LOCUS       NM_011190                906 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus proteasome (prosome, macropain) activator subunit 2
            (PA28 beta) (Psme2), transcript variant 1, mRNA.
ACCESSION   NM_011190
VERSION     NM_011190.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 906)
  AUTHORS   Ngwaga,T., Chauhan,D., Salberg,A.G. and Shames,S.R.
  TITLE     Effector-mediated subversion of proteasome activator
            (PA)28alphabeta enhances host defense against Legionella
            pneumophila under inflammatory and oxidative stress conditions
  JOURNAL   PLoS Pathog 19 (6), e1011473 (2023)
   PUBMED   37347796
  REMARK    Erratum:[PLoS Pathog. 2023 Aug 22;19(8):e1011604. doi:
            10.1371/journal.ppat.1011604.. PMID: 37607134]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 906)
  AUTHORS   Imai,T., Suzue,K., Ngo-Thanh,H., Ono,S., Orita,W., Suzuki,H.,
            Shimokawa,C., Olia,A., Obi,S., Taniguchi,T., Ishida,H., Van
            Kaer,L., Murata,S., Tanaka,K. and Hisaeda,H.
  TITLE     Fluctuations of Spleen Cytokine and Blood Lactate, Importance of
            Cellular Immunity in Host Defense Against Blood Stage Malaria
            Plasmodium yoelii
  JOURNAL   Front Immunol 10, 2207 (2019)
   PUBMED   31608052
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 906)
  AUTHORS   Adelof,J., Andersson,M., Porritt,M., Petersen,A., Zetterberg,M.,
            Wiseman,J. and Hernebring,M.
  TITLE     PA28alphabeta overexpression enhances learning and memory of female
            mice without inducing 20S proteasome activity
  JOURNAL   BMC Neurosci 19 (1), 70 (2018)
   PUBMED   30400847
  REMARK    GeneRIF: Overexpression of PA28alpha and concomitant upregulation
            of PA28beta protein reduces depressive-like behavior and enhances
            learning and memory in female mice. The overexpression of PA28alpha
            does not increase PA28alphabeta-dependent proteasome activity but
            could still be linked to its protective functions upon oxidative
            stress and proteinopathy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 906)
  AUTHORS   Basler,M., Mundt,S. and Groettrup,M.
  TITLE     The immunoproteasome subunit LMP7 is required in the murine thymus
            for filling up a hole in the T cell repertoire
  JOURNAL   Eur J Immunol 48 (3), 419-429 (2018)
   PUBMED   29067678
REFERENCE   5  (bases 1 to 906)
  AUTHORS   Huber,E.M. and Groll,M.
  TITLE     The Mammalian Proteasome Activator PA28 Forms an Asymmetric
            alpha4beta3 Complex
  JOURNAL   Structure 25 (10), 1473-1480 (2017)
   PUBMED   28867616
  REMARK    GeneRIF: Study clarifies the subunit composition and arrangement of
            PA28ab and provides key insights into the assembly of an asymmetric
            complex from two highly homologous subunits. Differential scanning
            fluorimetry experiments and activity assays classify
            PA28alpha4beta3 as most stable and most active, indicating that
            this assembly might represent the physiologically relevant species.
REFERENCE   6  (bases 1 to 906)
  AUTHORS   Kohda,K., Ishibashi,T., Shimbara,N., Tanaka,K., Matsuda,Y. and
            Kasahara,M.
  TITLE     Characterization of the mouse PA28 activator complex gene family:
            complete organizations of the three member genes and a physical map
            of the approximately 150-kb region containing the alpha- and
            beta-subunit genes
  JOURNAL   J Immunol 160 (10), 4923-4935 (1998)
   PUBMED   9590240
REFERENCE   7  (bases 1 to 906)
  AUTHORS   Soza,A., Knuehl,C., Groettrup,M., Henklein,P., Tanaka,K. and
            Kloetzel,P.M.
  TITLE     Expression and subcellular localization of mouse 20S proteasome
            activator complex PA28
  JOURNAL   FEBS Lett 413 (1), 27-34 (1997)
   PUBMED   9287111
REFERENCE   8  (bases 1 to 906)
  AUTHORS   Kohda,K., Matsuda,Y., Ishibashi,T., Tanaka,K. and Kasahara,M.
  TITLE     Structural analysis and chromosomal localization of the mouse Psmb5
            gene coding for the constitutively expressed beta-type proteasome
            subunit
  JOURNAL   Immunogenetics 47 (1), 77-87 (1997)
   PUBMED   9382924
REFERENCE   9  (bases 1 to 906)
  AUTHORS   Kandil,E., Kohda,K., Ishibashi,T., Tanaka,K. and Kasahara,M.
