LOCUS       NM_025682               2385 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus paraspeckle protein 1 (Pspc1), transcript variant 1,
            mRNA.
ACCESSION   NM_025682
VERSION     NM_025682.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2385)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2385)
  AUTHORS   Li,J., Cui,P., Sun,Q., Du,Z., Chen,Z., Li,Z., Liu,C., Cao,Y.,
            Yang,Z., Liu,R. and Luo,M.
  TITLE     PSPC1 regulates CHK1 phosphorylation through phase separation and
            participates in mouse oocyte maturation
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 53 (11), 1527-1537 (2021)
   PUBMED   34490876
  REMARK    GeneRIF: PSPC1 regulates CHK1 phosphorylation through phase
            separation and participates in mouse oocyte maturation.
REFERENCE   3  (bases 1 to 2385)
  AUTHORS   Major,A.T., Hogarth,C.A., Young,J.C., Kurihara,Y., Jans,D.A. and
            Loveland,K.L.
  TITLE     Dynamic paraspeckle component localisation during spermatogenesis
  JOURNAL   Reproduction 158 (3), 267-280 (2019)
   PUBMED   31299635
REFERENCE   4  (bases 1 to 2385)
  AUTHORS   Hupalowska,A., Jedrusik,A., Zhu,M., Bedford,M.T., Glover,D.M. and
            Zernicka-Goetz,M.
  TITLE     CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo
            Development
  JOURNAL   Cell 175 (7), 1902-1916 (2018)
   PUBMED   30550788
REFERENCE   5  (bases 1 to 2385)
  AUTHORS   Wang,J., Rajbhandari,P., Damianov,A., Han,A., Sallam,T., Waki,H.,
            Villanueva,C.J., Lee,S.D., Nielsen,R., Mandrup,S., Reue,K.,
            Young,S.G., Whitelegge,J., Saez,E., Black,D.L. and Tontonoz,P.
  TITLE     RNA-binding protein PSPC1 promotes the differentiation-dependent
            nuclear export of adipocyte RNAs
  JOURNAL   J Clin Invest 127 (3), 987-1004 (2017)
   PUBMED   28192372
  REMARK    GeneRIF: These findings highlight a role for PSPC1-dependent RNA
            maturation in the posttranscriptional control of adipose
            development and function.
REFERENCE   6  (bases 1 to 2385)
  AUTHORS   Kuwahara,S., Ikei,A., Taguchi,Y., Tabuchi,Y., Fujimoto,N.,
            Obinata,M., Uesugi,S. and Kurihara,Y.
  TITLE     PSPC1, NONO, and SFPQ are expressed in mouse Sertoli cells and may
            function as coregulators of androgen receptor-mediated
            transcription
  JOURNAL   Biol Reprod 75 (3), 352-359 (2006)
   PUBMED   16641145
  REMARK    GeneRIF: PSPC1, NONO, and SFPQ form complexes with each other in
            Sertoli cells and may regulate androgen receptor-mediated
            transcriptional activity
REFERENCE   7  (bases 1 to 2385)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2385)
  AUTHORS   Myojin,R., Kuwahara,S., Yasaki,T., Matsunaga,T., Sakurai,T.,
            Kimura,M., Uesugi,S. and Kurihara,Y.
  TITLE     Expression and functional significance of mouse paraspeckle protein
            1 on spermatogenesis
  JOURNAL   Biol Reprod 71 (3), 926-932 (2004)
   PUBMED   15140795
  REMARK    GeneRIF: mPSP1 may regulate multiple phases of important nuclear
            events during spermatogenesis.
REFERENCE   9  (bases 1 to 2385)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2385)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB244768.1, AK011272.1, AK017689.1 and AC154731.2.
