LOCUS       NM_134101               3000 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus proteasome (prosome, macropain) 26S subunit,
            non-ATPase, 2 (Psmd2), transcript variant 1, mRNA.
ACCESSION   NM_134101
VERSION     NM_134101.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3000)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3000)
  AUTHORS   Xing,L., Simon,J.M., Ptacek,T.S., Yi,J.J., Loo,L., Mao,H.,
            Wolter,J.M., McCoy,E.S., Paranjape,S.R., Taylor-Blake,B. and
            Zylka,M.J.
  TITLE     Autism-linked UBE3A gain-of-function mutation causes interneuron
            and behavioral phenotypes when inherited maternally or paternally
            in mice
  JOURNAL   Cell Rep 42 (7), 112706 (2023)
   PUBMED   37389991
REFERENCE   3  (bases 1 to 3000)
  AUTHORS   Lo,J.C., Jamsai,D., O'Connor,A.E., Borg,C., Clark,B.J.,
            Whisstock,J.C., Field,M.C., Adams,V., Ishikawa,T., Aitken,R.J.,
            Whittle,B., Goodnow,C.C., Ormandy,C.J. and O'Bryan,M.K.
  TITLE     RAB-like 2 has an essential role in male fertility, sperm
            intra-flagellar transport, and tail assembly
  JOURNAL   PLoS Genet 8 (10), e1002969 (2012)
   PUBMED   23055941
REFERENCE   4  (bases 1 to 3000)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   5  (bases 1 to 3000)
  AUTHORS   Zhang,D., Harry,G.J., Blackshear,P.J. and Zeldin,D.C.
  TITLE     G-protein pathway suppressor 2 (GPS2) interacts with the regulatory
            factor X4 variant 3 (RFX4_v3) and functions as a transcriptional
            co-activator
  JOURNAL   J Biol Chem 283 (13), 8580-8590 (2008)
   PUBMED   18218630
REFERENCE   6  (bases 1 to 3000)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   7  (bases 1 to 3000)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 3000)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3000)
  AUTHORS   Lopez-Fernandez,L.A., Parraga,M. and del Mazo,J.
  TITLE     Tex261, a novel gene presumably related but distinct from
            steroidogenic acute regulatory (StAR) gene, is regulated during the
            development of germ cells
  JOURNAL   Biochem Biophys Res Commun 242 (3), 565-569 (1998)
   PUBMED   9464256
REFERENCE   10 (bases 1 to 3000)
  AUTHORS   Lopez-Fernandez,L.A. and del Mazo,J.
  TITLE     Characterization of genes expressed early in mouse spermatogenesis,
            isolated from a subtractive cDNA library
  JOURNAL   Mamm Genome 7 (9), 698-700 (1996)
   PUBMED   8703127
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY307723.1 and BC024830.1.
            
            On Apr 14, 2009 this sequence version replaced NM_134101.1.
