LOCUS       NP_036098                246 aa            linear   ROD 28-APR-2025
DEFINITION  proteasome subunit alpha type-6 isoform 1 [Mus musculus].
ACCESSION   NP_036098
VERSION     NP_036098.1
DBSOURCE    REFSEQ: accession NM_011968.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 246)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 246)
  AUTHORS   Yoo,D., Park,J., Lee,C., Song,I., Lee,Y.H., Yun,T., Lee,H.,
            Heguy,A., Han,J.Y., Dasen,J.S., Kim,H. and Baek,M.
  TITLE     Little skate genome provides insights into genetic programs
            essential for limb-based locomotion
  JOURNAL   Elife 11, e78345 (2022)
   PUBMED   36288084
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 246)
  AUTHORS   Kondo,H., Matsumura,T., Kaneko,M., Inoue,K., Kosako,H., Ikawa,M.,
            Takahama,Y. and Ohigashi,I.
  TITLE     PITHD1 is a proteasome-interacting protein essential for male
            fertilization
  JOURNAL   J Biol Chem 295 (6), 1658-1672 (2020)
   PUBMED   31915251
REFERENCE   4  (residues 1 to 246)
  AUTHORS   Lukic,Z., Hausmann,S., Sebastian,S., Rucci,J., Sastri,J.,
            Robia,S.L., Luban,J. and Campbell,E.M.
  TITLE     TRIM5alpha associates with proteasomal subunits in cells while in
            complex with HIV-1 virions
  JOURNAL   Retrovirology 8, 93 (2011)
   PUBMED   22078707
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 246)
  AUTHORS   Zhang,W. and Wei,Q.
  TITLE     Calcineurin stimulates the expression of inflammatory factors in
            RAW 264.7 cells by interacting with proteasome subunit alpha type 6
  JOURNAL   Biochem Biophys Res Commun 407 (4), 668-673 (2011)
   PUBMED   21420386
  REMARK    GeneRIF: In this study a novel interaction between calcineurin and
            the 20S proteasome subunit PSMA6 that increased intracellular
            proteasomal activity was identified.
REFERENCE   6  (residues 1 to 246)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   7  (residues 1 to 246)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   8  (residues 1 to 246)
  AUTHORS   De Conto,F., Pilotti,E., Razin,S.V., Ferraglia,F., Geraud,G.,
            Arcangeletti,C. and Scherrer,K.
  TITLE     In mouse myoblasts nuclear prosomes are associated with the nuclear
            matrix and accumulate preferentially in the perinucleolar areas
  JOURNAL   J Cell Sci 113 (Pt 13), 2399-2407 (2000)
   PUBMED   10852819
REFERENCE   9  (residues 1 to 246)
  AUTHORS   Elenich,L.A., Nandi,D., Kent,A.E., McCluskey,T.S., Cruz,M.,
            Iyer,M.N., Woodward,E.C., Conn,C.W., Ochoa,A.L., Ginsburg,D.B. and
            Monaco,J.J.
  TITLE     The complete primary structure of mouse 20S proteasomes
  JOURNAL   Immunogenetics 49 (10), 835-842 (1999)
   PUBMED   10436176
REFERENCE   10 (residues 1 to 246)
  AUTHORS   Coux,O., Nothwang,H.G., Silva Pereira,I., Recillas Targa,F., Bey,F.
            and Scherrer,K.
  TITLE     Phylogenic relationships of the amino acid sequences of prosome
            (proteasome, MCP) subunits
  JOURNAL   Mol Gen Genet 245 (6), 769-780 (1994)
   PUBMED   7830725
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY340104.1, BC086685.1 and AV265469.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV074934.1, BU520349.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..246
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 23.94 cM"
     Protein         1..246
                     /product="proteasome subunit alpha type-6 isoform 1"
                     /EC_number="3.4.25.1"
                     /note="proteasome subunit alpha type-6; macropain iota
                     chain; alpha-1; proteasome iota chain; multicatalytic
                     endopeptidase complex iota chain; proteasome (prosome,
                     macropain) subunit, alpha type 6; proteasome subunit
                     alpha-1"
                     /calculated_mol_wt=27241
     Site            5
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) serine.
                     /evidence=ECO:0000269|PubMed:22556278; propagated from
                     UniProtKB/Swiss-Prot (Q9QUM9.1)"
     Region          8..220
                     /region_name="proteasome_alpha_type_6"
                     /note="The 20S proteasome, multisubunit proteolytic
                     complex, is the central enzyme of nonlysosomal protein
                     degradation in both the cytosol and nucleus. It is
                     composed of 28 subunits arranged as four homoheptameric
                     rings that stack on top of one another forming...;
                     cd03754"
                     /db_xref="CDD:239723"
     Site            order(11..14,16..17,19..20,24,27,30..31,34,43,58,60..61,
                     84..86,88..89,120,123,126..127,130..134,152,157..158,160,
                     162..163,165)
                     /site_type="other"
                     /note="alpha subunit interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:239723"
     Site            17
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P60900; propagated from
                     UniProtKB/Swiss-Prot (Q9QUM9.1)"
     Site            order(37,53,55,68,170)
                     /site_type="active"
                     /db_xref="CDD:239723"
     Site            63
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P60900; propagated from
                     UniProtKB/Swiss-Prot (Q9QUM9.1)"
     Site            64
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P60900; propagated from
                     UniProtKB/Swiss-Prot (Q9QUM9.1)"
     Site            102
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P60900; propagated from
                     UniProtKB/Swiss-Prot (Q9QUM9.1)"
     Site            104
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q9QUM9.1)"
     Site            159
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:18034455; propagated from
                     UniProtKB/Swiss-Prot (Q9QUM9.1)"
     CDS             1..246
                     /gene="Psma6"
                     /gene_synonym="IOTA"
                     /coded_by="NM_011968.3:92..832"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS25917.1"
                     /db_xref="GeneID:26443"
                     /db_xref="MGI:MGI:1347006"
ORIGIN      
        1 msrgssagfd rhitifspeg rlyqveyafk ainqggltsv avrgkdcavi vtqkkvpdkl
       61 ldsstvthlf kitesigcvm tgmtadsrsq vqraryeaan wkykygyeip vdmlckriad
      121 isqvytqnae mrplgccmil igideeqgpq vykcdpagyy cgfkataagv kqtestsfle
      181 kkvkkkfdwt feqtvetait clstvlsidf kpseievgvv tvenpkfril teaeidahlv
      241 alaerd
//
