LOCUS       NM_009439               2167 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus proteasome (prosome, macropain) 26S subunit,
            non-ATPase, 3 (Psmd3), mRNA.
ACCESSION   NM_009439
VERSION     NM_009439.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2167)
  AUTHORS   Hjerpe,R., Bett,J.S., Keuss,M.J., Solovyova,A., McWilliams,T.G.,
            Johnson,C., Sahu,I., Varghese,J., Wood,N., Wightman,M., Osborne,G.,
            Bates,G.P., Glickman,M.H., Trost,M., Knebel,A., Marchesi,F. and
            Kurz,T.
  TITLE     UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance
            by the Proteasome
  JOURNAL   Cell 166 (4), 935-949 (2016)
   PUBMED   27477512
REFERENCE   2  (bases 1 to 2167)
  AUTHORS   Lo,J.C., Jamsai,D., O'Connor,A.E., Borg,C., Clark,B.J.,
            Whisstock,J.C., Field,M.C., Adams,V., Ishikawa,T., Aitken,R.J.,
            Whittle,B., Goodnow,C.C., Ormandy,C.J. and O'Bryan,M.K.
  TITLE     RAB-like 2 has an essential role in male fertility, sperm
            intra-flagellar transport, and tail assembly
  JOURNAL   PLoS Genet 8 (10), e1002969 (2012)
   PUBMED   23055941
REFERENCE   3  (bases 1 to 2167)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   4  (bases 1 to 2167)
  AUTHORS   Wei,S.J., Williams,J.G., Dang,H., Darden,T.A., Betz,B.L.,
            Humble,M.M., Chang,F.M., Trempus,C.S., Johnson,K., Cannon,R.E. and
            Tennant,R.W.
  TITLE     Identification of a specific motif of the DSS1 protein required for
            proteasome interaction and p53 protein degradation
  JOURNAL   J Mol Biol 383 (3), 693-712 (2008)
   PUBMED   18775730
REFERENCE   5  (bases 1 to 2167)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   6  (bases 1 to 2167)
  AUTHORS   Dyson,P.J., de Smet,C., Knight,A.M., Simon-Chazottes,D.,
            Guenet,J.L. and Boon,T.
  TITLE     Mapping of the genes encoding tum- transplantation antigens P91A,
            P35B, and P198
  JOURNAL   Immunogenetics 35 (5), 316-323 (1992)
   PUBMED   1348494
REFERENCE   7  (bases 1 to 2167)
  AUTHORS   Hearne,C.M., McAleer,M.A., Love,J.M., Aitman,T.J., Cornall,R.J.,
            Ghosh,S., Knight,A.M., Prins,J.B. and Todd,J.A.
  TITLE     Additional microsatellite markers for mouse genome mapping
  JOURNAL   Mamm Genome 1 (4), 273-282 (1991)
   PUBMED   1794058
REFERENCE   8  (bases 1 to 2167)
  AUTHORS   Szikora,J.P., Van Pel,A., Brichard,V., Andre,M., Van Baren,N.,
            Henry,P., De Plaen,E. and Boon,T.
  TITLE     Structure of the gene of tum- transplantation antigen P35B:
            presence of a point mutation in the antigenic allele
  JOURNAL   EMBO J 9 (4), 1041-1050 (1990)
   PUBMED   2108859
REFERENCE   9  (bases 1 to 2167)
  AUTHORS   Lurquin,C., Van Pel,A., Mariame,B., De Plaen,E., Szikora,J.P.,
            Janssens,C., Reddehase,M.J., Lejeune,J. and Boon,T.
  TITLE     Structure of the gene of tum- transplantation antigen P91A: the
            mutated exon encodes a peptide recognized with Ld by cytolytic T
            cells
  JOURNAL   Cell 58 (2), 293-303 (1989)
   PUBMED   2568889
REFERENCE   10 (bases 1 to 2167)
  AUTHORS   De Plaen,E., Lurquin,C., Van Pel,A., Mariame,B., Szikora,J.P.,
            Wolfel,T., Sibille,C., Chomez,P. and Boon,T.
