LOCUS       NM_011186                871 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus proteasome (prosome, macropain) subunit, beta type 5
            (Psmb5), mRNA.
ACCESSION   NM_011186
VERSION     NM_011186.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 871)
  AUTHORS   Zhang,R., Pan,S., Zheng,S., Liao,Q., Jiang,Z., Wang,D., Li,X.,
            Hu,A., Li,X., Zhu,Y., Shen,X., Lei,J., Zhong,S., Zhang,X.,
            Huang,L., Wang,X., Huang,L., Shen,L., Song,B.L., Zhao,J.W.,
            Wang,Z., Yang,B. and Guo,X.
  TITLE     Lipid-anchored proteasomes control membrane protein homeostasis
  JOURNAL   Sci Adv 9 (48), eadj4605 (2023)
   PUBMED   38019907
REFERENCE   2  (bases 1 to 871)
  AUTHORS   Choi,J.H., Jo,H.S., Lim,S., Kim,H.T., Lee,K.W., Moon,K.H., Ha,T.,
            Kwak,S.S., Kim,Y., Lee,E.J., Joe,C.O. and Kim,J.W.
  TITLE     mTORC1 accelerates retinal development via the immunoproteasome
  JOURNAL   Nat Commun 9 (1), 2502 (2018)
   PUBMED   29950673
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 871)
  AUTHORS   de Diego-Garcia,L., Ramirez-Escudero,M., Sebastian-Serrano,A.,
            Diaz-Hernandez,J.I., Pintor,J., Lucas,J.J. and Diaz-Hernandez,M.
  TITLE     Regulation of proteasome activity by P2Y2 receptor underlies the
            neuroprotective effects of extracellular nucleotides
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1863 (1), 43-51 (2017)
   PUBMED   27768902
  REMARK    GeneRIF: The P2Y2R enhances Ubiquitin-Proteasome System activity by
            increasing the subunits expression beta 5 and beta 1.
REFERENCE   4  (bases 1 to 871)
  AUTHORS   Ranek,M.J., Zheng,H., Huang,W., Kumarapeli,A.R., Li,J., Liu,J. and
            Wang,X.
  TITLE     Genetically induced moderate inhibition of 20S proteasomes in
            cardiomyocytes facilitates heart failure in mice during systolic
            overload
  JOURNAL   J Mol Cell Cardiol 85, 273-281 (2015)
   PUBMED   26116868
  REMARK    GeneRIF: The role of the ubiquitin-proteasome system in pressure
            overloaded hearts andheart failure.
REFERENCE   5  (bases 1 to 871)
  AUTHORS   Wang,X., Wu,T., Hu,Y., Marcinkiewicz,M., Qi,S.,
            Valderrama-Carvajal,H., Luo,H. and Wu,J.
  TITLE     Pno1 tissue-specific expression and its functions related to the
            immune responses and proteasome activities
  JOURNAL   PLoS One 7 (9), e46093 (2012)
   PUBMED   23029399
REFERENCE   6  (bases 1 to 871)
  AUTHORS   Murata,S., Sasaki,K., Kishimoto,T., Niwa,S., Hayashi,H.,
            Takahama,Y. and Tanaka,K.
  TITLE     Regulation of CD8+ T cell development by thymus-specific
            proteasomes
  JOURNAL   Science 316 (5829), 1349-1353 (2007)
   PUBMED   17540904
REFERENCE   7  (bases 1 to 871)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   8  (bases 1 to 871)
  AUTHORS   Li,Z., Arnaud,L., Rockwell,P. and Figueiredo-Pereira,M.E.
  TITLE     A single amino acid substitution in a proteasome subunit triggers
            aggregation of ubiquitinated proteins in stressed neuronal cells
  JOURNAL   J Neurochem 90 (1), 19-28 (2004)
   PUBMED   15198663
REFERENCE   9  (bases 1 to 871)
  AUTHORS   Elenich,L.A., Nandi,D., Kent,A.E., McCluskey,T.S., Cruz,M.,
            Iyer,M.N., Woodward,E.C., Conn,C.W., Ochoa,A.L., Ginsburg,D.B. and
            Monaco,J.J.
