LOCUS       NM_008947               1502 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus protease (prosome, macropain) 26S subunit, ATPase 1
            (Psmc1), mRNA.
ACCESSION   NM_008947
VERSION     NM_008947.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1502)
  AUTHORS   Zhang,R., Pan,S., Zheng,S., Liao,Q., Jiang,Z., Wang,D., Li,X.,
            Hu,A., Li,X., Zhu,Y., Shen,X., Lei,J., Zhong,S., Zhang,X.,
            Huang,L., Wang,X., Huang,L., Shen,L., Song,B.L., Zhao,J.W.,
            Wang,Z., Yang,B. and Guo,X.
  TITLE     Lipid-anchored proteasomes control membrane protein homeostasis
  JOURNAL   Sci Adv 9 (48), eadj4605 (2023)
   PUBMED   38019907
REFERENCE   2  (bases 1 to 1502)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1502)
  AUTHORS   Geiszler,P.C., Ugun-Klusek,A., Lawler,K., Pardon,M.C., Yuchun,D.,
            Bai,L., Daykin,C.A., Auer,D.P. and Bedford,L.
  TITLE     Dynamic metabolic patterns tracking neurodegeneration and gliosis
            following 26S proteasome dysfunction in mouse forebrain neurons
  JOURNAL   Sci Rep 8 (1), 4833 (2018)
   PUBMED   29555943
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1502)
  AUTHORS   Ugun-Klusek,A., Tatham,M.H., Elkharaz,J., Constantin-Teodosiu,D.,
            Lawler,K., Mohamed,H., Paine,S.M., Anderson,G., John Mayer,R.,
            Lowe,J., Ellen Billett,E. and Bedford,L.
  TITLE     Continued 26S proteasome dysfunction in mouse brain cortical
            neurons impairs autophagy and the Keap1-Nrf2 oxidative defence
            pathway
  JOURNAL   Cell Death Dis 8 (1), e2531 (2017)
   PUBMED   28055010
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1502)
  AUTHORS   Wang,S., Ni,H.M., Dorko,K., Kumer,S.C., Schmitt,T.M., Nawabi,A.,
            Komatsu,M., Huang,H. and Ding,W.X.
  TITLE     Increased hepatic receptor interacting protein kinase 3 expression
            due to impaired proteasomal functions contributes to
            alcohol-induced steatosis and liver injury
  JOURNAL   Oncotarget 7 (14), 17681-17698 (2016)
   PUBMED   26769846
REFERENCE   6  (bases 1 to 1502)
  AUTHORS   Katiyar,S., Li,G. and Lennarz,W.J.
  TITLE     A complex between peptide:N-glycanase and two proteasome-linked
            proteins suggests a mechanism for the degradation of misfolded
            glycoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (38), 13774-13779 (2004)
   PUBMED   15358861
REFERENCE   7  (bases 1 to 1502)
  AUTHORS   Easterday,M.C., Dougherty,J.D., Jackson,R.L., Ou,J., Nakano,I.,
            Paucar,A.A., Roobini,B., Dianati,M., Irvin,D.K., Weissman,I.L.,
            Terskikh,A.V., Geschwind,D.H. and Kornblum,H.I.
  TITLE     Neural progenitor genes. Germinal zone expression and analysis of
            genetic overlap in stem cell populations
  JOURNAL   Dev Biol 264 (2), 309-322 (2003)
   PUBMED   14651920
REFERENCE   8  (bases 1 to 1502)
  AUTHORS   Park,H., Suzuki,T. and Lennarz,W.J.
  TITLE     Identification of proteins that interact with mammalian
            peptide:N-glycanase and implicate this hydrolase in the
            proteasome-dependent pathway for protein degradation
  JOURNAL   Proc Natl Acad Sci U S A 98 (20), 11163-11168 (2001)
   PUBMED   11562482
REFERENCE   9  (bases 1 to 1502)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 1502)
  AUTHORS   Hoyle,J. and Fisher,E.M.
  TITLE     Genomic organization and mapping of the mouse P26s4 ATPase gene: a
            member of the remarkably conserved AAA gene family
  JOURNAL   Genomics 31 (1), 115-118 (1996)
   PUBMED   8808288
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC159243.2 and
            AC166349.4.
