LOCUS       NM_011185               1036 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus proteasome (prosome, macropain) subunit, beta type 1
            (Psmb1), mRNA.
ACCESSION   NM_011185
VERSION     NM_011185.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1036)
  AUTHORS   Ge,T., Yuan,L., Xu,L., Yang,F., Xu,W., Niu,C., Li,G., Zhou,H. and
            Zheng,Y.
  TITLE     Coiled-coil domain containing 159 is required for spermatid head
            and tail assembly in micedagger
  JOURNAL   Biol Reprod 110 (5), 877-894 (2024)
   PUBMED   38236177
REFERENCE   2  (bases 1 to 1036)
  AUTHORS   Xing,L., Simon,J.M., Ptacek,T.S., Yi,J.J., Loo,L., Mao,H.,
            Wolter,J.M., McCoy,E.S., Paranjape,S.R., Taylor-Blake,B. and
            Zylka,M.J.
  TITLE     Autism-linked UBE3A gain-of-function mutation causes interneuron
            and behavioral phenotypes when inherited maternally or paternally
            in mice
  JOURNAL   Cell Rep 42 (7), 112706 (2023)
   PUBMED   37389991
REFERENCE   3  (bases 1 to 1036)
  AUTHORS   de Diego-Garcia,L., Ramirez-Escudero,M., Sebastian-Serrano,A.,
            Diaz-Hernandez,J.I., Pintor,J., Lucas,J.J. and Diaz-Hernandez,M.
  TITLE     Regulation of proteasome activity by P2Y2 receptor underlies the
            neuroprotective effects of extracellular nucleotides
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1863 (1), 43-51 (2017)
   PUBMED   27768902
  REMARK    GeneRIF: The P2Y2R enhances Ubiquitin-Proteasome System activity by
            increasing the subunits expression beta 5 and beta 1.
REFERENCE   4  (bases 1 to 1036)
  AUTHORS   Lichter,D.I., Danaee,H., Pickard,M.D., Tayber,O., Sintchak,M.,
            Shi,H., Richardson,P.G., Cavenagh,J., Blade,J., Facon,T.,
            Niesvizky,R., Alsina,M., Dalton,W., Sonneveld,P., Lonial,S., van de
            Velde,H., Ricci,D., Esseltine,D.L., Trepicchio,W.L., Mulligan,G.
            and Anderson,K.C.
  TITLE     Sequence analysis of beta-subunit genes of the 20S proteasome in
            patients with relapsed multiple myeloma treated with bortezomib or
            dexamethasone
  JOURNAL   Blood 120 (23), 4513-4516 (2012)
   PUBMED   23018640
  REMARK    GeneRIF: Data indicate that treatment-emergent resistance to
            single-agent bortezomib was independent of variants in the
            proteasome genes PSMB1, PSMB5, PSMB6, PSMB8, PSMB9, and PSMB10.
REFERENCE   5  (bases 1 to 1036)
  AUTHORS   Kohr,M.J., Aponte,A.M., Sun,J., Wang,G., Murphy,E., Gucek,M. and
            Steenbergen,C.
  TITLE     Characterization of potential S-nitrosylation sites in the
            myocardium
  JOURNAL   Am J Physiol Heart Circ Physiol 300 (4), H1327-H1335 (2011)
   PUBMED   21278135
REFERENCE   6  (bases 1 to 1036)
  AUTHORS   Trachtulec,Z. and Forejt,J.
  TITLE     Transcription and RNA processing of mammalian genes in
            Saccharomyces cerevisiae
  JOURNAL   Nucleic Acids Res 27 (2), 526-531 (1999)
   PUBMED   9862975
REFERENCE   7  (bases 1 to 1036)
  AUTHORS   Trachtulec,Z., Hamvas,R.M., Forejt,J., Lehrach,H.R., Vincek,V. and
            Klein,J.
  TITLE     Linkage of TATA-binding protein and proteasome subunit C5 genes in
            mice and humans reveals synteny conserved between mammals and
            invertebrates
  JOURNAL   Genomics 44 (1), 1-7 (1997)
   PUBMED   9286694
REFERENCE   8  (bases 1 to 1036)
  AUTHORS   Trachtulec,Z., Mnukova-Fajdelova,M., Hamvas,R.M., Gregorova,S.,
            Mayer,W.E., Lehrach,H.R., Vincek,V., Forejt,J. and Klein,J.
  TITLE     Isolation of candidate hybrid sterility 1 genes by cDNA selection
            in a 1.1 megabase pair region on mouse chromosome 17
  JOURNAL   Mamm Genome 8 (5), 312-316 (1997)
   PUBMED   9107673
REFERENCE   9  (bases 1 to 1036)
  AUTHORS   Savioz,A., Houghton,I. and Davies,R.W.
  TITLE     Cloning and sequencing of a murine cDNA encoding the proteasome
            component C5
  JOURNAL   DNA Seq 5 (5), 307-309 (1995)
   PUBMED   7579585
REFERENCE   10 (bases 1 to 1036)
  AUTHORS   Fruh,K., Gossen,M., Wang,K., Bujard,H., Peterson,P.A. and Yang,Y.
