LOCUS       NM_001281472            1066 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus protease (prosome, macropain) activator subunit 2B
            (Psme2b), mRNA.
ACCESSION   NM_001281472
VERSION     NM_001281472.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1066)
  AUTHORS   Oliver KR and Greene WK.
  TITLE     Transposable elements and viruses as factors in adaptation and
            evolution: an expansion and strengthening of the TE-Thrust
            hypothesis
  JOURNAL   Ecol Evol 2 (11), 2912-2933 (2012)
   PUBMED   23170223
REFERENCE   2  (bases 1 to 1066)
  AUTHORS   Ossendorp F, Fu N, Camps M, Granucci F, Gobin SJ, van den Elsen PJ,
            Schuurhuis D, Adema GJ, Lipford GB, Chiba T, Sijts A, Kloetzel PM,
            Ricciardi-Castagnoli P and Melief CJ.
  TITLE     Differential expression regulation of the alpha and beta subunits
            of the PA28 proteasome activator in mature dendritic cells
  JOURNAL   J Immunol 174 (12), 7815-7822 (2005)
   PUBMED   15944286
  REMARK    GeneRIF: Induction of PA28 beta expression allows proper PA28 alpha
            beta complex formation, thereby enhancing proteasome activity in
            activated dendritic cells.
REFERENCE   3  (bases 1 to 1066)
  AUTHORS   Murata S, Udono H, Tanahashi N, Hamada N, Watanabe K, Adachi K,
            Yamano T, Yui K, Kobayashi N, Kasahara M, Tanaka K and Chiba T.
  TITLE     Immunoproteasome assembly and antigen presentation in mice lacking
            both PA28alpha and PA28beta
  JOURNAL   EMBO J 20 (21), 5898-5907 (2001)
   PUBMED   11689430
  REMARK    GeneRIF: MEF from mice deficient for PA28a and PA28b do not have
            detectable mRNA and protein for these proteins even after gamma
            interferon stimulation, suggesting only one functional copy of
            PA28a and PA28b.
REFERENCE   4  (bases 1 to 1066)
  AUTHORS   Yawata M, Murata S, Tanaka K, Ishigatsubo Y and Kasahara M.
  TITLE     Nucleotide sequence analysis of the approximately 35-kb segment
            containing interferon-gamma-inducible mouse proteasome activator
            genes
  JOURNAL   Immunogenetics 53 (2), 119-129 (2001)
   PUBMED   11345588
REFERENCE   5  (bases 1 to 1066)
  AUTHORS   Zaiss DM and Kloetzel PM.
  TITLE     A second gene encoding the mouse proteasome activator PA28beta
            subunit is part of a LINE1 element and is driven by a LINE1
            promoter
  JOURNAL   J Mol Biol 287 (5), 829-835 (1999)
   PUBMED   10222192
  REMARK    GeneRIF: Psme2b is an expressed retrotransposon. Unlike Psme2,
            Psme2b is constitutive not cytokine-inducible, as a result of
            insertion into a transcriptionally active LINE1 element.
REFERENCE   6  (bases 1 to 1066)
  AUTHORS   Li Y, Chambers J, Pang J, Ngo K, Peterson PA, Leung WP and Yang Y.
  TITLE     Characterization of the mouse proteasome regulator PA28b gene
  JOURNAL   Immunogenetics 49 (3), 149-157 (1999)
   PUBMED   9914329
  REMARK    GeneRIF: Psme2b is intronless and lacks a structured promoter so
            appears to be a processed Psme2 pseudogene.
REFERENCE   7  (bases 1 to 1066)
  AUTHORS   Kohda K, Ishibashi T, Shimbara N, Tanaka K, Matsuda Y and Kasahara
            M.
  TITLE     Characterization of the mouse PA28 activator complex gene family:
            complete organizations of the three member genes and a physical map
            of the approximately 150-kb region containing the alpha- and
            beta-subunit genes
  JOURNAL   J Immunol 160 (10), 4923-4935 (1998)
   PUBMED   9590240
REFERENCE   8  (bases 1 to 1066)
  AUTHORS   Kandil E, Kohda K, Ishibashi T, Tanaka K and Kasahara M.
  TITLE     PA28 subunits of the mouse proteasome: primary structures and
            chromosomal localization of the genes
  JOURNAL   Immunogenetics 46 (4), 337-344 (1997)
   PUBMED   9218537
REFERENCE   9  (bases 1 to 1066)
  AUTHORS   Jiang H and Monaco JJ.
