LOCUS       NM_011969                952 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus proteasome subunit alpha 7 (Psma7), transcript variant
            1, mRNA.
ACCESSION   NM_011969
VERSION     NM_011969.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 952)
  AUTHORS   Zhang,Q., Ji,S.Y., Busayavalasa,K., Shao,J. and Yu,C.
  TITLE     Meiosis I progression in spermatogenesis requires a type of
            testis-specific 20S core proteasome
  JOURNAL   Nat Commun 10 (1), 3387 (2019)
   PUBMED   31358751
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 952)
  AUTHORS   Werber,M., Wittler,L., Timmermann,B., Grote,P. and Herrmann,B.G.
  TITLE     The tissue-specific transcriptomic landscape of the mid-gestational
            mouse embryo
  JOURNAL   Development 141 (11), 2325-2330 (2014)
   PUBMED   24803591
REFERENCE   3  (bases 1 to 952)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   4  (bases 1 to 952)
  AUTHORS   Jia,Y., Song,T., Wei,C., Ni,C., Zheng,Z., Xu,Q., Ma,H., Li,L.,
            Zhang,Y., He,X., Xu,Y., Shi,W. and Zhong,H.
  TITLE     Negative regulation of MAVS-mediated innate immune response by
            PSMA7
  JOURNAL   J Immunol 183 (7), 4241-4248 (2009)
   PUBMED   19734229
  REMARK    GeneRIF: Expression of proteasomal subunit PSMA7 results in potent
            inhibition of retinoic acid induced gene-1 (RIG)-1 and
            MAVS-mediated interferon-beta promoter activity.
REFERENCE   5  (bases 1 to 952)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   6  (bases 1 to 952)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   7  (bases 1 to 952)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 952)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   9  (bases 1 to 952)
  AUTHORS   Tokumoto,M., Horiguchi,R., Nagahama,Y., Ishikawa,K. and Tokumoto,T.
  TITLE     Two proteins, a goldfish 20S proteasome subunit and the protein
            interacting with 26S proteasome, change in the meiotic cell cycle
  JOURNAL   Eur J Biochem 267 (1), 97-103 (2000)
   PUBMED   10601855
REFERENCE   10 (bases 1 to 952)
  AUTHORS   Elenich,L.A., Nandi,D., Kent,A.E., McCluskey,T.S., Cruz,M.,
            Iyer,M.N., Woodward,E.C., Conn,C.W., Ochoa,A.L., Ginsburg,D.B. and
            Monaco,J.J.
  TITLE     The complete primary structure of mouse 20S proteasomes
  JOURNAL   Immunogenetics 49 (10), 835-842 (1999)
   PUBMED   10436176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU841938.1, BY779773.1, AK146765.1, DV049235.1 and CJ307624.1.
            
            On Jan 22, 2014 this sequence version replaced NM_011969.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168234.1, BU525605.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BU841938.1         4-16
            14-46               BY779773.1         2-34
            47-491              AK146765.1         4-448
            492-822             DV049235.1         461-791
            823-952             CJ307624.1         319-448
FEATURES             Location/Qualifiers
     source          1..952
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 102.55 cM"
     gene            1..952
                     /gene="Psma7"
                     /gene_synonym="C6-I"
                     /note="proteasome subunit alpha 7"
                     /db_xref="GeneID:26444"
                     /db_xref="MGI:MGI:1347070"
     exon            1..187
                     /gene="Psma7"
                     /gene_synonym="C6-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..838
                     /gene="Psma7"
                     /gene_synonym="C6-I"
                     /EC_number="3.4.25.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     proteasome subunit alpha type-7; proteasome subunit RC6-1;
                     proteasome (prosome, macropain) subunit, alpha type 7;
                     alpha-4; proteasome subunit alpha-4"
                     /codon_start=1
                     /product="proteasome subunit alpha type-7 isoform 1"
                     /protein_id="NP_036099.1"
                     /db_xref="CCDS:CCDS17166.1"
                     /db_xref="GeneID:26444"
                     /db_xref="MGI:MGI:1347070"
                     /translation="MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGKDIVVLG
                     VEKKSVAKLQDERTVRKICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPV
                     TVEYITRYIASLKQRYTQSNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANA
                     IGRGAKSVREFLEKNYTDDAIETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQPLK
                     ILNPEEIEKYVAEIEKEKEENEKKKQKKAS"
     exon            188..314
                     /gene="Psma7"
                     /gene_synonym="C6-I"
                     /inference="alignment:Splign:2.1.0"
     exon            315..439
                     /gene="Psma7"
                     /gene_synonym="C6-I"
                     /inference="alignment:Splign:2.1.0"
     exon            440..562
                     /gene="Psma7"
                     /gene_synonym="C6-I"
                     /inference="alignment:Splign:2.1.0"
     exon            563..682
                     /gene="Psma7"
                     /gene_synonym="C6-I"
                     /inference="alignment:Splign:2.1.0"
     exon            683..745
                     /gene="Psma7"
                     /gene_synonym="C6-I"
                     /inference="alignment:Splign:2.1.0"
     exon            746..952
                     /gene="Psma7"
                     /gene_synonym="C6-I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      924..929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psma7"
                     /gene_synonym="C6-I"
                     /note="hexamer: AATAAA"
     polyA_site      945
                     /gene="Psma7"
                     /gene_synonym="C6-I"
                     /note="major polyA site"
ORIGIN      
        1 agacgccagc agcgtggccc gggagggcgg ggcgctgacg gtgagtgtgc gcttttgagc
       61 ggcggcggcc cgagctagtg cgtccgcagt gatgagctac gaccgcgcca tcaccgtctt
      121 ctcgcccgac ggccacctct tccaagtgga gtacgcgcag gaggcggtca aaaagggctc
      181 caccgcggtt ggtgttcgag gaaaggacat tgttgttctt ggtgtggaaa aaaaatcagt
      241 ggccaagcta caagatgaaa gaacagtacg aaaaatctgc gccttggacg ataacgtctg
      301 tatggccttt gcaggtctca ccgctgatgc aaggatagtc atcaacagag cccgggtaga
      361 gtgccagagc caccggctga cagtggagga cccagtgact gtggagtaca tcacccgcta
      421 cattgcgagt ctgaagcagc gttatacaca gagcaatggg cgcaggccat ttggtatctc
      481 ggccctaatt gtgggttttg actttgatgg cactcccaga ctctatcaga ctgacccctc
      541 gggcacatac catgcttgga aggccaatgc cataggccgg ggcgccaagt cagtgcgtga
      601 atttctggag aagaactaca cagatgatgc cattgaaaca gatgatctga ccatcaaact
      661 tgtgatcaag gcactgttag aggtggtcca gtcaggtggc aaaaacatcg aacttgccgt
      721 catgaggcgg gatcagccgc tcaagattct aaatcctgaa gaaattgaga agtatgttgc
      781 tgaaattgag aaggagaaag aagaaaatga aaagaagaag caaaagaaag catcttgatg
      841 aagaggcact ggtcagagca gctttgagcc tctatccggg caagcctcgg tgctgtgggc
      901 cttgtggcca tttgtccgag ttcaataaac tactacattt tttaactctg tg
//
