LOCUS       NM_021526               1560 bp    mRNA    linear   ROD 10-OCT-2024
DEFINITION  Mus musculus proteasome (prosome, macropain) 26S subunit,
            non-ATPase, 14 (Psmd14), mRNA.
ACCESSION   NM_021526
VERSION     NM_021526.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1560)
  AUTHORS   Zhou,B., Luo,Y., Bi,H., Zhang,N., Ma,M., Dong,Z., Ji,N., Zhang,S.,
            Wang,X., Liu,Y., Guo,X., Wei,W., Xie,C., Wu,L., Wan,X., Zheng,M.H.,
            Zhao,B., Li,Y., Hu,C. and Lu,Y.
  TITLE     Amelioration of nonalcoholic fatty liver disease by inhibiting the
            deubiquitylating enzyme RPN11
  JOURNAL   Cell Metab 36 (10), 2228-2244 (2024)
   PUBMED   39146936
REFERENCE   2  (bases 1 to 1560)
  AUTHORS   Zhang,R., Pan,S., Zheng,S., Liao,Q., Jiang,Z., Wang,D., Li,X.,
            Hu,A., Li,X., Zhu,Y., Shen,X., Lei,J., Zhong,S., Zhang,X.,
            Huang,L., Wang,X., Huang,L., Shen,L., Song,B.L., Zhao,J.W.,
            Wang,Z., Yang,B. and Guo,X.
  TITLE     Lipid-anchored proteasomes control membrane protein homeostasis
  JOURNAL   Sci Adv 9 (48), eadj4605 (2023)
   PUBMED   38019907
REFERENCE   3  (bases 1 to 1560)
  AUTHORS   Sukenik,S., Braunstein,I. and Stanhill,A.
  TITLE     An Arsenite Relay between PSMD14 and AIRAP Enables Revival of
            Proteasomal DUB Activity
  JOURNAL   Biomolecules 11 (9), 1317 (2021)
   PUBMED   34572530
  REMARK    GeneRIF: An Arsenite Relay between PSMD14 and AIRAP Enables Revival
            of Proteasomal DUB Activity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1560)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1560)
  AUTHORS   Tomita,T., Hirayama,S., Sakurai,Y., Ohte,Y., Yoshihara,H.,
            Saeki,Y., Hamazaki,J. and Murata,S.
  TITLE     Specific Modification of Aged Proteasomes Revealed by
            Tag-Exchangeable Knock-In Mice
  JOURNAL   Mol Cell Biol 39 (1), e00426-18 (2018)
   PUBMED   30348842
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1560)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   7  (bases 1 to 1560)
  AUTHORS   Stanhill,A., Haynes,C.M., Zhang,Y., Min,G., Steele,M.C.,
            Kalinina,J., Martinez,E., Pickart,C.M., Kong,X.P. and Ron,D.
  TITLE     An arsenite-inducible 19S regulatory particle-associated protein
            adapts proteasomes to proteotoxicity
  JOURNAL   Mol Cell 23 (6), 875-885 (2006)
   PUBMED   16973439
REFERENCE   8  (bases 1 to 1560)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   9  (bases 1 to 1560)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 1560)
  AUTHORS   Penney,M., Wilkinson,C., Wallace,M., Javerzat,J.P., Ferrell,K.,
            Seeger,M., Dubiel,W., McKay,S., Allshire,R. and Gordon,C.
  TITLE     The Pad1+ gene encodes a subunit of the 26 S proteasome in fission
            yeast
  JOURNAL   J Biol Chem 273 (37), 23938-23945 (1998)
   PUBMED   9727008
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY324928.1, AK012013.1 and AI448878.1.
            
            On Apr 27, 2007 this sequence version replaced NM_021526.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003742.1, AK151104.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                BY324928.1         3-73
            72-1476             AK012013.1         3-1407
            1477-1560           AI448878.1         1-84                c
FEATURES             Location/Qualifiers
     source          1..1560
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 35.56 cM"
     gene            1..1560
                     /gene="Psmd14"
                     /gene_synonym="2610312C03Rik; 3200001M20Rik; Pad1; Poh1;
                     rpm11"
                     /note="proteasome (prosome, macropain) 26S subunit,
                     non-ATPase, 14"
                     /db_xref="GeneID:59029"
                     /db_xref="MGI:MGI:1913284"
     exon            1..180
                     /gene="Psmd14"
                     /gene_synonym="2610312C03Rik; 3200001M20Rik; Pad1; Poh1;
                     rpm11"
                     /inference="alignment:Splign:2.1.0"
     exon            181..308
                     /gene="Psmd14"
                     /gene_synonym="2610312C03Rik; 3200001M20Rik; Pad1; Poh1;
                     rpm11"
                     /inference="alignment:Splign:2.1.0"
     exon            309..360
                     /gene="Psmd14"
                     /gene_synonym="2610312C03Rik; 3200001M20Rik; Pad1; Poh1;
                     rpm11"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..1245
                     /gene="Psmd14"
                     /gene_synonym="2610312C03Rik; 3200001M20Rik; Pad1; Poh1;
                     rpm11"
                     /EC_number="3.4.19.-"
                     /note="26S proteasome non-ATPase subunit; proteasome 26S
                     subunit, non-ATPase 14; MAD1; 26S proteasome regulatory
                     subunit rpn11; 26S proteasome-associated pad1 homolog"
                     /codon_start=1
                     /product="26S proteasome non-ATPase regulatory subunit 14"
