LOCUS       NM_016883               1456 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus proteasome (prosome, macropain) 26S subunit,
            non-ATPase, 10 (Psmd10), transcript variant 1, mRNA.
ACCESSION   NM_016883
VERSION     NM_016883.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1456)
  AUTHORS   Sakurai,T., Komeda,Y., Nagai,T., Kamata,K., Minaga,K., Yamao,K.,
            Takenaka,M., Hagiwara,S., Watanabe,T., Nishida,N., Kashida,H.,
            Nakagawa,K. and Kudo,M.
  TITLE     Gankyrin Contributes to Tumorigenesis and Chemoresistance in
            Sporadic Colorectal Cancer
  JOURNAL   Digestion 100 (3), 192-200 (2019)
   PUBMED   30513515
  REMARK    GeneRIF: Study in APC and/or gankyrin-deficient mice revealed that
            gankyrin in epithelial cell contributes to the development of
            sporadic colorectal cancer by reducing the expression of c-Myc, a
            critical mediator of the APC signaling pathway, and interleukin-6.
REFERENCE   2  (bases 1 to 1456)
  AUTHORS   D'Souza,A.M., Jiang,Y., Cast,A., Valanejad,L., Wright,M., Lewis,K.,
            Kumbaji,M., Shah,S., Smithrud,D., Karns,R., Shin,S. and
            Timchenko,N.
  TITLE     Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive
            Hepatocyte Proliferation
  JOURNAL   Cell Mol Gastroenterol Hepatol 6 (3), 239-255 (2018)
   PUBMED   30109252
  REMARK    GeneRIF: These studies show that Gank protein promotes hepatocyte
            proliferation by elimination of tumor-suppressor proteins.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1456)
  AUTHORS   Lewis,K., Valanejad,L., Cast,A., Wright,M., Wei,C., Iakova,P.,
            Stock,L., Karns,R., Timchenko,L. and Timchenko,N.
  TITLE     RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a
            Phosphorylation-Dependent Manner
  JOURNAL   Mol Cell Biol 37 (16), e00128-17 (2017)
   PUBMED   28559429
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1456)
  AUTHORS   Liu,Y., Higashitsuji,H., Higashitsuji,H., Itoh,K., Sakurai,T.,
            Koike,K., Hirota,K., Fukumoto,M. and Fujita,J.
  TITLE     Overexpression of gankyrin in mouse hepatocytes induces hemangioma
            by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1)
            and activating hypoxia-inducible factor-1
  JOURNAL   Biochem Biophys Res Commun 432 (1), 22-27 (2013)
   PUBMED   23376718
  REMARK    GeneRIF: the present study clarified, at least partly, mechanisms
            of vascular tumorigenesis, and suggests that gankyrin might play a
            physiological role in hypoxic responses besides its roles as an
            oncoprotein.
REFERENCE   5  (bases 1 to 1456)
  AUTHORS   Jiang,Y., Iakova,P., Jin,J., Sullivan,E., Sharin,V., Hong,I.H.,
            Anakk,S., Mayor,A., Darlington,G., Finegold,M., Moore,D. and
            Timchenko,N.A.
  TITLE     Farnesoid X receptor inhibits gankyrin in mouse livers and prevents
            development of liver cancer
  JOURNAL   Hepatology 57 (3), 1098-1106 (2013)
   PUBMED   23172628
  REMARK    GeneRIF: FXR prevents liver cancer by inhibiting the gankyrin
            promoter via C/EBPbeta-HDAC1 complexes, leading to subsequent
            protection of tumor suppressor proteins from degradation.
REFERENCE   6  (bases 1 to 1456)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 1456)
  AUTHORS   Ortiz,C.M., Ito,T., Tanaka,E., Tsunoda,S., Nagayama,S., Sakai,Y.,
            Higashitsuji,H., Fujita,J. and Shimada,Y.
  TITLE     Gankyrin oncoprotein overexpression as a critical factor for tumor
            growth in human esophageal squamous cell carcinoma and its clinical
            significance
  JOURNAL   Int J Cancer 122 (2), 325-332 (2008)
   PUBMED   17935131
  REMARK    GeneRIF: Gankyrin oncoprotein has a role in progression of
            esophageal squamous cell carcinoma
REFERENCE   8  (bases 1 to 1456)
  AUTHORS   Nitta,R.T., Smith,C.L. and Kennedy,B.K.
  TITLE     Evidence that proteasome-dependent degradation of the
            retinoblastoma protein in cells lacking A-type lamins occurs
            independently of gankyrin and MDM2
  JOURNAL   PLoS One 2 (9), e963 (2007)
   PUBMED   17896003
  REMARK    GeneRIF: Findings suggest that retinoblastoma protein degradation
            in Lmna-/- cells occurs by gankyrin and MDM2-independent
            mechanisms.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1456)
  AUTHORS   Nakamura,Y., Nakano,K., Umehara,T., Kimura,M., Hayashizaki,Y.,
            Tanaka,A., Horikoshi,M., Padmanabhan,B. and Yokoyama,S.
  TITLE     Structure of the oncoprotein gankyrin in complex with S6 ATPase of
            the 26S proteasome
  JOURNAL   Structure 15 (2), 179-189 (2007)
   PUBMED   17292836
REFERENCE   10 (bases 1 to 1456)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY057263.1, AK136400.1 and AV292699.1.
