LOCUS       NM_175204               4247 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus proteasome (prosome, macropain) subunit, beta type, 11
            (Psmb11), mRNA.
ACCESSION   NM_175204
VERSION     NM_175204.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4247)
  AUTHORS   Grammer,C., Komorowska,J.A. and Swann,J.B.
  TITLE     Vhl safeguards thymic epithelial cell identity and thymopoietic
            capacity by constraining Hif1a activity during development
  JOURNAL   iScience 27 (7), 110258 (2024)
   PUBMED   39040069
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4247)
  AUTHORS   Ushio,A., Matsuda-Lennikov,M., Kalle-Youngoue,F., Shimizu,A.,
            Abdelmaksoud,A., Kelly,M.C., Ishimaru,N. and Takahama,Y.
  TITLE     Functionally diverse thymic medullary epithelial cells interplay to
            direct central tolerance
  JOURNAL   Cell Rep 43 (4), 114072 (2024)
   PUBMED   38581680
REFERENCE   3  (bases 1 to 4247)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4247)
  AUTHORS   Morimoto,J., Matsumoto,M., Oya,T., Tsuneyama,K. and Matsumoto,M.
  TITLE     Cooperative but Distinct Role of Medullary Thymic Epithelial Cells
            and Dendritic Cells in the Production of Regulatory T Cells in the
            Thymus
  JOURNAL   J Immunol 210 (11), 1653-1666 (2023)
   PUBMED   37067332
REFERENCE   5  (bases 1 to 4247)
  AUTHORS   Depoers,L., Dumont-Lagace,M., Trinh,V.Q., Houques,C., Cote,C.,
            Larouche,J.D., Brochu,S. and Perreault,C.
  TITLE     Klf4 protects thymus integrity during late pregnancy
  JOURNAL   Front Immunol 14, 1016378 (2023)
   PUBMED   37180153
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4247)
  AUTHORS   Heinonen,K.M., Vanegas,J.R., Brochu,S., Shan,J., Vainio,S.J. and
            Perreault,C.
  TITLE     Wnt4 regulates thymic cellularity through the expansion of thymic
            epithelial cells and early thymic progenitors
  JOURNAL   Blood 118 (19), 5163-5173 (2011)
   PUBMED   21937690
REFERENCE   7  (bases 1 to 4247)
  AUTHORS   Nowell,C.S., Bredenkamp,N., Tetelin,S., Jin,X., Tischner,C.,
            Vaidya,H., Sheridan,J.M., Stenhouse,F.H., Heussen,R., Smith,A.J.
            and Blackburn,C.C.
  TITLE     Foxn1 regulates lineage progression in cortical and medullary
            thymic epithelial cells but is dispensable for medullary sublineage
            divergence
  JOURNAL   PLoS Genet 7 (11), e1002348 (2011)
   PUBMED   22072979
REFERENCE   8  (bases 1 to 4247)
  AUTHORS   Ripen,A.M., Nitta,T., Murata,S., Tanaka,K. and Takahama,Y.
  TITLE     Ontogeny of thymic cortical epithelial cells expressing the
            thymoproteasome subunit beta5t
  JOURNAL   Eur J Immunol 41 (5), 1278-1287 (2011)
   PUBMED   21469133
  REMARK    GeneRIF: results indicate that beta5t expression in thymic cortical
            epithelial cells is dependent on Foxn1 but independent of thymocyte
            crosstalk or thymic medulla formation
REFERENCE   9  (bases 1 to 4247)
  AUTHORS   Nitta,T., Murata,S., Sasaki,K., Fujii,H., Ripen,A.M., Ishimaru,N.,
            Koyasu,S., Tanaka,K. and Takahama,Y.
  TITLE     Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells
  JOURNAL   Immunity 32 (1), 29-40 (2010)
   PUBMED   20045355
REFERENCE   10 (bases 1 to 4247)
  AUTHORS   Murata,S., Sasaki,K., Kishimoto,T., Niwa,S., Hayashi,H.,
            Takahama,Y. and Tanaka,K.
