LOCUS       NM_001029855             806 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus proteasome (prosome, macropain) activator subunit 2
            (PA28 beta) (Psme2), transcript variant 2, mRNA.
ACCESSION   NM_001029855
VERSION     NM_001029855.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 806)
  AUTHORS   Ngwaga,T., Chauhan,D., Salberg,A.G. and Shames,S.R.
  TITLE     Effector-mediated subversion of proteasome activator
            (PA)28alphabeta enhances host defense against Legionella
            pneumophila under inflammatory and oxidative stress conditions
  JOURNAL   PLoS Pathog 19 (6), e1011473 (2023)
   PUBMED   37347796
  REMARK    Erratum:[PLoS Pathog. 2023 Aug 22;19(8):e1011604. doi:
            10.1371/journal.ppat.1011604.. PMID: 37607134]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 806)
  AUTHORS   Imai,T., Suzue,K., Ngo-Thanh,H., Ono,S., Orita,W., Suzuki,H.,
            Shimokawa,C., Olia,A., Obi,S., Taniguchi,T., Ishida,H., Van
            Kaer,L., Murata,S., Tanaka,K. and Hisaeda,H.
  TITLE     Fluctuations of Spleen Cytokine and Blood Lactate, Importance of
            Cellular Immunity in Host Defense Against Blood Stage Malaria
            Plasmodium yoelii
  JOURNAL   Front Immunol 10, 2207 (2019)
   PUBMED   31608052
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 806)
  AUTHORS   Adelof,J., Andersson,M., Porritt,M., Petersen,A., Zetterberg,M.,
            Wiseman,J. and Hernebring,M.
  TITLE     PA28alphabeta overexpression enhances learning and memory of female
            mice without inducing 20S proteasome activity
  JOURNAL   BMC Neurosci 19 (1), 70 (2018)
   PUBMED   30400847
  REMARK    GeneRIF: Overexpression of PA28alpha and concomitant upregulation
            of PA28beta protein reduces depressive-like behavior and enhances
            learning and memory in female mice. The overexpression of PA28alpha
            does not increase PA28alphabeta-dependent proteasome activity but
            could still be linked to its protective functions upon oxidative
            stress and proteinopathy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 806)
  AUTHORS   Basler,M., Mundt,S. and Groettrup,M.
  TITLE     The immunoproteasome subunit LMP7 is required in the murine thymus
            for filling up a hole in the T cell repertoire
  JOURNAL   Eur J Immunol 48 (3), 419-429 (2018)
   PUBMED   29067678
REFERENCE   5  (bases 1 to 806)
  AUTHORS   Huber,E.M. and Groll,M.
  TITLE     The Mammalian Proteasome Activator PA28 Forms an Asymmetric
            alpha4beta3 Complex
  JOURNAL   Structure 25 (10), 1473-1480 (2017)
   PUBMED   28867616
  REMARK    GeneRIF: Study clarifies the subunit composition and arrangement of
            PA28ab and provides key insights into the assembly of an asymmetric
            complex from two highly homologous subunits. Differential scanning
            fluorimetry experiments and activity assays classify
            PA28alpha4beta3 as most stable and most active, indicating that
            this assembly might represent the physiologically relevant species.
REFERENCE   6  (bases 1 to 806)
  AUTHORS   Kohda,K., Ishibashi,T., Shimbara,N., Tanaka,K., Matsuda,Y. and
            Kasahara,M.
  TITLE     Characterization of the mouse PA28 activator complex gene family:
            complete organizations of the three member genes and a physical map
            of the approximately 150-kb region containing the alpha- and
            beta-subunit genes
  JOURNAL   J Immunol 160 (10), 4923-4935 (1998)
   PUBMED   9590240
REFERENCE   7  (bases 1 to 806)
  AUTHORS   Soza,A., Knuehl,C., Groettrup,M., Henklein,P., Tanaka,K. and
            Kloetzel,P.M.
  TITLE     Expression and subcellular localization of mouse 20S proteasome
            activator complex PA28
  JOURNAL   FEBS Lett 413 (1), 27-34 (1997)
   PUBMED   9287111
REFERENCE   8  (bases 1 to 806)
  AUTHORS   Kohda,K., Matsuda,Y., Ishibashi,T., Tanaka,K. and Kasahara,M.
  TITLE     Structural analysis and chromosomal localization of the mouse Psmb5
            gene coding for the constitutively expressed beta-type proteasome
            subunit
  JOURNAL   Immunogenetics 47 (1), 77-87 (1997)
   PUBMED   9382924
REFERENCE   9  (bases 1 to 806)
  AUTHORS   Kandil,E., Kohda,K., Ishibashi,T., Tanaka,K. and Kasahara,M.
