LOCUS       NM_001282017            1286 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus proteasome (prosome, macropain) 26S subunit,
            non-ATPase, 4 (Psmd4), transcript variant 1, mRNA.
ACCESSION   NM_001282017
VERSION     NM_001282017.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1286)
  AUTHORS   Zhang,R., Pan,S., Zheng,S., Liao,Q., Jiang,Z., Wang,D., Li,X.,
            Hu,A., Li,X., Zhu,Y., Shen,X., Lei,J., Zhong,S., Zhang,X.,
            Huang,L., Wang,X., Huang,L., Shen,L., Song,B.L., Zhao,J.W.,
            Wang,Z., Yang,B. and Guo,X.
  TITLE     Lipid-anchored proteasomes control membrane protein homeostasis
  JOURNAL   Sci Adv 9 (48), eadj4605 (2023)
   PUBMED   38019907
REFERENCE   2  (bases 1 to 1286)
  AUTHORS   Xing,L., Simon,J.M., Ptacek,T.S., Yi,J.J., Loo,L., Mao,H.,
            Wolter,J.M., McCoy,E.S., Paranjape,S.R., Taylor-Blake,B. and
            Zylka,M.J.
  TITLE     Autism-linked UBE3A gain-of-function mutation causes interneuron
            and behavioral phenotypes when inherited maternally or paternally
            in mice
  JOURNAL   Cell Rep 42 (7), 112706 (2023)
   PUBMED   37389991
REFERENCE   3  (bases 1 to 1286)
  AUTHORS   Avagliano Trezza,R., Sonzogni,M., Bossuyt,S.N.V., Zampeta,F.I.,
            Punt,A.M., van den Berg,M., Rotaru,D.C., Koene,L.M.C., Munshi,S.T.,
            Stedehouder,J., Kros,J.M., Williams,M., Heussler,H., de
            Vrij,F.M.S., Mientjes,E.J., van Woerden,G.M., Kushner,S.A.,
            Distel,B. and Elgersma,Y.
  TITLE     Loss of nuclear UBE3A causes electrophysiological and behavioral
            deficits in mice and is associated with Angelman syndrome
  JOURNAL   Nat Neurosci 22 (8), 1235-1247 (2019)
   PUBMED   31235931
REFERENCE   4  (bases 1 to 1286)
  AUTHORS   Medvedev,A.E., Buneeva,O.A., Kopylov,A.T., Tikhonova,O.V.,
            Medvedeva,M.V., Nerobkova,L.N., Kapitsa,I.G. and Zgoda,V.G.
  TITLE     Brain Mitochondrial Subproteome of Rpn10-Binding Proteins and Its
            Changes Induced by the Neurotoxin MPTP and the Neuroprotector
            Isatin
  JOURNAL   Biochemistry (Mosc) 82 (3), 330-339 (2017)
   PUBMED   28320274
  REMARK    GeneRIF: the neuroprotective dose of isatin used in this study can
            result in brain isatin concentrations that are proapoptotic for
            cells in vitro, the altered repertoire of mitochondrial
            Rpn10-binding proteins may thus represent a part of a switch
            mechanism from targeted elimination of individual (damaged)
            proteins to more efficient ('global') elimination of damaged
            organelles and whole damaged cells.
REFERENCE   5  (bases 1 to 1286)
  AUTHORS   Hamazaki,J., Hirayama,S. and Murata,S.
  TITLE     Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated
            Proteins and Cellular Homeostasis
  JOURNAL   PLoS Genet 11 (7), e1005401 (2015)
   PUBMED   26222436
  REMARK    GeneRIF: this study showed that Rpn13 plays a redundant role with
            Rpn10 in recognition and degradation of ubiquitinated proteins in
            mouse livers.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1286)
  AUTHORS   Sabherwal,Y., Rothman,V.L., Dimitrov,S., L'Heureux,D.Z.,
            Marcinkiewicz,C., Sharma,M. and Tuszynski,G.P.
  TITLE     Integrin alpha2beta1 mediates the anti-angiogenic and anti-tumor
            activities of angiocidin, a novel tumor-associated protein
  JOURNAL   Exp Cell Res 312 (13), 2443-2453 (2006)
   PUBMED   16762342
REFERENCE   7  (bases 1 to 1286)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1286)
  AUTHORS   Kawahara,H., Kasahara,M., Nishiyama,A., Ohsumi,K., Goto,T.,
            Kishimoto,T., Saeki,Y., Yokosawa,H., Shimbara,N., Murata,S.,
            Chiba,T., Suzuki,K. and Tanaka,K.
  TITLE     Developmentally regulated, alternative splicing of the Rpn10 gene
            generates multiple forms of 26S proteasomes
  JOURNAL   EMBO J 19 (15), 4144-4153 (2000)
   PUBMED   10921894
REFERENCE   9  (bases 1 to 1286)
  AUTHORS   Pusch,W., Jahner,D. and Ivell,R.
  TITLE     Molecular cloning and testicular expression of the gene transcripts
            encoding the murine multiubiquitin-chain-binding protein (Mcb1)
  JOURNAL   Gene 207 (1), 19-24 (1998)
   PUBMED   9511739
REFERENCE   10 (bases 1 to 1286)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087062.25.
