LOCUS       NP_001355590             433 aa            linear   ROD 02-MAY-2024
DEFINITION  26S proteasome regulatory subunit 7 [Mus musculus].
ACCESSION   NP_001355590
VERSION     NP_001355590.1
DBSOURCE    REFSEQ: accession NM_001368661.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 433)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 433)
  AUTHORS   Zhou,B., Peng,K., Wang,G., Chen,W. and Kang,Y.
  TITLE     Silencing Proteasome 26S Subunit ATPase 2 (PSMC2) Protects the
            Osteogenic Differentiation In Vitro and Osteogenesis In Vivo
  JOURNAL   Calcif Tissue Int 109 (1), 44-54 (2021)
   PUBMED   33625534
  REMARK    GeneRIF: Silencing Proteasome 26S Subunit ATPase 2 (PSMC2) Protects
            the Osteogenic Differentiation In Vitro and Osteogenesis In Vivo.
REFERENCE   3  (residues 1 to 433)
  AUTHORS   Lukic,Z., Hausmann,S., Sebastian,S., Rucci,J., Sastri,J.,
            Robia,S.L., Luban,J. and Campbell,E.M.
  TITLE     TRIM5alpha associates with proteasomal subunits in cells while in
            complex with HIV-1 virions
  JOURNAL   Retrovirology 8, 93 (2011)
   PUBMED   22078707
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 433)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   5  (residues 1 to 433)
  AUTHORS   Combes,A.N., Lesieur,E., Harley,V.R., Sinclair,A.H., Little,M.H.,
            Wilhelm,D. and Koopman,P.
  TITLE     Three-dimensional visualization of testis cord morphogenesis, a
            novel tubulogenic mechanism in development
  JOURNAL   Dev Dyn 238 (5), 1033-1041 (2009)
   PUBMED   19334288
REFERENCE   6  (residues 1 to 433)
  AUTHORS   Kratz,C.P., Emerling,B.M., Donovan,S., Laig-Webster,M.,
            Taylor,B.R., Thompson,P., Jensen,S., Banerjee,A., Bonifas,J.,
            Makalowski,W., Green,E.D., Le Beau,M.M. and Shannon,K.M.
  TITLE     Candidate gene isolation and comparative analysis of a commonly
            deleted segment of 7q22 implicated in myeloid malignancies
  JOURNAL   Genomics 77 (3), 171-180 (2001)
   PUBMED   11597142
REFERENCE   7  (residues 1 to 433)
  AUTHORS   Weninger,S.C., Peters,L.L. and Majzoub,J.A.
  TITLE     Urocortin expression in the Edinger-Westphal nucleus is
            up-regulated by stress and corticotropin-releasing hormone
            deficiency
  JOURNAL   Endocrinology 141 (1), 256-263 (2000)
   PUBMED   10614646
REFERENCE   8  (residues 1 to 433)
  AUTHORS   Schwan,W.R. and Kopecko,D.J.
  TITLE     Uptake of pathogenic intracellular bacteria into human and murine
            macrophages downregulates the eukaryotic 26S protease complex
            ATPase gene
  JOURNAL   Infect Immun 65 (11), 4754-4760 (1997)
   PUBMED   9353061
REFERENCE   9  (residues 1 to 433)
  AUTHORS   Allen,J., Colleaux,L., Davidson,D., Graham,E., Lee,M., Hill,R.,
            Abbott,C. and Gordon,C.
  TITLE     Expression and mapping of the mouse S7/Pmsc2 gene, homolog of an
            essential mitotic gene in yeast
  JOURNAL   Mamm Genome 8 (5), 352-354 (1997)
   PUBMED   9107682
REFERENCE   10 (residues 1 to 433)
  AUTHORS   Gordon,C., McGurk,G., Dillon,P., Rosen,C. and Hastie,N.D.
  TITLE     Defective mitosis due to a mutation in the gene for a fission yeast
            26S protease subunit
  JOURNAL   Nature 366 (6453), 355-357 (1993)
   PUBMED   8247131
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125313.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168548.1, BC005462.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 9.97 cM"
     Protein         1..433
                     /product="26S proteasome regulatory subunit 7"
                     /note="26S protease regulatory subunit 7; proteasome 26S
                     subunit ATPase 2; 26S proteasome AAA-ATPase subunit RPT1"
                     /calculated_mol_wt=48517
     Region          1..21
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P46471.5)"
     Region          44..430
                     /region_name="PRK03992"
                     /note="proteasome-activating nucleotidase; Provisional"
                     /db_xref="CDD:179699"
     Site            116
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P35998; propagated from
                     UniProtKB/Swiss-Prot (P46471.5)"
     Site            422
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P35998; propagated from
                     UniProtKB/Swiss-Prot (P46471.5)"
     CDS             1..433
                     /gene="Psmc2"
                     /coded_by="NM_001368661.1:69..1370"
                     /db_xref="CCDS:CCDS19108.1"
                     /db_xref="GeneID:19181"
                     /db_xref="MGI:MGI:109555"
ORIGIN      
        1 mpdylgadqr ktkeeekddk piraldegdi allktygqst ysrqikqved diqqllkkin
       61 eltgikesdt glappalwdl aadkqtlqse qplqvarctk iinadsedpk yiinvkqfak
      121 fvvdlsdqva ptdieegmrv gvdrnkyqih iplppkidpt vtmmqveekp dvtysdvggc
      181 keqieklrev vetpllhper fvnlgieppk gvllfgppgt gktlcarava nrtdacfirv
      241 igselvqkyv gegarmvrel femartkkac liffdeidai ggarfddgag gdnevqrtml
      301 elinqldgfd prgnikvlma tnrpdtldpa lmrpgrldrk iefslpdleg rthifkihar
      361 smsverdirf ellarlcpns tgaeirsvct eagmfairar rkiatekdfl eavnkviksy
      421 akfsatprym tyn
//
