LOCUS       NM_019976               1739 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus proline/serine-rich coiled-coil 1 (Psrc1), transcript
            variant 2, mRNA.
ACCESSION   NM_019976
VERSION     NM_019976.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1739)
  AUTHORS   Pan,H., Guo,Z., Lv,P., Hu,K., Wu,T., Lin,Z., Xue,Y., Zhang,Y. and
            Guo,Z.
  TITLE     Proline/serine-rich coiled-coil protein 1 inhibits macrophage
            inflammation and delays atherosclerotic progression by binding to
            Annexin A2
  JOURNAL   Clin Transl Med 13 (3), e1220 (2023)
   PUBMED   36932468
  REMARK    GeneRIF: Proline/serine-rich coiled-coil protein 1 inhibits
            macrophage inflammation and delays atherosclerotic progression by
            binding to Annexin A2.
REFERENCE   2  (bases 1 to 1739)
  AUTHORS   Comerford,S.A., Hinnant,E.A., Chen,Y. and Hammer,R.E.
  TITLE     Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed
            bile duct development and loss of hepatocyte viability; a
            ribosomopathy-like phenotype that is partially p53-dependent
  JOURNAL   PLoS Genet 19 (1), e1010595 (2023)
   PUBMED   36656901
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1739)
  AUTHORS   Luo,T., Liu,D., Guo,Z., Chen,P., Guo,Z., Ou,C. and Chen,M.
  TITLE     Deficiency of proline/serine-rich coiled-coil protein 1 (PSRC1)
            accelerates trimethylamine N-oxide-induced atherosclerosis in
            ApoE-/- mice
  JOURNAL   J Mol Cell Cardiol 170, 60-74 (2022)
   PUBMED   35690006
  REMARK    GeneRIF: Deficiency of proline/serine-rich coiled-coil protein 1
            (PSRC1) accelerates trimethylamine N-oxide-induced atherosclerosis
            in ApoE(-/-) mice.
REFERENCE   4  (bases 1 to 1739)
  AUTHORS   Luo,T., Guo,Z., Liu,D., Guo,Z., Wu,Q., Li,Q., Lin,R., Chen,P.,
            Ou,C. and Chen,M.
  TITLE     Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO
            production via manipulating gut microbiota and flavin monooxygenase
            3
  JOURNAL   Gut Microbes 14 (1), 2077602 (2022)
   PUBMED   35613310
  REMARK    GeneRIF: Deficiency of PSRC1 accelerates atherosclerosis by
            increasing TMAO production via manipulating gut microbiota and
            flavin monooxygenase 3.
REFERENCE   5  (bases 1 to 1739)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1739)
  AUTHORS   Sun,W.T., Hsieh,P.C., Chiang,M.L., Wang,M.C. and Wang,F.F.
  TITLE     p53 target DDA3 binds ASPP2 and inhibits its stimulation on
            p53-mediated BAX activation
  JOURNAL   Biochem Biophys Res Commun 376 (2), 395-398 (2008)
   PUBMED   18793611
REFERENCE   7  (bases 1 to 1739)
  AUTHORS   Hsieh,P.C., Chang,J.C., Sun,W.T., Hsieh,S.C., Wang,M.C. and
            Wang,F.F.
  TITLE     p53 downstream target DDA3 is a novel microtubule-associated
            protein that interacts with end-binding protein EB3 and activates
            beta-catenin pathway
  JOURNAL   Oncogene 26 (34), 4928-4940 (2007)
   PUBMED   17310996
  REMARK    GeneRIF: DDA3 is a novel microtubule-associated protein that binds
            to EB3, and results implicate DDA3 and EB3 in the
            beta-catenin-mediated growth signaling.
REFERENCE   8  (bases 1 to 1739)
  AUTHORS   Lo,P.K. and Wang,F.F.
  TITLE     Cloning and characterization of human and mouse DDA3 genes
  JOURNAL   Biochim Biophys Acta 1579 (2-3), 214-218 (2002)
   PUBMED   12427559
  REMARK    GeneRIF: molecular cloning, sequence analysis and gene expression
REFERENCE   9  (bases 1 to 1739)
  AUTHORS   Hsieh,S.C., Lo,P.K. and Wang,F.F.
  TITLE     Mouse DDA3 gene is a direct transcriptional target of p53 and p73
  JOURNAL   Oncogene 21 (19), 3050-3057 (2002)
   PUBMED   12082536
  REMARK    GeneRIF: A p53 response element mediates transcriptional activation
REFERENCE   10 (bases 1 to 1739)
  AUTHORS   Lo,P.K., Chen,J.Y., Lo,W.C., Chen,B.F., Hsin,J.P., Tang,P.P. and
            Wang,F.F.
  TITLE     Identification of a novel mouse p53 target gene DDA3
  JOURNAL   Oncogene 18 (54), 7765-7774 (1999)
   PUBMED   10618717
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY080522.1, AF156598.1 and AK041835.1.