  TITLE     Regulation of CD8+ T cell development by thymus-specific
            proteasomes
  JOURNAL   Science 316 (5829), 1349-1353 (2007)
   PUBMED   17540904
  REMARK    GeneRIF: results suggest a key role for proteasome subunit beta5t
            in generating the MHC class I-restricted CD8(+) T cell repertoire
            during thymic selection
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK162727.1 and CT009512.6.
            
            On Sep 12, 2009 this sequence version replaced NM_175204.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK162727.1, AK037368.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2208              AK162727.1         3-2210
            2209-4247           CT009512.6         152052-154090       c
FEATURES             Location/Qualifiers
     source          1..4247
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 27.87 cM"
     gene            1..4247
                     /gene="Psmb11"
                     /gene_synonym="5830406J20Rik; beta5t"
                     /note="proteasome (prosome, macropain) subunit, beta type,
                     11"
                     /db_xref="GeneID:73902"
                     /db_xref="MGI:MGI:1921152"
     exon            1..4247
                     /gene="Psmb11"
                     /gene_synonym="5830406J20Rik; beta5t"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..926
                     /gene="Psmb11"
                     /gene_synonym="5830406J20Rik; beta5t"
                     /EC_number="3.4.25.1"
                     /note="proteasome beta 11 subunit; proteasome subunit
                     beta5t; proteasome subunit beta-5t"
                     /codon_start=1
                     /product="proteasome subunit beta type-11"
                     /protein_id="NP_780413.1"
                     /db_xref="CCDS:CCDS49491.1"
                     /db_xref="GeneID:73902"
                     /db_xref="MGI:MGI:1921152"
                     /translation="MALQDVCKWQTPDTPRPSIHLPQAGGWAVPRGCDPQTFLQIHGP
                     RLAHGTTTLAFRFRHGVIAAADTRSSCGSYVACPASRKVIPVHQRLLGTTSGTSADCA
                     TWYRVLRRELRLRELREGQLPSVAGTAKLLAAMMSCYRGLDLCVATALCGWDHSGPAL
                     FYVYSDGTCLQGDIFSVGSGSPYAYGVLDRGYHYDMTIQEAYTLARCAVAHATHRDAY
                     SGGSVDLFHVRESGWEYVSRSDACVLYRELQKARSLEQELEAKACGIYPEPATPQGAR
                     ECKELFVEQEEVTPEDCAIIMKTETM"
     regulatory      1156..1161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmb11"
                     /gene_synonym="5830406J20Rik; beta5t"
                     /note="hexamer: AACAAA"
     polyA_site      1176
                     /gene="Psmb11"
                     /gene_synonym="5830406J20Rik; beta5t"
                     /note="major polyA site"
     regulatory      3581..3586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmb11"
                     /gene_synonym="5830406J20Rik; beta5t"