            
            On Feb 3, 2018 this sequence version replaced NM_025682.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026772.1, AK017689.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 CB244768.1         1-5
            6-2029              AK011272.1         1-2024
            2030-2377           AK017689.1         2029-2376
            2378-2385           AC154731.2         31352-31359
FEATURES             Location/Qualifiers
     source          1..2385
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.4 cM"
     gene            1..2385
                     /gene="Pspc1"
                     /gene_synonym="5730470C09Rik; PSP1"
                     /note="paraspeckle protein 1"
                     /db_xref="GeneID:66645"
                     /db_xref="MGI:MGI:1913895"
     exon            1..528
                     /gene="Pspc1"
                     /gene_synonym="5730470C09Rik; PSP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1731
                     /gene="Pspc1"
                     /gene_synonym="5730470C09Rik; PSP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     paraspeckle component 1"
                     /codon_start=1
                     /product="paraspeckle component 1 isoform 1"
                     /protein_id="NP_079958.3"
                     /db_xref="CCDS:CCDS27151.1"
                     /db_xref="GeneID:66645"
                     /db_xref="MGI:MGI:1913895"
                     /translation="MMLRGNLKQVRIEKNPARLRALESAAGESEPVAAAAMALTLAGE
                     QAPPPAPSEEHPDEELGFTIDIKSFLKPGEKTYTQRCRLFVGNLPTDITEEDFKRLFE
                     RYGEPSEVFINRDRGFGFIRLESRTLAEIAKAELDGTILKSRPLRIRFATHGAALTVK
                     NLSPVVSNELLEQAFSQFGPVEKAVVVVDDRGRATGKGFVEFAAKPPARKALERCGDG
                     AFLLTTTPRPVIVEPMEQFDDEDGLPEKLMQKTQQYHKEREQPPRFAQPGTFEFEYAS
                     RWKALDEMEKQQREQVDRNIREAKEKLEAEMEAARHEHQLMLMRQDLMRRQEELRRLE
                     ELRNQELQKRKQIQLRHEEEHRRREEEMIRHREQEELRRQQEGGFKPNYMENREQEMR
                     MGDMGPRGAINMGDAFSPAPAGTQGPPPMMGMNMNNRGTIPGPPMGPGPAMGPEGAAN
                     MGTPMIPDNGAVHNDRFPQGPPSQMGSPMGNRTGSETPQAPMSGVGPVSGGPGGFGRG
                     SQGGNFEGPNKRRRY"
     exon            529..830
                     /gene="Pspc1"
                     /gene_synonym="5730470C09Rik; PSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..926
                     /gene="Pspc1"
                     /gene_synonym="5730470C09Rik; PSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1123
                     /gene="Pspc1"
                     /gene_synonym="5730470C09Rik; PSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1208
                     /gene="Pspc1"
                     /gene_synonym="5730470C09Rik; PSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1317
                     /gene="Pspc1"
                     /gene_synonym="5730470C09Rik; PSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1375
                     /gene="Pspc1"
                     /gene_synonym="5730470C09Rik; PSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1545
                     /gene="Pspc1"
                     /gene_synonym="5730470C09Rik; PSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..2385
                     /gene="Pspc1"
                     /gene_synonym="5730470C09Rik; PSP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2013..2018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pspc1"
