LOCUS       NM_011874               1436 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus proteasome (prosome, macropain) 26S subunit, ATPase, 4
            (Psmc4), mRNA.
ACCESSION   NM_011874
VERSION     NM_011874.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1436)
  AUTHORS   Kiryu-Seo,S., Matsushita,R., Tashiro,Y., Yoshimura,T., Iguchi,Y.,
            Katsuno,M., Takahashi,R. and Kiyama,H.
  TITLE     Impaired disassembly of the axon initial segment restricts
            mitochondrial entry into damaged axons
  JOURNAL   EMBO J 41 (20), e110486 (2022)
   PUBMED   36004759
REFERENCE   2  (bases 1 to 1436)
  AUTHORS   Kitajima,Y., Suzuki,N., Yoshioka,K., Izumi,R., Tateyama,M.,
            Tashiro,Y., Takahashi,R., Aoki,M. and Ono,Y.
  TITLE     Inducible Rpt3, a Proteasome Component, Knockout in Adult Skeletal
            Muscle Results in Muscle Atrophy
  JOURNAL   Front Cell Dev Biol 8, 859 (2020)
   PUBMED   32984340
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1436)
  AUTHORS   Sitaraman,S., Na,C.L., Yang,L., Filuta,A., Bridges,J.P. and
            Weaver,T.E.
  TITLE     Proteasome dysfunction in alveolar type 2 epithelial cells is
            associated with acute respiratory distress syndrome
  JOURNAL   Sci Rep 9 (1), 12509 (2019)
   PUBMED   31467330
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1436)
  AUTHORS   Hjerpe,R., Bett,J.S., Keuss,M.J., Solovyova,A., McWilliams,T.G.,
            Johnson,C., Sahu,I., Varghese,J., Wood,N., Wightman,M., Osborne,G.,
            Bates,G.P., Glickman,M.H., Trost,M., Knebel,A., Marchesi,F. and
            Kurz,T.
  TITLE     UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance
            by the Proteasome
  JOURNAL   Cell 166 (4), 935-949 (2016)
   PUBMED   27477512
REFERENCE   5  (bases 1 to 1436)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1436)
  AUTHORS   Evsikov,A.V., de Vries,W.N., Peaston,A.E., Radford,E.E.,
            Fancher,K.S., Chen,F.H., Blake,J.A., Bult,C.J., Latham,K.E.,
            Solter,D. and Knowles,B.B.
  TITLE     Systems biology of the 2-cell mouse embryo
  JOURNAL   Cytogenet Genome Res 105 (2-4), 240-250 (2004)
   PUBMED   15237213
REFERENCE   7  (bases 1 to 1436)
  AUTHORS   McClive,P.J., Hurley,T.M., Sarraj,M.A., van den Bergen,J.A. and
            Sinclair,A.H.
  TITLE     Subtractive hybridisation screen identifies sexually dimorphic gene
            expression in the embryonic mouse gonad
  JOURNAL   Genesis 37 (2), 84-90 (2003)
   PUBMED   14595844
REFERENCE   8  (bases 1 to 1436)
  AUTHORS   Tanaka,K., Tamura,H., Tanaka,H., Katoh,M., Futamata,Y., Seki,N.,
            Nishimune,Y. and Hara,T.
  TITLE     Spermatogonia-dependent expression of testicular genes in mice
  JOURNAL   Dev Biol 246 (2), 466-479 (2002)
   PUBMED   12051830
REFERENCE   9  (bases 1 to 1436)
  AUTHORS   Sakao,Y., Kawai,T., Takeuchi,O., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Takeda,K. and Akira,S.
  TITLE     Mouse proteasomal ATPases Psmc3 and Psmc4: genomic organization and
            gene targeting
  JOURNAL   Genomics 67 (1), 1-7 (2000)
   PUBMED   10945464
REFERENCE   10 (bases 1 to 1436)
  AUTHORS   Choi,H.S., Seol,W. and Moore,D.D.
  TITLE     A component of the 26S proteasome binds on orphan member of the
            nuclear hormone receptor superfamily
  JOURNAL   J Steroid Biochem Mol Biol 56 (1-6 Spec No), 23-30 (1996)
   PUBMED   8603043
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV646128.1, AK077507.1 and BY385516.1.
