LOCUS       NM_011189                977 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus proteasome (prosome, macropain) activator subunit 1
            (PA28 alpha) (Psme1), mRNA.
ACCESSION   NM_011189
VERSION     NM_011189.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 977)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 977)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 977)
  AUTHORS   Ngwaga,T., Chauhan,D., Salberg,A.G. and Shames,S.R.
  TITLE     Effector-mediated subversion of proteasome activator
            (PA)28alphabeta enhances host defense against Legionella
            pneumophila under inflammatory and oxidative stress conditions
  JOURNAL   PLoS Pathog 19 (6), e1011473 (2023)
   PUBMED   37347796
  REMARK    Erratum:[PLoS Pathog. 2023 Aug 22;19(8):e1011604. doi:
            10.1371/journal.ppat.1011604.. PMID: 37607134]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 977)
  AUTHORS   Adelof,J., Wiseman,J., Zetterberg,M. and Hernebring,M.
  TITLE     PA28alpha overexpressing female mice maintain exploratory behavior
            and capacity to prevent protein aggregation in hippocampus as they
            age
  JOURNAL   Aging Cell 20 (4), e13336 (2021)
   PUBMED   33720528
  REMARK    GeneRIF: PA28alpha overexpressing female mice maintain exploratory
            behavior and capacity to prevent protein aggregation in hippocampus
            as they age.
REFERENCE   5  (bases 1 to 977)
  AUTHORS   Imai,T., Suzue,K., Ngo-Thanh,H., Ono,S., Orita,W., Suzuki,H.,
            Shimokawa,C., Olia,A., Obi,S., Taniguchi,T., Ishida,H., Van
            Kaer,L., Murata,S., Tanaka,K. and Hisaeda,H.
  TITLE     Fluctuations of Spleen Cytokine and Blood Lactate, Importance of
            Cellular Immunity in Host Defense Against Blood Stage Malaria
            Plasmodium yoelii
  JOURNAL   Front Immunol 10, 2207 (2019)
   PUBMED   31608052
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 977)
  AUTHORS   Kohda,K., Ishibashi,T., Shimbara,N., Tanaka,K., Matsuda,Y. and
            Kasahara,M.
  TITLE     Characterization of the mouse PA28 activator complex gene family:
            complete organizations of the three member genes and a physical map
            of the approximately 150-kb region containing the alpha- and
            beta-subunit genes
  JOURNAL   J Immunol 160 (10), 4923-4935 (1998)
   PUBMED   9590240
REFERENCE   7  (bases 1 to 977)
  AUTHORS   Kohda,K., Matsuda,Y., Ishibashi,T., Tanaka,K. and Kasahara,M.
  TITLE     Structural analysis and chromosomal localization of the mouse Psmb5
            gene coding for the constitutively expressed beta-type proteasome
            subunit
  JOURNAL   Immunogenetics 47 (1), 77-87 (1997)
   PUBMED   9382924
REFERENCE   8  (bases 1 to 977)
  AUTHORS   Kandil,E., Kohda,K., Ishibashi,T., Tanaka,K. and Kasahara,M.
  TITLE     PA28 subunits of the mouse proteasome: primary structures and
            chromosomal localization of the genes
  JOURNAL   Immunogenetics 46 (4), 337-344 (1997)
   PUBMED   9218537
REFERENCE   9  (bases 1 to 977)
  AUTHORS   Jiang,H. and Monaco,J.J.
  TITLE     Sequence and expression of mouse proteasome activator PA28 and the
            related autoantigen Ki
  JOURNAL   Immunogenetics 46 (2), 93-98 (1997)
   PUBMED   9162094
REFERENCE   10 (bases 1 to 977)
  AUTHORS   Groettrup,M., Soza,A., Eggers,M., Kuehn,L., Dick,T.P., Schild,H.,
            Rammensee,H.G., Koszinowski,U.H. and Kloetzel,P.M.
