LOCUS       NM_134013               6454 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus proteasome (prosome, macropain) activator subunit 4
            (Psme4), mRNA.
ACCESSION   NM_134013 XM_203562
VERSION     NM_134013.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6454)
  AUTHORS   VerPlank,J.J., Gawron,J.M., Silvestri,N.J., Wrabetz,L. and
            Feltri,M.L.
  TITLE     Knockout of PA200 improves proteasomal degradation and myelination
            in a proteotoxic neuropathy
  JOURNAL   Life Sci Alliance 7 (4), e202302349 (2024)
   PUBMED   38320810
  REMARK    GeneRIF: Knockout of PA200 improves proteasomal degradation and
            myelination in a proteotoxic neuropathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6454)
  AUTHORS   Kim,M., Kim,Y.S., Ahn,Y., Eom,G.H. and Yoon,S.
  TITLE     PSME4 determines mesenchymal stem cell fate towards cardiac
            commitment through YAP1 degradation
  JOURNAL   Korean J Physiol Pharmacol 27 (4), 407-416 (2023)
   PUBMED   37386838
REFERENCE   3  (bases 1 to 6454)
  AUTHORS   Sato,B., Kim,J., Morohoshi,K., Kang,W., Miyado,K., Tsuruta,F.,
            Kawano,N. and Chiba,T.
  TITLE     Proteasome-Associated Proteins, PA200 and ECPAS, Are Essential for
            Murine Spermatogenesis
  JOURNAL   Biomolecules 13 (4), 586 (2023)
   PUBMED   37189334
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6454)
  AUTHORS   Kim,Y.S., Kim,M., Cho,D.I., Lim,S.Y., Jun,J.H., Kim,M.R.,
            Kang,B.G., Eom,G.H., Kang,G., Yoon,S. and Ahn,Y.
  TITLE     PSME4 Degrades Acetylated YAP1 in the Nucleus of Mesenchymal Stem
            Cells
  JOURNAL   Pharmaceutics 14 (8), 1659 (2022)
   PUBMED   36015285
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6454)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6454)
  AUTHORS   Pickering,A.M. and Davies,K.J.
  TITLE     Differential roles of proteasome and immunoproteasome regulators
            Pa28alphabeta, Pa28gamma and Pa200 in the degradation of oxidized
            proteins
  JOURNAL   Arch Biochem Biophys 523 (2), 181-190 (2012)
   PUBMED   22564544
REFERENCE   7  (bases 1 to 6454)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   8  (bases 1 to 6454)
  AUTHORS   Khor,B., Bredemeyer,A.L., Huang,C.Y., Turnbull,I.R., Evans,R.,
            Maggi,L.B. Jr., White,J.M., Walker,L.M., Carnes,K., Hess,R.A. and
            Sleckman,B.P.
  TITLE     Proteasome activator PA200 is required for normal spermatogenesis
  JOURNAL   Mol Cell Biol 26 (8), 2999-3007 (2006)
   PUBMED   16581775
REFERENCE   9  (bases 1 to 6454)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 6454)
  AUTHORS   Ustrell,V., Hoffman,L., Pratt,G. and Rechsteiner,M.
  TITLE     PA200, a nuclear proteasome activator involved in DNA repair
  JOURNAL   EMBO J 21 (13), 3516-3525 (2002)
   PUBMED   12093752
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662891.9, AF296169.1, CV557303.1, CV557020.1, CX566261.1,
            AK131932.1, AK169447.1 and BE944080.1.