            
            Transcript Variant: This transcript (1) is the protein-coding
            transcript variant.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027767.1, SRR1660817.183040.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                BY307723.1         2-61
            61-3000             BC024830.1         1-2940
FEATURES             Location/Qualifiers
     source          1..3000
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 12.49 cM"
     gene            1..3000
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /note="proteasome (prosome, macropain) 26S subunit,
                     non-ATPase, 2"
                     /db_xref="GeneID:21762"
                     /db_xref="MGI:MGI:1096584"
     exon            1..200
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..2792
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /note="26S proteasome subunit p97; 26S proteasome
                     regulatory subunit S2; 26S proteasome regulatory subunit
                     RPN1; testis expressed gene 190"
                     /codon_start=1
                     /product="26S proteasome non-ATPase regulatory subunit 2"
                     /protein_id="NP_598862.1"
                     /db_xref="CCDS:CCDS28053.1"
                     /db_xref="GeneID:21762"
                     /db_xref="MGI:MGI:1096584"
                     /translation="MEEGGRDKTPVQSQQPSATTPSGADEKSSGKERRDAGEKDKEQE
                     LSEEDKQLQDELEMLVERLGEKDTSLYRPALEELRRQIRSSTTSMTSVPKPLKFLRPH
                     YGKLKEIYENMAPGENKCFAADIISVLAMTMSGERECLKYRLVGSQEELASWGHEYVR
                     HLAGEVAKEWQELDDAEKAQREPLLTLVKEIVPYNMAHNAEHEACDLLMEIEQVDMLE
                     KDIDENAYAKVCLYLTSCVNYVPEPENSALLRCALGVFRKFSRFPEALRLALMLNDME
                     LVEDIFTSCKDVVVQKQMAFMLGRHGVFLELSEDVEEYEDLTEIMSNVQLNSNFLALA
                     RELDIMEPKVPDDIYKTHLENNRFGGSGSQVDSARMNLASSFVNGFVNAAFGQDKLLT
                     DDGNKWLYKNKDHGMLSAAASLGMILLWDVDGGLTQIDKYLYSSEDYIKSGALLACGI
                     VNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLLLPVMGDS
                     KSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNH
                     LGKGEAIEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKE
                     KEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRYG
                     EPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNAR
                     LAAMLRQLAQYHAKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLT
                     VLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVVGQA
                     GKPKTITGFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVILRKNPNYDL"
     exon            201..257
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /inference="alignment:Splign:2.1.0"
     exon            258..422
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /inference="alignment:Splign:2.1.0"
     exon            423..544
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /inference="alignment:Splign:2.1.0"
     exon            545..769
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /inference="alignment:Splign:2.1.0"
     exon            770..928
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1073
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1134
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1281
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1388
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1516
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1604
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1767
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1869
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2015
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2099
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2268
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2363
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2490
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2609
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2961
