LOCUS       NM_001413204             931 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus proteasome (prosome, macropain) subunit, beta type 9
            (large multifunctional peptidase 2) (Psmb9), transcript variant 2,
            mRNA.
ACCESSION   NM_001413204
VERSION     NM_001413204.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 931)
  AUTHORS   Zhang,Y., Hu,W., Liu,Q., Ma,Z., Hu,S., Zhang,Z., Jia,H. and He,X.
  TITLE     Expression of immunoproteasome subunits in the brains of Toxoplasma
            gondii-infected mice
  JOURNAL   Exp Mol Pathol 123, 104684 (2021)
   PUBMED   34547302
  REMARK    GeneRIF: Expression of immunoproteasome subunits in the brains of
            Toxoplasma gondii-infected mice.
REFERENCE   2  (bases 1 to 931)
  AUTHORS   Kanazawa,N., Hemmi,H., Kinjo,N., Ohnishi,H., Hamazaki,J.,
            Mishima,H., Kinoshita,A., Mizushima,T., Hamada,S., Hamada,K.,
            Kawamoto,N., Kadowaki,S., Honda,Y., Izawa,K., Nishikomori,R.,
            Tsumura,M., Yamashita,Y., Tamura,S., Orimo,T., Ozasa,T., Kato,T.,
            Sasaki,I., Fukuda-Ohta,Y., Wakaki-Nishiyama,N., Inaba,Y.,
            Kunimoto,K., Okada,S., Taketani,T., Nakanishi,K., Murata,S.,
            Yoshiura,K.I. and Kaisho,T.
  TITLE     Heterozygous missense variant of the proteasome subunit beta-type 9
            causes neonatal-onset autoinflammation and immunodeficiency
  JOURNAL   Nat Commun 12 (1), 6819 (2021)
   PUBMED   34819510
  REMARK    GeneRIF: Heterozygous missense variant of the proteasome subunit
            beta-type 9 causes neonatal-onset autoinflammation and
            immunodeficiency.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 931)
  AUTHORS   Lim,S., Kim,Y.J., Park,S., Choi,J.H., Sung,Y.H., Nishimori,K.,
            Kozmik,Z., Lee,H.W. and Kim,J.W.
  TITLE     mTORC1-induced retinal progenitor cell overproliferation leads to
            accelerated mitotic aging and degeneration of descendent Muller
            glia
  JOURNAL   Elife 10, e70079 (2021)
   PUBMED   34677125
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 931)
  AUTHORS   de Freitas Chama,L.L., Ebstein,F., Wiesrecker,B., Wagh,P.R.,
            Hammer,E., Weiss,F.U., Junker,H., Studencka-Turski,M., Lerch,M.M.,
            Kruger,E. and Sendler,M.
  TITLE     Immunoproteasome impairment via beta5i/LMP7-deletion leads to
            sustained pancreatic injury from experimental pancreatitis
  JOURNAL   J Cell Mol Med 25 (14), 6786-6799 (2021)
   PUBMED   34132031
  REMARK    GeneRIF: Immunoproteasome impairment via beta5i/LMP7-deletion leads
            to sustained pancreatic injury from experimental pancreatitis.
REFERENCE   5  (bases 1 to 931)
  AUTHORS   French,T., Israel,N., Dusedau,H.P., Tersteegen,A., Steffen,J.,
            Cammann,C., Topfstedt,E., Dieterich,D., Schuler,T., Seifert,U. and
            Dunay,I.R.
  TITLE     The Immunoproteasome Subunits LMP2, LMP7 and MECL-1 Are Crucial
            Along the Induction of Cerebral Toxoplasmosis
  JOURNAL   Front Immunol 12, 619465 (2021)
   PUBMED   33968021
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 931)
  AUTHORS   Ikegami,H., Makino,S., Yamato,E., Kawaguchi,Y., Ueda,H.,
            Sakamoto,T., Takekawa,K. and Ogihara,T.
  TITLE     Identification of a new susceptibility locus for insulin-dependent
            diabetes mellitus by ancestral haplotype congenic mapping
  JOURNAL   J Clin Invest 96 (4), 1936-1942 (1995)
   PUBMED   7560085
REFERENCE   7  (bases 1 to 931)
  AUTHORS   Fruh,K., Yang,Y., Arnold,D., Chambers,J., Wu,L., Waters,J.B.,
            Spies,T. and Peterson,P.A.
  TITLE     Alternative exon usage and processing of the major
            histocompatibility complex-encoded proteasome subunits
  JOURNAL   J Biol Chem 267 (31), 22131-22140 (1992)
   PUBMED   1429565
REFERENCE   8  (bases 1 to 931)
  AUTHORS   Martinez,C.K. and Monaco,J.J.