            
            On Nov 15, 2006 this sequence version replaced NM_134013.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF296169.1, BC141381.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-450               AL662891.9         10183-10632
            451-1153            AF296169.1         162-864
            1154-1866           CV557303.1         23-735
            1867-2571           CV557020.1         107-811
            2572-3695           AF296169.1         2283-3406
            3696-4402           CX566261.1         84-790
            4403-5419           AK131932.1         1-1017
            5420-6395           AK169447.1         317-1292
            6396-6454           BE944080.1         1-59                c
FEATURES             Location/Qualifiers
     source          1..6454
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 18.16 cM"
     gene            1..6454
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /note="proteasome (prosome, macropain) activator subunit
                     4"
                     /db_xref="GeneID:103554"
                     /db_xref="MGI:MGI:2143994"
     exon            1..450
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..5740
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /note="protein BLM10 homolog; proteasome activator PA200"
                     /codon_start=1
                     /product="proteasome activator complex subunit 4"
                     /protein_id="NP_598774.2"
                     /db_xref="CCDS:CCDS36124.1"
                     /db_xref="GeneID:103554"
                     /db_xref="MGI:MGI:2143994"
                     /translation="MEAPERAGGGEPPEPGGRPVLGPRAFVPQKEIVYNKLLPYAERL
                     DAESDLQLAQIKSNLGRAVQLQELWPGGLFWTRKLSTYIRLYGRKFSKEDHVLFIKLL
                     YELVSIPKLEISMMQGFARLLINLLKKKELLSRDDLELPWRPLYDLVERILYSKTEHL
                     RLNSFPNSIENVLKTLVKSCRPYFPADSTAEMLEEWRPLMCPFDVTMQKAISYFEIFL
                     PTSLPPELHHKGFKLWFDELIGLWVSVQNLPQWEGQLVNLFARLATDNIGYIDWDPYV
                     PKIFTRILRSLNLPVGSSQVLVPRFLTNAYDIGHAVIWITAMMGGPSKLVQKHLAGLF
                     NSITSFYHPSNNGRWLNKLMKLLQRLPNSVVRRLHRERFKKPSWLTPVPESHKLTDED
                     VTDFVQCIIQPVLLAMFSKTGSLEAAQALQNLALMRPELVIPPVLERTYPALETLTEP
                     HQLTATLNCVIGVARSLVSGSKWFPEGPTHMLPLLMRALPGVDPNDFSKCMITFQFIG
                     TFSTLVPLVDCSSVLQERNDLTEIEKELCSATAEFEDFVLQFMDRCFGLIESSTLEQT
                     REETETEKMTHLESLVELGLSSTFSTILTQCSKDIFMVALQKVFNFSVSHIFETRVAG
                     RMVADMCRAAVKCCPEESLKLFVPHCYGVITQLTMNDDVLNEEELDKELLWNLQLLSE
                     ITRVDGKKLLLYREQLVKILQRTLHLTCKQGYTLSCNLLHHLLRSTTLIYPTEYCSVP
                     GGFNKPPSEYFPVKDWGKPGDLWNLGIQWHVPSSEEVSFAFYLLDSFLQPELIKLQCC
                     GDGELEMSRDDILQSLTIVHSCLIGSGNLLPPLKGEAVTNLVPSMVSLEETKLYTGLE
                     HDLSRENYREVIASVIRKLLSHILDNSEDDTKSLFLIIKIIGDLLHFQGSHKHEFDSR
                     WKSFNLVKKSMENRLHGKKQHIRALLIDRVMLQHELRTLTVEGCEYKKIHQDMIRDLL
                     RLSTSSYSQVRNKAQQTFFAALGAYNFCCRDIIPLVLEFLRPDRKDVTQQQFKGALYC
                     LLGNHSGVCLANLHDWDCIVQTWPALVSSGLSQAMSLEKPSIVRLFDDLAEKIHRQYE
                     TIGLDFTIPKSCAAIAELLQQSKNPSISQTLLSPEKIKEGQKRQQDKNADALRNYECL
                     VNTLLDGVEQRNLPWKFEHIGIGLLSLLLRDDRVLPLRAIRFFVENLNHDAIVVRKMA
                     ISAVAGILKQLKRTHKKLTINPYEISGCPKPTKILAGDRPDNHWLHYDSKNIPRTKKE
                     WESSCFVEKTHWGYYNWPKNMVVYAGVEEQPKLGRSREDMIEAEQIIYDRFSDPKFVE
                     QLITFLSLEDRKGRDKFSPRRFCLFKGIFRNFDDAFLPVLKPHLERLVADSHESTQRC
                     VAEIIAGLIRGSKHWTFEKVEKLWELLCPLLRTALSNMTVETYNDWGTCIATSCESRD
                     PRKLHWLFELLLESPLSGEGGSFVDACRLYVLQGGLAQQEWRVPELLHRLLKYLEPKL
                     TQVYKNVRERIGSVLTYIFMIDVSLPNTAPTTSPCIPEFTARVLEKLKPLTDVDEEIQ
                     NHVMEENGIGEEDERTQGIKLLKTILKWLMASAGRSFSTAVKEQLQLLPLFFKIAPVE
                     NDNSYDELKRDAKLCLSLMSQGLLYPQQVPLILQVLSQTARSSSWHARYTVLTYLQTM