            
            On Aug 14, 2009 this sequence version replaced NM_016883.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136400.1, BC056196.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BY057263.1         1-22
            23-1448             AK136400.1         2-1427
            1449-1456           AV292699.1         224-231
FEATURES             Location/Qualifiers
     source          1..1456
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 61.67 cM"
     gene            1..1456
                     /gene="Psmd10"
                     /note="proteasome (prosome, macropain) 26S subunit,
                     non-ATPase, 10"
                     /db_xref="GeneID:53380"
                     /db_xref="MGI:MGI:1858898"
     exon            1..158
                     /gene="Psmd10"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..740
                     /gene="Psmd10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     proteosome (prosome, macropain) 26S subunit, non-ATPase,
                     10; gankyrin; 26S proteasome non-ATPase regulatory subunit
                     10; 26S proteasome regulatory subunit p28; proteasome
                     subunit p28; proteosome subunit p28"
                     /codon_start=1
                     /product="26S proteasome non-ATPase regulatory subunit 10
                     isoform 1"
                     /protein_id="NP_058579.2"
                     /db_xref="CCDS:CCDS30444.1"
                     /db_xref="GeneID:53380"
                     /db_xref="MGI:MGI:1858898"
                     /translation="MEGCVSNIMICNLAYSGKLDELKERILADKSLATRTDQDSRTAL
                     HWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLVKGAHVNAV
                     NQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYDATAMHRAAAKGNLKMVHILLF
                     YKASTNIQDTEGNTPLHLACDEERVEEAKFLVTQGASIYIENKEEKTPLQVAKGGLGL
                     ILKRLAESEEASM"
     exon            159..257
                     /gene="Psmd10"
                     /inference="alignment:Splign:2.1.0"
     exon            258..404
                     /gene="Psmd10"
                     /inference="alignment:Splign:2.1.0"
     exon            405..571
                     /gene="Psmd10"
                     /inference="alignment:Splign:2.1.0"
     exon            572..1456
                     /gene="Psmd10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      916..921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmd10"
                     /note="hexamer: ATTAAA"
     polyA_site      941
                     /gene="Psmd10"
                     /note="major polyA site"
     regulatory      1437..1442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmd10"
                     /note="hexamer: AATAAA"
     polyA_site      1454
                     /gene="Psmd10"
                     /note="major polyA site"
ORIGIN      
        1 gagtgggcgg ggcttgagtt tcacggaggt cttgggaagg cgaaatggag gggtgtgtgt
       61 ctaacataat gatctgtaac ctggcctaca gtgggaagct ggatgagttg aaggagcgca
      121 ttttggctga taaatctctg gctactagaa ctgatcagga cagcagaaca gctttgcact
      181 gggcatgctc agctggccat acagaaattg ttgaattctt gctgcaactt ggagtgccag
      241 tgaatgataa agatgacgca ggttggtctc ctcttcatat tgctgcctcc gctggccggg
      301 atgagattgt aaaagccctt ctggtgaaag gtgcacatgt gaatgctgtc aatcaaaacg
      361 gctgcactcc actccattat gcagcttcga agaataggca tgagattgct gttatgttac
      421 tagaaggtgg ggctaaccca gatgcgaagg accattacga tgctacagca atgcaccggg
      481 cagcagccaa gggtaacttg aagatggttc acatccttct gttctacaaa gcatccacaa
      541 acatccaaga cactgagggt aacactcctc tacacttagc ctgtgatgaa gagagagtgg
      601 aagaggcaaa atttctggtg actcaaggag caagtattta cattgagaat aaagaagaaa
      661 agacacccct gcaagtggcc aaagggggcc tgggtttaat actcaagaga ctagcagaaa
      721 gtgaagaggc ttctatgtag tctgtgtgcg gtctgtggtc ctcagtgtcc ggaaagtgtt
      781 ggacacatga agatgtttcc tcaccttcgt aacttgataa tgtgtggtgt tgctcctact
      841 gaagtaccgg gtctatgctt tctacccact ttccagggtt gaaaaactgg tcagcttgtt
      901 ctactgatgc cattcattaa atcttgatta ctttggagta agtggttgtg gctgtcctgt
      961 cttgagcgtc ttccatgcac ctgctgaccc accgtggacc ggaacaagtt cagaaataga
     1021 ttccacttgg gccaggttgt tctagggagc tttcctctgt gcagtcaaac caaatcctga
     1081 cctgtttttt aagttcactc aagagaccta tgccaaacag ttcttttttt tcaactacaa
     1141 ggttaattta tttttgttac aggaggaagt tgtatatttt agaggagcag gttttaagtt
     1201 gaattgtatg ttcttaaaat aatgaagaac aagagtttgt gtccatgtat ctttttaact
     1261 aactgttctc ctctaaaata agacatatca tttttaaaaa aagaaataaa aagtgtctat
     1321 agtgactcac cttgtgttga aaagaattgt caaacttatt aaagagatgt ataacaaaaa
     1381 ttatattttg atttgtattt caagtactac agacctggat ttcaagtatt acaaacaata
     1441 aactgttgaa agaatc
//
