LOCUS       NM_025894               1723 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus proteasome (prosome, macropain) 26S subunit,
            non-ATPase, 12 (Psmd12), mRNA.
ACCESSION   NM_025894
VERSION     NM_025894.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1723)
  AUTHORS   Du,X., Shen,X., Dai,L., Bi,F., Zhang,H. and Lu,C.
  TITLE     PSMD12 promotes breast cancer growth via inhibiting the expression
            of pro-apoptotic genes
  JOURNAL   Biochem Biophys Res Commun 526 (2), 368-374 (2020)
   PUBMED   32222279
  REMARK    GeneRIF: PSMD12 promotes breast cancer growth via inhibiting the
            expression of pro-apoptotic genes.
REFERENCE   2  (bases 1 to 1723)
  AUTHORS   Nakahara,M., Tateyama,H., Araki,M., Nakagata,N., Yamamura,K. and
            Araki,K.
  TITLE     Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from
            MSM/Ms mice
  JOURNAL   Mamm Genome 24 (5-6), 228-239 (2013)
   PUBMED   23604909
REFERENCE   3  (bases 1 to 1723)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   4  (bases 1 to 1723)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   5  (bases 1 to 1723)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   6  (bases 1 to 1723)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 1723)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK009969.1.
            
            On Apr 5, 2007 this sequence version replaced NM_025894.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009969.1, AK151242.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1723              AK009969.1         4-1726
FEATURES             Location/Qualifiers
     source          1..1723
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 70.29 cM"
     gene            1..1723
                     /gene="Psmd12"
                     /gene_synonym="1500002F15Rik; P55"
                     /note="proteasome (prosome, macropain) 26S subunit,
                     non-ATPase, 12"
                     /db_xref="GeneID:66997"
                     /db_xref="MGI:MGI:1914247"
     exon            1..157
                     /gene="Psmd12"
                     /gene_synonym="1500002F15Rik; P55"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1420
                     /gene="Psmd12"
                     /gene_synonym="1500002F15Rik; P55"
                     /note="26S proteasome regulatory subunit p55; 26S
                     proteasome regulatory subunit RPN5"
                     /codon_start=1
                     /product="26S proteasome non-ATPase regulatory subunit 12"
                     /protein_id="NP_080170.1"
                     /db_xref="CCDS:CCDS25568.1"
                     /db_xref="GeneID:66997"
                     /db_xref="MGI:MGI:1914247"
                     /translation="MADGGSERADGRIVKMEVDYSATVDQRLPECEKLAKEGRLQEVI
                     ETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVA
                     KMVQQCCTYVEEITDLPVKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVK
                     EAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEEN
                     TENLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESDKWQQALKSVVLYVIL
                     APFDNEQSDLVHRISSDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGVELRKGSSE
                     TPATDVFSSTEEGEKRWKDLKSRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAF
                     LSNLVVNKTIFAKVDRLAGVINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEE
                     MIHNLQ"
     exon            158..217
                     /gene="Psmd12"
                     /gene_synonym="1500002F15Rik; P55"
                     /inference="alignment:Splign:2.1.0"
     exon            218..346
                     /gene="Psmd12"
                     /gene_synonym="1500002F15Rik; P55"
                     /inference="alignment:Splign:2.1.0"
     exon            347..454
                     /gene="Psmd12"
                     /gene_synonym="1500002F15Rik; P55"