                     VFYNLFIFLNNEDAVKDIRWLIICLLEDEQLEVREMAATTLSGLLQCNFLTMDSAMQI
                     HFEQLCKTKLPKKRKRDPGSVGDTIPSAELVKRHAGVLGLGACVLSSPYDVPTWMPQL
                     LMNLSAHLNDPQPIEMTVKKTLSNFRRTHHDNWQEHKQQFTDDQLLVLTDLLVSPCYY
                     A"
     exon            451..591
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            592..708
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            709..753
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            754..903
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            904..967
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1042
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1165
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1258
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1524
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1711
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1801
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1866
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2017
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2116
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2186
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2254
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2470
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2628
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2724
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2780
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..2837
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..2893
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..2992
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3055
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3151
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3283
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..3493
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            3494..3630
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            3631..3684
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            3685..3814
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            3815..3896
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            3897..4050
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            4051..4120
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            4121..4246
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            4247..4399
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            4400..4504
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            4505..4596
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            4597..4728
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            4729..4937
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            4938..5023
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            5024..5152
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            5153..5308
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            5309..5471
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            5472..5605
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            5606..5744
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            5745..6442
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6419..6424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /note="hexamer: AATAAA"
     polyA_site      6440
                     /gene="Psme4"
                     /gene_synonym="Blm10; mBlm10; mKIAA0077; TEMO"
                     /note="major polyA site"
ORIGIN      
        1 caccagaaga gccggagggg tccgggccga gcagccgctg ccaccgccaa cgaaccgggt
       61 gccgcgcggg gtccagcagc gcgccgggca gccggggcgg gaggggggcc cagcggtcgg
      121 gccgagggcg aggcgacgcg gacgaggctg agcccgcagc ggggcggggg ccggggccgg
      181 gggtcgggcc gggggcggcc ccgggctaat ggaggctccg gagcgggcgg gcggcgggga
