LOCUS       NM_013640               1270 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus proteasome (prosome, macropain) subunit, beta type 10
            (Psmb10), mRNA.
ACCESSION   NM_013640
VERSION     NM_013640.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1270)
  AUTHORS   Oliveri,F., Basler,M., Rao,T.N., Fehling,H.J. and Groettrup,M.
  TITLE     Immunoproteasome Inhibition Reduces the T Helper 2 Response in
            Mouse Models of Allergic Airway Inflammation
  JOURNAL   Front Immunol 13, 870720 (2022)
   PUBMED   35711460
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1270)
  AUTHORS   Zhang,Y., Hu,W., Liu,Q., Ma,Z., Hu,S., Zhang,Z., Jia,H. and He,X.
  TITLE     Expression of immunoproteasome subunits in the brains of Toxoplasma
            gondii-infected mice
  JOURNAL   Exp Mol Pathol 123, 104684 (2021)
   PUBMED   34547302
  REMARK    GeneRIF: Expression of immunoproteasome subunits in the brains of
            Toxoplasma gondii-infected mice.
REFERENCE   3  (bases 1 to 1270)
  AUTHORS   Lim,S., Kim,Y.J., Park,S., Choi,J.H., Sung,Y.H., Nishimori,K.,
            Kozmik,Z., Lee,H.W. and Kim,J.W.
  TITLE     mTORC1-induced retinal progenitor cell overproliferation leads to
            accelerated mitotic aging and degeneration of descendent Muller
            glia
  JOURNAL   Elife 10, e70079 (2021)
   PUBMED   34677125
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1270)
  AUTHORS   French,T., Israel,N., Dusedau,H.P., Tersteegen,A., Steffen,J.,
            Cammann,C., Topfstedt,E., Dieterich,D., Schuler,T., Seifert,U. and
            Dunay,I.R.
  TITLE     The Immunoproteasome Subunits LMP2, LMP7 and MECL-1 Are Crucial
            Along the Induction of Cerebral Toxoplasmosis
  JOURNAL   Front Immunol 12, 619465 (2021)
   PUBMED   33968021
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1270)
  AUTHORS   Liao,J., An,X., Yang,X., Lin,Q.Y., Liu,S., Xie,Y., Bai,J., Xia,Y.L.
            and Li,H.H.
  TITLE     Deficiency of LMP10 Attenuates Diet-Induced Atherosclerosis by
            Inhibiting Macrophage Polarization and Inflammation in
            Apolipoprotein E Deficient Mice
  JOURNAL   Front Cell Dev Biol 8, 592048 (2020)
   PUBMED   33195259
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1270)
  AUTHORS   Fruh,K. and Yang,Y.
  TITLE     Antigen presentation by MHC class I and its regulation by
            interferon gamma
  JOURNAL   Curr Opin Immunol 11 (1), 76-81 (1999)
   PUBMED   10047537
  REMARK    Review article
REFERENCE   7  (bases 1 to 1270)
  AUTHORS   Cruz,M., Elenich,L.A., Smolarek,T.A., Menon,A.G. and Monaco,J.J.
  TITLE     DNA sequence, chromosomal localization, and tissue expression of
            the mouse proteasome subunit lmp10 (Psmb10) gene
  JOURNAL   Genomics 45 (3), 618-622 (1997)
   PUBMED   9367687
REFERENCE   8  (bases 1 to 1270)
  AUTHORS   Hayashi,M., Ishibashi,T., Tanaka,K. and Kasahara,M.
  TITLE     The mouse genes encoding the third pair of beta-type proteasome
            subunits regulated reciprocally by IFN-gamma: structural
            comparison, chromosomal localization, and analysis of the promoter
  JOURNAL   J Immunol 159 (6), 2760-2770 (1997)
   PUBMED   9300697
REFERENCE   9  (bases 1 to 1270)
  AUTHORS   Stohwasser,R., Standera,S., Peters,I., Kloetzel,P.M. and
            Groettrup,M.
  TITLE     Molecular cloning of the mouse proteasome subunits MC14 and MECL-1:
            reciprocally regulated tissue expression of
            interferon-gamma-modulated proteasome subunits
  JOURNAL   Eur J Immunol 27 (5), 1182-1187 (1997)
   PUBMED   9174609
REFERENCE   10 (bases 1 to 1270)
  AUTHORS   Strosberg,A.D.
  TITLE     Structure and function of the beta 3-adrenergic receptor
  JOURNAL   Annu Rev Pharmacol Toxicol 37, 421-450 (1997)
   PUBMED   9131260
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159265.2, D85561.1 and BY686068.1.
