LOCUS       NM_008945                949 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus proteasome (prosome, macropain) subunit, beta type 4
            (Psmb4), mRNA.
ACCESSION   NM_008945 XM_131064
VERSION     NM_008945.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 949)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   2  (bases 1 to 949)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   3  (bases 1 to 949)
  AUTHORS   Qiu,X.B., Ouyang,S.Y., Li,C.J., Miao,S., Wang,L. and Goldberg,A.L.
  TITLE     hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the
            deubiquitinating enzyme, UCH37
  JOURNAL   EMBO J 25 (24), 5742-5753 (2006)
   PUBMED   17139257
REFERENCE   4  (bases 1 to 949)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   5  (bases 1 to 949)
  AUTHORS   Karim,S.A., Johnson,K.J., Griffiths,I.R. and Vouyiouklis,D.A.
  TITLE     A physical map of the genomic region on mouse chromosome 3
            containing the hindshaker (hsh) mutation
  JOURNAL   Genomics 83 (2), 225-230 (2004)
   PUBMED   14706451
REFERENCE   6  (bases 1 to 949)
  AUTHORS   Qureshi,N., Perera,P.Y., Shen,J., Zhang,G., Lenschat,A.,
            Splitter,G., Morrison,D.C. and Vogel,S.N.
  TITLE     The proteasome as a lipopolysaccharide-binding protein in
            macrophages: differential effects of proteasome inhibition on
            lipopolysaccharide-induced signaling events
  JOURNAL   J Immunol 171 (3), 1515-1525 (2003)
   PUBMED   12874245
REFERENCE   7  (bases 1 to 949)
  AUTHORS   De Conto,F., Pilotti,E., Razin,S.V., Ferraglia,F., Geraud,G.,
            Arcangeletti,C. and Scherrer,K.
  TITLE     In mouse myoblasts nuclear prosomes are associated with the nuclear
            matrix and accumulate preferentially in the perinucleolar areas
  JOURNAL   J Cell Sci 113 (Pt 13), 2399-2407 (2000)
   PUBMED   10852819
REFERENCE   8  (bases 1 to 949)
  AUTHORS   Cruz,M., Nandi,D., Hendil,K.B. and Monaco,J.J.
  TITLE     Cloning and characterization of mouse Lmp3 cDNA, encoding a
            proteasome beta subunit
  JOURNAL   Gene 190 (2), 251-256 (1997)
   PUBMED   9197541
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB058553.1 and AK077448.1.
            
            On Jul 21, 2009 this sequence version replaced NM_008945.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077448.1, AK137044.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-721               CB058553.1         1-721
            722-949             AK077448.1         699-926
FEATURES             Location/Qualifiers
     source          1..949
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.74 cM"
     gene            1..949
                     /gene="Psmb4"
                     /gene_synonym="Pros-27"
                     /note="proteasome (prosome, macropain) subunit, beta type
                     4"
                     /db_xref="GeneID:19172"
                     /db_xref="MGI:MGI:1098257"
     exon            1..190
                     /gene="Psmb4"
                     /gene_synonym="Pros-27"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..845
                     /gene="Psmb4"
                     /gene_synonym="Pros-27"
                     /EC_number="3.4.25.1"
                     /note="proteasome chain 3; macropain beta chain;
                     proteasome beta chain; multicatalytic endopeptidase
                     complex beta chain; low molecular mass protein 3; beta-7;
                     proteasome subunit beta-7"
                     /codon_start=1
                     /product="proteasome subunit beta type-4"
                     /protein_id="NP_032971.2"
                     /db_xref="CCDS:CCDS17597.1"
                     /db_xref="GeneID:19172"
                     /db_xref="MGI:MGI:1098257"
                     /translation="MEAFWESRAGHWAGGPAPGQFYRIPATPSGLMDPASAPCEGPIT
                     RTQNPMVTGTSVLGVKFDGGVVIAADMLGSYGSLARFRNISRIMRVNDSTMLGASGDY
                     ADFQYLKQVLGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGY
                     ADGESFLGYVDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARELVERCM
                     RVLYYRDARSYNRFQIATVTEKGVEIEGPLSAQTNWDIAHMISGFE"
     exon            191..397
                     /gene="Psmb4"
                     /gene_synonym="Pros-27"
                     /inference="alignment:Splign:2.1.0"
     exon            398..544
                     /gene="Psmb4"
                     /gene_synonym="Pros-27"
                     /inference="alignment:Splign:2.1.0"
     exon            545..626
                     /gene="Psmb4"
                     /gene_synonym="Pros-27"
                     /inference="alignment:Splign:2.1.0"
     exon            627..743
                     /gene="Psmb4"
                     /gene_synonym="Pros-27"
                     /inference="alignment:Splign:2.1.0"
     exon            744..832
                     /gene="Psmb4"
                     /gene_synonym="Pros-27"
                     /inference="alignment:Splign:2.1.0"
     exon            833..949
                     /gene="Psmb4"
                     /gene_synonym="Pros-27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      926..931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmb4"
                     /gene_synonym="Pros-27"
                     /note="hexamer: AATAAA"
     polyA_site      949
                     /gene="Psmb4"
                     /gene_synonym="Pros-27"
                     /note="major polyA site"
ORIGIN      
        1 cgtttccggt gacgctagcg ctttcatttc tgtcggctga ggtgactaag atggaagcgt
       61 tttgggagtc acgggctggc cactgggccg ggggtccggc tccagggcag ttttaccgca
      121 tcccggccac ccccagcggc ctcatggacc cggcgtcggc gccctgcgag ggtcccatca
      181 ctcggaccca gaaccccatg gtgaccggga catcggtact cggggtgaag ttcgacggcg
      241 gagtggtgat tgctgcagac atgctgggct cctacggctc cctggctcgt ttccgcaata
      301 tctctcgtat tatgcgagtc aacgacagca ctatgctggg tgcctcggga gactacgctg
      361 atttccagta tttgaaacaa gttctcggcc agatggtgat tgatgaagag ctgttgggag
      421 atggacacag ctatagccct agagctattc attcatggtt gacaagagcc atgtacagcc
      481 gccgctccaa gatgaatccc ctgtggaaca ccatggtcat tggaggctat gctgacggag
      541 aaagcttcct cggttatgtg gacatgcttg gtgtagctta tgaagcccct tcactggcca
      601 ctggttatgg tgcatacttg gctcagcctc tgcttcgaga agttctagag aagcagccag
      661 tgctgagtca gactgaggct cgggagcttg tggagcgctg catgagagtg ctgtactaca
      721 gagatgcccg ttcgtataac cggtttcaaa ttgccactgt gactgaaaag ggtgtcgaga
      781 tagaaggacc gctgtccgca cagaccaact gggacatcgc tcacatgatc agtggctttg
      841 aatgaaatcc agttgaatgt ccagagtgtt gaagctttgc tcttctaaac gtgactgtag
      901 ctggctcaaa ggcagacttt tgtaaaataa atcagtcgtt tgaagtgtt
//