  TITLE     Sequence and expression of mouse proteasome activator PA28 and the
            related autoantigen Ki
  JOURNAL   Immunogenetics 46 (2), 93-98 (1997)
   PUBMED   9162094
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE624310.1, D87910.1 and
            BB844325.1.
            
            Summary: This gene may encode proteasome activator complex subunit
            2 protein (PMID: 10222192). This gene, located on chromosome 11,
            lacks a structured promoter and is intronless. It has also been
            described as a pseudogene (PMID: 9914329), however, it has an
            intact coding region and transcripts can be placed at this location
            unambiguously. An interferon-inducible gene located on chromosome
            14, near the gene that encodes proteasome activator complex subunit
            1 protein, is considered the functional gene. [provided by RefSeq,
            Jul 2013].
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               BE624310.1         1-341
            342-1057            D87910.1           69-784
            1058-1066           BB844325.1         85-93
FEATURES             Location/Qualifiers
     source          1..1066
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 28.93 cM"
     gene            1..1066
                     /gene="Psme2b"
                     /gene_synonym="PA28b-p; PA28b2; Psme2-like; Psme2b-ps"
                     /note="protease (prosome, macropain) activator subunit 2B"
                     /db_xref="GeneID:621823"
                     /db_xref="MGI:MGI:1341073"
     exon            1..1066
                     /gene="Psme2b"
                     /gene_synonym="PA28b-p; PA28b2; Psme2-like; Psme2b-ps"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..1012
                     /gene="Psme2b"
                     /gene_synonym="PA28b-p; PA28b2; Psme2-like; Psme2b-ps"
                     /note="proteasome activator complex like; protease
                     (prosome, macropain) 28 subunit, beta, b; PA28 beta
                     subunit (PA28b) pseudogene; protease (prosome, macropain)
                     28 subunit beta B, pseudogene"
                     /codon_start=1
                     /product="protease (prosome, macropain) 28 subunit beta B"
                     /protein_id="NP_001268401.1"
                     /db_xref="CCDS:CCDS78934.1"
                     /db_xref="GeneID:621823"
                     /db_xref="MGI:MGI:1341073"
                     /translation="MAKPCGVRLSGEARKQVDVFRQNLFQEADDFLCTFLPRKIISLS
                     QLLQEDSLNVADLSSLRAPLDIPIPDPPPKDDEMETDKQEKKEVPKCGYLPGNEKLLA
                     LLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAF
                     QTTISKYFSERGDAVAKASKDTHVMDYRALVHERDEAAYGALRAMVLDLRAFYAELYH
                     IISSNLEKIVNPKGEEKPSMY"
ORIGIN      
        1 cacaggagga acaggctcca gacagagaca gctataacaa ctaacaccag agattaccag
       61 atggtgaaag gcaaatgtaa gaatcttgcc aacagaaacc aagaccgctc accatcatca
      121 gaacccagca ctcccatctc agccagtcct ggataccgca acacaccgga agagcaagat
      181 tcagattcaa aatcatatct catgatgctg gtagaggacc ttaagaaggg cattaataac
      241 tcacttaaag aaatacagga cgaggctcga gagctgccaa gtggggggaa gcatggccaa
      301 gccttgtggg gtccgcttga gtggagaagc ccgaaaacag gtggatgtct tcagacaaaa
      361 tcttttccag gaggctgatg acttcctctg cactttcttg ccacggaaaa tcatatccct
      421 gagtcagctc ttgcaggagg attccctcaa tgtggccgac ctctcctccc tccgggctcc
      481 tctggacatc cctatcccag atcctccacc caaggatgac gagatggaaa cagacaagca
      541 ggagaagaag gaagtcccta agtgtggcta cctcccgggg aacgagaagc ttctggcctt
      601 gcttgctttg gttaagccag aagtctggac tctcaaagag aagtgcattc tggtaatcac
      661 gtggatccag cacctgatcc ccaagattga ggatggaaat gattttgggg tggcaattca
      721 ggagaaggtg ctggagagag tgaatgctgt caagaccaaa gtagaagctt tccagacaac
      781 tatttccaag tacttctcag aacgagggga tgctgtagcc aaggcttcca aggataccca
      841 tgtaatggat taccgggcct tggtgcatga gcgagatgaa gcagcctatg gggcgcttag
      901 ggccatggtg ctggacctga gggccttcta tgctgagctt tatcatatca tcagcagcaa
      961 cctagagaaa atcgtcaacc cgaagggtga agaaaagcca tcgatgtact gagctaagga
     1021 ttagaaggaa aataaatgat ttatacttta tgtatataaa aaaaaa
//
