LOCUS       NM_011970                861 bp    mRNA    linear   ROD 21-DEC-2022
DEFINITION  Mus musculus proteasome (prosome, macropain) subunit, beta type 2
            (Psmb2), mRNA.
ACCESSION   NM_011970
VERSION     NM_011970.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 861)
  AUTHORS   Belanger C, Cardinal T, Leduc E, Viger RS and Pilon N.
  TITLE     CHARGE syndrome-associated proteins FAM172A and CHD7 influence male
            sex determination and differentiation through transcriptional and
            alternative splicing mechanisms
  JOURNAL   FASEB J 36 (3), e22176 (2022)
   PUBMED   35129866
REFERENCE   2  (bases 1 to 861)
  AUTHORS   Sasaki K, Hamazaki J, Koike M, Hirano Y, Komatsu M, Uchiyama Y,
            Tanaka K and Murata S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   3  (bases 1 to 861)
  AUTHORS   Ling KH, Hewitt CA, Beissbarth T, Hyde L, Banerjee K, Cheah PS,
            Cannon PZ, Hahn CN, Thomas PQ, Smyth GK, Tan SS, Thomas T and Scott
            HS.
  TITLE     Molecular networks involved in mouse cerebral corticogenesis and
            spatio-temporal regulation of Sox4 and Sox11 novel antisense
            transcripts revealed by transcriptome profiling
  JOURNAL   Genome Biol 10 (10), R104 (2009)
   PUBMED   19799774
REFERENCE   4  (bases 1 to 861)
  AUTHORS   Murata S, Sasaki K, Kishimoto T, Niwa S, Hayashi H, Takahama Y and
            Tanaka K.
  TITLE     Regulation of CD8+ T cell development by thymus-specific
            proteasomes
  JOURNAL   Science 316 (5829), 1349-1353 (2007)
   PUBMED   17540904
REFERENCE   5  (bases 1 to 861)
  AUTHORS   Gomes AV, Zong C, Edmondson RD, Li X, Stefani E, Zhang J, Jones RC,
            Thyparambil S, Wang GW, Qiao X, Bardag-Gorce F and Ping P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   6  (bases 1 to 861)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 861)
  AUTHORS   De Conto F, Pilotti E, Razin SV, Ferraglia F, Geraud G,
            Arcangeletti C and Scherrer K.
  TITLE     In mouse myoblasts nuclear prosomes are associated with the nuclear
            matrix and accumulate preferentially in the perinucleolar areas
  JOURNAL   J Cell Sci 113 (Pt 13), 2399-2407 (2000)
   PUBMED   10852819
REFERENCE   8  (bases 1 to 861)
  AUTHORS   Elenich LA, Nandi D, Kent AE, McCluskey TS, Cruz M, Iyer MN,
            Woodward EC, Conn CW, Ochoa AL, Ginsburg DB and Monaco JJ.
  TITLE     The complete primary structure of mouse 20S proteasomes
  JOURNAL   Immunogenetics 49 (10), 835-842 (1999)
   PUBMED   10436176
REFERENCE   9  (bases 1 to 861)
  AUTHORS   Ko MS, Threat TA, Wang X, Horton JH, Cui Y, Wang X, Pryor E, Paris
            J, Wells-Smith J, Kitchen JR, Rowe LB, Eppig J, Satoh T, Brant L,
            Fujiwara H, Yotsumoto S and Nakashima H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB853639.1, CB321399.1 and BQ043213.1.
            
            [WARNING] On Oct 17, 2023 this sequence was replaced by
            NM_011970.5.
            
            On Apr 21, 2009 this sequence version replaced NM_011970.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV045027.1, DV064013.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BB853639.1         14-18
            6-724               CB321399.1         2-720
            725-861             BQ043213.1         208-344
FEATURES             Location/Qualifiers
     source          1..861
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 60.9 cM"
     gene            1..861
                     /gene="Psmb2"
                     /gene_synonym="C7-I; D4Wsu33e; HC7-I"
                     /note="proteasome (prosome, macropain) subunit, beta type
                     2"
                     /db_xref="GeneID:26445"
                     /db_xref="MGI:MGI:1347045"
     exon            1..203
                     /gene="Psmb2"
                     /gene_synonym="C7-I; D4Wsu33e; HC7-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..718
                     /gene="Psmb2"
                     /gene_synonym="C7-I; D4Wsu33e; HC7-I"
                     /EC_number="3.4.25.1"
                     /note="macropain subunit C7-I; proteasome component C7-I;
                     multicatalytic endopeptidase complex subunit C7-I"
                     /codon_start=1
                     /product="proteasome subunit beta type-2"
                     /protein_id="NP_036100.3"
                     /db_xref="CCDS:CCDS18657.1"
                     /db_xref="GeneID:26445"
                     /db_xref="MGI:MGI:1347045"
                     /translation="MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILL
                     LCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNL
                     LLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELL
                     RKCLEELQKRFILNLPTFSVRVIDKDGIHNLENIAFPKRDS"
     exon            204..326
                     /gene="Psmb2"
                     /gene_synonym="C7-I; D4Wsu33e; HC7-I"
                     /inference="alignment:Splign:2.1.0"
     exon            327..397
                     /gene="Psmb2"
                     /gene_synonym="C7-I; D4Wsu33e; HC7-I"
                     /inference="alignment:Splign:2.1.0"
     exon            398..560
                     /gene="Psmb2"
                     /gene_synonym="C7-I; D4Wsu33e; HC7-I"
                     /inference="alignment:Splign:2.1.0"
     exon            561..610
                     /gene="Psmb2"
                     /gene_synonym="C7-I; D4Wsu33e; HC7-I"
                     /inference="alignment:Splign:2.1.0"
     exon            611..847
                     /gene="Psmb2"
                     /gene_synonym="C7-I; D4Wsu33e; HC7-I"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgtcttgc gtcaccccca gctcagtccg ggtgtgctgt ctcactggtg aggtcgtgta
       61 cccgggaagt gtccctgtcc gtggcctctg cagcctcccg cttcccggca ccatggagta
      121 cctcattggc atccagggcc cagactatgt cctcgtcgct tccgaccgag tggccgccag
      181 caatattgtc cagatgaagg acgatcatga caagatgttt aagatgagtg aaaaaatctt
      241 actcctatgt gttggagagg ctggagacac tgtacagttt gcagaatata tccagaaaaa
      301 cgtgcaactt tataaaatgc ggaatggata tgaattgtct cccacagcag cagctaactt
      361 cacacggcgg aacctggctg actgtcttcg gagtcggacc ccatatcatg tgaacctcct
      421 cctggctggc tatgacgagc atgaagggcc agccctttac tacatggact acctggcagc
      481 cttggctaag gctccttttg cagctcatgg ctatggtgcc tttctgactc tcagcatcct
      541 tgaccgatac tacacaccta ccatctcacg tgagagggca gtggagcttc ttaggaagtg
      601 tctggaggag ctccagaagc gcttcatctt gaatctgccc accttcagtg tccgggtcat
      661 tgacaaagat ggcatccaca atctggagaa cattgccttc cctaagcggg actcctaacg
      721 tcacgtcctt ccctcccact caccagggaa cttttttgat gggctcattt tttttttttc
      781 tactcttttg acgttcactc ttgatagatg gttaattcaa aataaagctg aatatagcta
      841 aattgataaa aaaaaaaaaa a
//
