LOCUS       NM_027357               3256 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus proteasome (prosome, macropain) 26S subunit,
            non-ATPase, 1 (Psmd1), mRNA.
ACCESSION   NM_027357
VERSION     NM_027357.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3256)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3256)
  AUTHORS   Xing,L., Simon,J.M., Ptacek,T.S., Yi,J.J., Loo,L., Mao,H.,
            Wolter,J.M., McCoy,E.S., Paranjape,S.R., Taylor-Blake,B. and
            Zylka,M.J.
  TITLE     Autism-linked UBE3A gain-of-function mutation causes interneuron
            and behavioral phenotypes when inherited maternally or paternally
            in mice
  JOURNAL   Cell Rep 42 (7), 112706 (2023)
   PUBMED   37389991
REFERENCE   3  (bases 1 to 3256)
  AUTHORS   Choi,J.H., Jo,H.S., Lim,S., Kim,H.T., Lee,K.W., Moon,K.H., Ha,T.,
            Kwak,S.S., Kim,Y., Lee,E.J., Joe,C.O. and Kim,J.W.
  TITLE     mTORC1 accelerates retinal development via the immunoproteasome
  JOURNAL   Nat Commun 9 (1), 2502 (2018)
   PUBMED   29950673
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3256)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   5  (bases 1 to 3256)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   6  (bases 1 to 3256)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   7  (bases 1 to 3256)
  AUTHORS   Ding,Q., Martin,S., Dimayuga,E., Bruce-Keller,A.J. and Keller,J.N.
  TITLE     LMP2 knock-out mice have reduced proteasome activities and
            increased levels of oxidatively damaged proteins
  JOURNAL   Antioxid Redox Signal 8 (1-2), 130-135 (2006)
   PUBMED   16487046
  REMARK    GeneRIF: Individual proteasome subunits are important for the
            regulation of age-related changes in both proteasome activity and
            protein oxidation.
REFERENCE   8  (bases 1 to 3256)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3256)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 3256)
  AUTHORS   Voges,D., Zwickl,P. and Baumeister,W.
  TITLE     The 26S proteasome: a molecular machine designed for controlled
            proteolysis
  JOURNAL   Annu Rev Biochem 68, 1015-1068 (1999)
   PUBMED   10872471
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK153386.1.
            
            On Apr 6, 2007 this sequence version replaced NM_027357.1.
            
            Summary: In eukaryotic cells, most proteins in the cytosol and
            nucleus are degraded via the ubiquitin-proteasome pathway. The 26S
            proteasome is a self-compartmentalizing protease comprised of
            approximately 31 different subunits. It contains a barrel-shaped
            proteolytic core complex (the 20S proteasome), capped at one or
            both ends by 19S regulatory complexes, which recognize
            ubiquitinated proteins. Protein degradation by proteasomes is the
            source of most antigenic peptides presented on MHC class I
            molecules. This gene encodes a non-ATPase subunit of the 26S
            proteasome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153386.1, AK159750.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3256              AK153386.1         2-3257
FEATURES             Location/Qualifiers
     source          1..3256
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 43.94 cM"
     gene            1..3256
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /note="proteasome (prosome, macropain) 26S subunit,
                     non-ATPase, 1"
                     /db_xref="GeneID:70247"
                     /db_xref="MGI:MGI:1917497"
     exon            1..187
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            188..231
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            232..305
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..475
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..681
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..825
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1052
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1113
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1242
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1331
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1410
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1584
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1696
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1893
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..1989
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2054
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2169
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2286
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2389
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2559