  TITLE     The complete primary structure of mouse 20S proteasomes
  JOURNAL   Immunogenetics 49 (10), 835-842 (1999)
   PUBMED   10436176
REFERENCE   10 (bases 1 to 871)
  AUTHORS   Kohda,K., Matsuda,Y., Ishibashi,T., Tanaka,K. and Kasahara,M.
  TITLE     Structural analysis and chromosomal localization of the mouse Psmb5
            gene coding for the constitutively expressed beta-type proteasome
            subunit
  JOURNAL   Immunogenetics 47 (1), 77-87 (1997)
   PUBMED   9382924
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF060091.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF060091.1, AB003304.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..871
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="B10.A"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 27.86 cM"
     gene            1..871
                     /gene="Psmb5"
                     /note="proteasome (prosome, macropain) subunit, beta type
                     5"
                     /db_xref="GeneID:19173"
                     /db_xref="MGI:MGI:1194513"
     exon            1..202
                     /gene="Psmb5"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..799
                     /gene="Psmb5"
                     /EC_number="3.4.25.1"
                     /note="proteasome chain 6; proteasome subunit X; macropain
                     epsilon chain; proteasome epsilon chain; multicatalytic
                     endopeptidase complex epsilon chain; proteasome beta type
                     subunit 5; beta-5; proteasome subunit beta-5"
                     /codon_start=1
                     /product="proteasome subunit beta type-5"
                     /protein_id="NP_035316.1"
                     /db_xref="CCDS:CCDS27095.1"
                     /db_xref="GeneID:19173"
                     /db_xref="MGI:MGI:1194513"
                     /translation="MALASVLQRPMPVNQHGFFGLGGGADLLDLGPGSPGDGLSLAAP
                     SWGVPEEPRIEMLHGTTTLAFKFLHGVIVAADSRATAGAYIASQTVKKVIEINPYLLG
                     TMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMI
                     CGWDKRGPGLYYVDSEGNRISGTAFSVGSGSVYAYGVMDRGYSYDLKVEEAYDLARRA
                     IYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHDKYSSVSVP"
     exon            203..509
                     /gene="Psmb5"
                     /inference="alignment:Splign:2.1.0"
     exon            510..871
                     /gene="Psmb5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacatggcg ctggctagcg tgttgcagcg gccgatgccg gtgaatcagc acgggttttt
       61 tgggctcgga ggtggtgcag atctgctgga cttgggtccg gggagtcctg gtgatgggct
      121 gagcctagcc gcgccgagct ggggcgtccc ggaggagccg cgaatcgaaa tgcttcacgg
      181 aaccaccacc ctggccttca agtttctcca tggagtcatt gttgcagcgg attcccgggc
      241 cacagcaggt gcttatattg cttcccagac ggtgaagaaa gtaatagaga tcaacccgta
      301 ccttctgggc accatggctg ggggtgcagc ggattgcagc ttctgggagc ggttgttggc
      361 tcggcagtgt cgaatctatg agcttcgcaa taaggaacgc atctcggtcg cagcagcctc
      421 caaactgctc gctaacatgg tgtatcagta caaaggcatg gggctgtcta tgggcaccat
      481 gatctgtggc tgggataaga gaggccctgg cctctactac gtagacagcg aggggaacag
      541 gatctctggg accgccttct cagtgggctc tggctccgtg tatgcttacg gcgttatgga
      601 tcgaggctac tcctatgacc tgaaagtgga ggaggcctat gatctggccc gccgagccat
      661 ctaccaagcc acctacagag atgcctactc cggaggggca gtcaacctct accacgtgcg
      721 ggaggatggc tggatccggg tgtccagtga caatgtagct gacttacatg acaagtacag
      781 tagtgtatct gtcccctgag ggaaggtgga tgcggttgtc tgcatctcta ggtgggtctc
      841 catggctata ataaataata gtacctcttt c
//
