LOCUS       NM_011187                969 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus proteasome (prosome, macropain) subunit, beta type 7
            (Psmb7), mRNA.
ACCESSION   NM_011187
VERSION     NM_011187.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 969)
  AUTHORS   Choi,J.H., Jo,H.S., Lim,S., Kim,H.T., Lee,K.W., Moon,K.H., Ha,T.,
            Kwak,S.S., Kim,Y., Lee,E.J., Joe,C.O. and Kim,J.W.
  TITLE     mTORC1 accelerates retinal development via the immunoproteasome
  JOURNAL   Nat Commun 9 (1), 2502 (2018)
   PUBMED   29950673
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 969)
  AUTHORS   Hamazaki,J., Hirayama,S. and Murata,S.
  TITLE     Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated
            Proteins and Cellular Homeostasis
  JOURNAL   PLoS Genet 11 (7), e1005401 (2015)
   PUBMED   26222436
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 969)
  AUTHORS   Reis,J., Guan,X.Q., Kisselev,A.F., Papasian,C.J., Qureshi,A.A.,
            Morrison,D.C., Van Way,C.W. 3rd, Vogel,S.N. and Qureshi,N.
  TITLE     LPS-induced formation of immunoproteasomes: TNF-alpha and nitric
            oxide production are regulated by altered composition of
            proteasome-active sites
  JOURNAL   Cell Biochem Biophys 60 (1-2), 77-88 (2011)
   PUBMED   21455682
  REMARK    GeneRIF: Data demonstrate that TNF-alpha expression is primarily
            dependent on both the chymotrypsin-and the trypsin-like activities
            of X, Y, Z subunits (PSMB5, PSMB6, PSMB7) of the proteasome.
REFERENCE   4  (bases 1 to 969)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   5  (bases 1 to 969)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   6  (bases 1 to 969)
  AUTHORS   Xia,Ch., Rahman,A., Yang,Z. and Goldstein,L.S.
  TITLE     Chromosomal localization reveals three kinesin heavy chain genes in
            mouse
  JOURNAL   Genomics 52 (2), 209-213 (1998)
   PUBMED   9782088
REFERENCE   7  (bases 1 to 969)
  AUTHORS   Chen,H., Lun,Y., Ovchinnikov,D., Kokubo,H., Oberg,K.C.,
            Pepicelli,C.V., Gan,L., Lee,B. and Johnson,R.L.
  TITLE     Limb and kidney defects in Lmx1b mutant mice suggest an involvement
            of LMX1B in human nail patella syndrome
  JOURNAL   Nat Genet 19 (1), 51-55 (1998)
   PUBMED   9590288
REFERENCE   8  (bases 1 to 969)
  AUTHORS   Hayashi,M., Ishibashi,T., Tanaka,K. and Kasahara,M.
  TITLE     The mouse genes encoding the third pair of beta-type proteasome
            subunits regulated reciprocally by IFN-gamma: structural
            comparison, chromosomal localization, and analysis of the promoter
  JOURNAL   J Immunol 159 (6), 2760-2770 (1997)
   PUBMED   9300697
REFERENCE   9  (bases 1 to 969)
  AUTHORS   Stohwasser,R., Standera,S., Peters,I., Kloetzel,P.M. and
            Groettrup,M.
  TITLE     Molecular cloning of the mouse proteasome subunits MC14 and MECL-1:
            reciprocally regulated tissue expression of
            interferon-gamma-modulated proteasome subunits
  JOURNAL   Eur J Immunol 27 (5), 1182-1187 (1997)
   PUBMED   9174609
REFERENCE   10 (bases 1 to 969)
  AUTHORS   Kasahara,M., Hayashi,M., Tanaka,K., Inoko,H., Sugaya,K., Ikemura,T.
            and Ishibashi,T.