            
            On Jun 13, 2010 this sequence version replaced NM_019976.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF156598.1, BC019165.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BY080522.1         1-5
            6-1677              AF156598.1         1-1672
            1678-1739           AK041835.1         1629-1690
FEATURES             Location/Qualifiers
     source          1..1739
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 47.01 cM"
     gene            1..1739
                     /gene="Psrc1"
                     /gene_synonym="5430413I02Rik; Dda3"
                     /note="proline/serine-rich coiled-coil 1"
                     /db_xref="GeneID:56742"
                     /db_xref="MGI:MGI:1913099"
     exon            1..89
                     /gene="Psrc1"
                     /gene_synonym="5430413I02Rik; Dda3"
                     /inference="alignment:Splign:2.1.0"
     exon            90..139
                     /gene="Psrc1"
                     /gene_synonym="5430413I02Rik; Dda3"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1110
                     /gene="Psrc1"
                     /gene_synonym="5430413I02Rik; Dda3"
                     /note="p53-regulated DDA3; differential display and
                     activated by p53"
                     /codon_start=1
                     /product="proline/serine-rich coiled-coil protein 1"
                     /protein_id="NP_064360.1"
                     /db_xref="CCDS:CCDS17758.1"
                     /db_xref="GeneID:56742"
                     /db_xref="MGI:MGI:1913099"
                     /translation="MEDLKEDIKFIVDETLDFGGLSPSDSHEEEDITVLVSPEKPLRR
                     GLAHRSNPNEVAPALQGVRFSLGPLSPEKLEEILDEANRLAAQLEECALKDRERAGTG
                     PGRPSPRGKPSPRRETFVLKDSPVRDLLPTVSSWSTPPPSSLAGLRSSDKKGSARAVR
                     VASGKKPSSIKKESPTCNLFPASKSPGRSPLAQPILPPRRKTGFGARTTASPPIPVRP
                     VPQSSASNSQCSSRLQGAAVKSSSRLPVPSAIPKPATRVPLIGRSLPPGKGALAPDSL
                     STQKGHPSAIGHRASVSQKTNLPTTSAARGRTTSAARGRAQPLRKAAVPGPTR"
     exon            140..197
                     /gene="Psrc1"
                     /gene_synonym="5430413I02Rik; Dda3"
                     /inference="alignment:Splign:2.1.0"
     exon            198..636
                     /gene="Psrc1"
                     /gene_synonym="5430413I02Rik; Dda3"
                     /inference="alignment:Splign:2.1.0"
     exon            637..751
                     /gene="Psrc1"
                     /gene_synonym="5430413I02Rik; Dda3"
                     /inference="alignment:Splign:2.1.0"
     exon            752..988
                     /gene="Psrc1"
                     /gene_synonym="5430413I02Rik; Dda3"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1106
                     /gene="Psrc1"
                     /gene_synonym="5430413I02Rik; Dda3"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1739
                     /gene="Psrc1"
                     /gene_synonym="5430413I02Rik; Dda3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1659..1664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psrc1"
                     /gene_synonym="5430413I02Rik; Dda3"
                     /note="hexamer: AATAAA"
     polyA_site      1677
                     /gene="Psrc1"
                     /gene_synonym="5430413I02Rik; Dda3"
                     /note="major polyA site"
ORIGIN      
        1 tttcccggga actgggagat tgtagaagaa aagcttcctg cgtagactgt gaagcgaggt
       61 ggggagtgga aaccgagtgt gcgctggagg tctaagccga ctcgcttatg ctggctgagc
      121 atggaggatc tgaaagagga tatcaagttc attgtggacg agaccttgga cttcggaggg
      181 ctgtctccat ctgacagtca tgaggaagaa gacataacag tattagtgag tccagagaaa
      241 ccacttcgac ggggcctcgc ccatcggagt aacccaaatg aagtagctcc cgccctccag
      301 ggtgtgcggt ttagcttggg cccgctcagc ccagagaagc tggaagagat tcttgatgaa
      361 gccaaccgcc tggcggctca gctggaggag tgtgccctga aagatcggga gagggctggt
      421 acaggccctg gaaggcccag ccccagaggg aaacccagtc ctcggcggga gaccttcgtc
      481 ctgaaggata gccctgtccg agatctgctg cccaccgtga gttcttggag caccccacct
      541 ccaagcagcc tagctgggct ccggagcagt gataaaaagg ggtcagccag ggctgtccgg
      601 gtggcatccg gaaagaagcc ctccagcata aagaaggaat cacccacttg caatctgttc
      661 cctgcatcca aaagcccggg gcgctctcct cttgcacaac caattcttcc acctcggcgg
      721 aaaactgggt tcggtgcccg gacaacagca agcccaccaa ttcctgtcag accagttcca
      781 cagtcctcag ctagcaactc ccaatgttca tcccggctcc agggagcagc tgtcaagtct
      841 tccagtcgac tccctgtccc ttcagccatc cccaagcctg ccacccgagt gccactcatt
      901 gggcggagtc taccacctgg aaaaggtgcc ctagctccag attctctctc aactcagaaa
      961 gggcatccaa gcgccatagg gcacagagcc tctgtttccc agaaaacaaa ccttccaacc
     1021 accagtgcgg ctcgaggcag gaccaccagt gccgctcgag gcagggcgca gcccctcagg
     1081 aaagctgcag tccctggacc gactaggtaa gaagagcacg tcagcaaaca aagactcaat
     1141 agcaagccac taccatctta gccatcaaag tctggactct cctctgccag tggtccctaa
     1201 ctccagtagc tctgtgccca gagatgggag gaagagatgc ctccagggct gacctctgaa
     1261 gtagagacta tgggggatcg ggtgccttga gcttgagggg actcaacccc accctaccct
     1321 gccctgaaag aagaagagag gggcagaggt catctgcccg tggagaaact cacaaacaaa
     1381 ataataaatg caggcagagt gacctatctg tctccttcca tcttgtggtc aggactagag
     1441 agcttgatct tctaccacgg ttcactggcc attcccatat gagcggcctt aggagcccgc
     1501 cggctcagtt ctctatgaca tgtcttcctg actggatact ggtctgtttg gaaaggccag
     1561 gaggacagct gatgtacaga acttgtttcc tatgaattct ttgacttctc acaggtcaat
     1621 cagttataag cttactcaca tcttcatatt ttttcttaaa taaatgaatt aaaaaaattt
     1681 ttttctgtat atctgaaagt agattttaac agttttaaaa taaacgtctg tgtaattct
//