                     /inference="alignment:Splign:2.1.0"
     exon            455..559
                     /gene="Psmd12"
                     /gene_synonym="1500002F15Rik; P55"
                     /inference="alignment:Splign:2.1.0"
     exon            560..709
                     /gene="Psmd12"
                     /gene_synonym="1500002F15Rik; P55"
                     /inference="alignment:Splign:2.1.0"
     exon            710..844
                     /gene="Psmd12"
                     /gene_synonym="1500002F15Rik; P55"
                     /inference="alignment:Splign:2.1.0"
     exon            845..957
                     /gene="Psmd12"
                     /gene_synonym="1500002F15Rik; P55"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1132
                     /gene="Psmd12"
                     /gene_synonym="1500002F15Rik; P55"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1210
                     /gene="Psmd12"
                     /gene_synonym="1500002F15Rik; P55"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1723
                     /gene="Psmd12"
                     /gene_synonym="1500002F15Rik; P55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1459..1464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmd12"
                     /gene_synonym="1500002F15Rik; P55"
                     /note="hexamer: ATTAAA"
     polyA_site      1478
                     /gene="Psmd12"
                     /gene_synonym="1500002F15Rik; P55"
                     /note="major polyA site"
     regulatory      1539..1544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmd12"
                     /gene_synonym="1500002F15Rik; P55"
                     /note="hexamer: AGTAAA"
     polyA_site      1561
                     /gene="Psmd12"
                     /gene_synonym="1500002F15Rik; P55"
ORIGIN      
        1 gagtggtggc cgaacctggg gtacagcagg ggactcttag gcagggacca tggcggacgg
       61 tggctcggag cgggccgatg ggcgcattgt gaagatggaa gtggactaca gcgccacggt
      121 ggaccagcgc ctgcctgagt gcgagaagct ggccaaggaa gggcggcttc aagaagtcat
      181 cgaaaccctt ctctctctag aaaagcagac ccggactgcc tctgacatgg tgtccacgtc
      241 ccgcatcttg gttgcagtag tgaaaatgtg ctatgaggct aaagaatggg acttacttaa
      301 tgaaaatatt atgcttctgt caaaacgacg gagtcagtta aaacaagcag ttgcaaaaat
      361 ggttcagcag tgctgtactt acgtggagga gatcacagac ctgccagtca agctgcgatt
      421 gattgatact ctgcggatgg ttacagaagg aaagatttat gttgaaattg agcgtgctcg
      481 gctgactaaa accttagcaa ctattaaaga gcaaaatggc gatgtgaaag aggctgcctc
      541 catccttcaa gagttacagg tggaaaccta tgggtccatg gagaagaagg agcgagtgga
      601 attcattctg gagcagatga gactctgcct agctgtgaag gattacattc gcacacagat
      661 cattagcaaa aaaattaata ccaaattctt ccaagaagaa aacacagaga acttgaagtt
      721 gaagtactat aacttaatga ttcagctgga tcagcacgag gggtcctatc tgtccatctg
      781 caaacactac agagccatct atgacactcc ctgcattcag gcagaaagtg acaagtggca
      841 gcaggctctg aaaagtgttg ttctctatgt tatcctggct ccttttgaca atgagcaatc
      901 agatttggtt caccggataa gcagtgacaa gaagctggaa gaaattccca aatacaagga
      961 tctgctgaag ctttttacca ccatggagct gatgcgctgg tccactcttg ttgaggacta
     1021 tggggtggag ctgcgaaaag gctcctcaga gaccccggcg actgacgttt tcagctctac
     1081 agaagaaggg gaaaagaggt ggaaagactt gaagagcaga gtggtggagc acaacatcag
     1141 aattatggcc aagtactaca ctcggataac aatgaaaagg atggcacaac ttctggatct
     1201 ctctgtggat gagtcagagg ctttcctctc gaatctagtc gttaacaaga ccatctttgc
     1261 taaagtagac aggttggctg gagtcatcaa cttccagaga cccaaggatc caaataattt
     1321 attaaatgac tggtctcaga aactgaactc gctgatgtct ctggttaaca aaacgacaca
     1381 cctcatagcc aaagaggaga tgatacataa tctacaatga ggctctggat gcttttagaa
     1441 gacacaaaat tggaggtcat taaaaaagaa agactgtttt catggtgtat atgttgtttt
     1501 tttcttactc tcgacctttt ttgctaaaat tttaagatag taaatgtgtt taagccccct
     1561 ctgcctttcc cactctctga tttcatgata actgcaaaac attttttcag tctgaagaca
     1621 gaaaggtttg tgtctcagct ttccttgagt gtgttcatac tatttgtttt tattcacctg
     1681 acagccacgt gatagtaata aaaacaggac atgtgttagc tcc
//