  TITLE     A role for the proteasome regulator PA28alpha in antigen
            presentation
  JOURNAL   Nature 381 (6578), 166-168 (1996)
   PUBMED   8610016
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D87909.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D87909.1, AK150708.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..977
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..977
                     /gene="Psme1"
                     /gene_synonym="PA28a"
                     /note="proteasome (prosome, macropain) activator subunit 1
                     (PA28 alpha)"
                     /db_xref="GeneID:19186"
                     /db_xref="MGI:MGI:1096367"
     exon            1..120
                     /gene="Psme1"
                     /gene_synonym="PA28a"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..831
                     /gene="Psme1"
                     /gene_synonym="PA28a"
                     /note="protease (prosome, macropain) 28 subunit, alpha;
                     PA28 alpha subunit; PA28alpha; REG-alpha; 11S regulator
                     complex subunit alpha; proteasome activator 28 subunit
                     alpha; activator of multicatalytic protease subunit 1;
                     proteasome (prosome, macropain) 28 subunit, alpha"
                     /codon_start=1
                     /product="proteasome activator complex subunit 1"
                     /protein_id="NP_035319.1"
                     /db_xref="CCDS:CCDS36931.1"
                     /db_xref="GeneID:19186"
                     /db_xref="MGI:MGI:1096367"
                     /translation="MATLRVHPEAQAKVDVFREDLCSKTENLLGSYFPKKISELDAFL
                     KEPALNEANLSNLKAPLDIPVPDPVKEKEKEERKKQQEKEEKEEKKKGDEDDKGPPCG
                     PVNCNEKIVVLLQRLKPEIKDVTEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELM
                     TNLHTKLEGFHTQISKYFSERGDAVAKAAKQPHVGDYRQLVHELDEAEYQEIRLMVME
                     IRNAYAVLYDIILKNFEKLKKPRGETKGMIY"
     exon            121..153
                     /gene="Psme1"
                     /gene_synonym="PA28a"
                     /inference="alignment:Splign:2.1.0"
     exon            154..216
                     /gene="Psme1"
                     /gene_synonym="PA28a"
                     /inference="alignment:Splign:2.1.0"
     exon            217..327
                     /gene="Psme1"
                     /gene_synonym="PA28a"
                     /inference="alignment:Splign:2.1.0"
     exon            328..373
                     /gene="Psme1"
                     /gene_synonym="PA28a"
                     /inference="alignment:Splign:2.1.0"
     exon            374..471
                     /gene="Psme1"
                     /gene_synonym="PA28a"
                     /inference="alignment:Splign:2.1.0"
     exon            472..540
                     /gene="Psme1"
                     /gene_synonym="PA28a"
                     /inference="alignment:Splign:2.1.0"
     exon            541..608
                     /gene="Psme1"
                     /gene_synonym="PA28a"
                     /inference="alignment:Splign:2.1.0"
     exon            609..663
                     /gene="Psme1"
                     /gene_synonym="PA28a"
                     /inference="alignment:Splign:2.1.0"
     exon            664..750
                     /gene="Psme1"
                     /gene_synonym="PA28a"
                     /inference="alignment:Splign:2.1.0"
     exon            751..977
                     /gene="Psme1"
                     /gene_synonym="PA28a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagctgtgct ttcgctttcc cttcccgctg cccaccccag gttcctcgtg cggcgctcac
       61 caccaccccc cggctctggc catggccaca ctgagggtcc atcccgaagc ccaagccaag
      121 gtggatgtgt tccgtgaaga cctgtgtagc aagacagaga acctgcttgg gagctatttt
      181 cccaagaaaa tctcagagtt ggatgcgttc ttaaaggagc cagctctcaa tgaagccaac
      241 ctgagcaatc tgaaggctcc attggacatc ccagtacccg atccagtcaa agagaaagag
      301 aaggaggagc ggaagaagca acaggagaag gaagagaagg aagagaagaa gaaaggggac
      361 gaagacgaca aaggtccccc ctgtggccca gtgaactgca atgagaagat tgtggtcctc
      421 ctgcaacgcc taaaacctga gatcaaggat gtcactgagc aactcaatct ggtcactacc
      481 tggttgcagc tacagatacc tcggatagag gatgggaata attttggcgt ggctgtccag
      541 gaaaaggtgt ttgagctgat gaccaacctt cacaccaagc tggaaggctt ccacacgcag
      601 atctccaagt acttctccga gaggggtgac gccgtggcca aagcagccaa gcagccccac
      661 gtgggtgact atcggcagct ggtgcacgag ctggacgagg cggagtacca ggagatccgt
      721 ctgatggtca tggagatccg aaatgcttat gctgtgttat atgacatcat cctgaagaac
      781 tttgagaagc tcaagaagcc ccgtggagaa accaagggaa tgatctattg agccccctct
      841 ctcattctgt gatgggtata gcagaaacct tcctgctttt caccaggaac tctagactgg
      901 acgcagtctt cttcctactg gctggggttt ctccctcact ctgcctccca aacacaataa
      961 atacatagtt gcccacc
//
