LOCUS       NM_133900               1554 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus phosphoserine phosphatase (Psph), mRNA.
ACCESSION   NM_133900
VERSION     NM_133900.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1554)
  AUTHORS   Ma,H., He,S., Li,Y., Zhang,X., Chang,H., Du,M., Yan,C., Jiang,S.,
            Gao,H., Zhao,J. and Wang,Q.
  TITLE     Augmented Mitochondrial Transfer Involved in Astrocytic PSPH
            Attenuates Cognitive Dysfunction in db/db Mice
  JOURNAL   Mol Neurobiol 61 (11), 8872-8885 (2024)
   PUBMED   38573412
  REMARK    GeneRIF: Augmented Mitochondrial Transfer Involved in Astrocytic
            PSPH Attenuates Cognitive Dysfunction in db/db Mice.
REFERENCE   2  (bases 1 to 1554)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1554)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1554)
  AUTHORS   Wang,T., Zhou,L.Y., Li,X.M., Liu,F., Liang,L., Chen,X.Z., Ju,J.,
            Ponnusamy,M., Wang,K., Liu,C.Y., Yan,K.W. and Wang,K.
  TITLE     ABRO1 arrests cardiomyocyte proliferation and myocardial repair by
            suppressing PSPH
  JOURNAL   Mol Ther 31 (3), 847-865 (2023)
   PUBMED   36639869
  REMARK    GeneRIF: ABRO1 arrests cardiomyocyte proliferation and myocardial
            repair by suppressing PSPH.
REFERENCE   5  (bases 1 to 1554)
  AUTHORS   Chee,J.M., Lanoue,L., Clary,D., Higgins,K., Bower,L., Flenniken,A.,
            Guo,R., Adams,D.J., Bosch,F., Braun,R.E., Brown,S.D.M., Chin,H.G.,
            Dickinson,M.E., Hsu,C.W., Dobbie,M., Gao,X., Galande,S.,
            Grobler,A., Heaney,J.D., Herault,Y., de Angelis,M.H., Mammano,F.,
            Nutter,L.M.J., Parkinson,H., Qin,C., Shiroishi,T., Sedlacek,R.,
            Seong,J.K., Xu,Y., Brooks,B., McKerlie,C., Lloyd,K.C.K.,
            Westerberg,H. and Moshiri,A.
  CONSRTM   International Mouse Phenotyping Consortium
  TITLE     Genome-wide screening reveals the genetic basis of mammalian
            embryonic eye development
  JOURNAL   BMC Biol 21 (1), 22 (2023)
   PUBMED   36737727
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1554)
  AUTHORS   Bachelor,M.A., Lu,Y. and Owens,D.M.
  TITLE     L-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous
            cell carcinoma proliferation independent of L-serine biosynthesis
  JOURNAL   J Dermatol Sci 63 (3), 164-172 (2011)
   PUBMED   21726982
  REMARK    GeneRIF: status of PSPH in normal skin epidermis and skin tumors
            along with its sub-cellular localization in epidermal keratinocytes
            and its requirement for squamous cell carcinoma proliferation
REFERENCE   7  (bases 1 to 1554)
  AUTHORS   Furuya,S., Yoshida,K., Kawakami,Y., Yang,J.H., Sayano,T., Azuma,N.,
            Tanaka,H., Kuhara,S. and Hirabayashi,Y.
  TITLE     Inactivation of the 3-phosphoglycerate dehydrogenase gene in mice:
            changes in gene expression and associated regulatory networks
            resulting from serine deficiency
  JOURNAL   Funct Integr Genomics 8 (3), 235-249 (2008)
   PUBMED   18228065
REFERENCE   8  (bases 1 to 1554)
  AUTHORS   Nakano,I., Dougherty,J.D., Kim,K., Klement,I., Geschwind,D.H. and
            Kornblum,H.I.
  TITLE     Phosphoserine phosphatase is expressed in the neural stem cell
            niche and regulates neural stem and progenitor cell proliferation
  JOURNAL   Stem Cells 25 (8), 1975-1984 (2007)
   PUBMED   17495110
  REMARK    GeneRIF: PSP has a role in neural stem cell proliferation and may
            regulate signaling between neural stem cells and other cells within
            the stem cell niche.
REFERENCE   9  (bases 1 to 1554)
  AUTHORS   Easterday,M.C., Dougherty,J.D., Jackson,R.L., Ou,J., Nakano,I.,
            Paucar,A.A., Roobini,B., Dianati,M., Irvin,D.K., Weissman,I.L.,
            Terskikh,A.V., Geschwind,D.H. and Kornblum,H.I.
  TITLE     Neural progenitor genes. Germinal zone expression and analysis of
            genetic overlap in stem cell populations
  JOURNAL   Dev Biol 264 (2), 309-322 (2003)
   PUBMED   14651920
REFERENCE   10 (bases 1 to 1554)
  AUTHORS   Geschwind,D.H., Ou,J., Easterday,M.C., Dougherty,J.D.,
            Jackson,R.L., Chen,Z., Antoine,H., Terskikh,A., Weissman,I.L.,
            Nelson,S.F. and Kornblum,H.I.
  TITLE     A genetic analysis of neural progenitor differentiation
  JOURNAL   Neuron 29 (2), 325-339 (2001)
   PUBMED   11239426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY127546.1, BY125431.1, CV560928.1, BQ177662.1, AA003039.1 and
            AI841354.1.
