LOCUS       NM_008948               1651 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus proteasome (prosome, macropain) 26S subunit, ATPase 3
            (Psmc3), mRNA.
ACCESSION   NM_008948
VERSION     NM_008948.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1651)
  AUTHORS   Ebstein,F., Kury,S., Most,V., Rosenfelt,C., Scott-Boyer,M.P., van
            Woerden,G.M., Besnard,T., Papendorf,J.J., Studencka-Turski,M.,
            Wang,T., Hsieh,T.C., Golnik,R., Baldridge,D., Forster,C., de
            Konink,C., Teurlings,S.M.W., Vignard,V., van Jaarsveld,R.H.,
            Ades,L., Cogne,B., Mignot,C., Deb,W., Jongmans,M.C.J., Cole,F.S.,
            van den Boogaard,M.H., Wambach,J.A., Wegner,D.J., Yang,S.,
            Hannig,V., Brault,J.A., Zadeh,N., Bennetts,B., Keren,B.,
            Gelineau,A.C., Powis,Z., Towne,M., Bachman,K., Seeley,A.,
            Beck,A.E., Morrison,J., Westman,R., Averill,K., Brunet,T.,
            Haasters,J., Carter,M.T., Osmond,M., Wheeler,P.G., Forzano,F.,
            Mohammed,S., Trakadis,Y., Accogli,A., Harrison,R., Guo,Y.,
            Hakonarson,H., Rondeau,S., Baujat,G., Barcia,G., Feichtinger,R.G.,
            Mayr,J.A., Preisel,M., Laumonnier,F., Kallinich,T., Knaus,A.,
            Isidor,B., Krawitz,P., Volker,U., Hammer,E., Droit,A.,
            Eichler,E.E., Elgersma,Y., Hildebrand,P.W., Bolduc,F., Kruger,E.
            and Bezieau,S.
  TITLE     PSMC3 proteasome subunit variants are associated with
            neurodevelopmental delay and type I interferon production
  JOURNAL   Sci Transl Med 15 (698), eabo3189 (2023)
   PUBMED   37256937
  REMARK    GeneRIF: PSMC3 proteasome subunit variants are associated with
            neurodevelopmental delay and type I interferon production.
REFERENCE   2  (bases 1 to 1651)
  AUTHORS   Lukic,Z., Hausmann,S., Sebastian,S., Rucci,J., Sastri,J.,
            Robia,S.L., Luban,J. and Campbell,E.M.
  TITLE     TRIM5alpha associates with proteasomal subunits in cells while in
            complex with HIV-1 virions
  JOURNAL   Retrovirology 8, 93 (2011)
   PUBMED   22078707
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1651)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 1651)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   5  (bases 1 to 1651)
  AUTHORS   Binato,R., Alvarez Martinez,C.E., Pizzatti,L., Robert,B. and
            Abdelhay,E.
  TITLE     SMAD 8 binding to mice Msx1 basal promoter is required for
            transcriptional activation
  JOURNAL   Biochem J 393 (Pt 1), 141-150 (2006)
   PUBMED   16101586
REFERENCE   6  (bases 1 to 1651)
  AUTHORS   Corn,P.G., McDonald,E.R. 3rd, Herman,J.G. and El-Deiry,W.S.
  TITLE     Tat-binding protein-1, a component of the 26S proteasome,
            contributes to the E3 ubiquitin ligase function of the von
            Hippel-Lindau protein
  JOURNAL   Nat Genet 35 (3), 229-237 (2003)
   PUBMED   14556007
REFERENCE   7  (bases 1 to 1651)
  AUTHORS   Sakao,Y., Kawai,T., Takeuchi,O., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Takeda,K. and Akira,S.
  TITLE     Mouse proteasomal ATPases Psmc3 and Psmc4: genomic organization and
            gene targeting
  JOURNAL   Genomics 67 (1), 1-7 (2000)
   PUBMED   10945464
REFERENCE   8  (bases 1 to 1651)
  AUTHORS   Nakamura,T., Tanaka,T., Takagi,H. and Sato,M.
  TITLE     Cloning and heterogeneous in vivo expression of Tat binding
            protein-1 (TBP-1) in the mouse
  JOURNAL   Biochim Biophys Acta 1399 (1), 93-100 (1998)
   PUBMED   9714759
REFERENCE   9  (bases 1 to 1651)
  AUTHORS   Tanaka,T., Nakamura,T., Takagi,H. and Sato,M.
  TITLE     Molecular cloning and characterization of a novel TBP-1 interacting
            protein (TBPIP):enhancement of TBP-1 action on Tat by TBPIP
  JOURNAL   Biochem Biophys Res Commun 239 (1), 176-181 (1997)
   PUBMED   9345291
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX201527.1, AK167002.1 and BE989849.1.