            
            On Apr 27, 2007 this sequence version replaced NM_008947.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK161641.1, AK166783.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC159243.2         153096-153105
            11-64               AC159243.2         155225-155278
            65-161              AC159243.2         155950-156046
            162-286             AC159243.2         157732-157856
            287-472             AC159243.2         158314-158499
            473-601             AC159243.2         158681-158809
            602-698             AC159243.2         159593-159689
            699-888             AC159243.2         161967-162156
            889-1040            AC159243.2         162881-163032
            1041-1195           AC166349.4         92080-92234
            1196-1502           AC166349.4         94145-94451
FEATURES             Location/Qualifiers
     source          1..1502
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 50.43 cM"
     gene            1..1502
                     /gene="Psmc1"
                     /gene_synonym="P26s4; rpt2; Rpt2/S4; S4"
                     /note="protease (prosome, macropain) 26S subunit, ATPase
                     1"
                     /db_xref="GeneID:19179"
                     /db_xref="MGI:MGI:106054"
     exon            1..10
                     /gene="Psmc1"
                     /gene_synonym="P26s4; rpt2; Rpt2/S4; S4"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..1330
                     /gene="Psmc1"
                     /gene_synonym="P26s4; rpt2; Rpt2/S4; S4"
                     /note="26S protease regulatory subunit 4; proteasome 26S
                     subunit ATPase 1; 26S proteasome AAA-ATPase subunit RPT2"
                     /codon_start=1
                     /product="26S proteasome regulatory subunit 4"
                     /protein_id="NP_032973.1"
                     /db_xref="CCDS:CCDS36522.1"
                     /db_xref="GeneID:19179"
                     /db_xref="MGI:MGI:106054"
                     /translation="MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPD
                     AASKLPLVTPHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDL
                     RGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVI
                     GVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKP
                     PKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEE
                     HAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRI
                     ETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSG
                     ADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL"
     exon            11..64
                     /gene="Psmc1"
                     /gene_synonym="P26s4; rpt2; Rpt2/S4; S4"
                     /inference="alignment:Splign:2.1.0"
     exon            65..161
                     /gene="Psmc1"
                     /gene_synonym="P26s4; rpt2; Rpt2/S4; S4"
                     /inference="alignment:Splign:2.1.0"
     exon            162..286
                     /gene="Psmc1"
                     /gene_synonym="P26s4; rpt2; Rpt2/S4; S4"
                     /inference="alignment:Splign:2.1.0"
     exon            287..472
                     /gene="Psmc1"
                     /gene_synonym="P26s4; rpt2; Rpt2/S4; S4"
                     /inference="alignment:Splign:2.1.0"
     exon            473..601
                     /gene="Psmc1"
                     /gene_synonym="P26s4; rpt2; Rpt2/S4; S4"
                     /inference="alignment:Splign:2.1.0"
     exon            602..698
                     /gene="Psmc1"
                     /gene_synonym="P26s4; rpt2; Rpt2/S4; S4"
                     /inference="alignment:Splign:2.1.0"
     exon            699..888
                     /gene="Psmc1"
                     /gene_synonym="P26s4; rpt2; Rpt2/S4; S4"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1040
                     /gene="Psmc1"
                     /gene_synonym="P26s4; rpt2; Rpt2/S4; S4"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1195
                     /gene="Psmc1"
                     /gene_synonym="P26s4; rpt2; Rpt2/S4; S4"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1502
                     /gene="Psmc1"
                     /gene_synonym="P26s4; rpt2; Rpt2/S4; S4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggaagatg ggtcaaagcc agagtggtgg ccatggtcct gggggtggca agaaggatga
       61 caaggacaag aaaaagaaat acgaacctcc tgtcccaact agagtgggga aaaagaagaa
      121 gaaaacaaag ggaccagatg ctgccagcaa actgccactg gtaacacctc acacccagtg
      181 ccgcctgaaa ttactgaagc tagagagaat aaaagactat cttctcatgg aggaggaatt
      241 cattagaaac caggaacaga tgaaaccatt agaagaaaag caagaggagg aaagatcaaa
      301 agtggatgat ctcaggggga cccccatgtc tgtaggaacc ttggaagaga tcattgatga
      361 taatcacgcc attgtgtcca catctgtggg ctcagaacac tacgtcagca tcctgtcgtt
      421 tgtagacaag gatctgctgg aaccaggctg ctccgtcctg ctcaaccaca aggtgcatgc
      481 tgtgataggg gtgctaatgg atgacacgga tcccctggtc acagtgatga aggtggaaaa
      541 ggccccccag gagacctacg cagatattgg gggactggac aaccagatcc aagaaattaa
      601 ggagtctgtg gagctcccgc ttacccatcc tgagtattac gaggagatgg ggataaagcc
      661 ccctaagggg gtcattctct acggtccgcc aggaacaggt aaaactctat tggccaaagc
      721 agtagcgaac cagacttcag ccactttctt gcgagtggtt ggctcagagc ttatccagaa
      781 gtacctaggt gacgggccca aacttgtccg ggagctcttc cgggtcgctg aggagcatgc
      841 gccgtccatc gtgttcattg atgagatcga cgccattggg accaaaagat atgattcaaa
      901 ttctggaggt gagagagaaa ttcagcgaac aatgttggaa ctgttgaacc agttggatgg
      961 atttgattcg aggggagatg taaaagttat catggccaca aaccgaatag aaactttgga
     1021 tccagcactt atcaggccag gccgcattga cagaaagatc gagttccccc tgccggatga
     1081 gaagaccaag aagcgtatct tccagattca caccagcagg atgacactgg ctgatgatgt
     1141 aaccttggat gacttgatca tggcaaagga tgacctctct ggggccgaca tcaaggcaat
     1201 ctgtacagaa gctggcttga tggccttgcg ggaacgcaga atgaaagtaa caaatgaaga
     1261 cttcaaaaaa tctaaagaga atgttcttta taaaaaacaa gaaggcaccc ctgaggggct
     1321 ctatctctag tggcccacag tcgtcctcag ggatggggag ctgtccccag gaacccattc
     1381 tccagttcag gtttgccagt agaaagcctg tatcgtggag gacactgtgc ctccatctgt
     1441 tgttggtcat tgtgccgtgc tgctctctac tcccaataaa ggattggcct ggtttgcttt
     1501 ct
//