  TITLE     Chromosomal localization of the proteasome Z subunit gene reveals
            an ancient chromosomal duplication involving the major
            histocompatibility complex
  JOURNAL   Proc Natl Acad Sci U S A 93 (17), 9096-9101 (1996)
   PUBMED   8799160
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D83585.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D83585.1, AK075759.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..969
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.42 cM"
     gene            1..969
                     /gene="Psmb7"
                     /gene_synonym="MC14"
                     /note="proteasome (prosome, macropain) subunit, beta type
                     7"
                     /db_xref="GeneID:19177"
                     /db_xref="MGI:MGI:107637"
     exon            1..66
                     /gene="Psmb7"
                     /gene_synonym="MC14"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..838
                     /gene="Psmb7"
                     /gene_synonym="MC14"
                     /EC_number="3.4.25.1"
                     /note="proteasome subunit beta type-7; macropain chain Z;
                     proteasome subunit Z; multicatalytic endopeptidase complex
                     chain Z; beta-2; proteasome subunit beta-2"
                     /codon_start=1
                     /product="proteasome subunit beta type-7 precursor"
                     /protein_id="NP_035317.1"
                     /db_xref="CCDS:CCDS16010.1"
                     /db_xref="GeneID:19177"
                     /db_xref="MGI:MGI:107637"
                     /translation="MAAVSVFQPPVGGFSFDNCRRNAVLEADFAKKGFKLPKARKTGT
                     TIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLI
                     SSNLELHSLTTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHG
                     STDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKKLVSEAIAAGIFNDLGSGSNIDL
                     CVISKSKLDFLRPFSVPNKKGTRLGRYRCEKGTTAVLTEKVTPLEIEVLEETVQTMDT
                     S"
     exon            67..160
                     /gene="Psmb7"
                     /gene_synonym="MC14"
                     /inference="alignment:Splign:2.1.0"
     exon            161..258
                     /gene="Psmb7"
                     /gene_synonym="MC14"
                     /inference="alignment:Splign:2.1.0"
     exon            259..399
                     /gene="Psmb7"
                     /gene_synonym="MC14"
                     /inference="alignment:Splign:2.1.0"
     exon            400..515
                     /gene="Psmb7"
                     /gene_synonym="MC14"
                     /inference="alignment:Splign:2.1.0"
     exon            516..574
                     /gene="Psmb7"
                     /gene_synonym="MC14"
                     /inference="alignment:Splign:2.1.0"
     exon            575..726
                     /gene="Psmb7"
                     /gene_synonym="MC14"
                     /inference="alignment:Splign:2.1.0"
     exon            727..969
                     /gene="Psmb7"
                     /gene_synonym="MC14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caagatggcg gctgtgtcgg tgtttcagcc accggtcgga ggcttttctt ttgataattg
       61 tcgcaggaat gctgtcttgg aagcggattt cgcaaaaaag gggttcaagc tcccgaaagc
      121 tcggaaaact ggcactacca tcgcgggggt ggtgtataag gatggcatag ttcttggagc
      181 agacacgaga gcaactgaag ggatggttgt tgctgacaaa aactgttcaa aaattcactt
      241 catatctcct aatatttatt gctgtggtgc tgggacagct gcagacacag acatgacaac
      301 ccagcttatt tcttccaact tggagctcca ctctctgacc actggccgcc tcccgagagt
      361 tgttacagct aatcggatgc tgaagcagat gctcttcagg tatcaaggtt acattggtgc
      421 agccctagtt ttggggggag tagatgttac tggacctcat ctctacagca tctatcctca
      481 tggatcaact gataaattgc cttatgtcac catgggttct ggctccttgg cagcaatggc
      541 tgtgtttgaa gataagttta ggccagatat ggaggaggaa gaagccaaga agctagtgag
      601 tgaggctatt gcagctggca tctttaatga cttggggtct ggaagcaaca ttgatctgtg
      661 tgttatcagc aagagcaagc tggactttct tcgtccattc tcagtgccca acaagaaagg
      721 gaccaggctt ggccggtaca gatgtgagaa aggcactacc gctgtcctca ccgagaaagt
      781 tacccctctg gagattgagg tgctagaaga gactgttcag acaatggata cttcgtgaat
      841 ggtgctgtgg gtggttggat aactctagat gactcggggt gcataccacc cctaccccaa
      901 ccccattcta ccccaaccag aaaacatgcc tttggcaatt gctcaattaa aataaataaa
      961 taaaaagac
//