                     /note="hexamer: AATACA"
     polyA_site      3618
                     /gene="Psmb11"
                     /gene_synonym="5830406J20Rik; beta5t"
     regulatory      4229..4234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmb11"
                     /gene_synonym="5830406J20Rik; beta5t"
                     /note="hexamer: ATTAAA"
     polyA_site      4246
                     /gene="Psmb11"
                     /gene_synonym="5830406J20Rik; beta5t"
ORIGIN      
        1 ctcactcagc ctcagggatg gctcttcagg atgtgtgcaa gtggcagact cccgacactc
       61 ccagaccatc cattcacttg cctcaggccg gtggctgggc tgtaccccgg ggctgtgacc
      121 ctcaaacctt cctgcagatc catggcccca ggctggctca tggcaccact accctggctt
      181 ttcgctttcg tcacggtgtc atcgctgcgg ctgatactcg gtcctcctgt ggcagctatg
      241 tggcatgtcc agcctcacgg aaggtcattc ctgtgcacca gcgtctcctg ggtaccacct
      301 ctgggacctc tgctgactgt gccacatggt accgggtgct acggcgggag ctgcggcttc
      361 gggaactgag ggaaggccag ctgcccagtg tggcaggcac ggccaaactc ttggcagcta
      421 tgatgtcctg ctaccgcggt ctggatctgt gtgtggccac tgccctctgt ggctgggacc
      481 actctggccc tgctctcttc tatgtctaca gcgatggcac ttgtctgcag ggagatatct
      541 tctcagtagg ctctgggtct ccctacgcct atggtgtgct tgatcgtggc taccactatg
      601 acatgaccat ccaggaagcc tacaccctgg cccgctgtgc tgtggcccat gccacccacc
      661 gtgatgctta ttcagggggc tcagtggacc tcttccacgt tcgggagagc ggatgggagt
      721 atgtatcccg cagtgatgct tgcgtgctgt atagggagct gcagaaagcc cggagcttgg
      781 agcaggagct ggaggcaaaa gcttgtggaa tctatcctga gcctgccacg ccgcaaggtg
      841 ctcgagaatg taaagaactc tttgtggagc aagaggaggt gacgccagaa gactgcgcga
      901 taataatgaa gactgaaaca atgtaagaaa ggacagaact tggggactgc caggacaagg
      961 gactagggga tgaagctgcc ttggcagggt tagttctggg agcagccccg ggcatctggc
     1021 tctggccctt ttgggtttcc tgctttgttt aagttcccat cctctctgct tcccagagct
     1081 actgatgtct ctgtccaaca tgttctgatg atacctgatg gatggtattg cctccttctg
     1141 cctctaaagt gactaaacaa acactcattg catgcctact ttgtgccaac tgtcatgcta
     1201 tgtgctgggc cctcttttgt cattctaccc cagttggtat tctcattttg gtccttatct
     1261 ggtttgtttt ctctttcagc tggtcacctt ttcaacttgg tcaggctgaa tggccaggag
     1321 agagcctagt ttagtgatgg gcttgtctct gctggccctc cacaccctga cccccaccat
     1381 gactgtaatg gctataatga ttccacctat actgagtgca gttcccatga cagcttttgc
     1441 aagcatgatt gtttattgaa gctgggtcag gtttagagag ttacaggact tacgcaggtt
     1501 acagtaggtg acaatgttgt ggggcttaag acactcttaa tccttcccca gctctctgca
     1561 tctttccctc ccagcctcca ctgtcttgcc ttgtttttct gcctgcattg caggcttctg
     1621 gggaatgggc caaacccctg cctgttgtct ggagatgaat gaactccaag gaactcatgg
     1681 gcttggaggg aagagctcag agaagctgcc cattcccggt ctcatcttgc tgtgttggtc
     1741 agggtttgag ccatgccctg tagcacacac atccctgctc tctaccctgc agatctctcc
     1801 ctgcttcttc gctccggcct ctcctggttg ctcctgctgg agaatgaaga ccagaggcag
     1861 ggtgctgtgc ctctggtgcc agctagcaca tctggccttc ctggcctgct ctggacgtcc