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2941..2946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /note="hexamer: AATAAA"
     polyA_site      2961
                     /gene="Psmd2"
                     /gene_synonym="9430095H01Rik; TEG-190; Tex190"
                     /note="major polyA site"
ORIGIN      
        1 ggccttctgg gaaaaggggc ggtgcgagca ggtgcgcgcg cagcaggccg gcagtagtgg
       61 cggagatgga ggagggtgga cgagacaaga cacccgtgca gtcccaacag ccctccgcga
      121 caacccccag cggcgcggac gagaagtcga gtggcaagga gcgaagggat gccggggaaa
      181 aagacaaaga gcaggagctg tctgaggagg acaaacagct tcaagatgaa ctggagatgc
      241 tcgtggagcg actcggggag aaagatacat ctctatatcg accagctctg gaggaactga
      301 gaagacaaat tcgttcttct acaacttcca tgacttcagt acccaagcct ctcaaatttc
      361 tgcgtccaca ctatggcaaa ttgaaggaaa tctatgagaa catggcccct ggggagaata
      421 agtgttttgc agctgacatc atctctgttt tggccatgac catgagtggt gagcgggagt
      481 gcctcaagta tcggctcgtg ggctcccagg aagaactggc gtcatggggc catgaatacg
      541 tcagacatct ggcaggagag gtggccaagg agtggcagga gctggatgat gcagagaaag
      601 cacagcggga accactgctt accttggtaa aggaaatcgt cccctacaac atggctcaca
      661 atgcagagca cgaggcttgt gacctgctca tggaaattga gcaggtggac atgctagaga
      721 aggacattga tgagaacgcc tacgccaagg tctgcctcta tctcaccagt tgtgtgaatt
      781 atgtaccaga acctgagaac tctgccctcc tgcgctgcgc cttgggcgtg ttccgaaagt
      841 ttagccgttt ccctgaagct ctgagattgg cactgatgct caatgacatg gaactggtag
      901 aagacatttt cacttcctgc aaagatgtgg tggtccagaa gcagatggca ttcatgctgg
      961 gtcggcatgg agtgttcctg gagctgagtg aagatgtaga ggaatatgaa gacctcacag
     1021 aaatcatgtc caatgtccag ctcaacagca acttcttggc tttagctcgg gagctggaca
     1081 tcatggagcc caaggtgcct gatgacatct acaaaaccca cctagagaat aacaggtttg
     1141 gtggcagtgg ctctcaagtg gattctgcac gaatgaacct agcctcctct tttgtaaatg
     1201 gctttgtgaa tgcagccttt ggtcaagata aactactgac tgatgatggc aacaaatggc
     1261 tttacaagaa caaggaccat gggatgctaa gtgctgctgc gtctcttggc atgattctgc
     1321 tgtgggatgt ggatggtggc ctcacccaga ttgacaagta tctgtactcc tctgaggact
     1381 acatcaagtc aggagctctc cttgcctgtg gtatcgtgaa ttctggagtc cggaatgagt
     1441 gtgatcctgc cctggcactg ctttcagact atgttctcca taacagcaat accatgagac
     1501 ttggctccat ctttgggcta ggtttggcct atgctggctc taatcgggaa gatgttctaa
     1561 cactgctgct acctgtaatg ggagattcca agtccagcat ggaggtggca ggtgtgacgg
     1621 ctctagcttg tgggatgata gcagtggggt cctgcaatgg agatgtcact tccaccatcc
     1681 ttcagaccat catggagaaa tctgagactg agctcaagga tacctatgct cgttggcttc
     1741 ctcttggcct gggcctcaat cacttgggga aaggcgaagc tattgaggcc atcctggctg
     1801 ccttggaggt ggtgtcagag ccattccgca gttttgccaa taccctggtg gatgtatgtg
     1861 cctatgcagg ctctgggaat gtgctgaagg ttcagcagct cctccacatc tgtagtgagc
     1921 actttgactc taaggaaaag gaggaagaca aagacaagaa ggaaaagaag gacaaggaca
     1981 agaaggaagc ccctgctgac atgggagcac atcagggagt agctgttctg ggcattgcac
     2041 ttattgctat gggggaagag attggtgcag agatggcatt gcgaactttt ggtcacttgc
     2101 tgagatatgg ggagcctacc ctccgtcgcg ctgtaccttt agcactggca ctaatttctg
     2161 tttcaaatcc acgactcaac atcctggata cgctaagcaa attctctcat gatgctgatc
     2221 cagaagtttc ctataactcc atctttgcta tgggcatggt gggcagtggt accaataatg
     2281 cccgtctggc tgcaatgttg cgccagttag ctcaatatca tgccaaggac cccaataacc
     2341 tcttcatggt gcgcttggca cagggcttga cacatttagg gaagggcaca cttaccctct
     2401 gcccctatca cagtgatcgg cagctcatga gtcaagtagc ggtggcaggg ctactcacgg
     2461 tgcttgtttc tttcctggat gttcgaaaca tcatcctagg caagtctcac tatgtcctgt
     2521 atgggctggt agccgccatg cagcctcgga tgctggttac atttgatgag gagctgcgac
     2581 cattgccagt ttctgtccgt gtgggtcagg cagtggatgt ggtgggccag gctgggaagc
     2641 caaaaacaat cacagggttc cagactcata caacgccagt gttgctggcc catggggagc
     2701 gggcagagtt ggccactgag gagtttcttc ctgtcacccc cattctggaa ggctttgtta
     2761 ttcttcggaa gaaccccaac tatgatcttt gaaaaagtgg cttctagaga ccctggctgc
     2821 agcggaattt tttgttttta gcaggctgtc ctgcctgcta tgaggggtgg atactgttcc
     2881 agatctttgg gggaattgtt acctcctgtt gttttgttac tgagtaagat aactttgttg
     2941 aataaagacc tttatcccca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