  TITLE     Immunogenic (tum-) variants of mouse tumor P815: cloning of the
            gene of tum- antigen P91A and identification of the tum- mutation
  JOURNAL   Proc Natl Acad Sci U S A 85 (7), 2274-2278 (1988)
   PUBMED   3127830
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC003197.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003197.1, AK145467.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2167
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.39 cM"
     gene            1..2167
                     /gene="Psmd3"
                     /gene_synonym="AntP91a; D11Bwg1349e; Psd3; Tstap91a"
                     /note="proteasome (prosome, macropain) 26S subunit,
                     non-ATPase, 3"
                     /db_xref="GeneID:22123"
                     /db_xref="MGI:MGI:98858"
     exon            1..384
                     /gene="Psmd3"
                     /gene_synonym="AntP91a; D11Bwg1349e; Psd3; Tstap91a"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1769
                     /gene="Psmd3"
                     /gene_synonym="AntP91a; D11Bwg1349e; Psd3; Tstap91a"
                     /note="tissue specific transplantation antigen P91A;
                     tum-P91A antigen; proteasome subunit p58; 26S proteasome
                     regulatory subunit S3; 26S proteasome regulatory subunit
                     RPN3"
                     /codon_start=1
                     /product="26S proteasome non-ATPase regulatory subunit 3"
                     /protein_id="NP_033465.1"
                     /db_xref="CCDS:CCDS25359.1"
                     /db_xref="GeneID:22123"
                     /db_xref="MGI:MGI:98858"
                     /translation="MKQEGSARRRGADKAKPPPGGEQEPPPPAPQDVEMKEEAAAGSG
                     STGEGDGKAAATEHSQRELDTVTLEDIKEHVRQLEKAVSGKEPRFVLRALRMLPSTSR
                     RLNHYVLYKAVHGFFTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASAPLLPEVE
                     AYLQLLMVIFLMNSKRYKEAQKISDDLMQKISTQNRRALDLVAAKCYYYHARVYEFLD
                     KLDVVRSFLHARLRTATLRHDADGQATLLNLLLRNYLHYSLYDQAEKLVSKSVFPEQA
                     NNNEWARYLYYTGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQTVHKLLIVVELL
                     LGEIPDRLQFRQPSLKRSLMPYFLLTQAVRTGNLAKFNQVLDQFGEKFQTDGTYTLII
                     RLRHNVIKTGVRMISLSYSRISLADIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHE
                     KGYVQSKEMIDIYSTREPQLAFHQRISFCLDIHNMSVKAMRFPPKSYNKDLESAEERR
                     EREQQDLEFAKEMAEDDDDSFP"
     exon            385..575
                     /gene="Psmd3"
                     /gene_synonym="AntP91a; D11Bwg1349e; Psd3; Tstap91a"
                     /inference="alignment:Splign:2.1.0"
     exon            576..713
                     /gene="Psmd3"
                     /gene_synonym="AntP91a; D11Bwg1349e; Psd3; Tstap91a"
                     /inference="alignment:Splign:2.1.0"
     exon            714..850
                     /gene="Psmd3"
                     /gene_synonym="AntP91a; D11Bwg1349e; Psd3; Tstap91a"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1041
                     /gene="Psmd3"
                     /gene_synonym="AntP91a; D11Bwg1349e; Psd3; Tstap91a"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1145
                     /gene="Psmd3"
                     /gene_synonym="AntP91a; D11Bwg1349e; Psd3; Tstap91a"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1260
                     /gene="Psmd3"
                     /gene_synonym="AntP91a; D11Bwg1349e; Psd3; Tstap91a"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1380
                     /gene="Psmd3"
                     /gene_synonym="AntP91a; D11Bwg1349e; Psd3; Tstap91a"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1484
