LOCUS       NM_001409691            1252 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus proteasome subunit alpha 4 (Psma4), transcript variant
            2, mRNA.
ACCESSION   NM_001409691 XM_006511198
VERSION     NM_001409691.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1252)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1252)
  AUTHORS   Zhang,Y., Lan,M., Liu,C., Wang,T., Liu,C., Wu,S. and Meng,Q.
  TITLE     Islr regulates insulin sensitivity by interacting with Psma4 to
            control insulin receptor alpha levels in obese mice
  JOURNAL   Int J Biochem Cell Biol 159, 106420 (2023)
   PUBMED   37116777
  REMARK    GeneRIF: Islr regulates insulin sensitivity by interacting with
            Psma4 to control insulin receptor alpha levels in obese mice.
REFERENCE   3  (bases 1 to 1252)
  AUTHORS   Zhang,Z.H., Jiang,T.X., Chen,L.B., Zhou,W., Liu,Y., Gao,F. and
            Qiu,X.B.
  TITLE     Proteasome subunit alpha4s is essential for formation of
            spermatoproteasomes and histone degradation during meiotic DNA
            repair in spermatocytes
  JOURNAL   J Biol Chem 296, 100130 (2021)
   PUBMED   33262216
  REMARK    GeneRIF: Proteasome subunit alpha4s is essential for formation of
            spermatoproteasomes and histone degradation during meiotic DNA
            repair in spermatocytes.
REFERENCE   4  (bases 1 to 1252)
  AUTHORS   Hamazaki,J., Hirayama,S. and Murata,S.
  TITLE     Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated
            Proteins and Cellular Homeostasis
  JOURNAL   PLoS Genet 11 (7), e1005401 (2015)
   PUBMED   26222436
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1252)
  AUTHORS   Uechi,H., Hamazaki,J. and Murata,S.
  TITLE     Characterization of the testis-specific proteasome subunit alpha4s
            in mammals
  JOURNAL   J Biol Chem 289 (18), 12365-12374 (2014)
   PUBMED   24668818
  REMARK    GeneRIF: Data indicate that proteasome subunit alpha4 (alpha4s) is
            exclusively expressed in germ cells that enter the meiotic
            prophase.
REFERENCE   6  (bases 1 to 1252)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   7  (bases 1 to 1252)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   8  (bases 1 to 1252)
  AUTHORS   Jung,T., Engels,M., Kaiser,B., Poppek,D. and Grune,T.
  TITLE     Intracellular distribution of oxidized proteins and proteasome in
            HT22 cells during oxidative stress
  JOURNAL   Free Radic Biol Med 40 (8), 1303-1312 (2006)
   PUBMED   16631520
REFERENCE   9  (bases 1 to 1252)
  AUTHORS   Kerns,R.T., Ravindranathan,A., Hassan,S., Cage,M.P., York,T.,
            Sikela,J.M., Williams,R.W. and Miles,M.F.
  TITLE     Ethanol-responsive brain region expression networks: implications
            for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J
            mice
  JOURNAL   J Neurosci 25 (9), 2255-2266 (2005)
   PUBMED   15745951
REFERENCE   10 (bases 1 to 1252)
  AUTHORS   Elenich,L.A., Nandi,D., Kent,A.E., McCluskey,T.S., Cruz,M.,
            Iyer,M.N., Woodward,E.C., Conn,C.W., Ochoa,A.L., Ginsburg,D.B. and
            Monaco,J.J.
  TITLE     The complete primary structure of mouse 20S proteasomes
  JOURNAL   Immunogenetics 49 (10), 835-842 (1999)
   PUBMED   10436176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161264.2.