            
            On Jan 27, 2007 this sequence version replaced NM_011874.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153991.1, AK050677.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                DV646128.1         11-48
            39-1425             AK077507.1         2-1388
            1426-1436           BY385516.1         419-429
FEATURES             Location/Qualifiers
     source          1..1436
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.11 cM"
     gene            1..1436
                     /gene="Psmc4"
                     /gene_synonym="CIP21; MIP224"
                     /note="proteasome (prosome, macropain) 26S subunit,
                     ATPase, 4"
                     /db_xref="GeneID:23996"
                     /db_xref="MGI:MGI:1346093"
     exon            1..110
                     /gene="Psmc4"
                     /gene_synonym="CIP21; MIP224"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1331
                     /gene="Psmc4"
                     /gene_synonym="CIP21; MIP224"
                     /note="CAR interacting protein 21; proteasome 26S ATPase
                     subunit 4; 26S protease regulatory subunit 6B; TBP-7;
                     TAT-binding protein 7; MB67-interacting protein;
                     proteasome 26S subunit ATPase 4; 26S proteasome AAA-ATPase
                     subunit RPT3; CAR interacing protein 21"
                     /codon_start=1
                     /product="26S proteasome regulatory subunit 6B"
                     /protein_id="NP_036004.2"
                     /db_xref="CCDS:CCDS21034.1"
                     /db_xref="GeneID:23996"
                     /db_xref="MGI:MGI:1346093"
                     /translation="MEEIGILVEKIQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRY
                     KKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAI
                     VGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKP
                     DVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKA
                     VAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFD
                     AQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFP
                     LPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRY
                     IVLAKDFEKAYKTVIKKDEQEHEFYK"
     exon            111..209
                     /gene="Psmc4"
                     /gene_synonym="CIP21; MIP224"
                     /inference="alignment:Splign:2.1.0"
     exon            210..396
                     /gene="Psmc4"
                     /gene_synonym="CIP21; MIP224"
                     /inference="alignment:Splign:2.1.0"
     exon            397..543
                     /gene="Psmc4"
                     /gene_synonym="CIP21; MIP224"
                     /inference="alignment:Splign:2.1.0"
     exon            544..653
                     /gene="Psmc4"
                     /gene_synonym="CIP21; MIP224"
                     /inference="alignment:Splign:2.1.0"
     exon            654..747
                     /gene="Psmc4"
                     /gene_synonym="CIP21; MIP224"
                     /inference="alignment:Splign:2.1.0"
     exon            748..915
                     /gene="Psmc4"
                     /gene_synonym="CIP21; MIP224"
                     /inference="alignment:Splign:2.1.0"
     exon            916..992
                     /gene="Psmc4"
                     /gene_synonym="CIP21; MIP224"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1161
                     /gene="Psmc4"
                     /gene_synonym="CIP21; MIP224"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1217
                     /gene="Psmc4"
                     /gene_synonym="CIP21; MIP224"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1436
                     /gene="Psmc4"
                     /gene_synonym="CIP21; MIP224"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1403..1408
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmc4"
                     /gene_synonym="CIP21; MIP224"
                     /note="hexamer: AATAAA"
     polyA_site      1431
                     /gene="Psmc4"
                     /gene_synonym="CIP21; MIP224"
                     /note="major polyA site"
ORIGIN      
        1 ctatgtgaag gacttccgtt ggcgtcagcg gaagccgtga ctggccgggc tgcactgagg
       61 ccggcttggt cactatggag gagataggca ttttggtgga aaagattcag gatgagattc
      121 cagcactgtc cgtgtctcgg ccgcagaccg gcctgtcctt tctgggaccc gaacctgaag
      181 acctggagga cctgtacagc cgctacaaga agctgcagca ggagctggag ttcctggaag
      241 tgcaggagga gtatatcaag gacgagcaga agaacctgaa gaaggaattc ctccacgccc
      301 aggaggaggt gaagcggatc cagagcatcc ccttggtcat cggtcagttc ttggaagctg
      361 tggatcagaa cacagccatc gtgggctcca ccacaggctc taactattat gtgcgcatcc
      421 tgagtaccat cgaccgggag ctgctcaagc ccaacgcctc ggtggccctg cacaagcaca
      481 gcaatgccct ggtggacgtg ctgcctcccg aggccgacag cagcatcatg atgctcacct
      541 cagaccagaa gccagatgtg atgtatgccg atatcggagg catggacatc cagaagcagg
      601 aggtgaggga ggctgtggaa ctcccgctta cacacttcga gctgtacaag cagattggca
      661 tcgatcctcc ccgaggtgtc ctcatgtatg gccctcctgg ctgtggaaag acaatgttag
      721 caaaggctgt ggcacatcac acgacagctg catttatccg tgtggtgggc tcggagtttg
      781 ttcagaagta cctgggtgag ggcccccgga tggtccggga tgtgttccgc ctagctaagg
      841 agaatgcacc tgccatcatc ttcatagatg aaattgatgc cattgccacc aagagattcg
      901 atgcccagac aggagctgac agggaggttc agaggatcct gctggaacta ctgaatcaaa
      961 tggatggatt tgaccagaac gtcaatgtga aggtaatcat ggccacaaac agagcagaca
     1021 ccttggatcc agctctactg cggccaggac gcctggaccg aaaaattgaa ttcccactcc
     1081 ctgaccgtcg ccagaagagg ttgattttct ccaccatcac cagcaaaatg aacctctctg
     1141 aggaggtcga cctggaagac tatgtggccc gtccagataa gatttcagga gccgatatca
     1201 actccatctg tcaggagagt ggaatgttgg ctgtccgtga gaaccgctac attgtcctgg
     1261 ccaaggactt cgagaaagca tacaagaccg tgatcaagaa agatgaacag gaacatgaat
     1321 tttacaagtg acctcctccc cacacttccc caggcacctg tcccaaaggc tagttttctc
     1381 tttacccagg attggtttag tcaataaatg gacgtgattg gatctattta atttct
//
