  (bases 1 to 1130)
  AUTHORS   Zheng,D., Li,C., Wang,S., Cang,Y., Song,Y., Liu,X., Li,X.,
            Mohan,C., Wu,T., Hu,D. and Peng,A.
  TITLE     PSTK is a novel gene associated with early lung injury in Paraquat
            Poisoning
  JOURNAL   Life Sci 123, 9-17 (2015)
   PUBMED   25592138
  REMARK    GeneRIF: PSTK is a novel gene associated with early lung injury in
            Paraquat Poisoning.
REFERENCE   4  (bases 1 to 1130)
  AUTHORS   Carlson,B.A., Xu,X.M., Kryukov,G.V., Rao,M., Berry,M.J.,
            Gladyshev,V.N. and Hatfield,D.L.
  TITLE     Identification and characterization of phosphoseryl-tRNA[Ser]Sec
            kinase
  JOURNAL   Proc Natl Acad Sci U S A 101 (35), 12848-12853 (2004)
   PUBMED   15317934
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK077585.1, AI173292.1, AV333054.1 and AU255311.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110381.1, SRR5189685.214915.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-814               AK077585.1         2-815
            815-963             AI173292.1         311-459
            964-1049            AV333054.1         36-121
            1050-1130           AU255311.1         68-148
FEATURES             Location/Qualifiers
     source          1..1130
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 73.94 cM"
     gene            1..1130
                     /gene="Pstk"
                     /gene_synonym="5430423O14Rik; 5730458D16Rik; Gm1099"
                     /note="phosphoseryl-tRNA kinase"
                     /db_xref="GeneID:214580"
                     /db_xref="MGI:MGI:2685945"
     exon            1..244
                     /gene="Pstk"
                     /gene_synonym="5430423O14Rik; 5730458D16Rik; Gm1099"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1108
                     /gene="Pstk"
                     /gene_synonym="5430423O14Rik; 5730458D16Rik; Gm1099"
                     /EC_number="2.7.1.164"
                     /note="isoform 1 is encoded by transcript variant 1;
                     L-seryl-tRNA(Sec) kinase; O-phosphoseryl-tRNA(Sec) kinase"
                     /codon_start=1
                     /product="L-seryl-tRNA(Sec) kinase isoform 1"
                     /protein_id="NP_001034623.1"
                     /db_xref="CCDS:CCDS21914.1"
                     /db_xref="GeneID:214580"
                     /db_xref="MGI:MGI:2685945"
                     /translation="MKTAAARGATRRDGQPKLGLCVLCGLPAAGKSTFARALALRLRR
                     ERGWAVGVLSYDDVLPLALPDCDGTQPRPSQWKMFRQELLKHLECFLVAVISGAQMSA
                     PPNRTEAVWEDFITCLKSQDLMIFPTALEAQPCHLLAKPAVSRPLFLVLDDNFYYQSM
                     RYEVYQLARKYSLGFCQLFLDCPLETCLKRNGERSQPLPDETIQLMGRKIEKPNPEKN
                     AWEHNSLIIQSSACSLEASLEVTGLLLTALENPIKCVEDNTEQKETDRIICSTNILHK
                     ADETLRRTVSQTMREAKDEQIPLNNLKHLAEELNKLKADVLEDLRQGNRKYLCFQQTT
                     DLSDIISSFCKERDTIVQKYFSKQH"
     exon            245..539
                     /gene="Pstk"
                     /gene_synonym="5430423O14Rik; 5730458D16Rik; Gm1099"
                     /inference="alignment:Splign:2.1.0"
     exon            540..738
                     /gene="Pstk"
                     /gene_synonym="5430423O14Rik; 5730458D16Rik; Gm1099"
                     /inference="alignment:Splign:2.1.0"
     exon            739..814
                     /gene="Pstk"
                     /gene_synonym="5430423O14Rik; 5730458D16Rik; Gm1099"
                     /inference="alignment:Splign:2.1.0"
     exon            815..908
                     /gene="Pstk"
                     /gene_synonym="5430423O14Rik; 5730458D16Rik; Gm1099"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1130
                     /gene="Pstk"
                     /gene_synonym="5430423O14Rik; 5730458D16Rik; Gm1099"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1104..1109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pstk"
                     /gene_synonym="5430423O14Rik; 5730458D16Rik; Gm1099"
                     /note="hexamer: ATTAAA"
     polyA_site      1130
                     /gene="Pstk"
                     /gene_synonym="5430423O14Rik; 5730458D16Rik; Gm1099"
                     /note="major polyA site"
ORIGIN      
        1 aaaggtttct ggagactgca gcaagggcat gaagaccgcg gcggctcgtg gggccactcg
       61 cagagacgga cagcccaaac taggactgtg cgtcctctgc ggcttgccgg cggccggaaa
      121 gtcgactttt gcacgtgcgc tggccctccg cctgcggcgg gagcggggtt gggccgtggg
      181 cgtcctctcc tacgacgatg tgctgcctct tgcgctcccg gactgcgatg gcacacagcc
      241 tcggccatcc cagtggaaaa tgttccgaca agaactgtta aagcacctgg aatgcttcct
      301 cgtggcggtc attagtgggg ctcagatgtc tgccccaccc aacaggactg aggccgtgtg
      361 ggaagacttc ataacctgct taaaaagtca ggatttgatg atctttccta cagcactaga
      421 ggcccagcct tgccacctct tggcaaaacc tgctgtttct agacctttgt ttttggtgtt
      481 agatgacaac ttttattacc aaagtatgag atatgaagtc taccaactgg ctcggaaata
      541 ttcgctaggc ttttgccagc tctttttaga ctgtcccctg gagacatgtt tgaagaggaa
      601 tggtgagagg tcccagccac tgcctgacga gaccatccag ctcatgggga gaaagataga
      661 gaagcccaac cctgagaaaa atgcctggga acacaacagc ctcataattc agagttcagc
      721 atgttctctg gaagccagcc tggaggtgac tggtttgttg cttactgcat tggaaaatcc
      781 cataaaatgt gttgaggata atacagaaca aaaggaaact gacagaatta tctgttctac
      841 taacatcctt cataaagctg atgagacact ccgaagaact gtctctcaga cgatgaggga
      901 agccaaagat gaacaaatac ctcttaataa cttgaagcat ctagcagaag aacttaacaa
      961 gctcaaagca gatgttttgg aagatctaag acaaggaaat agaaaatatc tgtgctttca
     1021 gcaaaccact gacttatcag atattatttc ttctttttgt aaggagagag atactattgt
     1081 gcagaagtat ttttcaaagc aacattaaac tttctgaatt tctagtcaaa
//