            
            On Aug 10, 2022 this sequence version replaced NM_001282017.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145524.1, AB029143.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AC087062.25        203933-203994       c
            63-203              AC087062.25        198030-198170       c
            204-318             AC087062.25        197235-197349       c
            319-405             AC087062.25        196663-196749       c
            406-474             AC087062.25        196367-196435       c
            475-690             AC087062.25        195991-196206       c
            691-808             AC087062.25        195334-195451       c
            809-940             AC087062.25        195058-195189       c
            941-1005            AC087062.25        194907-194971       c
            1006-1286           AC087062.25        194129-194409       c
FEATURES             Location/Qualifiers
     source          1..1286
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.74 cM"
     gene            1..1286
                     /gene="Psmd4"
                     /gene_synonym="Af1; angiocidin; Mcb1"
                     /note="proteasome (prosome, macropain) 26S subunit,
                     non-ATPase, 4"
                     /db_xref="GeneID:19185"
                     /db_xref="MGI:MGI:1201670"
     exon            1..62
                     /gene="Psmd4"
                     /gene_synonym="Af1; angiocidin; Mcb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1176
                     /gene="Psmd4"
                     /gene_synonym="Af1; angiocidin; Mcb1"
                     /note="isoform 1 is encoded by transcript variant 1; 26S
                     proteasome non-ATPase regulatory subunit 4; multiubiquitin
                     chain-binding protein; 26S proteasome regulatory subunit
                     S5A; RPN10 homolog; 26S proteasome regulatory subunit
                     RPN10; anti secretory factor 1"
                     /codon_start=1
                     /product="26S proteasome non-ATPase regulatory subunit 4
                     isoform 1"
                     /protein_id="NP_001268946.1"
                     /db_xref="CCDS:CCDS71287.1"
                     /db_xref="GeneID:19185"
                     /db_xref="MGI:MGI:1201670"
                     /translation="MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSN
                     PENNVGLITLANDCEVLTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQG
                     KNHKMRIIAFVGSPVEDNEKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTL
                     NGKDGTGSHLVTVPPGPSLADALISSPILAGEGGAMLGLGASDFEFGVDPSADPELAL
                     ALRVSMEEQRQRQEEEARRAAAASAAEAGIATPGTEGERDSDDALLKMTINQQEFGRP
                     GLPDLSSMTEEEQIAYAMQMSLQGTEFSQESADMDASSAMDTSDPVKEEDDYDVMQDP
                     EFLQSVLENLPGVDPNNAAIRSVMGALASQATKDGKNDKKEEEKK"
     exon            63..203
                     /gene="Psmd4"
                     /gene_synonym="Af1; angiocidin; Mcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            204..318
                     /gene="Psmd4"
                     /gene_synonym="Af1; angiocidin; Mcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            319..405
                     /gene="Psmd4"
                     /gene_synonym="Af1; angiocidin; Mcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            406..474
                     /gene="Psmd4"
                     /gene_synonym="Af1; angiocidin; Mcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..690
                     /gene="Psmd4"
                     /gene_synonym="Af1; angiocidin; Mcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..808
                     /gene="Psmd4"
                     /gene_synonym="Af1; angiocidin; Mcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            809..940
                     /gene="Psmd4"
                     /gene_synonym="Af1; angiocidin; Mcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1005
                     /gene="Psmd4"
                     /gene_synonym="Af1; angiocidin; Mcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1286
                     /gene="Psmd4"
                     /gene_synonym="Af1; angiocidin; Mcb1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1267..1272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmd4"
                     /gene_synonym="Af1; angiocidin; Mcb1"
                     /note="hexamer: AATAAA"
     polyA_site      1286
                     /gene="Psmd4"
                     /gene_synonym="Af1; angiocidin; Mcb1"
                     /note="major polyA site"
ORIGIN      
        1 agtcccggag ccggtccgca gagggaagga ggcaagatgg tgttggagag cactatggtt
       61 tgtgtggaca acagtgagta catgcggaac ggagacttcc ttcccacccg gctgcaggcc
      121 cagcaggatg ccgtcaacat tgtatgtcac tcaaagaccc gaagcaaccc tgagaataac
      181 gtgggcctga tcacactggc caatgactgt gaggtgctga ccacactcac cccggacact
      241 ggccgtatcc tctccaagct ccacactgtc caacccaaag gcaagatcac cttctgcact
      301 ggcatccgcg tggcccactt ggctctgaag caccggcagg gcaagaatca caagatgcgc
      361 atcatcgcct ttgtcggtag ccctgtggag gacaacgaga aggatctggt gaaactagct
      421 aaacgcctta agaaagaaaa agtgaatgtt gacatcatta attttgggga agaggaggtg
      481 aacacagaga agctgacagc ctttgtgaac acactgaatg gcaaggatgg aactgggtcc
      541 catctagtga cagtgcctcc tggacctagc ttggctgatg ctctcatcag ttctcctatt
      601 ctggctggtg aaggcggtgc catgctgggt cttggtgcca gtgactttga gtttggagta
      661 gatcccagtg ctgatcctga attggccctg gcccttcgag tctctatgga agagcagcgg
      721 cagcggcagg aggaagaggc acggcgggcc gctgcggcct ctgcagctga ggctggaatt
      781 gctacacctg ggactgaagg tgaaagagac tcggatgacg ccctactgaa gatgaccatc
      841 aaccagcagg agtttggccg tcctgggctt ccagacctaa gcagcatgac tgaggaagag
      901 cagatcgcct acgccatgca gatgtccctg cagggaacag agtttagcca agaatcggct
      961 gacatggatg ccagctcagc catggacaca tctgatccag tcaaggagga ggatgactat
     1021 gacgtcatgc aggacccgga gttccttcag agcgtcctag agaaccttcc aggtgtggat
     1081 cccaacaatg cagccattcg aagtgtcatg ggggctctgg cctcccaggc caccaaggat
     1141 ggcaagaatg acaagaaaga ggaagagaag aagtgagacc ggagggaggg gtagctgtgt
     1201 ctgcccgggg actgtaaaga cggggttgga tagaggctta gatgtgctct gctgccttta
     1261 tgatggaata aagcttggca agtttt
//
