LOCUS       NM_008954                765 bp    mRNA    linear   ROD 08-AUG-2023
DEFINITION  Mus musculus persephin (Pspn), mRNA.
ACCESSION   NM_008954
VERSION     NM_008954.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 765)
  AUTHORS   Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K,
            Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre
            A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt
            AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,
            Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S,
            Wohnoutka P, Hawrylycz MJ, Puelles L and Jones AR.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   2  (bases 1 to 765)
  AUTHORS   Patel A, Harker N, Moreira-Santos L, Ferreira M, Alden K, Timmis J,
            Foster K, Garefalaki A, Pachnis P, Andrews P, Enomoto H, Milbrandt
            J, Pachnis V, Coles MC, Kioussis D and Veiga-Fernandes H.
  TITLE     Differential RET signaling pathways drive development of the
            enteric lymphoid and nervous systems
  JOURNAL   Sci Signal 5 (235), ra55 (2012)
   PUBMED   22855506
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 765)
  AUTHORS   Roussa E, Oehlke O, Rahhal B, Heermann S, Heidrich S, Wiehle M and
            Krieglstein K.
  TITLE     Transforming growth factor beta cooperates with persephin for
            dopaminergic phenotype induction
  JOURNAL   Stem Cells 26 (7), 1683-1694 (2008)
   PUBMED   18420832
  REMARK    GeneRIF: TGF-beta with neurturin and persephin are required for the
            induction of dopaminergic neurons, whereas GDNF is required for
            regulating and/or maintaining a differentiated neuronal phenotype
REFERENCE   4  (bases 1 to 765)
  AUTHORS   Brantley MA Jr, Jain S, Barr EE, Johnson EM Jr and Milbrandt J.
  TITLE     Neurturin-mediated ret activation is required for retinal function
  JOURNAL   J Neurosci 28 (16), 4123-4135 (2008)
   PUBMED   18417692
REFERENCE   5  (bases 1 to 765)
  AUTHORS   Baudet C, Pozas E, Adameyko I, Andersson E, Ericson J and Ernfors
            P.
  TITLE     Retrograde signaling onto Ret during motor nerve terminal
            maturation
  JOURNAL   J Neurosci 28 (4), 963-975 (2008)
   PUBMED   18216204
REFERENCE   6  (bases 1 to 765)
  AUTHORS   Lindfors PH, Lindahl M, Rossi J, Saarma M and Airaksinen MS.
  TITLE     Ablation of persephin receptor glial cell line-derived neurotrophic
            factor family receptor alpha4 impairs thyroid calcitonin production
            in young mice
  JOURNAL   Endocrinology 147 (5), 2237-2244 (2006)
   PUBMED   16497798
REFERENCE   7  (bases 1 to 765)
  AUTHORS   Tomac AC, Agulnick AD, Haughey N, Chang CF, Zhang Y, Backman C,
            Morales M, Mattson MP, Wang Y, Westphal H and Hoffer BJ.
  TITLE     Effects of cerebral ischemia in mice deficient in Persephin
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9521-9526 (2002)
   PUBMED   12093930
  REMARK    GeneRIF: Mice lacking Pspn by homologous recombination show normal
            development and behavior, but are hypersensitive to cerebral
            ischemia.
REFERENCE   8  (bases 1 to 765)
  AUTHORS   Davies JA, Fisher CE and Barnett MW.
  TITLE     Glycosaminoglycans in the study of mammalian organ development
  JOURNAL   Biochem Soc Trans 29 (Pt 2), 166-171 (2001)
   PUBMED   11356147
REFERENCE   9  (bases 1 to 765)
  AUTHORS   Milbrandt J, de Sauvage FJ, Fahrner TJ, Baloh RH, Leitner ML,
            Tansey MG, Lampe PA, Heuckeroth RO, Kotzbauer PT, Simburger KS,
            Golden JP, Davies JA, Vejsada R, Kato AC, Hynes M, Sherman D,
            Nishimura M, Wang LC, Vandlen R, Moffat B, Klein RD, Poulsen K,
            Gray C, Garces A, Johnson EM Jr et al.
  TITLE     Persephin, a novel neurotrophic factor related to GDNF and
            neurturin
  JOURNAL   Neuron 20 (2), 245-253 (1998)
   PUBMED   9491986
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073683.3.
            
            On Oct 11, 2022 this sequence version replaced NM_008954.3.
            
            Summary: This gene encodes a secreted ligand of the GDNF (glial
            cell line-derived neurotrophic factor) subfamily and TGF-beta
            (transforming growth factor-beta) superfamily of proteins. The
            encoded preproprotein is proteolytically processed to generate the
            mature protein. This protein signals through the RET receptor
            tyrosine kinase and a GPI-linked coreceptor, and promotes survival
            of neuronal populations. This protein may play a role in cell
            death, and nervous system development and function. Mice lacking a
            functional copy of this gene exhibit hypersensitivity to cerebral
            ischemia. [provided by RefSeq, Aug 2016].
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.440535.1, AF040960.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               AC073683.3         7727-7970
            245-765             AC073683.3         8059-8579
FEATURES             Location/Qualifiers
     source          1..765
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.62 cM"
     gene            1..765
                     /gene="Pspn"
                     /gene_synonym="PSP"
                     /note="persephin"
                     /db_xref="GeneID:19197"
                     /db_xref="MGI:MGI:1201684"
     exon            1..244
                     /gene="Pspn"
                     /gene_synonym="PSP"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..561
                     /gene="Pspn"
                     /gene_synonym="PSP"
                     /codon_start=1
                     /product="persephin preproprotein"
                     /protein_id="NP_032980.2"
                     /db_xref="CCDS:CCDS28922.1"
                     /db_xref="GeneID:19197"
                     /db_xref="MGI:MGI:1201684"
                     /translation="MAAGRLRILCLLLLSLHPSLGWVLDLQEASVADKLSFGKMAETR
                     GTWTPHQGNNHVRLPRALAGSCRLWSLTLPVAELGLGYASEEKVIFRYCAGSCPQEAH
                     TQHSLVLARLRGRGRAHGRPCCQPTSYADVTFLDDQHHWQQLPQLSAAACGCGG"
     exon            245..765
                     /gene="Pspn"
                     /gene_synonym="PSP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggtgctggc agtagtttta atccccagga caggcaggga ataaattcag ggcaccaagg
       61 tctctcggca tccagggacc tgctgtcaca atggctgcag gaagacttcg gatcctgtgt
      121 ctgctgctcc tgtccttgca cccgagcctc ggctgggtcc ttgatcttca agaggcttct
      181 gtggcagata agctctcatt tgggaagatg gcagagacta gagggacctg gacgccccat
      241 cagggtaaca accatgtccg tcttccaaga gccttggctg gttcatgccg actgtggagc
      301 ctgaccctac cagtggctga gctgggcctg ggctatgcct cggaggagaa ggtcatcttc
      361 cgatactgtg ctggcagctg tccccaagag gcccataccc agcacagtct ggtactggcc
      421 cggcttcgag ggcggggtcg agcccatggc cgaccctgct gccagcccac cagctatgct
      481 gatgtgacct tccttgatga tcagcaccat tggcagcagc tgcctcagct ctcagctgca
      541 gcttgtggct gtggtggctg aaggaggcca gtctggtgtc tcagaatcac aagcatgaga
      601 caggctgggc tttgaaaggc tcaggtgaca ttactagaaa tttgcatagg taaagataag
      661 aagggaaagg accagggttt tttgtttctt tctttgcttg cttgttagtt tttttttttt
      721 tttaatcagc agtggatgca ataaatgata ttctcgtggc cttaa
//
