LOCUS       NM_134138               1090 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus proteasome (prosome, macropain) assembly chaperone 2
            (Psmg2), transcript variant 1, mRNA.
ACCESSION   NM_134138 XM_915052
VERSION     NM_134138.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1090)
  AUTHORS   Koss,M., Bolze,A., Brendolan,A., Saggese,M., Capellini,T.D.,
            Bojilova,E., Boisson,B., Prall,O.W., Elliott,D.A., Solloway,M.,
            Lenti,E., Hidaka,C., Chang,C.P., Mahlaoui,N., Harvey,R.P.,
            Casanova,J.L. and Selleri,L.
  TITLE     Congenital asplenia in mice and humans with mutations in a
            Pbx/Nkx2-5/p15 module
  JOURNAL   Dev Cell 22 (5), 913-926 (2012)
   PUBMED   22560297
REFERENCE   2  (bases 1 to 1090)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   3  (bases 1 to 1090)
  AUTHORS   Bahar,R., O-Wang,J., Kawamura,K., Seimiya,M., Wang,Y., Hatano,M.,
            Okada,S., Tokuhisa,T., Watanabe,T. and Tagawa,M.
  TITLE     Growth retardation, polyploidy, and multinucleation induced by
            Clast3, a novel cell cycle-regulated protein
  JOURNAL   J Biol Chem 277 (42), 40012-40019 (2002)
   PUBMED   12147697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY012642.1, AK077569.1 and AW123048.1.
            
            On Jan 17, 2019 this sequence version replaced NM_134138.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB031387.1, AK077569.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-358               BY012642.1         17-374
            359-1071            AK077569.1         334-1046
            1072-1090           AW123048.1         15-33               c
FEATURES             Location/Qualifiers
     source          1..1090
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 40.05 cM"
     gene            1..1090
                     /gene="Psmg2"
                     /gene_synonym="1700017I17Rik; Clast3; Pba2; Tnfsf5ip1"
                     /note="proteasome (prosome, macropain) assembly chaperone
                     2"
                     /db_xref="GeneID:107047"
                     /db_xref="MGI:MGI:1922901"
     exon            1..149
                     /gene="Psmg2"
                     /gene_synonym="1700017I17Rik; Clast3; Pba2; Tnfsf5ip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..887
                     /gene="Psmg2"
                     /gene_synonym="1700017I17Rik; Clast3; Pba2; Tnfsf5ip1"
                     /note="isoform 1 is encoded by transcript variant 1; CD40
                     ligand-activated specific transcript 3; tumor necrosis
                     factor superfamily, member 5-induced protein 1; proteasome
                     assembly chaperone 2; proteasome chaperone homolog 2"
                     /codon_start=1
                     /product="proteasome assembly chaperone 2 isoform 1"
                     /protein_id="NP_598899.1"
                     /db_xref="CCDS:CCDS29324.1"
                     /db_xref="GeneID:107047"
                     /db_xref="MGI:MGI:1922901"
                     /translation="MFVPCGESVPDLTNFTLLMPAVSVGNVGQLAIDLIISTLNMCKI
                     GYFYTDCLVPMVGNNPYATEEENSNELSINTEVYSLPSKKLVVLQLRSIFIKYKSKSF
                     CEKLLAWVESSGCARIIVLSSSHSYHRNDAQLRSTPFRYLLTPCLQKSVQNKIKSLNW
                     LEMEKSRCIPEMSDSEFCIRIPGGGITKTLYDESCSKEIQMAVLLKFVSEGDNIPDAV
                     SLVEYLNEWLQIIKPCNDGPMASALPWKIPSSWRLLFGSGLPPALF"
     exon            150..321
                     /gene="Psmg2"
                     /gene_synonym="1700017I17Rik; Clast3; Pba2; Tnfsf5ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            322..380
                     /gene="Psmg2"
                     /gene_synonym="1700017I17Rik; Clast3; Pba2; Tnfsf5ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..499
                     /gene="Psmg2"
                     /gene_synonym="1700017I17Rik; Clast3; Pba2; Tnfsf5ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            500..673
                     /gene="Psmg2"
                     /gene_synonym="1700017I17Rik; Clast3; Pba2; Tnfsf5ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            674..794
                     /gene="Psmg2"
                     /gene_synonym="1700017I17Rik; Clast3; Pba2; Tnfsf5ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1090
                     /gene="Psmg2"
                     /gene_synonym="1700017I17Rik; Clast3; Pba2; Tnfsf5ip1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1055..1060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmg2"
                     /gene_synonym="1700017I17Rik; Clast3; Pba2; Tnfsf5ip1"
                     /note="hexamer: AATAAA"
     polyA_site      1073
                     /gene="Psmg2"
                     /gene_synonym="1700017I17Rik; Clast3; Pba2; Tnfsf5ip1"
                     /note="major polyA site"
ORIGIN      
        1 ccccggacga tcgcgagttg cgccttctgt cccaaggagg tggcctcgct atcccggcgg
       61 gcgctcaagc tgctcccacg cccactgcag tcatgttcgt tccctgcggg gagtcggtcc
      121 ccgacctaac gaactttaca ctcctgatgc cagcagtatc cgttggaaat gttggccagc
      181 ttgcaataga tctgattatt tctacactga acatgtgtaa gattggttat ttctatactg
      241 attgcctggt gccaatggtt ggaaacaatc catatgcaac tgaagaagaa aattcaaatg
      301 agctcagtat aaatactgaa gtgtattcct taccgtcaaa gaagctagtg gtgcttcagt
      361 taaggtccat ctttattaag tacaaatcga agtcattctg tgaaaagctg ctggcctggg
      421 tggaaagcag cggctgtgcc aggatcattg ttctctcaag cagccattcg tatcaccgca
      481 acgatgccca gctgcgcagt actcccttcc ggtatctgct tacaccttgt ttgcaaaaga
      541 gtgttcagaa taaaataaag agcctgaact ggctagaaat ggaaaagagt cggtgcatcc
      601 ctgagatgag cgattctgag ttttgtattc gcattcctgg aggtggaatc acaaaaacgc
      661 tctatgacga aagctgttct aaagagatcc agatggcagt tctgctaaaa tttgtttcag
      721 aaggggacaa tatcccagat gccgtcagcc ttgtggagta ccttaatgaa tggcttcaga
      781 taatcaaacc ctgtaacgac ggccccatgg catctgccct gccttggaag atccccagct
      841 cttggcggct gctctttggc agtgggcttc ctcccgcgct gttttgatct gttttcagtt
      901 tctccctcat cctgctgaga tcacaaaaga ggctgttggg tgtgtgctgt acagaaattt
      961 gtgctacccg gggatgggtt agaagtgata ttgtaaaacc tcaaagaaaa gaggtagtta
     1021 tgtttgttat atacaataaa tgtaaattct gtacaataaa ctttattacc taagcggttt
     1081 tatctggaaa
//
