LOCUS       NM_008946               1036 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus proteasome (prosome, macropain) subunit, beta type 6
            (Psmb6), mRNA.
ACCESSION   NM_008946 XM_001471617
VERSION     NM_008946.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1036)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1036)
  AUTHORS   Choi,J.H., Jo,H.S., Lim,S., Kim,H.T., Lee,K.W., Moon,K.H., Ha,T.,
            Kwak,S.S., Kim,Y., Lee,E.J., Joe,C.O. and Kim,J.W.
  TITLE     mTORC1 accelerates retinal development via the immunoproteasome
  JOURNAL   Nat Commun 9 (1), 2502 (2018)
   PUBMED   29950673
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1036)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1036)
  AUTHORS   Reis,J., Guan,X.Q., Kisselev,A.F., Papasian,C.J., Qureshi,A.A.,
            Morrison,D.C., Van Way,C.W. 3rd, Vogel,S.N. and Qureshi,N.
  TITLE     LPS-induced formation of immunoproteasomes: TNF-alpha and nitric
            oxide production are regulated by altered composition of
            proteasome-active sites
  JOURNAL   Cell Biochem Biophys 60 (1-2), 77-88 (2011)
   PUBMED   21455682
  REMARK    GeneRIF: Data demonstrate that TNF-alpha expression is primarily
            dependent on both the chymotrypsin-and the trypsin-like activities
            of X, Y, Z subunits (PSMB5, PSMB6, PSMB7) of the proteasome.
REFERENCE   5  (bases 1 to 1036)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   6  (bases 1 to 1036)
  AUTHORS   Watters,J.W. and Dietrich,W.F.
  TITLE     Genetic, physical, and transcript map of the Ltxs1 region of mouse
            chromosome 11
  JOURNAL   Genomics 73 (2), 223-231 (2001)
   PUBMED   11318612
  REMARK    Erratum:[Genomics 2002 Mar;79(3):462]
REFERENCE   7  (bases 1 to 1036)
  AUTHORS   Wertz,K. and Herrmann,B.G.
  TITLE     Large-scale screen for genes involved in gonad development
  JOURNAL   Mech Dev 98 (1-2), 51-70 (2000)
   PUBMED   11044607
REFERENCE   8  (bases 1 to 1036)
  AUTHORS   Hayashi,M., Ishibashi,T., Tanaka,K. and Kasahara,M.
  TITLE     The mouse genes encoding the third pair of beta-type proteasome
            subunits regulated reciprocally by IFN-gamma: structural
            comparison, chromosomal localization, and analysis of the promoter
  JOURNAL   J Immunol 159 (6), 2760-2770 (1997)
   PUBMED   9300697
REFERENCE   9  (bases 1 to 1036)
  AUTHORS   Woodward,E.C. and Monaco,J.J.
  TITLE     Characterization and mapping of the gene encoding mouse proteasome
            subunit DELTA (Lmp19)
  JOURNAL   Immunogenetics 42 (1), 28-34 (1995)
   PUBMED   7797265
REFERENCE   10 (bases 1 to 1036)
  AUTHORS   Fruh,K., Gossen,M., Wang,K., Bujard,H., Peterson,P.A. and Yang,Y.
  TITLE     Displacement of housekeeping proteasome subunits by MHC-encoded
            LMPs: a newly discovered mechanism for modulating the
            multicatalytic proteinase complex
  JOURNAL   EMBO J 13 (14), 3236-3244 (1994)
   PUBMED   8045254
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY069663.1, AK167227.1, BM202854.2 and AV072442.1.