  TITLE     PA28 subunits of the mouse proteasome: primary structures and
            chromosomal localization of the genes
  JOURNAL   Immunogenetics 46 (4), 337-344 (1997)
   PUBMED   9218537
REFERENCE   10 (bases 1 to 806)
  AUTHORS   Jiang,H. and Monaco,J.J.
  TITLE     Sequence and expression of mouse proteasome activator PA28 and the
            related autoantigen Ki
  JOURNAL   Immunogenetics 46 (2), 93-98 (1997)
   PUBMED   9162094
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB869062.1, AA267668.1, AK012344.1 and AA216967.1.
            
            Transcript Variant: This variant (2) uses an alternate
            transcription initiation site and uses a distinct start codon,
            compared to variant 1. The resulting protein (isoform 2) has a
            distinct N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.888146.1,
                                           SRR13862101.2132328.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-351               BB869062.1         1-351
            352-552             AA267668.1         343-543
            553-788             AK012344.1         582-817
            789-806             AA216967.1         167-184
FEATURES             Location/Qualifiers
     source          1..806
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..806
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /note="proteasome (prosome, macropain) activator subunit 2
                     (PA28 beta)"
                     /db_xref="GeneID:19188"
                     /db_xref="MGI:MGI:1096365"
     exon            1..80
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..752
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protease (prosome, macropain) 28 subunit, beta; proteasome
                     activator complex subunit 2; PA28beta; REG-beta; 11S
                     regulator complex subunit beta; proteasome activator 28
                     subunit beta; activator of multicatalytic protease subunit
                     2; proteasome (prosome, macropain) 28 subunit, beta"
                     /codon_start=1
                     /product="proteasome activator complex subunit 2 isoform
                     2"
                     /protein_id="NP_001025026.1"
                     /db_xref="CCDS:CCDS49495.1"
                     /db_xref="GeneID:19188"
                     /db_xref="MGI:MGI:1096365"
                     /translation="MAEGVLLTVDVFRQNLFQEADDFLCTFLPRKIISLSQLLQEDSL
                     NVADLSSLRAPLDIPIPDPPPKDDEMETDKQEKKEVPKCGYLPGNEKLLALLALVKPE
                     VWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYF
                     SERGDAVAKASKDTHVMDYRALVHERDEAAYGALRAMVLDLRAFYAELYHIISSNLEK
                     IVNPKGEEKPSMY"
     exon            81..113
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /inference="alignment:Splign:2.1.0"
     exon            114..176
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /inference="alignment:Splign:2.1.0"
     exon            177..263
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /inference="alignment:Splign:2.1.0"
     exon            264..294
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /inference="alignment:Splign:2.1.0"
     exon            295..392
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /inference="alignment:Splign:2.1.0"
     exon            393..461
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /inference="alignment:Splign:2.1.0"
     exon            462..529
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /inference="alignment:Splign:2.1.0"
     exon            530..584
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /inference="alignment:Splign:2.1.0"
     exon            585..671
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /inference="alignment:Splign:2.1.0"
     exon            672..797
                     /gene="Psme2"
                     /gene_synonym="PA28b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      771..776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psme2"
                     /gene_synonym="PA28b"
     polyA_site      797
                     /gene="Psme2"
                     /gene_synonym="PA28b"
ORIGIN      
        1 ggacagcccc tgatgatgaa gccaacaccg cccttcctag tggcaactag ctgggaatgg
       61 ctgagggggt actactcacg gtggatgtct tcagacaaaa tcttttccag gaggctgatg
      121 acttcctctg cactttcttg ccacggaaaa tcatatccct gagtcagctc ttgcaggagg
      181 attccctcaa tgtggccgac ctctcctccc tccgggctcc tctggacatc cctatcccag
      241 atcctccacc caaggatgac gagatggaaa cagacaagca ggagaagaag gaagtcccta
      301 agtgtggcta cctcccgggg aacgagaagc ttctggcctt gctcgctttg gttaagccag
      361 aagtctggac tctcaaagag aagtgcattc tggtaatcac atggatccag cacctgatcc
      421 ccaagattga ggatggaaat gattttgggg tggcaattca ggagaaggtg ctggagagag
      481 tgaatgctgt caagaccaaa gtagaagctt tccagacaac catttccaag tacttctcag
      541 aacgagggga cgctgtagcc aaggcttcca aggacaccca tgtaatggat taccgggcct
      601 tggtgcatga gcgagatgaa gcagcctatg gggcgcttag ggccatggtg ctggacctga
      661 gggccttcta tgctgagctt tatcatatca tcagcagcaa cctagagaaa atcgtcaacc
      721 cgaagggtga agaaaagcca tcgatgtact gagctaagga ttagaaggaa aataaatgat
      781 ttatacttta tgtatataaa aaaaaa
//
