LOCUS       NM_010724               1223 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus proteasome (prosome, macropain) subunit, beta type 8
            (large multifunctional peptidase 7) (Psmb8), mRNA.
ACCESSION   NM_010724
VERSION     NM_010724.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1223)
  AUTHORS   Ishii,Y., Fukui-Miyazaki,A., Iwasaki,S., Tsuji,T., Hotta,K.,
            Sasaki,H., Nakagawa,S., Yoshida,T., Murata,E., Taniguchi,K.,
            Shinohara,N., Ishizu,A., Kasahara,M. and Tomaru,U.
  TITLE     Impaired immunoproteasomal function exacerbates renal
            ischemia-reperfusion injury
  JOURNAL   Exp Mol Pathol 140, 104939 (2024)
   PUBMED   39426027
REFERENCE   2  (bases 1 to 1223)
  AUTHORS   Su,H.X., Xu,L.L., Li,P.B., Bi,H.L., Jiang,W.X. and Li,H.H.
  TITLE     Psmb8 inhibits mitochondrial fission and alleviates myocardial
            ischaemia/reperfusion injury by targeting Drp1 degradation
  JOURNAL   Cell Death Dis 15 (11), 803 (2024)
   PUBMED   39516219
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1223)
  AUTHORS   Dimasuay,K.G., Schaunaman,N., Berg,B., Cervantes,D., Kruger,E.,
            Heppner,F.L., Ferrington,D.A. and Chu,H.W.
  TITLE     Airway epithelial immunoproteasome subunit LMP7 protects against
            rhinovirus infection
  JOURNAL   Sci Rep 12 (1), 14507 (2022)
   PUBMED   36008456
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1223)
  AUTHORS   Oliveri,F., Basler,M., Rao,T.N., Fehling,H.J. and Groettrup,M.
  TITLE     Immunoproteasome Inhibition Reduces the T Helper 2 Response in
            Mouse Models of Allergic Airway Inflammation
  JOURNAL   Front Immunol 13, 870720 (2022)
   PUBMED   35711460
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1223)
  AUTHORS   Lim,S., Kim,Y.J., Park,S., Choi,J.H., Sung,Y.H., Nishimori,K.,
            Kozmik,Z., Lee,H.W. and Kim,J.W.
  TITLE     mTORC1-induced retinal progenitor cell overproliferation leads to
            accelerated mitotic aging and degeneration of descendent Muller
            glia
  JOURNAL   Elife 10, e70079 (2021)
   PUBMED   34677125
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1223)
  AUTHORS   Zanelli,E., Zhou,P., Cao,H., Smart,M.K. and David,C.S.
  TITLE     Genetic polymorphism of the mouse major histocompatibility
            complex-associated proteasome subunit Lmp7
  JOURNAL   Immunogenetics 41 (4), 251-254 (1995)
   PUBMED   7890328
REFERENCE   7  (bases 1 to 1223)
  AUTHORS   Fruh,K., Yang,Y., Arnold,D., Chambers,J., Wu,L., Waters,J.B.,
            Spies,T. and Peterson,P.A.
  TITLE     Alternative exon usage and processing of the major
            histocompatibility complex-encoded proteasome subunits
  JOURNAL   J Biol Chem 267 (31), 22131-22140 (1992)
   PUBMED   1429565
REFERENCE   8  (bases 1 to 1223)
  AUTHORS   Frentzel,S., Graf,U., Hammerling,G.J. and Kloetzel,P.M.
  TITLE     Isolation and characterization of the MHC linked beta-type
            proteasome subunit MC13 cDNA
  JOURNAL   FEBS Lett 302 (2), 121-125 (1992)
   PUBMED   1633842
REFERENCE   9  (bases 1 to 1223)
  AUTHORS   Cho,S., Attaya,M., Brown,M.G. and Monaco,J.J.
  TITLE     A cluster of transcribed sequences between the Pb and Ob genes of
            the murine major histocompatibility complex
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5197-5201 (1991)
   PUBMED   1711220
REFERENCE   10 (bases 1 to 1223)
  AUTHORS   Monaco,J.J. and McDevitt,H.O.
  TITLE     The LMP antigens: a stable MHC-controlled multisubunit protein
            complex
  JOURNAL   Hum Immunol 15 (4), 416-426 (1986)
   PUBMED   3700147
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ235673.1, AK031801.1 and AK150674.1.