            
            On or before May 28, 2009 this sequence version replaced
            XM_001471617.1, NM_008946.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132042.1, DV051713.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                BY069663.1         1-33
            34-828              AK167227.1         2-796
            829-1001            BM202854.2         36-208              c
            1002-1036           AV072442.1         250-284
FEATURES             Location/Qualifiers
     source          1..1036
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.99 cM"
     gene            1..1036
                     /gene="Psmb6"
                     /gene_synonym="Lmp19; Mpnd"
                     /note="proteasome (prosome, macropain) subunit, beta type
                     6"
                     /db_xref="GeneID:19175"
                     /db_xref="MGI:MGI:104880"
     exon            1..139
                     /gene="Psmb6"
                     /gene_synonym="Lmp19; Mpnd"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..757
                     /gene="Psmb6"
                     /gene_synonym="Lmp19; Mpnd"
                     /EC_number="3.4.25.1"
                     /note="proteasome subunit Y; macropain delta chain;
                     proteasome delta chain; multicatalytic endopeptidase
                     complex delta chain; low molecular mass protein 19;
                     subunit 2; beta-1; proteasome subunit beta-1"
                     /codon_start=1
                     /product="proteasome subunit beta type-6"
                     /protein_id="NP_032972.3"
                     /db_xref="CCDS:CCDS48836.1"
                     /db_xref="GeneID:19175"
                     /db_xref="MGI:MGI:104880"
                     /translation="MAAALAVRRAGSAPAFGPEALTPDWENREVSTGTTIMAVQFNGG
                     VVLGADSRTTTGSYIANRVTDKLTPIHDHIFCCRSGSAADTQAVADAVTYQLGFHSIE
                     LNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAI
                     GGSGSSYIYGYVDATYREGMTKDECLQFTANALALAMERDGSSGGVIRLAAIQESGVE
                     RQVLLGDQIPKFTIATLPPP"
     exon            140..207
                     /gene="Psmb6"
                     /gene_synonym="Lmp19; Mpnd"
                     /inference="alignment:Splign:2.1.0"
     exon            208..339
                     /gene="Psmb6"
                     /gene_synonym="Lmp19; Mpnd"
                     /inference="alignment:Splign:2.1.0"
     exon            340..469
                     /gene="Psmb6"
                     /gene_synonym="Lmp19; Mpnd"
                     /inference="alignment:Splign:2.1.0"
     exon            470..614
                     /gene="Psmb6"
                     /gene_synonym="Lmp19; Mpnd"
                     /inference="alignment:Splign:2.1.0"
     exon            615..1036
                     /gene="Psmb6"
                     /gene_synonym="Lmp19; Mpnd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      810..815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmb6"
                     /gene_synonym="Lmp19; Mpnd"
                     /note="hexamer: AATAAA"
     polyA_site      831
                     /gene="Psmb6"
                     /gene_synonym="Lmp19; Mpnd"
                     /note="major polyA site"
     regulatory      1014..1019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmb6"
                     /gene_synonym="Lmp19; Mpnd"
                     /note="hexamer: AATAAA"
     polyA_site      1036
                     /gene="Psmb6"
                     /gene_synonym="Lmp19; Mpnd"
ORIGIN      
        1 gctttacgac ggttgctttg tggcagagta gcagaggaag atggcggccg ccttagctgt
       61 tcgtcgagcg gggtctgcac cggcctttgg gccggaggct ctcaccccag actgggaaaa
      121 ccgggaagtc tccacaggga ccacgatcat ggctgtgcag tttaatgggg gcgtggttct
      181 aggagcggac tccaggacaa ccactgggtc ctacatcgcc aatcgagtga ctgacaagct
      241 gacccctatc cacgatcaca tcttctgctg ccgctcaggc tcagccgctg atacccaagc
      301 agtggcagac gctgtcactt accagcttgg tttccacagt attgaactga acgagcctcc
      361 actagtccac acagccgcca gtctctttaa ggagatgtgt taccggtaca gagaagatct
      421 gatggcagga atcatcattg caggctggga ccctcaagaa ggagggcagg tgtactctgt
      481 tcccatgggg ggtatgatgg taagacagtc ctttgccatc ggaggctccg ggagctcgta
      541 catctatggc tatgttgatg ctacgtatcg ggaaggcatg accaaggacg aatgtctgca
      601 gttcactgcc aatgctctcg ctttggccat ggaacgcgac ggctccagtg gaggggtgat
      661 ccgcttggca gccattcagg agtcaggggt agagcggcag gtgcttttgg gagaccaaat
      721 ccccaagttc accattgcca cgttgccacc tccctgaggc ctggtgttct agggagtagt
      781 aaaggatggt ccataccgac gcagaagcta ataaacagtt tgttaaagag acgtttctgt
      841 gtgaaggttc ttgacttcaa cttcaacttg ccaaaaccat tgtcttgcgt aaactattgc
      901 actgagctcg gtaggaatta gagaggtaag gaaggtttat cagtgcgctg ttcttttatc
      961 attactagca ttattggatt attttgggga tggctggttg cattatgttt ttaaataaaa
     1021 tggtttgttt tatgtg
//