            
            On Apr 29, 2009 this sequence version replaced NM_008948.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167061.1, AK167002.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                CX201527.1         8-60
            54-1625             AK167002.1         2-1573
            1626-1651           BE989849.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..1651
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.44 cM"
     gene            1..1651
                     /gene="Psmc3"
                     /gene_synonym="TBP-1"
                     /note="proteasome (prosome, macropain) 26S subunit, ATPase
                     3"
                     /db_xref="GeneID:19182"
                     /db_xref="MGI:MGI:1098754"
     exon            1..316
                     /gene="Psmc3"
                     /gene_synonym="TBP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..1561
                     /gene="Psmc3"
                     /gene_synonym="TBP-1"
                     /note="26S protease regulatory subunit 6A; TAT-binding
                     protein 1; proteasome 26S subunit ATPase 3; 26S proteasome
                     AAA-ATPase subunit RPT5; Tat binding protein 1"
                     /codon_start=1
                     /product="26S proteasome regulatory subunit 6A"
                     /protein_id="NP_032974.2"
                     /db_xref="CCDS:CCDS16423.1"
                     /db_xref="GeneID:19182"
                     /db_xref="MGI:MGI:1098754"
                     /translation="MQEMNLLPTPESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEI
                     VQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDV
                     DPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDS
                     YLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENL
                     GIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFA
                     LAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAA
                     TNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTD
                     DFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA"
     exon            317..400
                     /gene="Psmc3"
                     /gene_synonym="TBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..526
                     /gene="Psmc3"
                     /gene_synonym="TBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..631
                     /gene="Psmc3"
                     /gene_synonym="TBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            632..694
                     /gene="Psmc3"
                     /gene_synonym="TBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..832
                     /gene="Psmc3"
                     /gene_synonym="TBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            833..976
                     /gene="Psmc3"
                     /gene_synonym="TBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1125
                     /gene="Psmc3"
                     /gene_synonym="TBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1222
                     /gene="Psmc3"
                     /gene_synonym="TBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1368
                     /gene="Psmc3"
                     /gene_synonym="TBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1450
                     /gene="Psmc3"
                     /gene_synonym="TBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1635
                     /gene="Psmc3"
                     /gene_synonym="TBP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1606..1611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmc3"
                     /gene_synonym="TBP-1"
                     /note="hexamer: AATAAA"
     polyA_site      1635
                     /gene="Psmc3"
                     /gene_synonym="TBP-1"
                     /note="major polyA site"
ORIGIN      
        1 agccctcgct cccgcacaaa ccggagcaac cggcgagcca cggggcgggc cctgtagcct
       61 cggtttggtt cgtggagtcc cagcggcaga ttcgctcgga gacgcggaca gaacccgttc
      121 tgtcgcgtca ggaatcgcgg gtgaagttct ccacgggtgg agagaagacg ttgagaaagg
      181 ctgcgctggg ctccctcagg ggctcgtgcg cactcccagt ttcggcctct tcatgcagga
      241 aatgaatctg ctgccgacgc ccgagagtcc agtgactcgg caggagaaga tggcgaccgt
      301 gtgggatgaa gctgagcaag atggcattgg ggaggaggtg ctcaagatgt ccacggaaga
      361 gattgtccag cgcacacggc tgttagacag cgagatcaag atcatgaaga gtgaagtatt
      421 gcgagtcacc catgaactcc aagccatgaa agacaaaatc aaagagaaca gtgagaaaat
      481 caaagtgaac aaaaccctgc cgtaccttgt ctccaatgtc atcgagttgc tggacgttga
      541 ccccaatgac caggaggagg atggtgccaa cattgacctg gactctcaga ggaagggcaa
      601 gtgtgcggtg atcaaaactt ctacccgaca gacatacttc ctgccagtga ttgggttggt
      661 ggatgcagaa aagctgaagc caggagacct ggtgggtgtg aacaaagact cctatctgat
      721 cctggagacc ctgcccactg aatatgactc tcgggtgaag gccatggagg tggacgagcg
      781 gcccacggag caatacagtg acatcggggg cctggacaag cagatccagg agctggtgga
      841 agccattgtc ttgcctatga accacaaaga gaagtttgag aacttgggta tccagccccc
      901 aaaaggagtg ctgatgtatg ggccgcctgg aacagggaag actctgcttg cccgagcctg
      961 tgctgctcag accaaggcca ccttcttgaa gctggcaggc cctcagctgg tacagatgtt
     1021 tattggagat ggcgccaagc tggtccgtga tgcttttgcc ctggccaagg agaaggcacc
     1081 atctattatt ttcatagacg aattggatgc cattggtacc aaacgcttcg acagtgaaaa
     1141 ggcaggagac cgagaggtgc agaggaccat gctggagcta ctgaaccagc tggacggctt
     1201 tcagcccaac actcaagtga aggtaattgc agccactaac agggtggaca tcctggatcc
     1261 agccctgctg cgctcaggcc gcctagaccg caagattgag tttccaatgc ccaacgagga
     1321 ggccagagcc agaatcatgc agatccactc acggaagatg aatgtcagtc ctgatgtgaa
     1381 ctatgaagag ctggctcggt gcactgatga cttcaatgga gcccagtgca aggccgtgtg
     1441 tgtggaggcg ggtatgatcg cattgcgcag gggagccacg gaactcactc atgaggacta
     1501 catggagggc atcctggagg ttcaggccaa gaagaaagcc aacctacaat actatgccta
     1561 ggggacacct ctagtctgtc cgctggtctg agggctaaag ttgataataa aaggtgtttt
     1621 ctgttcttcg ccacaaaaaa aaaaaaaaaa a
//