                     /gene="Psmd3"
                     /gene_synonym="AntP91a; D11Bwg1349e; Psd3; Tstap91a"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1640
                     /gene="Psmd3"
                     /gene_synonym="AntP91a; D11Bwg1349e; Psd3; Tstap91a"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1691
                     /gene="Psmd3"
                     /gene_synonym="AntP91a; D11Bwg1349e; Psd3; Tstap91a"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..2147
                     /gene="Psmd3"
                     /gene_synonym="AntP91a; D11Bwg1349e; Psd3; Tstap91a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2130..2135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmd3"
                     /gene_synonym="AntP91a; D11Bwg1349e; Psd3; Tstap91a"
                     /note="hexamer: AATAAA"
     polyA_site      2147
                     /gene="Psmd3"
                     /gene_synonym="AntP91a; D11Bwg1349e; Psd3; Tstap91a"
                     /note="major polyA site"
ORIGIN      
        1 ctggcatttc ccagaagccc cagcgccggg aaggagtttg cagctgctcg gtcatcgtgc
       61 ggcccgacgc gagcccgcgc tggtgtgcag gcccggctct gtgcctggtc tctggtgtga
      121 gggtttacgc gaggcccctg cttcggtccc cggactaggc ctcgaccccg ggcgccatga
      181 agcaggaggg ctcggcgcgg cgccgaggcg ccgacaaggc aaagccgccg ccgggagggg
      241 aacaagaacc gccgccaccg gccccccagg atgtggagat gaaagaggag gcagcagctg
      301 ggagcggctc cacgggggag ggagacggca aggcagctgc gaccgagcac tcccagagag
      361 agctggacac tgtcacctta gaagacatca aagagcacgt gagacagcta gagaaggctg
      421 tttccggcaa ggagcctcgg ttcgtgctga gggcgctgcg gatgctgccg tccacgtcac
      481 gccgcctcaa ccactatgtt ctgtacaagg ctgtgcatgg cttcttcacc tccaataacg
      541 ccactcgaga cttcttgcta cccttcctag aagaacccat ggacacagaa gccgacctgc
      601 agtttcgtcc tcgcacagga aaagcggcat cagcgcctct cctgcctgag gtggaagcct
      661 acctgcagct gctcatggtc atcttcctga tgaacagcaa gcgctacaaa gaggcacaga
      721 aaatctctga tgacctgatg cagaagatca gcactcagaa ccgccgagcc ctggacctcg
      781 tagctgccaa gtgttactat tatcacgccc gggtctatga gttcctggac aagctggatg
      841 tggtgcgcag cttcttgcat gcccggctcc ggacagccac cctgcggcac gatgctgacg
      901 gacaggctac ccttttgaac ctcctgcttc ggaattacct gcactacagc ttgtatgacc
      961 aggctgagaa gctggtatcc aagtctgtgt tccctgagca agccaacaac aatgagtggg
     1021 ccaggtacct ctattacaca gggcgaatca aggctatcca gctggagtac tctgaagccc
     1081 ggagaacgat gaccaatgcc cttcgaaagg ctccacagca cacagctgtt ggcttcaaac
     1141 agacggtgca caagcttctg atcgtggtag agctcctgct gggggagatc ccagaccgcc
     1201 tgcagttccg ccagccctcc ctaaagcgct ccctcatgcc ctacttcctt ctcacccaag
     1261 ctgttaggac aggaaatctt gccaagttca accaagttct ggatcagttt ggggagaagt
     1321 ttcaaacgga tgggacctac accctgatta tccgactgcg acacaatgtg atcaagacag
     1381 gtgtgcgcat gatcagcctg tcctattccc ggatctccct ggccgacatc gcccagaagc
     1441 tgcagctgga tagcccagaa gatgcagagt tcattgtcgc caaggccatc cgggacggcg
     1501 tgattgaggc cagcatcaat cacgagaagg gatacgtcca atccaaagag atgattgaca
     1561 tctattccac ccgggagccc cagctggcct tccaccagcg catctccttc tgtctggaca
     1621 tccacaacat gtctgtcaag gccatgcgct ttcctcccaa atcctacaac aaggacctgg
     1681 agtctgcaga ggagcggcga gagcgggagc agcaggacct ggagtttgcc aaggagatgg
     1741 cggaggatga cgacgacagc ttcccctgag ccaggccggg ggaggggcgg gctgagtgga
     1801 gactggcttt ttctcttttc cctcaggtgt cccctgcccg ggaaactgtt ctccgtttcc
     1861 cacacacggc tcacagactg catatgtgca ggggtcaggg atgctgggag ccaaccgtcc
     1921 ccttcttgct accatgcctc tctgtagctg gtgacagtac cctgtgggcg ggagagaggt
     1981 ggcagcctcc aggaggcagg gtcctgcctc atggtggtgt cggtggcagg aggggacgga
     2041 cagaaccatg gattagggtg tggactaggg cctggagttg ggacacgttg ggttctatgt
     2101 ttttgaagct tcaattatga tttttaaaca ataaaaagtt ctccagaaaa aaaaaaaaaa
     2161 aaaaaaa
//