  TITLE     Homology of proteasome subunits to a major histocompatibility
            complex-linked LMP gene
  JOURNAL   Nature 353 (6345), 664-667 (1991)
   PUBMED   1681432
REFERENCE   9  (bases 1 to 931)
  AUTHORS   Shiroishi,T., Hanzawa,N., Sagai,T., Ishiura,M., Gojobori,T.,
            Steinmetz,M. and Moriwaki,K.
  TITLE     Recombinational hotspot specific to female meiosis in the mouse
            major histocompatibility complex
  JOURNAL   Immunogenetics 31 (2), 79-88 (1990)
   PUBMED   1968049
REFERENCE   10 (bases 1 to 931)
  AUTHORS   Monaco,J.J. and McDevitt,H.O.
  TITLE     The LMP antigens: a stable MHC-controlled multisubunit protein
            complex
  JOURNAL   Hum Immunol 15 (4), 416-426 (1986)
   PUBMED   3700147
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974422.14.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.1773820.1,
                                           SRR17253012.4156068.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               CR974422.14        54350-54488         c
            140-207             CR974422.14        52845-52912         c
            208-339             CR974422.14        51397-51528         c
            340-469             CR974422.14        50730-50859         c
            470-611             CR974422.14        50204-50345         c
            612-931             CR974422.14        49147-49466         c
FEATURES             Location/Qualifiers
     source          1..931
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..931
                     /gene="Psmb9"
                     /gene_synonym="Lmp-2; Lmp2; Ring12"
                     /note="proteasome (prosome, macropain) subunit, beta type
                     9 (large multifunctional peptidase 2)"
                     /db_xref="GeneID:16912"
                     /db_xref="MGI:MGI:1346526"
     exon            1..139
                     /gene="Psmb9"
                     /gene_synonym="Lmp-2; Lmp2; Ring12"
                     /inference="alignment:Splign:2.1.0"
     exon            140..207
                     /gene="Psmb9"
                     /gene_synonym="Lmp-2; Lmp2; Ring12"
                     /inference="alignment:Splign:2.1.0"
     exon            208..339
                     /gene="Psmb9"
                     /gene_synonym="Lmp-2; Lmp2; Ring12"
                     /inference="alignment:Splign:2.1.0"
     exon            340..469
                     /gene="Psmb9"
                     /gene_synonym="Lmp-2; Lmp2; Ring12"
                     /inference="alignment:Splign:2.1.0"
     exon            470..611
                     /gene="Psmb9"
                     /gene_synonym="Lmp-2; Lmp2; Ring12"
                     /inference="alignment:Splign:2.1.0"
     exon            612..931
                     /gene="Psmb9"
                     /gene_synonym="Lmp-2; Lmp2; Ring12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      900..905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmb9"
                     /gene_synonym="Lmp-2; Lmp2; Ring12"
                     /note="hexamer: AATAAA"
     polyA_site      922
                     /gene="Psmb9"
                     /gene_synonym="Lmp-2; Lmp2; Ring12"
                     /note="major polyA site"
ORIGIN      
        1 agtctgcaag ttgcctgcac cgcgcgcagc cgctgattgg aaagccgagc cccgctctgc
       61 tgagatgctg cgggcaggag cacctaccgc cggctcgttc cggacggaag aagtccacac
      121 cggggtaatg ggtctcggga caaccatcat ggcagtggag tttgacgggg gtgtcgtggt
      181 gggctctgat tcccgggtgt cagcgggaac agcagtggtg aaccgcgtgt tcgacaagct
      241 ctcccctctg caccagcaca tcttctgtgc cctctcaggt tccgctgctg atgcccaagc
      301 catagctgac atggccgcct accagctgga gctacacggg ttggagctgg aggagccgcc
      361 cctcgttctg gctgctgcaa acgtggtgaa gaacatctcc tacaagtacc gtgaggactt
      421 gttagcgcat ctcatagtag ctggctggga ccaatgtgag gggggacagg tatatggaac
      481 catgggaggg atgctaattc gacagccctt taccatcggc ggttccggaa gctcctacat
      541 ttatggttat gtggacgcag cttataagcc aggcatgacc cctgaggagt gccggcgttt
      601 caccacagat gccatcactc tggccatgaa ccgagatggc tctagtgggg gtgtcatcta
      661 cctggtcacc atcacagctg ctggtgtgga ccatcgagtc atcctgggag atgagctgcc
      721 aaaattctac gatgagtgac tgatccccag aagtcccttc cttgtttgta ataaactttc
      781 tggaaccaga aggccggtgc gatgggcaaa ggtgaaatat gtgtatcaga gagacacggt
      841 gtgtggaggg aagcgtcctc cccggcccag atcagcatgc ccttccattc ttttgtaaaa
      901 ataaacttta ttattaaaaa aataaataaa t
//
