LOCUS       NM_008950               1277 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus protease (prosome, macropain) 26S subunit, ATPase 5
            (Psmc5), mRNA.
ACCESSION   NM_008950
VERSION     NM_008950.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1277)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1277)
  AUTHORS   Bi,W., Bao,K., Zhou,X., Deng,Y., Li,X., Zhang,J., Lan,X., Zhao,J.,
            Lu,D., Xu,Y., Cen,Y., Cao,R., Xu,M., Zhong,W. and Zhu,L.
  TITLE     PSMC5 regulates microglial polarization and activation in
            LPS-induced cognitive deficits and motor impairments by interacting
            with TLR4
  JOURNAL   J Neuroinflammation 20 (1), 277 (2023)
   PUBMED   38001534
  REMARK    GeneRIF: PSMC5 regulates microglial polarization and activation in
            LPS-induced cognitive deficits and motor impairments by interacting
            with TLR4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1277)
  AUTHORS   Scudder,S.L., Gonzales,F.R., Howell,K.K., Stein,I.S., Dozier,L.E.,
            Anagnostaras,S.G., Zito,K. and Patrick,G.N.
  TITLE     Altered Phosphorylation of the Proteasome Subunit Rpt6 Has Minimal
            Impact on Synaptic Plasticity and Learning
  JOURNAL   eNeuro 8 (3) (2021)
   PUBMED   33658307
  REMARK    GeneRIF: Altered Phosphorylation of the Proteasome Subunit Rpt6 Has
            Minimal Impact on Synaptic Plasticity and Learning.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1277)
  AUTHORS   Gonzales,F.R., Howell,K.K., Dozier,L.E., Anagnostaras,S.G. and
            Patrick,G.N.
  TITLE     Proteasome phosphorylation regulates cocaine-induced sensitization
  JOURNAL   Mol Cell Neurosci 88, 62-69 (2018)
   PUBMED   29217409
REFERENCE   5  (bases 1 to 1277)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   6  (bases 1 to 1277)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   7  (bases 1 to 1277)
  AUTHORS   Miyamoto-Sato,E., Ishizaka,M., Horisawa,K., Tateyama,S.,
            Takashima,H., Fuse,S., Sue,K., Hirai,N., Masuoka,K. and Yanagawa,H.
  TITLE     Cell-free cotranslation and selection using in vitro virus for
            high-throughput analysis of protein-protein interactions and
            complexes
  JOURNAL   Genome Res 15 (5), 710-717 (2005)
   PUBMED   15867431
REFERENCE   8  (bases 1 to 1277)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1277)
  AUTHORS   Weeda,G., Rossignol,M., Fraser,R.A., Winkler,G.S., Vermeulen,W.,
            van 't Veer,L.J., Ma,L., Hoeijmakers,J.H. and Egly,J.M.
  TITLE     The XPB subunit of repair/transcription factor TFIIH directly
            interacts with SUG1, a subunit of the 26S proteasome and putative
            transcription factor
  JOURNAL   Nucleic Acids Res 25 (12), 2274-2283 (1997)
   PUBMED   9173976
REFERENCE   10 (bases 1 to 1277)
  AUTHORS   vom Baur,E., Zechel,C., Heery,D., Heine,M.J., Garnier,J.M.,
            Vivat,V., Le Douarin,B., Gronemeyer,H., Chambon,P. and Losson,R.