            
            On Dec 4, 2009 this sequence version replaced NM_133900.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088865.1, SRR5189682.91652.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                BY127546.1         2-41
            41-362              BY125431.1         2-323
            363-731             CV560928.1         299-667
            732-1104            BQ177662.1         298-670
            1105-1533           AA003039.1         50-478
            1534-1554           AI841354.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..1554
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 68.26 cM"
     gene            1..1554
                     /gene="Psph"
                     /gene_synonym="PSP; PSPase"
                     /note="phosphoserine phosphatase"
                     /db_xref="GeneID:100678"
                     /db_xref="MGI:MGI:97788"
     exon            1..299
                     /gene="Psph"
                     /gene_synonym="PSP; PSPase"
                     /inference="alignment:Splign:2.1.0"
     exon            300..382
                     /gene="Psph"
                     /gene_synonym="PSP; PSPase"
                     /inference="alignment:Splign:2.1.0"
     exon            383..609
                     /gene="Psph"
                     /gene_synonym="PSP; PSPase"
                     /inference="alignment:Splign:2.1.0"
     exon            610..766
                     /gene="Psph"
                     /gene_synonym="PSP; PSPase"
                     /inference="alignment:Splign:2.1.0"
     CDS             627..1304
                     /gene="Psph"
                     /gene_synonym="PSP; PSPase"
                     /EC_number="3.1.3.3"
                     /note="O-phosphoserine phosphohydrolase"
                     /codon_start=1
                     /product="phosphoserine phosphatase"
                     /protein_id="NP_598661.1"
                     /db_xref="CCDS:CCDS19699.1"
                     /db_xref="GeneID:100678"
                     /db_xref="MGI:MGI:97788"
                     /translation="MVSHSELRKLFCSADAVCFDVDSTVIREEGIDELAKFCGVEAAV
                     SEMTRRAMGGALPFKDALTQRLALIQPSRDQVQRLLAEHPPHLTPGIRELVSRLQERN
                     VQVFLISGGFRSIVEHVAAKLNIPTTNVFANRLKFYFNGEYAGFDEMQPTAESGGKGK
                     VIRFLKEKFHFKKIIMIGDGATDMEACPPADAFIGFGGNVIRQQVKDNAKWYITDFVE
                     LLGELEE"
     exon            767..901
                     /gene="Psph"
                     /gene_synonym="PSP; PSPase"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1047
                     /gene="Psph"
                     /gene_synonym="PSP; PSPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1196
                     /gene="Psph"
                     /gene_synonym="PSP; PSPase"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1537
                     /gene="Psph"
                     /gene_synonym="PSP; PSPase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1511..1516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psph"
                     /gene_synonym="PSP; PSPase"
                     /note="hexamer: ATTAAA"
     polyA_site      1533
                     /gene="Psph"
                     /gene_synonym="PSP; PSPase"
                     /note="major polyA site"
ORIGIN      
        1 agttgcgacg tcattgcgca tctgagaaac tggttctccc gtcatcggca ctctggatct
       61 taaggttccg ttgtgctcgc cccccagcgt cacggttcgg cgcttttaag agtttgcagc
      121 gtggaggctg cgcggctccg cggtgcagga aaagccctgc aggtcgtgtg tgagggatgc
      181 ttcggcctct gcactcgact gggtgtgaca ggaagcagag gcgtcggcct ctagttgcag
      241 ggtgtctcta gctactggac tccgggatgc ttccctcaca ctctcgcgag atttcccagg
      301 gatccggcac tgggacgcag cttctaaaag tccaggagct ctttcgagcc aactcaacaa
      361 actaggaatc acagatctta caagctgagt tctggctgct ccagttggaa gcccacatgc
      421 caaactgctc tggagtcgcc ggaggcatca gcagatccca gccgagcctt gagtgaggac
      481 tgtgatctgc cttacgggtc acctcactca ggactcagcg ctcgcacgtt gcagcagctc
      541 cagaccccac tgctaccgga aagttacagg taccggaacc gagaagacca gcgcggccca
      601 ggaaccgcgg aggaaaactt cccaggatgg tctcccactc agagctgagg aagctcttct
      661 gttcagcgga tgcagtgtgc tttgatgttg atagcaccgt catcagagaa gaaggaatcg
      721 atgagctggc caaattctgt ggtgtggagg ccgcagtgtc tgaaatgaca cggagagcca
      781 tgggaggagc attgcctttt aaagacgcgc tcactcagcg cctggcactg atccagccct
      841 ccagggatca agtccagagg ctcctagctg agcacccgcc acatctgact cctggcataa
      901 gggagctggt aagccgcctc caggagcgta atgtccaggt gttcctcatc tctggtggct
      961 ttcggagcat tgtggagcac gttgctgcaa agctcaatat cccaacaacc aatgtgtttg
     1021 ccaataggct gaagttctac tttaatggtg agtacgcagg ttttgatgag atgcagccga
     1081 cagccgagtc gggtgggaaa ggaaaggtta ttcggttttt aaaggaaaaa tttcacttta
     1141 agaaaataat catgattgga gatggagcta cggacatgga agcctgtcct cctgctgatg
     1201 ctttcattgg ctttggaggc aatgtgatca ggcagcaggt taaggacaac gccaagtggt
     1261 acatcactga cttcgtggag ctgctgggag aactggagga gtgagcttga cttcccgctc
     1321 actcagaaca actccacctt ctcaaagcca cacagttagg ctcctgggag aatctaggag
     1381 acagctattt ttttctactg tagttctaat attaatatga ctactaatta catggagaat
     1441 tttatactct gaattctttg tgtatattct tacaaacatt ttacttgtag ctttctgagg
     1501 tgcacagtaa attaaagact tttactcttg caacatgaaa aaaaaaaaaa aaaa
//