                     /protein_id="NP_067501.2"
                     /db_xref="CCDS:CCDS38127.1"
                     /db_xref="GeneID:59029"
                     /db_xref="MGI:MGI:1913284"
                     /translation="MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKH
                     GRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQT
                     GRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAF
                     RLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLL
                     NLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVG
                     KQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK"
     exon            361..432
                     /gene="Psmd14"
                     /gene_synonym="2610312C03Rik; 3200001M20Rik; Pad1; Poh1;
                     rpm11"
                     /inference="alignment:Splign:2.1.0"
     exon            433..552
                     /gene="Psmd14"
                     /gene_synonym="2610312C03Rik; 3200001M20Rik; Pad1; Poh1;
                     rpm11"
                     /inference="alignment:Splign:2.1.0"
     exon            553..623
                     /gene="Psmd14"
                     /gene_synonym="2610312C03Rik; 3200001M20Rik; Pad1; Poh1;
                     rpm11"
                     /inference="alignment:Splign:2.1.0"
     exon            624..774
                     /gene="Psmd14"
                     /gene_synonym="2610312C03Rik; 3200001M20Rik; Pad1; Poh1;
                     rpm11"
                     /inference="alignment:Splign:2.1.0"
     exon            775..882
                     /gene="Psmd14"
                     /gene_synonym="2610312C03Rik; 3200001M20Rik; Pad1; Poh1;
                     rpm11"
                     /inference="alignment:Splign:2.1.0"
     exon            883..957
                     /gene="Psmd14"
                     /gene_synonym="2610312C03Rik; 3200001M20Rik; Pad1; Poh1;
                     rpm11"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1083
                     /gene="Psmd14"
                     /gene_synonym="2610312C03Rik; 3200001M20Rik; Pad1; Poh1;
                     rpm11"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1146
                     /gene="Psmd14"
                     /gene_synonym="2610312C03Rik; 3200001M20Rik; Pad1; Poh1;
                     rpm11"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1541
                     /gene="Psmd14"
                     /gene_synonym="2610312C03Rik; 3200001M20Rik; Pad1; Poh1;
                     rpm11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1520..1525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmd14"
                     /gene_synonym="2610312C03Rik; 3200001M20Rik; Pad1; Poh1;
                     rpm11"
                     /note="hexamer: AATAAA"
     polyA_site      1541
                     /gene="Psmd14"
                     /gene_synonym="2610312C03Rik; 3200001M20Rik; Pad1; Poh1;
                     rpm11"
                     /note="major polyA site"
ORIGIN      
        1 gactccaatt ggcggtagaa gaaaggaagc cgaaggaagc cgggaacccg gaagtacttc
       61 tctgcagagg cctgggcgac tcttttgaat ggaatcgggc tgattcatcg cctgttctcc
      121 gagccaggtc cttgttgagt gtgaggcgct gccctcgccg ccgcgtcgcc acaaggccag
      181 gagagagagg aaaaactact tgtgaaaaat tgtatctgcc agaattagca agacttggag
      241 ttaataacaa atttgtcaaa ttcaacaaat tgaagtttaa cactgtaaga attacagtta
      301 ctgaacagaa atatggacag acttcttaga cttggaggag gtatgcctgg actgggccag
      361 ggcccaccta cagatgctcc tgccgtggac acagcagaac aagtttatat ctcttccttg
      421 gccttgctaa agatgttaaa acatggtcgt gctggagtgc ctatggaagt tatgggtcta
      481 atgcttggtg aatttgttga tgattacacc gtcagagtga ttgatgtgtt tgctatgcca
      541 cagtcaggaa ctggtgtcag tgttgaagca gttgatccag tgttccaagc caaaatgttg
      601 gatatgctga aacaaacagg aaggcccgag atggttgttg gttggtatca cagtcaccct
      661 ggctttggct gttggctttc tggtgtggat atcaacactc agcagagctt tgaagccttg
      721 tcggagagag ctgtggcagt ggttgtggat cccattcaga gtgtaaaagg aaaggttgtt
      781 attgatgcct tcagactgat caatgctaat atgatggtct taggacatga accaagacaa
      841 acgacttcaa atctgggcca cttaaacaag ccatctatcc aggcattaat tcacggacta
      901 aacagacatt attactccat cactattaat taccggaaaa atgaactgga acagaagatg
      961 ctgttaaatt tgcataagaa gagttggatg gaaggattga cacttcagga ctacagtgaa
     1021 cactgtaaac acaatgaatc ggtggtaaaa gaaatgttgg aattagccaa gaattataat
     1081 aaggctgtgg aagaagaaga taagatgaca cctgaacagc tggcaataaa gaatgttggc
     1141 aagcaggatc ccaaacgtca tttggaagaa catgtggatg tgcttatgac ttcaaatatt
     1201 gtccagtgtt tggccgcaat gttggatact gttgtattta aataaagtga cgtagagagc
     1261 tgtcagtggc gctctgagtg tatcgtcctt cttcgttccc aatgctcaca gttaagggaa
     1321 ctgaaggtga tctggtgatg tgtgagacac ctgtgccacc tcccatctca gttgtgcact
     1381 cgcttctgtt tattttgtcc gggttttgca gattccaaag ttgttcagga atacatcaaa
     1441 gtgaacaaat tttgttaaga tcccatttac tatttgaaaa aaatcagtag cacaaatata
     1501 ttttgattgt tgcttacaaa ataaaataca tttacaatcc aaaaaaaaaa aaaaaaaaaa
//