  TITLE     Differential ligand-dependent interactions between the AF-2
            activating domain of nuclear receptors and the putative
            transcriptional intermediary factors mSUG1 and TIF1
  JOURNAL   EMBO J 15 (1), 110-124 (1996)
   PUBMED   8598193
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from Z54219.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z54219.1, AK010505.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1277
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 68.89 cM"
     gene            1..1277
                     /gene="Psmc5"
                     /gene_synonym="mSUG1; Rpt6"
                     /note="protease (prosome, macropain) 26S subunit, ATPase
                     5"
                     /db_xref="GeneID:19184"
                     /db_xref="MGI:MGI:105047"
     exon            1..30
                     /gene="Psmc5"
                     /gene_synonym="mSUG1; Rpt6"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..1227
                     /gene="Psmc5"
                     /gene_synonym="mSUG1; Rpt6"
                     /function="putative transcriptional mediator of nuclear
                     receptors and PA700 proteasome subunit"
                     /note="26S protease regulatory subunit 8; p45/SUG;
                     proteasome subunit p45; proteasome 26S subunit ATPase 5;
                     26S proteasome AAA-ATPase subunit RPT6"
                     /codon_start=1
                     /product="26S proteasome regulatory subunit 8"
                     /protein_id="NP_032976.1"
                     /db_xref="CCDS:CCDS25553.1"
                     /db_xref="GeneID:19184"
                     /db_xref="MGI:MGI:105047"
                     /translation="MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRR
                     LQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKN
                     IDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKE
                     IKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSE
                     LVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLEL
                     LNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSR
                     KMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQ
                     KDSEKNMSIKKLWK"
     exon            31..102
                     /gene="Psmc5"
                     /gene_synonym="mSUG1; Rpt6"
                     /inference="alignment:Splign:2.1.0"
     exon            103..172
                     /gene="Psmc5"
                     /gene_synonym="mSUG1; Rpt6"
                     /inference="alignment:Splign:2.1.0"
     exon            173..270
                     /gene="Psmc5"
                     /gene_synonym="mSUG1; Rpt6"
                     /inference="alignment:Splign:2.1.0"
     exon            271..558
                     /gene="Psmc5"
                     /gene_synonym="mSUG1; Rpt6"
                     /inference="alignment:Splign:2.1.0"
     exon            559..685
                     /gene="Psmc5"
                     /gene_synonym="mSUG1; Rpt6"
                     /inference="alignment:Splign:2.1.0"
     exon            686..876
                     /gene="Psmc5"
                     /gene_synonym="mSUG1; Rpt6"
                     /inference="alignment:Splign:2.1.0"
     exon            877..975
                     /gene="Psmc5"
                     /gene_synonym="mSUG1; Rpt6"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1086
                     /gene="Psmc5"
                     /gene_synonym="mSUG1; Rpt6"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1173
                     /gene="Psmc5"
                     /gene_synonym="mSUG1; Rpt6"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1277
                     /gene="Psmc5"
                     /gene_synonym="mSUG1; Rpt6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaagatgg cgcttgatgg gccagagcag atggaactgg aagaggggaa ggcaggcagt
       61 ggactccgtc aatattatct gtccaagatt gaagaactcc agttgattgt aaatgataag
      121 agccagaatc tccgtagact gcaggcacag aggaatgagc tgaatgcaaa agttcgcctg
      181 ttgcgggagg agctgcagct gttgcaggaa cagggctcct acgttggaga agtcgtgagg
      241 gccatggata agaaaaaagt attggtcaag gtccatcctg agggcaaatt tgttgttgat
      301 gtggacaaga acattgatat caacgatgtg acgcccaatt gtcgggtcgc tctaagaaat
      361 gacagctaca ctctgcataa gatcttacct aacaaggtgg accctttggt gtcactaatg
      421 atggtggaga aggtgccaga ctcaacctac gagatgattg gcggcctgga caagcagatc
      481 aaggagatta aagaagtgat cgagctgccc gtgaagcacc ccgagctctt tgaagcactg
      541 ggcatcgcac agccaaaggg agtcctgctc tacggacccc caggcactgg gaagacattg
      601 ttggcccgcg ctgtggctca tcatacagac tgtaccttta ttcgtgtctc tggctctgaa
      661 ctggtacaga aattcatcgg ggaaggggca agaatggtga gggagctgtt tgtcatggcc
      721 cgagaacatg ctccatccat catcttcatg gacgagattg actctattgg ctcctcacgg
      781 ctggaggggg gctctggagg cgacagtgag gtacagcgca cgatgctgga actgctcaat
      841 cagctggatg gctttgaggc caccaagaat atcaaggtta tcatggctac taataggatt
      901 gatatcctgg actctgccct gcttcgtcct gggaggattg acagaaaaat tgaattccca
      961 ccccccaacg aggaggcccg gctggacatt ttgaaaatcc actctcggaa aatgaacttg
     1021 accaggggga tcaacctgag gaaaattgct gagttgatgc cgggagcttc aggggctgaa
     1081 gtgaagggtg tgtgcacaga agctggcatg tacgccctgc gggaacggcg tgtccacgtc
     1141 actcaggagg actttgagat ggcagtagct aaggtcatgc aaaaggatag tgagaaaaac
     1201 atgtccatca agaagctatg gaagtgaggc tgtgtccttt gtgtgctccc cccccccaac
     1261 caataaaggt ctgtgtg
//