     1921 aggatttcag cttcaggaac accactgcct cctcctcagg gctgggcatc cagagaaagg
     1981 gaacccaaag aactttcctc tcacctgaag cctccagtcc taagactgac aactgcttct
     2041 ccttccttga cagtgtgcac ttcgaattaa gaattctttg aaatcagact tagacttaca
     2101 gattcttacc cagactctcc aaactctgga gagtcaaaag gcaagctggg gagcccagag
     2161 aaaatggagg atgggcagtg gtgatgcaca actttaatcc cagcactcag taggcagcag
     2221 caggcggatt tctgagttgg aggccagcct ggtctacaga gtgagttcca ggacagccag
     2281 ggctacacag agaaaccctg tcttgaaaaa ccaaaccaaa ccaaaccaaa ccaaaccaaa
     2341 ccaaaccaaa ccaaaccaaa ccaaaccaaa ccaaaccaaa ccaagccaag ccaaaccaag
     2401 ccaaacaaac aaacaaacaa acaaacaaac aaccctacaa aaaacaagaa acaaacaaac
     2461 tcccaaaccc agagtgctac agaaaggttc ccaatacatg gggtctggct tgcaagccag
     2521 ggtagaaatc tggctattgg ccttcaaagc atccttcatc ccctgcaaac ttcctagcct
     2581 tggggaagag atatgatcct ccaggagtga catccaaagg ttagggatac tgaagaagca
     2641 aatgaggaga ggtcattttt ttttttttta agatttattt cttttaatgt cctgttttca
     2701 aacacaccag aagagggcat cagatcccat tacagatgat tgtgagccac cgtgtggttg
     2761 ctgggatttg aactcaggac ctctggaaga gcaggcagtg ctcttaacct ctgagccacc
     2821 tctccagcct gagaggtaac ttttgcacag gcataagtgg gttcagattc atggccattg
     2881 atgagggtct tatgtccagc tgtcggggaa tgagttaaga taggcatctg cacttcagtg
     2941 tggtgggcga ggcatgtggt gttgttctgt ggaagagaga ggagcagcac ttgactcaga
     3001 gcagccgctg cagcctgtgt agcccagcgc tagccatcat gcacagtgga gagccacaaa
     3061 aaagaggagg ttggggcggg gctgtatagg agcctatggc tgctcctcac cctggtctac
     3121 tctgaggctt tcaggcagtg aacagaggca ggggcagagg gatggtctgg gacctgggat
     3181 gaacatctgg gaccagccaa aggctgctgt gcatctcaat cccctgagat gctctgtgcc
     3241 tctcttctca gactggacaa ggaggctaga accctgaaag agcagaactt gcatctacat
     3301 ccgtctcctc ctctctcctc tctcttcctt ccatgatctt attcttggtc ttattcatga
     3361 tcttattctt attcttgatc ttcattcttc ttggcaggtg atgagatatg taagcttaca
     3421 ggttttgctg atgagcttgt atccccaaac cctgtaagaa tttcgagggg ctgagagatg
     3481 gctctgcagg taaaggtact tgccaccaaa cccgatgaca tacgagttta gtccccagga
     3541 ctgacatgtg gaaaaggata ggaaaaagat acactgtgta aatacatgaa ccaggaaaac
     3601 atttaaacag tgtttgagga aatgtttgtc ttgttgttgt tgttgacttt aaatatgagt
     3661 gtatgcatgt atgcatgtat gtatgtatgc atgtcacatg catgcctggt gcccacagag
     3721 gttagaagag ggtatcaggt ctcctggaag cagagttctg gatgattgtg atccaccacg
     3781 tgggggcagg gaatcaaaca ggaggacctt ctggaagagt caatgctaag tcacctctcc
     3841 agccccaggt tcctctcagt gtttttgctt taatgctttt tttagactca tgtgcatgga
     3901 tgggtatttt gctccatgta tgtattgttc cacatacttg cctgctgcct gcaggtcaga
     3961 agaggatatc aaatcccctg gagtcagaga tgcttgtgag ccatcatgtg ggtgctgttt
     4021 gttgtgagtt tatagccaat cagcctctat ccacataaca acttcttagt ttttctattt
     4081 ctaatttatg ctgtactttt gttttgtttt gttttgtttt tcgagacagg gtttctctgt
     4141 atagccctgg ctgtcctgga actcactttg tagaccaggt tggcctcgat ctcagaaatt
     4201 cacctgcctc tgcctcccga gtgctgggat taaaggtgtg tgttacc
//