      241 gccccccgag cctggcgggc ggccggtact gggcccgcgg gccttcgtcc cgcagaagga
      301 gatcgtgtac aacaagcttc tgccctatgc cgagcggctg gacgccgagt ccgacttgca
      361 gctggcacag atcaagagca acctgggccg ggccgtgcag ctccaagagc tgtggcccgg
      421 gggcctcttc tggacgcgga aactctccac ttatatccga ctttatggga gaaaatttag
      481 caaagaagat catgttcttt ttattaagtt actgtatgag ctggtatcaa ttccaaaact
      541 agaaatcagc atgatgcagg gatttgcccg tctcttgatc aacttgttaa aaaaaaagga
      601 acttctttca agagatgatt tagagttacc ttggagacca ctttatgact tggtagaaag
      661 aatattatat tccaagacag agcacctgag attaaattca tttcctaatt ctatagaaaa
      721 tgttctcaaa acactggtga aaagctgccg accatacttt ccagcagatt caacagcaga
      781 aatgttagaa gaatggcggc ctttaatgtg tccttttgat gtaacaatgc aaaaggccat
      841 cagttatttt gaaatatttc ttcctacctc ccttcctcca gaactgcatc ataaaggttt
      901 taaactttgg tttgatgaat taattggcct ttgggtttca gtgcaaaatc tcccacagtg
      961 ggaggggcaa ttagtaaatc tctttgctcg attggctaca gataatatag gatacataga
     1021 ttgggatcca tatgtaccga agatatttac aagaattctg agaagcctga acctcccagt
     1081 gggaagcagt caagttttag tcccaagatt tttaacaaat gcttatgata taggacatgc
     1141 tgtaatatgg atcaccgcaa tgatgggtgg accaagtaaa ttagtacaaa aacatttagc
     1201 tggtttgttt aacagcatca catcatttta tcatccttca aataatgggc gttggctgaa
     1261 caagttaatg aaactccttc agcggttgcc aaacagtgtt gttaggagat tacatcgtga
     1321 aagattcaag aagccctcct ggttaactcc tgtgcctgaa agccataagc ttactgatga
     1381 agatgttaca gactttgtac aatgcattat tcagcctgtc ctcttggcta tgtttagcaa
     1441 aactggtagt ctagaagcag cccaggctct gcagaacctt gcacttatga gacctgagtt
     1501 agtaataccc cctgtgcttg aaagaacata ccctgcttta gagacattaa cagaacctca
     1561 ccagctcaca gctactttaa attgtgtaat tggagtagcc cgaagtttgg tatcaggcag
     1621 caaatggttt cccgaagggc caacacacat gctacctctg ttgatgagag cattgcctgg
     1681 ggtagatcca aacgacttta gtaagtgcat gatcacattc caatttatag gaacattttc
     1741 tactctggtg cctttagtag actgttcatc tgtactgcaa gaaagaaatg acctcacaga
     1801 aattgaaaaa gaactttgtt cggcaacagc tgaatttgag gattttgtgt tacaatttat
     1861 ggacagatgc tttggactaa tagaaagtag tacattggag caaacaaggg aagagacaga
     1921 aacagagaaa atgactcatt tggagagttt ggttgaatta ggcttatctt ctacgtttag
     1981 tacaatcctc acacaatgtt ccaaagacat atttatggtg gcccttcaga aggtctttaa
     2041 cttttctgtt tcacatatat ttgaaacaag agttgcaggt cgcatggtgg cagacatgtg
     2101 ccgagctgct gtgaagtgtt gcccagaaga atccctgaag ctgtttgttc cccactgcta
     2161 tggtgttata actcagctta caatgaatga tgatgtattg aatgaagaag agctagacaa
     2221 ggagttgctg tggaaccttc agcttctgtc tgagattact cgtgtagacg ggaagaagtt
     2281 acttctgtat agggagcagc ttgtaaagat tctccagcga accttacacc tgacctgtaa
     2341 gcagggctac acgctgtctt gcaaccttct gcatcatctt cttcgttcta ccacactaat
     2401 ctaccctaca gagtactgca gtgttccggg gggctttaac aagccgcctt ctgaatactt
     2461 ccctgtcaag gactggggta agcctggaga tttgtggaat ctggggatcc agtggcatgt
     2521 tccttcttca gaagaagtct cttttgcctt ctatttgtta gactcctttc ttcagcctga
     2581 gcttatcaaa ctccagtgtt gtggagatgg agaacttgaa atgtctagag atgatattct
     2641 acagagtctg actatagtac acagctgctt gattggttca gggaaccttc tacctccatt
     2701 gaaaggagag gcagttacta acttggtacc aagtatggtc tccttagagg aaacaaaatt
     2761 gtataccgga ctggaacatg acctatccag agaaaactac cgagaagtaa ttgctagtgt
     2821 cataaggaaa cttcttagcc acatacttga taattcagaa gatgatacca aatcactgtt
     2881 tctcatcata aagatcattg gagaccttct gcacttccaa ggatctcata aacatgaatt
     2941 tgactctcga tggaaaagct ttaacttagt aaagaaatca atggaaaatc ggctccatgg
     3001 aaaaaagcaa catatcagag cattactaat tgacagagtg atgctgcagc atgagttgcg
     3061 aacactaact gttgagggtt gtgagtacaa aaaaatacat caagatatga tcagagatct
     3121 tcttcgatta tcaacaagct catacagtca ggtcagaaac aaagctcagc aaacattttt
     3181 tgctgctttg ggggcatata acttctgttg cagagatatt atccccttgg ttttggaatt
     3241 cctacggcct gatagaaagg atgtcacaca gcagcagttc aagggcgcct tatattgtct
     3301 acttggaaat cacagtggtg tgtgcctggc aaaccttcat gattgggact gtattgtgca