                     /gene_synonym="5730470C09Rik; PSP1"
                     /note="hexamer: AAGAAA"
     polyA_site      2038
                     /gene="Pspc1"
                     /gene_synonym="5730470C09Rik; PSP1"
                     /note="major polyA site"
ORIGIN      
        1 gcgccatttt gagcgttcgg ccaccgcggg cgtgattgcg gggaggctgg gcttccctcc
       61 gttacctggc tttccttgct tcgtttccat agatacatgt ggagacgtgt gtaccttgac
      121 gtctaggcct catccagcat cccaagcgaa cttgctaaga tgatgttaag aggaaacctg
      181 aagcaagtac gtattgagaa aaacccggct cgtcttcgcg ccctggagtc ggcggccgga
      241 gagagcgaac cggtggccgc ggcggccatg gcgctgacgc tggccggcga gcaggcgccg
      301 ccacccgcac cttccgagga gcacccggac gaggaattgg gcttcaccat cgacatcaag
      361 agtttcctca agccgggcga gaagacgtac acgcagcgct gccgcctctt cgtgggtaac
      421 ctgcccacag acatcacgga ggaggacttc aagcgcctct ttgagcgcta cggagagccc
      481 agcgaggtct tcatcaaccg cgaccgaggc ttcggcttca tccgcctgga atcgagaaca
      541 ctggctgaaa ttgcaaaagc agagttggat ggcaccatac tgaagagcag acctctccga
      601 attcgctttg ctacacatgg agcagcccta acggtcaaga acctttctcc ggttgtttcc
      661 aatgagcttc tagagcaagc attttcccag tttggcccag tagagaaagc tgttgtggtt
      721 gtggatgatc gtggtagagc cacaggaaaa ggttttgtag aatttgcagc gaaacctcct
      781 gcacgaaagg ctctggagag atgtggtgat ggggcgttct tgctaacaac aacacctcgt
      841 ccagtcattg tagaacccat ggagcagttt gatgatgaag atggtttacc agagaagcta
      901 atgcagaaaa ctcaacagta ccataaggaa agagaacagc caccacggtt tgctcaacct
      961 gggacatttg aatttgaata tgcgtctcga tggaaggctc ttgatgaaat ggaaaagcag
     1021 cagcgggaac aagttgatag aaacatcaga gaagccaaag agaaactgga ggcagagatg
     1081 gaagcagcta gacatgaaca ccagttaatg ctaatgaggc aagatctaat gagacgtcaa
     1141 gaagaactca gacgtttgga agaactcaga aatcaagaac tgcagaaacg aaagcaaata
     1201 caactgagac acgaagaaga gcatcgtcgt cgtgaagaag aaatgatccg tcacagagag
     1261 caggaggagc tgaggcgaca gcaagagggc ggctttaaac caaactatat ggaaaataga
     1321 gaacaggaaa tgagaatggg tgatatgggt ccccgtggag caataaacat gggagatgca
     1381 tttagcccag cacctgctgg tacccaaggt cctcctccaa tgatgggtat gaatatgaac
     1441 aacagaggaa ctatacctgg cccaccaatg ggtcctggtc ctgccatggg accagaagga
     1501 gctgcaaata tgggaactcc aatgatacca gataatggcg cagtgcacaa tgataggttt
     1561 ccccaaggac ctccatccca gatgggttca cccatgggaa atagaacagg ttctgaaact
     1621 ccccaggcac cgatgagtgg tgtagggcct gtaagtggtg gtcctggcgg ctttggtaga
     1681 gggagtcaag ggggcaattt tgaaggccct aataagcgtc ggagatatta aataatggtt
     1741 cattcctgac tgtttagaaa aacattcaat ggtatgtctt tacaccatgt ctgttactag
     1801 ggagaaatgg ttttactgtt aatgtatgta gactaaagtt tttcttttgt aaaacttgag
     1861 ttttttttgt attttcttta ttcataagct ttgtagatta gcttggtgaa aaagatgccc
     1921 atcattgtga atgttgaaaa gtgtttgtga ccttagctaa cgatagctat gtggcattat
     1981 tattaagtct gtgtagttac ttaatctcaa taaagaaatg attttgccta atttaaaatg
     2041 ttcttagtgg tattccctca tgaccttaca aaacttgcta tggttgcttt agctaatcct
     2101 acctatttaa acgtgaagat gactttgttt ttctgtttgt tcctgtagcc cttaagtcag
     2161 actgttagtg aaagctgatg tcaataaggg acacatactg tagtatacta gtgggtggga
     2221 ggcatggggg ttaagattgt ataaaccata gatcctgtgt aagttagagt tgttgcttac
     2281 atttcatata gagtctcact attcatatat tctgagaaaa gttattgagg ctatctttgt
     2341 tctgtgctga tttttccaaa taaacctttt gaatcttaaa aaaaa
//