            
            On Jul 2, 2009 this sequence version replaced NM_013640.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D85561.1, AK144096.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-305               AC159265.2         195648-195952       c
            306-1256            D85561.1           1-951
            1257-1270           BY686068.1         398-411
FEATURES             Location/Qualifiers
     source          1..1270
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.06 cM"
     gene            1..1270
                     /gene="Psmb10"
                     /gene_synonym="Mecl-1; Mecl1"
                     /note="proteasome (prosome, macropain) subunit, beta type
                     10"
                     /db_xref="GeneID:19171"
                     /db_xref="MGI:MGI:1096380"
     exon            1..438
                     /gene="Psmb10"
                     /gene_synonym="Mecl-1; Mecl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..1204
                     /gene="Psmb10"
                     /gene_synonym="Mecl-1; Mecl1"
                     /EC_number="3.4.25.1"
                     /note="prosome Mecl1; proteasome subunit MECL1; proteasome
                     MECl-1; macropain subunit MECl-1; proteasome subunit
                     beta-2i; low molecular mass protein 10; multicatalytic
                     endopeptidase complex subunit MECl-1; proteasome
                     (prosomome, macropain) subunit, beta type 10"
                     /codon_start=1
                     /product="proteasome subunit beta type-10"
                     /protein_id="NP_038668.2"
                     /db_xref="CCDS:CCDS22621.1"
                     /db_xref="GeneID:19171"
                     /db_xref="MGI:MGI:1096380"
                     /translation="MLKQAVEPTGGFSFENCQRNASLEHVLPGLRVPHARKTGTTIAG
                     LVFRDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADTEMTTRMAASKM
                     ELHALSTGREPRVATVTRILRQTLFRYQGHVGASLVVGGVDLNGPQLYEVHPHGSYSR
                     LPFTALGSGQGAAVALLEDRFQPNMTLEAAQELLVEAITAGILSDLGSGGNVDACVIT
                     AGGAKLQRALSTPTEPVQRAGRYRFAPGTTPVLTREVRPLTLELLEETVQAMEVE"
     exon            439..526
                     /gene="Psmb10"
                     /gene_synonym="Mecl-1; Mecl1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..624
                     /gene="Psmb10"
                     /gene_synonym="Mecl-1; Mecl1"
                     /inference="alignment:Splign:2.1.0"
     exon            625..765
                     /gene="Psmb10"
                     /gene_synonym="Mecl-1; Mecl1"
                     /inference="alignment:Splign:2.1.0"
     exon            766..881
                     /gene="Psmb10"
                     /gene_synonym="Mecl-1; Mecl1"
                     /inference="alignment:Splign:2.1.0"
     exon            882..940
                     /gene="Psmb10"
                     /gene_synonym="Mecl-1; Mecl1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1092
                     /gene="Psmb10"
                     /gene_synonym="Mecl-1; Mecl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1270
                     /gene="Psmb10"
                     /gene_synonym="Mecl-1; Mecl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1239..1244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmb10"
                     /gene_synonym="Mecl-1; Mecl1"
                     /note="hexamer: AATAAA"
     polyA_site      1267
                     /gene="Psmb10"
                     /gene_synonym="Mecl-1; Mecl1"
                     /note="major polyA site"
ORIGIN      
        1 acacacataa ctaagcctgc aagggcttca tttctactta cttttaaggg gttatgtgtg
       61 tgagtgtttt acctgaatac atgtatgtgc ctgcagtgct cagggggtgt cagcagagat
      121 gggaatggag gatctaaggc gcaccatagg tctggcaagg agtgtaatag ccccttcctc
      181 aagttatctg ggactagcag caaagacgaa agtgaaagag aagatgcaca cagcagccaa
      241 cagcctctga actagggtgg gggtgaaagc gaaagtagga agcgtccgga aaaaccccac
      301 agaagccagg acagacgcct ctgctccccc tggctgatcc actcatcgag acccccgcat
      361 tctcacttgg ccttcctgcg agatgctgaa gcaggcagtg gaacccacag gaggcttctc
      421 tttcgagaac tgccagagga atgcgtcctt ggaacacgtc cttccgggac ttcgggttcc
      481 tcatgcacgc aagaccggga ctaccatcgc ggggcttgtg ttccgagatg gagtcatcct
      541 gggagcggac acgcgggcca ctaacgattc ggttgtggcg gacaaaagct gcgagaagat
      601 ccacttcatc gcccctaaaa tctactgctg tggggctgga gtagctgcgg acactgagat
      661 gactacgcgg atggcagctt ccaagatgga actacatgcg ctgtccaccg gccgtgagcc
      721 tcgggtggcc acggtcaccc gtatcctgcg ccagacgctt ttccggtacc aaggccacgt
      781 gggggcatca ctggtcgtgg gcggggttga tttgaacgga cctcagctct acgaggtgca
      841 cccacatggt tcctacagcc gtctgccctt tactgccctt ggctctggtc agggtgcagc
      901 cgtggcactg ttggaagacc ggttccagcc aaacatgacg ctggaggctg cgcaagagct
      961 gttggtggaa gccatcacag cagggatcct gagtgacctg ggctctgggg gcaatgtgga
     1021 tgcctgtgtg atcactgcag ggggtgccaa gctgcagaga gcattgagca cccccaccga
     1081 gcctgtgcag agagctggcc gttaccgatt tgctcctgga accacacctg tcctgacccg
     1141 ggaagtgaga cccctgaccc tggaacttct tgaggaaact gtgcaggcca tggaggtgga
     1201 atgaagtggc ctgagatgta gagtttggaa tgagggtgaa taaatccggg aaacacaaac
     1261 acttaaacag
//
