LOCUS       NM_001368661            1453 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus proteasome (prosome, macropain) 26S subunit, ATPase 2
            (Psmc2), transcript variant 1, mRNA.
ACCESSION   NM_001368661
VERSION     NM_001368661.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1453)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1453)
  AUTHORS   Zhou,B., Peng,K., Wang,G., Chen,W. and Kang,Y.
  TITLE     Silencing Proteasome 26S Subunit ATPase 2 (PSMC2) Protects the
            Osteogenic Differentiation In Vitro and Osteogenesis In Vivo
  JOURNAL   Calcif Tissue Int 109 (1), 44-54 (2021)
   PUBMED   33625534
  REMARK    GeneRIF: Silencing Proteasome 26S Subunit ATPase 2 (PSMC2) Protects
            the Osteogenic Differentiation In Vitro and Osteogenesis In Vivo.
REFERENCE   3  (bases 1 to 1453)
  AUTHORS   Lukic,Z., Hausmann,S., Sebastian,S., Rucci,J., Sastri,J.,
            Robia,S.L., Luban,J. and Campbell,E.M.
  TITLE     TRIM5alpha associates with proteasomal subunits in cells while in
            complex with HIV-1 virions
  JOURNAL   Retrovirology 8, 93 (2011)
   PUBMED   22078707
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1453)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   5  (bases 1 to 1453)
  AUTHORS   Combes,A.N., Lesieur,E., Harley,V.R., Sinclair,A.H., Little,M.H.,
            Wilhelm,D. and Koopman,P.
  TITLE     Three-dimensional visualization of testis cord morphogenesis, a
            novel tubulogenic mechanism in development
  JOURNAL   Dev Dyn 238 (5), 1033-1041 (2009)
   PUBMED   19334288
REFERENCE   6  (bases 1 to 1453)
  AUTHORS   Kratz,C.P., Emerling,B.M., Donovan,S., Laig-Webster,M.,
            Taylor,B.R., Thompson,P., Jensen,S., Banerjee,A., Bonifas,J.,
            Makalowski,W., Green,E.D., Le Beau,M.M. and Shannon,K.M.
  TITLE     Candidate gene isolation and comparative analysis of a commonly
            deleted segment of 7q22 implicated in myeloid malignancies
  JOURNAL   Genomics 77 (3), 171-180 (2001)
   PUBMED   11597142
REFERENCE   7  (bases 1 to 1453)
  AUTHORS   Weninger,S.C., Peters,L.L. and Majzoub,J.A.
  TITLE     Urocortin expression in the Edinger-Westphal nucleus is
            up-regulated by stress and corticotropin-releasing hormone
            deficiency
  JOURNAL   Endocrinology 141 (1), 256-263 (2000)
   PUBMED   10614646
REFERENCE   8  (bases 1 to 1453)
  AUTHORS   Schwan,W.R. and Kopecko,D.J.
  TITLE     Uptake of pathogenic intracellular bacteria into human and murine
            macrophages downregulates the eukaryotic 26S protease complex
            ATPase gene
  JOURNAL   Infect Immun 65 (11), 4754-4760 (1997)
   PUBMED   9353061
REFERENCE   9  (bases 1 to 1453)
  AUTHORS   Allen,J., Colleaux,L., Davidson,D., Graham,E., Lee,M., Hill,R.,
            Abbott,C. and Gordon,C.
  TITLE     Expression and mapping of the mouse S7/Pmsc2 gene, homolog of an
            essential mitotic gene in yeast
  JOURNAL   Mamm Genome 8 (5), 352-354 (1997)
   PUBMED   9107682
REFERENCE   10 (bases 1 to 1453)
  AUTHORS   Gordon,C., McGurk,G., Dillon,P., Rosen,C. and Hastie,N.D.