            
            On Oct 16, 2007 this sequence version replaced NM_010724.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150674.1, AK146182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               CJ235673.1         60-235              c
            177-1212            AK031801.1         2-1037
            1213-1223           AK150674.1         1042-1052
FEATURES             Location/Qualifiers
     source          1..1223
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..1223
                     /gene="Psmb8"
                     /gene_synonym="Lmp-7; Lmp7"
                     /note="proteasome (prosome, macropain) subunit, beta type
                     8 (large multifunctional peptidase 7)"
                     /db_xref="GeneID:16913"
                     /db_xref="MGI:MGI:1346527"
     exon            1..351
                     /gene="Psmb8"
                     /gene_synonym="Lmp-7; Lmp7"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1035
                     /gene="Psmb8"
                     /gene_synonym="Lmp-7; Lmp7"
                     /EC_number="3.4.25.1"
                     /note="proteosome beta 8 subunit; MC13 (LMP7); proteasome
                     subunit MC13; macropain subunit C13; proteasome component
                     C13; proteasome subunit beta-5i; multicatalytic
                     endopeptidase complex subunit C13; low molecular mass
                     protein 7; large multifunctional protease 7; proteosome
                     (prosome, macropain) subunit, beta type 8 (large
                     multifunctional peptidase 7)"
                     /codon_start=1
                     /product="proteasome subunit beta type-8"
                     /protein_id="NP_034854.2"
                     /db_xref="CCDS:CCDS50073.1"
                     /db_xref="GeneID:16913"
                     /db_xref="MGI:MGI:1346527"
                     /translation="MALLDLCGAARGQRPEWAALDAGSGGRSDPGHYSFSAQAPELAL
                     PRGMQPTAFLRSFGGDQERNVQIEMAHGTTTLAFKFQHGVIVAVDSRATAGSYISSLR
                     MNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMML
                     QYRGMGLSMGSMICGWDKKGPGLYYVDDNGTRLSGQMFSTGSGNTYAYGVMDSGYRQD
                     LSPEEAYDLGRRAIAYATHRDNYSGGVVNMYHMKEDGWVKVESSDVSDLLYKYGEAAL
                     "
     exon            352..499
                     /gene="Psmb8"
                     /gene_synonym="Lmp-7; Lmp7"
                     /inference="alignment:Splign:2.1.0"
     exon            500..611
                     /gene="Psmb8"
                     /gene_synonym="Lmp-7; Lmp7"
                     /inference="alignment:Splign:2.1.0"
     exon            612..741
                     /gene="Psmb8"
                     /gene_synonym="Lmp-7; Lmp7"
                     /inference="alignment:Splign:2.1.0"
     exon            742..946
                     /gene="Psmb8"
                     /gene_synonym="Lmp-7; Lmp7"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1223
                     /gene="Psmb8"
                     /gene_synonym="Lmp-7; Lmp7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1197..1202
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmb8"
                     /gene_synonym="Lmp-7; Lmp7"
                     /note="hexamer: AATAAA"
     polyA_site      1215
                     /gene="Psmb8"
                     /gene_synonym="Lmp-7; Lmp7"
                     /note="major polyA site"
ORIGIN      
        1 gcccattctc tagctggttt cactgatgtg gcagcaggaa aactcgtccc caacacattg
       61 ttttagttca gacacccatt aactgggctc tactcggaaa gggcagggga tgggggtggg
      121 ggactggttc cctccccttg gtactgtggc tttcgctttc acttccttgt cgcagagtcg
      181 acggatcttc ggggccaagt ggtcatggcg ttactggatc tgtgcggtgc cgctcggggg
      241 cagcggcccg agtgggctgc cctggatgcg ggaagcgggg gtcgctcgga cccgggacac
      301 tacagtttct ccgcgcaagc tccggagctc gcacttcccc ggggaatgca gcccaccgca
      361 ttcctgaggt cctttggtgg tgaccaggaa aggaatgttc aaattgagat ggcccacggc
      421 acaaccacac tcgccttcaa gttccagcat ggcgtcatcg tggctgtgga ctccagggcc
      481 actgcaggga gttacattag ctccttaagg atgaacaaag tgatcgagat taacccttac
      541 ctgcttggca ccatgtctgg ttgtgcagcc gactgccagt actgggagag gctgttggcc
      601 aaggagtgca ggttgtatta tcttcggaat ggggaacgca tctccgtgtc tgcagcatcc
      661 aagctgcttt ccaacatgat gctgcagtac cgggggatgg gcctctccat gggcagcatg
      721 atctgtggct gggacaagaa gggaccagga ctttactacg tagatgacaa tgggactcgg
      781 ctctcgggac agatgttttc cactggcagc gggaacacct atgcctatgg ggtgatggac
      841 agtggttacc ggcaggacct cagtcctgaa gaggcctacg accttggccg cagagctatt
      901 gcttatgcta cccacagaga caactattct ggaggagtcg tcaacatgta ccacatgaag
      961 gaagacggtt gggtgaaagt ggagagttcc gatgtcagtg acctgctgta caagtacgga
     1021 gaggccgctc tgtgatggct gctgggcagg cctcccccag cattggtggc actggctggc
     1081 agactcagag acctgggact acttcagtct taggaaaaag aagggctcaa cctgggctgg
     1141 agacaaagct ctgtttaccc tctcggcccc cgcactcaca gataccttct aagtacaata
     1201 aaagaaaaac ggttatacat gtc
//