  TITLE     PA28 subunits of the mouse proteasome: primary structures and
            chromosomal localization of the genes
  JOURNAL   Immunogenetics 46 (4), 337-344 (1997)
   PUBMED   9218537
REFERENCE   10 (bases 1 to 906)
  AUTHORS   Jiang,H. and Monaco,J.J.
  TITLE     Sequence and expression of mouse proteasome activator PA28 and the
            related autoantigen Ki
  JOURNAL   Immunogenetics 46 (2), 93-98 (1997)
   PUBMED   9162094
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU563130.1, BY134400.1, CA536627.1, AK012344.1, BY498670.1 and
            AA216967.1.
            
            On Aug 3, 2005 this sequence version replaced NM_011190.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057859.1, AK143556.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                BU563130.1         70-104
            36-91               BY134400.1         2-57
            92-622              CA536627.1         4-534
            623-888             AK012344.1         552-817
            889-895             BY498670.1         394-400
            896-906             AA216967.1         174-184
FEATURES             Location/Qualifiers
     source          1..906
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..906
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /note="proteasome (prosome, macropain) activator subunit 2
                     (PA28 beta)"
                     /db_xref="GeneID:19188"
                     /db_xref="MGI:MGI:1096365"
     exon            1..180
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..852
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protease (prosome, macropain) 28 subunit, beta; proteasome
                     activator complex subunit 2; PA28beta; REG-beta; 11S
                     regulator complex subunit beta; proteasome activator 28
                     subunit beta; activator of multicatalytic protease subunit
                     2; proteasome (prosome, macropain) 28 subunit, beta"
                     /codon_start=1
                     /product="proteasome activator complex subunit 2 isoform
                     1"
                     /protein_id="NP_035320.1"
                     /db_xref="CCDS:CCDS49494.1"
                     /db_xref="GeneID:19188"
                     /db_xref="MGI:MGI:1096365"
                     /translation="MAKPCGVRLSGEARKQVDVFRQNLFQEADDFLCTFLPRKIISLS
                     QLLQEDSLNVADLSSLRAPLDIPIPDPPPKDDEMETDKQEKKEVPKCGYLPGNEKLLA
                     LLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAF
                     QTTISKYFSERGDAVAKASKDTHVMDYRALVHERDEAAYGALRAMVLDLRAFYAELYH
                     IISSNLEKIVNPKGEEKPSMY"
     exon            181..213
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /inference="alignment:Splign:2.1.0"
     exon            214..276
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /inference="alignment:Splign:2.1.0"
     exon            277..363
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /inference="alignment:Splign:2.1.0"
     exon            364..394
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /inference="alignment:Splign:2.1.0"
     exon            395..492
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /inference="alignment:Splign:2.1.0"
     exon            493..561
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /inference="alignment:Splign:2.1.0"
     exon            562..629
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /inference="alignment:Splign:2.1.0"
     exon            630..684
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /inference="alignment:Splign:2.1.0"
     exon            685..771
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /inference="alignment:Splign:2.1.0"
     exon            772..897
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      871..876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psme2"
                     /gene_synonym="PA28b"
     polyA_site      897
                     /gene="Psme2"
                     /gene_synonym="PA28b"
ORIGIN      
        1 gttggtggcc ggccaggagg aggagaaaaa agggaggggg cgtggctgag gggggtgggt
       61 ctgggcctgg agagtgaaag cgaaagctgg ggctgctagc ccaggctcga gagctgccaa
      121 gtggggggaa gcatggccaa gccttgtggg gtccgcttga gtggagaagc ccgaaaacag
      181 gtggatgtct tcagacaaaa tcttttccag gaggctgatg acttcctctg cactttcttg
      241 ccacggaaaa tcatatccct gagtcagctc ttgcaggagg attccctcaa tgtggccgac
      301 ctctcctccc tccgggctcc tctggacatc cctatcccag atcctccacc caaggatgac
      361 gagatggaaa cagacaagca ggagaagaag gaagtcccta agtgtggcta cctcccgggg
      421 aacgagaagc ttctggcctt gctcgctttg gttaagccag aagtctggac tctcaaagag
      481 aagtgcattc tggtaatcac atggatccag cacctgatcc ccaagattga ggatggaaat
      541 gattttgggg tggcaattca ggagaaggtg ctggagagag tgaatgctgt caagaccaaa
      601 gtagaagctt tccagacaac catttccaag tacttctcag aacgagggga cgctgtagcc
      661 aaggcttcca aggacaccca tgtaatggat taccgggcct tggtgcatga gcgagatgaa
      721 gcagcctatg gggcgcttag ggccatggtg ctggacctga gggccttcta tgctgagctt
      781 tatcatatca tcagcagcaa cctagagaaa atcgtcaacc cgaagggtga agaaaagcca
      841 tcgatgtact gagctaagga ttagaaggaa aataaatgat ttatacttta tgtatataaa
      901 aaaaaa
//