            
            On Jul 21, 2022 this sequence version replaced XM_006511198.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4565010.1,
                                           SRR3224863.9583.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC161264.2         73064-73177         c
            115-199             AC161264.2         72539-72623         c
            200-226             AC161264.2         71859-71885         c
            227-269             AC161264.2         71584-71626         c
            270-432             AC161264.2         71126-71288         c
            433-510             AC161264.2         69227-69304         c
            511-599             AC161264.2         68998-69086         c
            600-730             AC161264.2         67580-67710         c
            731-854             AC161264.2         67033-67156         c
            855-1252            AC161264.2         65935-66332         c
FEATURES             Location/Qualifiers
     source          1..1252
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 29.84 cM"
     gene            1..1252
                     /gene="Psma4"
                     /gene_synonym="C9"
                     /note="proteasome subunit alpha 4"
                     /db_xref="GeneID:26441"
                     /db_xref="MGI:MGI:1347060"
     exon            1..114
                     /gene="Psma4"
                     /gene_synonym="C9"
                     /inference="alignment:Splign:2.1.0"
     exon            115..199
                     /gene="Psma4"
                     /gene_synonym="C9"
                     /inference="alignment:Splign:2.1.0"
     exon            200..226
                     /gene="Psma4"
                     /gene_synonym="C9"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..1009
                     /gene="Psma4"
                     /gene_synonym="C9"
                     /EC_number="3.4.25.1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     proteasome subunit alpha type-4; proteasome (prosome,
                     macropain) subunit, alpha type 4; macropain subunit C9;
                     proteasome subunit L; proteasome component C9;
                     multicatalytic endopeptidase complex subunit C9; alpha-3;
                     proteasome subunit alpha-3"
                     /codon_start=1
                     /product="proteasome subunit alpha type-4 isoform 1"
                     /protein_id="NP_001396620.1"
                     /db_xref="GeneID:26441"
                     /db_xref="MGI:MGI:1347060"
                     /translation="MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVL
                     LAAERRNIHKLLDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQ
                     EPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWK
                     ATCIGNNSAAAVSMLKQDYKEGEMTLKSALALAVKVLNKTMDVSKLSAEKVEIATLTR
                     ESGKTVIRVLKQKEVEQLIKKHEEEEAKAEREKKEKEQREKDK"
     exon            227..269
                     /gene="Psma4"
                     /gene_synonym="C9"
                     /inference="alignment:Splign:2.1.0"
     exon            270..432
                     /gene="Psma4"
                     /gene_synonym="C9"
                     /inference="alignment:Splign:2.1.0"
     exon            433..510
                     /gene="Psma4"
                     /gene_synonym="C9"
                     /inference="alignment:Splign:2.1.0"
     exon            511..599
                     /gene="Psma4"
                     /gene_synonym="C9"
                     /inference="alignment:Splign:2.1.0"
     exon            600..730
                     /gene="Psma4"
                     /gene_synonym="C9"
                     /inference="alignment:Splign:2.1.0"
     exon            731..854
                     /gene="Psma4"
                     /gene_synonym="C9"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1252
                     /gene="Psma4"
                     /gene_synonym="C9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1231..1236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psma4"
                     /gene_synonym="C9"
                     /note="hexamer: AATAAA"
     polyA_site      1252
                     /gene="Psma4"
                     /gene_synonym="C9"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcctgc gcacgcgcgg gagccatatt cgccgcggat gcttggccat ccgggttggt
       61 tcttctccag ctgagtaaag aggcgctgat ctgcaccctc accgtcttcc tctggttaac
      121 tctccttagg cctgacgact cttctaaaat gtcacttccc gtggtccttg aatccagccc
      181 gtcggtgaag cggtcttaag aatcaacata aagttcagaa accatgtctc gaagatatga
      241 ctccaggacc acaatatttt ctccagaagg tcgcttatac caagtggagt atgccatgga
      301 agccattgga catgcaggca cctgtttggg gattttagcc aatgatggag ttttgcttgc
      361 agcggagagg cgcaacatcc acaagcttct tgatgaagtc ttcttttctg agaaaattta
      421 taaacttaat gaggacatgg cttgcagcgt ggcaggcata acatctgatg ctaacgttct
      481 gactaacgag ctaaggctca ttgctcaacg gtacttatta cagtatcagg agccaattcc
      541 ctgtgagcag ttggttacag cactgtgtga tatcaaacag gcgtacacac agtttggagg
      601 caaacgtccc tttggtgttt ctttgctgta tattggctgg gataagcact atggctttca
      661 gctctatcag agtgacccaa gtggaaacta tgggggatgg aaagccacat gcattgggaa
      721 caacagtgct gcggctgtgt caatgttgaa acaagactac aaagaaggcg aaatgactct
      781 gaagtcagcg cttgctctgg ctgttaaggt gctaaataag acaatggatg ttagtaaact
      841 gtcagctgaa aaagtggaaa tcgccacact aacaagagag agtgggaaga cggtgatcag
      901 agtcctcaag caaaaggaag tggaacagtt gatcaaaaaa catgaagagg aagaagctaa
      961 ggctgagcgg gagaagaaag aaaaagaaca gagagaaaag gataaataga cagaatcacg
     1021 gattttataa ctccttagag gcaccaattc acttaggagc tgtcctggcc ttccaccccg
     1081 gaagtgtttt cttgtattat cttccttacc ttggccatcg gggaaatagg acattacata
     1141 ctgaattggg tccatgtctg tccagttgga tgctttattg taatgatgga catctttata
     1201 aacatcttaa tctcaacaca taatttttgg aataaaactt ggaaagattg gt
//