  TITLE     Displacement of housekeeping proteasome subunits by MHC-encoded
            LMPs: a newly discovered mechanism for modulating the
            multicatalytic proteinase complex
  JOURNAL   EMBO J 13 (14), 3236-3244 (1994)
   PUBMED   8045254
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK132161.1.
            
            On Apr 6, 2007 this sequence version replaced NM_011185.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132161.1, SRR1660811.423420.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1036              AK132161.1         2-1037
FEATURES             Location/Qualifiers
     source          1..1036
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.95 cM"
     gene            1..1036
                     /gene="Psmb1"
                     /gene_synonym="Lmpc5"
                     /note="proteasome (prosome, macropain) subunit, beta type
                     1"
                     /db_xref="GeneID:19170"
                     /db_xref="MGI:MGI:104884"
     exon            1..124
                     /gene="Psmb1"
                     /gene_synonym="Lmpc5"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..737
                     /gene="Psmb1"
                     /gene_synonym="Lmpc5"
                     /EC_number="3.4.25.1"
                     /note="component C5 of proteasome; proteasome subunit C5;
                     proteasome beta-subunit C5; macropain subunit C5;
                     proteasome gamma chain; proteasome component C5;
                     multicatalytic endopeptidase complex subunit C5; beta-6;
                     proteasome subunit beta-6"
                     /codon_start=1
                     /product="proteasome subunit beta type-1"
                     /protein_id="NP_035315.1"
                     /db_xref="CCDS:CCDS28411.1"
                     /db_xref="GeneID:19170"
                     /db_xref="MGI:MGI:104884"
                     /translation="MLSTAAYRDVERELGMGPHGSAGPVQLRFSPYAFNGGTVLAIAG
                     EDFSIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMY
                     KHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRD
                     SFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLTLDRAMRLVKDVFISAAERDVYTGD
                     ALRICIVTKEGIREETVPLRKD"
     exon            125..232
                     /gene="Psmb1"
                     /gene_synonym="Lmpc5"
                     /inference="alignment:Splign:2.1.0"
     exon            233..314
                     /gene="Psmb1"
                     /gene_synonym="Lmpc5"
                     /inference="alignment:Splign:2.1.0"
     exon            315..444
                     /gene="Psmb1"
                     /gene_synonym="Lmpc5"
                     /inference="alignment:Splign:2.1.0"
     exon            445..551
                     /gene="Psmb1"
                     /gene_synonym="Lmpc5"
                     /inference="alignment:Splign:2.1.0"
     exon            552..1036
                     /gene="Psmb1"
                     /gene_synonym="Lmpc5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      779..784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psmb1"
                     /gene_synonym="Lmpc5"
                     /note="hexamer: ATTAAA"
     polyA_site      798
                     /gene="Psmb1"
                     /gene_synonym="Lmpc5"
                     /note="major polyA site"
ORIGIN      
        1 aggagttagg cgcgatgctt tccactgctg cttaccgaga cgtggaacga gagctgggaa
       61 tggggcctca cggctccgcc ggccctgtgc agctgcggtt ttcgccttat gccttcaacg
      121 gaggtactgt attggcaatt gctggagaag atttttccat cgtcgcttca gacactcgat
      181 tgagtgaagg attttcaatt catacccgag atagccccaa atgctacaaa ctgacagaca
      241 agacagtaat tggctgcagt ggtttccatg gagattgtct cactttgaca aagattattg
      301 aagcaagatt aaagatgtac aagcattcca ataacaaggc catgacaacg ggggcgattg
      361 ctgcaatgct gtctaccatc ctgtactcac ggcgcttctt cccttactat gtttacaaca
      421 tcattggagg acttgatgaa gaaggaaagg gagctgtgta cagctttgac ccagtgggct
      481 cttaccagag agactctttc aaggcgggag gctcagcaag tgccatgctg cagcctctgc
      541 tcgacaacca ggttggcttc aaaaatatgc agaatgtaga gcacgtcccc ctgacgctgg
      601 acagagccat gaggctggtg aaagatgtct tcatttctgc agccgagagg gatgtgtata
      661 ctggagatgc tctcaggatc tgcatcgtga ccaaagaggg catcagggag gaaactgttc
      721 ccctgcggaa agactgacat gcgggtcata tattggagct gtggcacaag tttgttttat
      781 taaaaagaat gtaaagtact cattttctta cactgtgtct tctctaagca tggcaaattg
      841 ggaagaattt cttccttagg ggtcggagag acaactctca gtttaaaaag tatggctctt
      901 gcagaggacc taagtttgat tcctagcacc cacctgtaac tccagttcca ggggctacag
      961 tgtcctcttc tggcctcgac aggcacatgc aaatacccac atacaaatgt atgtaatgaa
     1021 aaataaaacc actaat
//
