LOCUS       NM_020576                850 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus psoriasis susceptibility 1 candidate 2 (human)
            (Psors1c2), mRNA.
ACCESSION   NM_020576
VERSION     NM_020576.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 850)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 850)
  AUTHORS   Pradervand,S., Yasukawa,H., Muller,O.G., Kjekshus,H., Nakamura,T.,
            St Amand,T.R., Yajima,T., Matsumura,K., Duplain,H., Iwatate,M.,
            Woodard,S., Pedrazzini,T., Ross,J., Firsov,D., Rossier,B.C.,
            Hoshijima,M. and Chien,K.R.
  TITLE     Small proline-rich protein 1A is a gp130 pathway- and
            stress-inducible cardioprotective protein
  JOURNAL   EMBO J 23 (22), 4517-4525 (2004)
   PUBMED   15510217
  REMARK    GeneRIF: spr1 is a gp130 pathway- and stress-inducible
            cardioprotective protein.
REFERENCE   3  (bases 1 to 850)
  AUTHORS   Holm,S.J., Carlen,L.M., Mallbris,L., Stahle-Backdahl,M. and
            O'Brien,K.P.
  TITLE     Polymorphisms in the SEEK1 and SPR1 genes on 6p21.3 associate with
            psoriasis in the Swedish population
  JOURNAL   Exp Dermatol 12 (4), 435-444 (2003)
   PUBMED   12930300
REFERENCE   4  (bases 1 to 850)
  AUTHORS   Lemon,W.J., Bernert,H., Sun,H., Wang,Y. and You,M.
  TITLE     Identification of candidate lung cancer susceptibility genes in
            mouse using oligonucleotide arrays
  JOURNAL   J Med Genet 39 (9), 644-655 (2002)
   PUBMED   12205107
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK137759.1 and AF484421.1.
            
            On Jun 9, 2010 this sequence version replaced NM_020576.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF484421.1, AK137759.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-841               AK137759.1         2-842
            842-850             AF484421.1         801-809
FEATURES             Location/Qualifiers
     source          1..850
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.7 cM"
     gene            1..850
                     /gene="Psors1c2"
                     /gene_synonym="Pcg; SPR1"
                     /note="psoriasis susceptibility 1 candidate 2 (human)"
                     /db_xref="GeneID:57390"
                     /db_xref="MGI:MGI:1930025"
     exon            1..94
                     /gene="Psors1c2"
                     /gene_synonym="Pcg; SPR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..447
                     /gene="Psors1c2"
                     /gene_synonym="Pcg; SPR1"
                     /note="psoriasis susceptibility 1 candidate gene 2 protein
                     homolog; MHC psoriasis candidate"
                     /codon_start=1
                     /product="psoriasis susceptibility 1 candidate gene 2
                     protein homolog precursor"
                     /protein_id="NP_065601.2"
                     /db_xref="CCDS:CCDS50091.1"
                     /db_xref="GeneID:57390"
                     /db_xref="MGI:MGI:1930025"
                     /translation="MMLTWKLLGLLVLCLCAGGISGNGDPSPGSTDTHEEEDSPPLPL
                     GPPIPGDPWPGAPPLFDEPPPPGSNRPWRDLPDSGAWPPKPPSTDPPKPPLPDDPWPA
                     GTQPPENPWPPAPEMDHESQEEPDLDPPQEEYR"
     exon            95..843
                     /gene="Psors1c2"
                     /gene_synonym="Pcg; SPR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      819..824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psors1c2"
                     /gene_synonym="Pcg; SPR1"
                     /note="hexamer: AATAAA"
     polyA_site      843
                     /gene="Psors1c2"
                     /gene_synonym="Pcg; SPR1"
                     /note="major polyA site"
ORIGIN      
        1 agactcggag caccccgcct tgggggccag tagacagcca tgatgctcac ctggaagctg
       61 ctaggcctgc tggtcctttg cctgtgtgca ggaggcattt caggcaatgg cgacccttct
      121 cccggatcta cagacaccca cgaagaggag gactccccac cattgcctct gggaccccca
      181 atccctggtg atccctggcc tggggcgcct cctttgtttg atgaacctcc gcctccaggc
      241 tccaaccgtc cctggagaga tcttcctgac agtggtgcct ggcccccaaa gcccccaagc
      301 actgatcccc ctaaacctcc tctgcctgat gacccctggc cagcaggaac ccagccccca
      361 gaaaacccct ggcctcctgc ccctgagatg gaccatgaat ctcaggagga gccagacctt
      421 gacccacccc aggaagagta tagatagggg accctaggga acgtgagcct ccacagagca
      481 caccaaagcc cacctttttc attggctgcc cgcttagaat ctcaattttc cctaatccct
      541 tagttccctt cctcagtctc tgtttgaatt gtgttctatg ttggaagtgt ctatgctctg
      601 caaccccccc tccctccact ttgtggtccc tgttcagtca ttatgttgtc ccttcgcttc
      661 tcttgatcag cagaaagcac actcctacct cactcagcct gttcttgctt gtctagacct
      721 ggacttctag gcagagcctg agctctgtgc tctctgctgc cccctggttt tcttagctgg
      781 gaactgacag tcgatcagga tggtgcttcc aatggaaaaa taaaagccac gttttcttct
      841 gaaaaaaaaa
//
