LOCUS       NM_025959               2182 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus proteasome (prosome, macropain) 26S subunit, ATPase, 6
            (Psmc6), transcript variant 1, mRNA.
ACCESSION   NM_025959
VERSION     NM_025959.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2182)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2182)
  AUTHORS   Piao,Y., Qi,Y., Zhang,H., Han,L., Zhong,X. and Liu,Q.
  TITLE     PSMC6 induces immune cell infiltration and inflammatory response to
            aggravate primary Sjogren's syndrome
  JOURNAL   J Hum Genet 68 (4), 263-271 (2023)
   PUBMED   36599955
  REMARK    GeneRIF: PSMC6 induces immune cell infiltration and inflammatory
            response to aggravate primary Sjogren's syndrome.
REFERENCE   3  (bases 1 to 2182)
  AUTHORS   Zhang,Y., Cao,X., Li,P., Fan,Y., Zhang,L., Li,W. and Liu,Y.
  TITLE     PSMC6 promotes osteoblast apoptosis through inhibiting PI3K/AKT
            signaling pathway activation in ovariectomy-induced osteoporosis
            mouse model
  JOURNAL   J Cell Physiol 235 (7-8), 5511-5524 (2020)
   PUBMED   32017075
  REMARK    GeneRIF: PSMC6 promotes osteoblast apoptosis through inhibiting
            PI3K/AKT signaling pathway activation in ovariectomy-induced
            osteoporosis mouse model.
REFERENCE   4  (bases 1 to 2182)
  AUTHORS   Hamazaki,J., Hirayama,S. and Murata,S.
  TITLE     Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated
            Proteins and Cellular Homeostasis
  JOURNAL   PLoS Genet 11 (7), e1005401 (2015)
   PUBMED   26222436
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2182)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2182)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   7  (bases 1 to 2182)
  AUTHORS   Vuong,B.Q., Arenzana,T.L., Showalter,B.M., Losman,J., Chen,X.P.,
            Mostecki,J., Banks,A.S., Limnander,A., Fernandez,N. and
            Rothman,P.B.
  TITLE     SOCS-1 localizes to the microtubule organizing complex-associated
            20S proteasome
  JOURNAL   Mol Cell Biol 24 (20), 9092-9101 (2004)
   PUBMED   15456882
  REMARK    Erratum:[Mol Cell Biol. 2005 Sep;25(17):7927]
REFERENCE   8  (bases 1 to 2182)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154575.2.
            
            On Jan 10, 2023 this sequence version replaced NM_025959.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043044.1, AK144728.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AC154575.2         24210-24314         c
            106-185             AC154575.2         23233-23312         c
            186-225             AC154575.2         23116-23155         c
            226-278             AC154575.2         22184-22236         c
            279-346             AC154575.2         19422-19489         c
            347-461             AC154575.2         19111-19225         c
            462-549             AC154575.2         16577-16664         c
            550-611             AC154575.2         13451-13512         c
            612-735             AC154575.2         13246-13369         c
            736-797             AC154575.2         12799-12860         c
            798-918             AC154575.2         10621-10741         c
            919-999             AC154575.2         10415-10495         c
            1000-1071           AC154575.2         7327-7398           c
            1072-2182           AC154575.2         4449-5559           c
FEATURES             Location/Qualifiers
     source          1..2182
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 22.89 cM"
     gene            1..2182
                     /gene="Psmc6"
                     /gene_synonym="2300001E01Rik"
                     /note="proteasome (prosome, macropain) 26S subunit,
                     ATPase, 6"
                     /db_xref="GeneID:67089"
                     /db_xref="MGI:MGI:1914339"
     exon            1..105
                     /gene="Psmc6"
                     /gene_synonym="2300001E01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            106..185
                     /gene="Psmc6"
                     /gene_synonym="2300001E01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            186..225
                     /gene="Psmc6"
                     /gene_synonym="2300001E01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            226..278
                     /gene="Psmc6"
                     /gene_synonym="2300001E01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            279..346
                     /gene="Psmc6"
                     /gene_synonym="2300001E01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            347..461
                     /gene="Psmc6"
                     /gene_synonym="2300001E01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            462..549