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2652
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2739
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2886
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..3040
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3256
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3227..3232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /note="hexamer: AATAAA"
     polyA_site      3248
                     /gene="Psmd1"
                     /gene_synonym="2410026J11Rik; P112; S1"
                     /note="major polyA site"
ORIGIN      
        1 agggcgggcg gggtcctcgg ctagaagcga gccggcggcc tgtggagggg actgactgag
       61 cagcgcaccc gggaccctgg aggtgcggta gagcaagcgg gccctgagct gacagatcca
      121 gggcttggcc aggactgtgg acgagtggat cggcgagtgc agggcgcagc catgatcact
      181 tcagccgctg gaattatttc tcttctggat gaagaagagc cacagcttaa ggaatttgca
      241 ctacacaaat tgaatgcagt cgtgaatgac ttctgggcag agatttctga gtctgtagat
      301 aaaatagaag ttttatatga agatgaaggt ttccgaagtc ggcagtttgc agccctggtg
      361 gcctcgaaag tgttttatca cctgggggct tttgaggagt ctctgaatta tgctcttgga
      421 gcaggtgacc tcttcaacgt caatgataac tctgaatatg tggagactat tatagcaaaa
      481 tgcattgatc attataccaa acagtgtgtg gaaaatgcag atttgcctga aggagaaaaa
      541 aagccaattg accagcgatt ggaaggcatc gtgaataaaa tgttccagcg atgtctcgat
      601 gatcacaagt ataagcaagc gattggcatt gctctggaga ccaggagact ggatgtcttt
      661 gagaagacta tactggaatc taatgatgtc ccaggaatgc tagcttacag cctcaaactc
      721 tgcatgtctt taatgcagaa taaacagttt cggaataaag tattgagagt cttggttaaa
      781 atctacatga acttggaaaa gcctgatttc atcaatgttt gtcagtgctt aattttctta
      841 gatgatcctc aggctgtgag tgatatttta gaaaaactgg taaaggagga caacctgctg
      901 atggcctatc agatttgttt tgatttgtac gaaagtgcta gccagcagtt cttgtcatct
      961 gtcatccaga atcttcgaac tgttggtacc cctattgctt ctgtgcctgg atctaccaat
     1021 acggggactg tgccaggatc agagaaagac agtgacccca tggagacgga ggagaagaca
     1081 gccagtgcag tggctgggaa gacaccagat gcgagtccag agcccaagga ccagacactg
     1141 aaaatgatta agattttaag tggtgaaatg gctattgaat tacacctgca gttcctaata
     1201 cgaaataata acacagacct catgattctg aaaaacacaa aggatgcagt acgaaattct
     1261 gtgtgtcata cagcaactgt aatagcaaac tcattcatgc actgtggtac taccagtgac
     1321 cagtttctta gagataactt ggaatggttg gccagagcca ccaactgggc caaatttact
     1381 gcaacggcca gcttgggtgt aatccataag ggccatgaga aggaagcact acagttaatg
     1441 gcaacatacc ttcctaagga cacttctcca ggatcagcct atcaggaagg gggcggtctc
     1501 tatgcattgg gtctcattca tgccaatcat ggtggtgaca taattgacta tctccttaat
     1561 cagctcaaga atgccagcaa tgatattgtt cgacatggag gcagcctggg ccttggtttg
     1621 gctgcaatgg gaactgcacg tcaggatgtg tatgatttgc tgaaaacaaa cctgtatcag
     1681 gatgatgctg tgacagggga ggcagctggc ctagccttag gtttggttat gttaggttct
     1741 aaaaatgccc aggcgattga ggatatggtt ggctatgcac aagagactca acacgagaag
     1801 attctgcgcg gtctggcagt tggcattgcg ttagtgatgt acgggaggat ggaggaggct
     1861 gatgctctca ttgagtctct ctgtcgtgac aaggacccaa ttcttagaag atctggaatg
     1921 tatactgtag ccatggctta ttgtggctct ggtaacaaca aagccattcg gcgcctgcta
     1981 catgttgctg taagtgatgt caatgatgat gtcagaagag cagcagtgga gtcacttggc
     2041 ttcattttgt tcaggacgcc tgaacagtgt ccaagtgtgg tttctttgtt gtcagagagt
     2101 tataaccctc acgtgcgcta tggagctgca atggccctgg gaatctgctg tgctggtaca
     2161 ggaaacaagg aagcaattaa tttactagag ccaatgacca acgaccctgt gaactacgtg
     2221 aggcaagggg ctctgatagc ttcagctctc atcatgatcc aacagactga gatcacgtgt
     2281 ccaaaggtga atcagttccg gcagctgtat tccaaagtca tcaatgacaa acatgatgat
     2341 gtcatggcca aatttggcgc tattctggcc caaggcatac tggatgcagg tggtcataat
     2401 gtcacaatct ccttacagtc caggactggg cacactcata tgccgtctgt ggttggcgtc
     2461 cttgtcttca cccagttctg gttctggttt cccctttcac acttcctgtc attggcttat
     2521 actcctacct gtgtcattgg ccttaacaag gatttaaaga tgccgaaagt tcaatataaa
     2581 tcaaattgta aaccatccac attcgcatat cctgcccctc tggaagtacc aaaagaaaaa
     2641 gaaaaggaaa aggtttccac cgctgtgttg tctattactg ccaaagctaa aaaaaaagaa
     2701 aaagaaaaag aaaaaaagga ggaggagaag atggaagtgg atgaagcaga gaagaaggaa
     2761 gagaaagaga agaaaaaaga acctgaacca aacttccagc tgttggataa tccagcacga
     2821 gttatgcctg cccagctgaa ggtcttaagt atgacagaga cctgcagata ccagcctttt
     2881 aaaccactct ccatcggggg catcataatt ctgaaagaca ccagcgaaga cgttgaagaa
     2941 ctcgtggaac ccgtggcagc acacggccca aagattgaag aggaagagca agagccagag
     3001 cccccagagc cgttcgagta tatcgatgac taaggccagg gatcccgcct gcccagctga
     3061 agaagactgt cctggcgcac actgaaatgt cgtgagggaa cccatgctga gacctgctca
     3121 atccacacac cattgcctac gctgacataa agaacctgtg tcccaagtct ttggttaaga
     3181 agatatacga ctgttcagtg ttctctttca caaaatttgg ttttcaaata aatatattaa
     3241 aatctccaca ttgacc
//
