LOCUS       NP_032974                442 aa            linear   ROD 04-JUN-2024
DEFINITION  26S proteasome regulatory subunit 6A [Mus musculus].
ACCESSION   NP_032974
VERSION     NP_032974.2
DBSOURCE    REFSEQ: accession NM_008948.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 442)
  AUTHORS   Ebstein,F., Kury,S., Most,V., Rosenfelt,C., Scott-Boyer,M.P., van
            Woerden,G.M., Besnard,T., Papendorf,J.J., Studencka-Turski,M.,
            Wang,T., Hsieh,T.C., Golnik,R., Baldridge,D., Forster,C., de
            Konink,C., Teurlings,S.M.W., Vignard,V., van Jaarsveld,R.H.,
            Ades,L., Cogne,B., Mignot,C., Deb,W., Jongmans,M.C.J., Cole,F.S.,
            van den Boogaard,M.H., Wambach,J.A., Wegner,D.J., Yang,S.,
            Hannig,V., Brault,J.A., Zadeh,N., Bennetts,B., Keren,B.,
            Gelineau,A.C., Powis,Z., Towne,M., Bachman,K., Seeley,A.,
            Beck,A.E., Morrison,J., Westman,R., Averill,K., Brunet,T.,
            Haasters,J., Carter,M.T., Osmond,M., Wheeler,P.G., Forzano,F.,
            Mohammed,S., Trakadis,Y., Accogli,A., Harrison,R., Guo,Y.,
            Hakonarson,H., Rondeau,S., Baujat,G., Barcia,G., Feichtinger,R.G.,
            Mayr,J.A., Preisel,M., Laumonnier,F., Kallinich,T., Knaus,A.,
            Isidor,B., Krawitz,P., Volker,U., Hammer,E., Droit,A.,
            Eichler,E.E., Elgersma,Y., Hildebrand,P.W., Bolduc,F., Kruger,E.
            and Bezieau,S.
  TITLE     PSMC3 proteasome subunit variants are associated with
            neurodevelopmental delay and type I interferon production
  JOURNAL   Sci Transl Med 15 (698), eabo3189 (2023)
   PUBMED   37256937
  REMARK    GeneRIF: PSMC3 proteasome subunit variants are associated with
            neurodevelopmental delay and type I interferon production.
REFERENCE   2  (residues 1 to 442)
  AUTHORS   Lukic,Z., Hausmann,S., Sebastian,S., Rucci,J., Sastri,J.,
            Robia,S.L., Luban,J. and Campbell,E.M.
  TITLE     TRIM5alpha associates with proteasomal subunits in cells while in
            complex with HIV-1 virions
  JOURNAL   Retrovirology 8, 93 (2011)
   PUBMED   22078707
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 442)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (residues 1 to 442)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   5  (residues 1 to 442)
  AUTHORS   Binato,R., Alvarez Martinez,C.E., Pizzatti,L., Robert,B. and
            Abdelhay,E.
  TITLE     SMAD 8 binding to mice Msx1 basal promoter is required for
            transcriptional activation
  JOURNAL   Biochem J 393 (Pt 1), 141-150 (2006)
   PUBMED   16101586
REFERENCE   6  (residues 1 to 442)
  AUTHORS   Corn,P.G., McDonald,E.R. 3rd, Herman,J.G. and El-Deiry,W.S.
  TITLE     Tat-binding protein-1, a component of the 26S proteasome,
            contributes to the E3 ubiquitin ligase function of the von
            Hippel-Lindau protein
  JOURNAL   Nat Genet 35 (3), 229-237 (2003)
   PUBMED   14556007
REFERENCE   7  (residues 1 to 442)
  AUTHORS   Sakao,Y., Kawai,T., Takeuchi,O., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Takeda,K. and Akira,S.
  TITLE     Mouse proteasomal ATPases Psmc3 and Psmc4: genomic organization and
            gene targeting
  JOURNAL   Genomics 67 (1), 1-7 (2000)
   PUBMED   10945464
REFERENCE   8  (residues 1 to 442)
  AUTHORS   Nakamura,T., Tanaka,T., Takagi,H. and Sato,M.
  TITLE     Cloning and heterogeneous in vivo expression of Tat binding
            protein-1 (TBP-1) in the mouse
  JOURNAL   Biochim Biophys Acta 1399 (1), 93-100 (1998)
   PUBMED   9714759
REFERENCE   9  (residues 1 to 442)
  AUTHORS   Tanaka,T., Nakamura,T., Takagi,H. and Sato,M.
  TITLE     Molecular cloning and characterization of a novel TBP-1 interacting
            protein (TBPIP):enhancement of TBP-1 action on Tat by TBPIP
  JOURNAL   Biochem Biophys Res Commun 239 (1), 176-181 (1997)
   PUBMED   9345291
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX201527.1, AK167002.1 and BE989849.1.
            
            On Apr 29, 2009 this sequence version replaced NP_032974.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167061.1, AK167002.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..442
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.44 cM"
     Protein         1..442
                     /product="26S proteasome regulatory subunit 6A"
                     /note="26S protease regulatory subunit 6A; TAT-binding
                     protein 1; proteasome 26S subunit ATPase 3; 26S proteasome
                     AAA-ATPase subunit RPT5; Tat binding protein 1"
                     /calculated_mol_wt=49418
     Site            12
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P17980; propagated from
                     UniProtKB/Swiss-Prot (O88685.2)"
     Region          42..435
                     /region_name="PRK03992"
                     /note="proteasome-activating nucleotidase; Provisional"
                     /db_xref="CDD:179699"
     Site            379
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P17980; propagated from
                     UniProtKB/Swiss-Prot (O88685.2)"
     CDS             1..442
                     /gene="Psmc3"
                     /gene_synonym="TBP-1"
                     /coded_by="NM_008948.2:233..1561"
                     /db_xref="CCDS:CCDS16423.1"
                     /db_xref="GeneID:19182"
                     /db_xref="MGI:MGI:1098754"
ORIGIN      
        1 mqemnllptp espvtrqekm atvwdeaeqd gigeevlkms teeivqrtrl ldseikimks
       61 evlrvthelq amkdkikens ekikvnktlp ylvsnviell dvdpndqeed ganidldsqr
      121 kgkcavikts trqtyflpvi glvdaeklkp gdlvgvnkds yliletlpte ydsrvkamev
      181 derpteqysd iggldkqiqe lveaivlpmn hkekfenlgi qppkgvlmyg ppgtgktlla
      241 racaaqtkat flklagpqlv qmfigdgakl vrdafalake kapsiifide ldaigtkrfd
      301 sekagdrevq rtmlellnql dgfqpntqvk viaatnrvdi ldpallrsgr ldrkiefpmp
      361 neeararimq ihsrkmnvsp dvnyeelarc tddfngaqck avcveagmia lrrgatelth
      421 edymegilev qakkkanlqy ya
//