  TITLE     Defective mitosis due to a mutation in the gene for a fission yeast
            26S protease subunit
  JOURNAL   Nature 366 (6453), 355-357 (1993)
   PUBMED   8247131
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125313.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168548.1, BC005462.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AC125313.2         69072-69209         c
            139-176             AC125313.2         60811-60848         c
            177-258             AC125313.2         60112-60193         c
            259-358             AC125313.2         59324-59423         c
            359-490             AC125313.2         56402-56533         c
            491-563             AC125313.2         55948-56020         c
            564-659             AC125313.2         55317-55412         c
            660-824             AC125313.2         54584-54748         c
            825-912             AC125313.2         53343-53430         c
            913-1115            AC125313.2         52684-52886         c
            1116-1212           AC125313.2         52494-52590         c
            1213-1453           AC125313.2         52169-52409         c
FEATURES             Location/Qualifiers
     source          1..1453
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 9.97 cM"
     gene            1..1453
                     /gene="Psmc2"
                     /note="proteasome (prosome, macropain) 26S subunit, ATPase
                     2"
                     /db_xref="GeneID:19181"
                     /db_xref="MGI:MGI:109555"
     exon            1..138
                     /gene="Psmc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1370
                     /gene="Psmc2"
                     /note="26S protease regulatory subunit 7; proteasome 26S
                     subunit ATPase 2; 26S proteasome AAA-ATPase subunit RPT1"
                     /codon_start=1
                     /product="26S proteasome regulatory subunit 7"
                     /protein_id="NP_001355590.1"
                     /db_xref="CCDS:CCDS19108.1"
                     /db_xref="GeneID:19181"
                     /db_xref="MGI:MGI:109555"
                     /translation="MPDYLGADQRKTKEEEKDDKPIRALDEGDIALLKTYGQSTYSRQ
                     IKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKII
                     NADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPT
                     VTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPP
                     GTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDE
                     IDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRP
                     GRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEA
                     GMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN"
     exon            139..176
                     /gene="Psmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            177..258
                     /gene="Psmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            259..358
                     /gene="Psmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            359..490
                     /gene="Psmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            491..563
                     /gene="Psmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            564..659
                     /gene="Psmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            660..824
                     /gene="Psmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            825..912
                     /gene="Psmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1115
                     /gene="Psmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1212
                     /gene="Psmc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1453
                     /gene="Psmc2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1432..1437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmc2"
                     /note="hexamer: AATAAA"
     polyA_site      1451
                     /gene="Psmc2"
                     /note="major polyA site"
ORIGIN      
        1 agacaccagc ggaagcggga aaggtgctgt gtaatcaccg agacgcggag gcacttgcgg
       61 cttctaaaat gccggattac ctaggtgcgg accagcggaa aaccaaagag gaggagaagg
      121 acgacaagcc catccgagct ctggatgaag gggatattgc cttgctgaaa acttacggcc
      181 aaagtactta ttcaaggcag atcaagcagg ttgaagatga cattcaacaa cttctcaaaa
      241 aaattaatga gctcactggt attaaagagt ctgacactgg gttggcacct ccggccctct
      301 gggatttggc tgcagacaaa caaacacttc agagtgaaca gccattacag gtggcaagat
      361 gtacgaagat aatcaacgct gattcggagg acccaaaata catcatcaat gtgaagcagt
      421 ttgccaagtt cgtggtggat ctcagtgatc aggtggcacc cactgacatt gaagaaggga
      481 tgagagtcgg tgtggacaga aataaatacc aaattcacat tccactacct cctaagatcg
      541 acccaacagt taccatgatg caggtggagg aaaaacccga cgtcacatac agtgatgttg
      601 gtggctgtaa ggaacagatt gagaaattgc gagaagtagt tgaaacccct ctgctccatc
      661 cagagaggtt tgttaacctt ggaatcgagc ctccaaaggg tgtactgctg tttgggccac
      721 caggcacagg caagacactc tgtgctaggg cagttgccaa tcggactgat gcttgcttca
      781 ttcgagttat tgggtctgag ctcgtacaga aatacgtcgg cgagggagct cgaatggttc
      841 gtgagctttt tgaaatggcc aggacaaaaa aagcctgcct tattttcttt gatgaaattg
      901 atgccattgg aggggctcgg tttgacgatg gcgctggggg tgacaatgaa gtgcagagaa
      961 ccatgctgga gctcatcaat cagctggatg gctttgatcc tcgcggcaac atcaaggtgc
     1021 tcatggccac taaccgccct gacactctgg acccagcgct catgagaccg gggaggctgg
     1081 acaggaagat tgagttcagc ttacctgact tagagggtcg aacgcacatc tttaagattc
     1141 acgctcgctc aatgagtgtg gaaagagaca ttcgatttga gctgttggcc cgcctgtgtc
     1201 caaacagtac tggagcggag attagaagtg tttgcacaga agctggtatg tttgcaatcc
     1261 gagcacggag aaaaattgct acagagaagg acttcttaga agctgtaaat aaggtcatca
     1321 agtcttacgc caaattcagc gctactcccc gctacatgac atacaattga gccccagggc
     1381 tctgagtgaa agaacttcct gtgcttttgt aacttgttgc caccgcacaa aaataaaaga
     1441 tttaaaaact gtg
//