                     /gene="Psmc6"
                     /gene_synonym="2300001E01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            550..611
                     /gene="Psmc6"
                     /gene_synonym="2300001E01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            612..735
                     /gene="Psmc6"
                     /gene_synonym="2300001E01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            736..797
                     /gene="Psmc6"
                     /gene_synonym="2300001E01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            798..918
                     /gene="Psmc6"
                     /gene_synonym="2300001E01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            919..999
                     /gene="Psmc6"
                     /gene_synonym="2300001E01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1071
                     /gene="Psmc6"
                     /gene_synonym="2300001E01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..2182
                     /gene="Psmc6"
                     /gene_synonym="2300001E01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1293..1298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmc6"
                     /gene_synonym="2300001E01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1316
                     /gene="Psmc6"
                     /gene_synonym="2300001E01Rik"
                     /note="major polyA site"
     regulatory      1536..1541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmc6"
                     /gene_synonym="2300001E01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1563
                     /gene="Psmc6"
                     /gene_synonym="2300001E01Rik"
                     /note="major polyA site"
     regulatory      2151..2156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmc6"
                     /gene_synonym="2300001E01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2182
                     /gene="Psmc6"
                     /gene_synonym="2300001E01Rik"
ORIGIN      
        1 atgagcgacg gcttctcatc atggcggacc ctagagataa ggcgcttcag gactatcgca
       61 agaagctgct agagcacaag gagattgacg gccgtcttaa ggagctaagg gaacaattaa
      121 aagaacttac caagcagtat gaaaagtctg aaaatgattt gaaggcacta caaagtgttg
      181 gacagattgt aggtgaagtg ctaaaacagt taacagaaga aaaattcatc gttaaagcaa
      241 caaatggacc aagatacgtt gtaggttgtc gtcgtcagct tgacaaaagt aagctgaagc
      301 caggaaccag agttgctttg gatatgacca cactaaccat catgagatat ctgccaagag
      361 aggtggatcc attggtttat aacatgtctc acgaggatcc tggaaatgta tcttattctg
      421 agattggagg cctgtcagaa cagattcggg agttaagaga ggtaatagaa ttgcctctta
      481 caaatccaga attattccag cgtgtaggaa taatacctcc aaaaggctgt ttgctctatg
      541 gaccgccagg cactgggaaa acactcttgg cacgagctgt tgccagccag ctggactgca
      601 acttcctaaa ggttgtatct agttctattg tagacaagta cattggtgaa agtgctcgtt
      661 tgattagaga aatgtttaat tatgccaggg accaccagcc atgcatcatt tttatggatg
      721 aaatagatgc tattggtggc cgtcggtttt ctgagggaac atcagctgac agagagattc
      781 agagaacttt aatggagtta ctaaatcaaa tggatggatt tgatactctg catagagtta
      841 aaatgatcat ggctacaaac agaccagata cactggatcc tgctttgctg cgcccaggaa
      901 gattagatag aaaaatacat atcgatttac caaatgaaca agcaagatta gatatattga
      961 aaatccacgc aggacctatt acaaagcatg gtgaaataga ttatgaagca attgtaaagc
     1021 tttcagatgg ctttaatgga gcagacctga gaaatgtttg tactgaagca ggtatgtttg
     1081 caattcgtgc cgatcatgat tttgtagttc aggaagactt catgaaagca gtcaggaaag
     1141 tggctgactc caagaagctg gagtccaagc tggactacaa acctgtgtga ttcactagaa
     1201 gggtttggtg gctgcatgac agacattggt ttaatgtaaa aataaagtta aggaaaataa
     1261 tgtatgtatt ggcaatgatc ttattaaaag tgaataaaca tgtataagca acataatagt
     1321 atgtaattca gtaatttttt aaaaattggt acagaagaaa gtcatgtttg gtgatgttgc
     1381 atttacttca gcagaattta caaaagacat cctgaagctt ttcatatttg ctttgtgagc
     1441 attttgtaca acattcaaaa tgattgagat agtagaggag agcatttctt atgacttatt
     1501 ttatattttg ttttcctcgt ccttaaaaaa aaagcaataa aatctgtttt aagttgtcct
     1561 atatatactc ttgtcttttc taaaagcaca tttattcttg tccttttgga ttagtaagta
     1621 tatgatttga aaacctggat gaagttgaaa attaaaatag ggctttgaat tttaaacagt
     1681 actcacagag tccacaagaa tgtcttcttt tatagatcat agagtgtggg gttatggagt
     1741 atatacatgt acttgtgtct tccaagaaat tctctttacc tattgcagtt aggtatttga
     1801 taattttaac tttttaaaga ttatgactgg aagtaatact tataatttgg tttatgtgaa
     1861 aaataattcc ctttttgtgg tctggatcca ggaaaagtct gttcatggac atgtaatttt
     1921 acatatatgt gatttctagc gatctattat ttcttaggtt caccagtgga ttctataaat
     1981 atcttccagt aaataccagg ctgagagtgt ctactctatg gaatgttaaa tgttcaaaac
     2041 aaaagttctg ttacctgtac acaattctaa tttcatgtgg caatcaaaag ttgtataagg
     2101 aaattgtcaa tgtctaaaaa ttgagattat ttatagttaa ttcttgttta aataaagaca
     2161 tcaaacttca gtttcataaa ta
//