     3361 gacctggcca gcacttgttt cttcagggct tagccaagca atgtcactgg aaaagccatc
     3421 aatagtgaga ctatttgatg accttgctga aaagattcat agacaatatg aaacaattgg
     3481 cttggatttt acaattccaa agtcatgtgc tgcaatagca gaattacttc aacaatcaaa
     3541 gaatccttcc attagccaga cactacttag cccagaaaag attaaagaag gacagaagcg
     3601 tcaacaagat aagaatgctg atgccctaag gaactatgaa tgtttggtaa atactttact
     3661 agatggtgtg gagcaaagaa atctgccttg gaaatttgag catataggaa tcgggcttct
     3721 gtctctactc ctaagggatg acagagtgtt gcctcttcgt gccatacgtt tttttgttga
     3781 aaatctcaac catgatgcaa ttgttgttcg aaagatggct atctcagctg ttgctggtat
     3841 tctcaagcag ctaaagagaa ctcacaaaaa gctgactatc aacccttatg aaatcagtgg
     3901 atgtcctaaa cctaccaaaa ttcttgctgg tgatagacct gataaccatt ggttgcatta
     3961 tgatagtaaa aatataccaa gaacaaaaaa agaatgggag tcaagttgct ttgttgaaaa
     4021 aactcactgg ggatactaca actggccaaa gaatatggtt gtttatgctg gtgtggaaga
     4081 acagcctaaa cttggcagaa gcagggagga tatgatagag gcagaacaga ttatatatga
     4141 tcgtttttct gatcctaagt ttgttgagca gttaatcaca tttctatctt tagaagacag
     4201 aaaaggaaga gataagttta gtccccggcg tttctgcctc tttaagggta tatttagaaa
     4261 ttttgatgat gcttttctgc ctgttctgaa gccccattta gaacgtttgg ttgcagattc
     4321 tcatgaaagt acccagagat gtgttgcaga aattatagct ggtttaatca gaggttctaa
     4381 gcattggacg tttgagaagg tggagaagct ttgggagctc ctgtgcccgc tgctgagaac
     4441 ggcactgtcc aacatgacag tggagacata caatgactgg gggacctgta tagccacttc
     4501 ctgtgaaagc agagatcccc ggaagcttca ctggcttttt gagctgctct tggagtcacc
     4561 attgagtggt gaaggggggt cctttgtaga tgcatgccga ctctatgtgc tacaaggtgg
     4621 ccttgcccag caagagtgga gagtccctga actattgcac agacttctga agtacttgga
     4681 accaaaactc acccaggttt acaaaaatgt cagagaaaga ataggaagtg tgctgaccta
     4741 catatttatg atagatgttt ctttgccaaa tactgctcca acaacatctc cttgtatccc
     4801 tgagtttact gctcgcgtcc tagaaaaact gaaaccactc acagatgtgg atgaagaaat
     4861 tcagaaccat gttatggaag aaaatggcat tggtgaagaa gatgaacgaa ctcagggcat
     4921 taaactctta aaaactatat tgaaatggct tatggcaagt gcaggaagat ctttttctac
     4981 agcagtcaaa gagcaacttc agcttctgcc tttgttcttt aagatcgctc cagtggaaaa
     5041 tgacaatagt tatgatgaac tgaaaagaga tgcaaagctc tgtttgtcac taatgtctca
     5101 ggggttgctg taccctcaac aagtgccttt gatacttcag gtgctaagcc agacagcaag
     5161 aagcagttct tggcatgcaa gatatacagt gctgacctac ctccagacca tggtatttta
     5221 taacctcttt attttcctaa acaatgaaga tgcagttaaa gacatcagat ggctgattat
     5281 atgccttttg gaggatgaac agttagaggt tcgagaaatg gctgctacca ccttaagtgg
     5341 tctgttacag tgtaacttcc ttaccatgga cagtgctatg cagattcatt ttgagcaact
     5401 ttgcaaaaca aaactaccca agaaaagaaa acgagaccct ggttctgtgg gagataccat
     5461 tccttctgca gagttggtca aacgtcatgc tggtgtgctt ggacttggtg catgtgttct
     5521 ttctagccct tatgatgttc ctacctggat gccccagctc cttatgaacc tcagtgcaca
     5581 tttgaatgat cctcagccta ttgagatgac tgtaaagaag accttatcca atttccgaag
     5641 gacacatcat gacaactggc aagaacacaa gcagcagttc actgatgacc agctgcttgt
     5701 cctcactgac ctccttgtgt caccatgcta ttatgcatag agggatgact agtcctcatt
     5761 ctgggctcat ttcatcaaaa actccagatc ctcaggtatc atccgtggtg actctgcaag
     5821 tttcacaact cagcttctct tgagctttca tcattttggt ggcttctctg tttggcctca
     5881 ttagtcttcg ctcacaggtt ctcagctgcc atttgatttc ctaacttgtt ctgaagtgtt
     5941 ccctgagtac tgatcacttt ttcttttgag acatatgaca aagtcacaaa gtctcagact
     6001 agaagtagcc tagtactatc atggtattat gaccaaacag tctcgaacgt tgttaaaaac
     6061 aacaatgtcc tcggaatgga gaatgctcat caattatgta ggttctctca tttcattcat
     6121 ctcacgttat tttgagttct tccccaaagg ctgttgagtt tagcattagt agggccatgg
     6181 gtcatgaatc tgaagttttg accgccttgt gtctagagag ccatgaagag aaaaggatca
     6241 aagggggcaa agtctcagag ttaacctaga acctgacacg ctcaaccaca ctgcagatgt
     6301 ctgtatctcc acagactgga gtttttggtg ctgagtaaga gccaattgct gaaaaactgg
     6361 gggtttggtg aataaatttt agactgattt gtatgtgtat acaatgtgtg attttaaaaa
     6421 taaaaaagaa catcaataaa caaaaaaaaa aaaa
//
