LOCUS       NM_019537               1057 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus proteasome (prosome, macropain) assembly chaperone 1
            (Psmg1), mRNA.
ACCESSION   NM_019537
VERSION     NM_019537.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1057)
  AUTHORS   Zhang,B., Zhu,Y., Zhang,Z., Wu,F., Ma,X., Sheng,W., Dai,R., Guo,Z.,
            Yan,W., Hao,L., Huang,G., Ma,D., Hao,B. and Ma,J.
  TITLE     SMC3 contributes to heart development by regulating super-enhancer
            associated genes
  JOURNAL   Exp Mol Med 56 (8), 1826-1842 (2024)
   PUBMED   39085358
REFERENCE   2  (bases 1 to 1057)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1057)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1057)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   5  (bases 1 to 1057)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   6  (bases 1 to 1057)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   7  (bases 1 to 1057)
  AUTHORS   Pletcher,M.T., Wiltshire,T., Cabin,D.E., Villanueva,M. and
            Reeves,R.H.
  TITLE     Use of comparative physical and sequence mapping to annotate mouse
            chromosome 16 and human chromosome 21
  JOURNAL   Genomics 74 (1), 45-54 (2001)
   PUBMED   11374901
REFERENCE   8  (bases 1 to 1057)
  AUTHORS   Vidal-Taboada,J.M., Lu,A., Pique,M., Pons,G., Gil,J. and Oliva,R.
  TITLE     Down syndrome critical region gene 2: expression during mouse
            development and in human cell lines indicates a function related to
            cell proliferation
  JOURNAL   Biochem Biophys Res Commun 272 (1), 156-163 (2000)
   PUBMED   10872820
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG086724.2 and BC032965.1.
            
            On Jan 24, 2017 this sequence version replaced NM_019537.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060285.1, AJ238270.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                BG086724.2         1-64
            65-1057             BC032965.1         1-993
FEATURES             Location/Qualifiers
     source          1..1057
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 56.76 cM"
     gene            1..1057
                     /gene="Psmg1"
                     /gene_synonym="Dscr2"
                     /note="proteasome (prosome, macropain) assembly chaperone
                     1"
                     /db_xref="GeneID:56088"
                     /db_xref="MGI:MGI:1860263"
     exon            1..207
                     /gene="Psmg1"
                     /gene_synonym="Dscr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..940
                     /gene="Psmg1"
                     /gene_synonym="Dscr2"
                     /note="down syndrome critical region protein 2 homolog;
                     Down syndrome critical region homolog 2"
                     /codon_start=1
                     /product="proteasome assembly chaperone 1"
                     /protein_id="NP_062410.1"
                     /db_xref="CCDS:CCDS28352.1"
                     /db_xref="GeneID:56088"
                     /db_xref="MGI:MGI:1860263"
                     /translation="MAATFFGEVVKAPCRAGTEEEEEEEEQSRRDTPEDREVRRQLAR
                     KREVRLLRRQTETSLEAVLLETHPCSKFIIAVGSNATAFLSAFVMNSGVWEEVGCAKL
                     WNEWCRTTDTVRLSPTDVFCVFYQLKSDPSVFLCQCSCYIAEDQQFQWLEKVFGFQPR
                     KSMQVTVLTCRHITDYKTPESTCSLSSPFLRALKTQTFKDALCCPLLEQPNIVHDLSA
                     AVLSYCQVWKIPAVLYLCYTDVMKLDRVTVEAFKPLLSSRSLKCLVKNIPESTEILKK
                     LMTTNEIQSNIYT"
     exon            208..314
                     /gene="Psmg1"
                     /gene_synonym="Dscr2"
                     /inference="alignment:Splign:2.1.0"
     exon            315..466
                     /gene="Psmg1"
                     /gene_synonym="Dscr2"
                     /inference="alignment:Splign:2.1.0"
     exon            467..529
                     /gene="Psmg1"
                     /gene_synonym="Dscr2"
                     /inference="alignment:Splign:2.1.0"
     exon            530..728
                     /gene="Psmg1"
                     /gene_synonym="Dscr2"
                     /inference="alignment:Splign:2.1.0"
     exon            729..865
                     /gene="Psmg1"
                     /gene_synonym="Dscr2"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1044
                     /gene="Psmg1"
                     /gene_synonym="Dscr2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1024..1029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmg1"
                     /gene_synonym="Dscr2"
                     /note="hexamer: AATAAA"
     polyA_site      1044
                     /gene="Psmg1"
                     /gene_synonym="Dscr2"
                     /note="major polyA site"
ORIGIN      
        1 cgtggcttgg agggggcgtg actgcgggcc ggcgcgcatg cgctgtctgg ccgcgcggag
       61 ctgagggacc atggctgcca cgttctttgg cgaggtggtg aaggcgccgt gcagagctgg
      121 gactgaggag gaagaagagg aggaggagca gagcaggcgg gacacgccgg aggaccggga
      181 ggtccggcgg cagctggcgc ggaagaggga ggttcggctt ctccgaagac agacagaaac
      241 atctctggag gctgtgctcc tagagacaca cccttgctcc aagtttataa ttgcagtagg
      301 aagcaacgca acagcattcc tgtcagcgtt tgttatgaac tcgggagtct gggaagaagt
      361 cggttgtgct aagctctgga atgaatggtg cagaactaca gacactgtcc gtctgtcccc
      421 tacagatgtt ttctgtgtgt tttatcaact gaaatcagat ccctcggttt ttctatgtca
      481 gtgtagctgc tacattgctg aggatcagca gttccagtgg ttggagaagg ttttcggctt
      541 ccaacccaga aagagcatgc aggtaaccgt tctcacatgc cggcacatca cagactacaa
      601 gacccccgag tctacctgca gcctttcctc tcctttcctg agagccctaa aaactcagac
      661 attcaaagat gccctctgct gcccactgct ggaacagccg aacattgtgc atgacctgtc
      721 tgcagcagtt ctgagctact gtcaagtatg gaaaatccct gcggttctgt atctgtgcta
      781 cactgatgtg atgaagttgg accgtgtcac ggttgaagct tttaaaccgt tactttcttc
      841 caggagcttg aaatgcttgg tgaagaacat tcctgaaagc acagaaattc tgaagaagtt
      901 gatgaccaca aatgagattc agagcaacat ttacacatga ccccaggtgg ccaggacctg
      961 cctgttccag ggggcagtca ctgatgtttt gtattttatt ctggcttggg atgttttgag
     1021 agtaataaaa attttaaaaa ttaaaaaaaa aaaaaaa
//
