LOCUS       NM_001310596            2369 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus proteasome subunit alpha 3 (Psma3), transcript variant
            3, mRNA.
ACCESSION   NM_001310596 XM_006515607
VERSION     NM_001310596.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2369)
  AUTHORS   Shin,S.W., Vogt,E.J., Jimenez-Movilla,M., Baibakov,B. and Dean,J.
  TITLE     Cytoplasmic cleavage of DPPA3 is required for intracellular
            trafficking and cleavage-stage development in mice
  JOURNAL   Nat Commun 8 (1), 1643 (2017)
   PUBMED   29158485
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2369)
  AUTHORS   Geng,S., White,S.N., Paine,M.L. and Snead,M.L.
  TITLE     Protein Interaction between Ameloblastin and Proteasome Subunit
            alpha Type 3 Can Facilitate Redistribution of Ameloblastin Domains
            within Forming Enamel
  JOURNAL   J Biol Chem 290 (34), 20661-20673 (2015)
   PUBMED   26070558
  REMARK    GeneRIF: Protein interaction between Ambn and Psma3 can facilitate
            redistribution of ameloblastin domains within forming enamel.
REFERENCE   3  (bases 1 to 2369)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   4  (bases 1 to 2369)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   5  (bases 1 to 2369)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 2369)
  AUTHORS   Tanida,I., Tanida-Miyake,E., Nishitani,T., Komatsu,M., Yamazaki,H.,
            Ueno,T. and Kominami,E.
  TITLE     Murine Apg12p has a substrate preference for murine Apg7p over
            three Apg8p homologs
  JOURNAL   Biochem Biophys Res Commun 292 (1), 256-262 (2002)
   PUBMED   11890701
REFERENCE   7  (bases 1 to 2369)
  AUTHORS   Gao,Y., Lecker,S., Post,M.J., Hietaranta,A.J., Li,J., Volk,R.,
            Li,M., Sato,K., Saluja,A.K., Steer,M.L., Goldberg,A.L. and
            Simons,M.
  TITLE     Inhibition of ubiquitin-proteasome pathway-mediated I kappa B alpha
            degradation by a naturally occurring antibacterial peptide
  JOURNAL   J Clin Invest 106 (3), 439-448 (2000)
   PUBMED   10930447
REFERENCE   8  (bases 1 to 2369)
  AUTHORS   Elenich,L.A., Nandi,D., Kent,A.E., McCluskey,T.S., Cruz,M.,
            Iyer,M.N., Woodward,E.C., Conn,C.W., Ochoa,A.L., Ginsburg,D.B. and
            Monaco,J.J.
  TITLE     The complete primary structure of mouse 20S proteasomes
  JOURNAL   Immunogenetics 49 (10), 835-842 (1999)
   PUBMED   10436176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132325.4.
            
            On Jul 16, 2015 this sequence version replaced XM_006515607.2.
            
            Transcript Variant: This variant (3) differs in the 5' structure,
            lacks a portion of the 5' coding region, and initiates translation
            at a downstream start site, compared to variant 1. The encoded
            isoform (b) has a shorter N-terminus compared to isoform a.
            Variants 2 and 3 encode the same isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA978494.1, SRR7345562.4768059.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AC132325.4         96887-97031
            146-228             AC132325.4         100997-101079
            229-347             AC132325.4         105588-105706
            348-449             AC132325.4         106757-106858
            450-523             AC132325.4         106936-107009
            524-596             AC132325.4         109127-109199
            597-662             AC132325.4         110688-110753
            663-709             AC132325.4         112749-112795
            710-777             AC132325.4         115277-115344
            778-842             AC132325.4         115770-115834
            843-2369            AC132325.4         116615-118141
FEATURES             Location/Qualifiers
     source          1..2369
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 29.39 cM"
     gene            1..2369
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /note="proteasome subunit alpha 3"
                     /db_xref="GeneID:19167"
                     /db_xref="MGI:MGI:104883"
     exon            1..145
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /inference="alignment:Splign:2.1.0"
     exon            146..228
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /inference="alignment:Splign:2.1.0"
     exon            229..347
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..887
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /EC_number="3.4.25.1"
                     /note="isoform b is encoded by transcript variant 3;
                     proteasome subunit alpha type-3; macropain subunit C8;
                     proteasome (prosome, macropain) subunit, alpha type 3;
                     proteasome subunit K; proteasome component C8;
                     multicatalytic endopeptidase complex subunit C8; alpha-7;
                     proteasome subunit alpha-7"
                     /codon_start=1
                     /product="proteasome subunit alpha type-3 isoform b"
                     /protein_id="NP_001297525.1"
                     /db_xref="CCDS:CCDS79119.1"
                     /db_xref="GeneID:19167"
                     /db_xref="MGI:MGI:104883"
                     /translation="MAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMY
                     VHAYTLYSAVRPFGCSFMLGSYSANDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEI
                     EKLQMKEMTCRDVVKEVAKIIYIVHDEVKDKAFELELSWVGELTKGRHEIVPKDIREE
                     AEKYAKESLKEEDESDDDNM"
     exon            348..449
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /inference="alignment:Splign:2.1.0"
     exon            450..523
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /inference="alignment:Splign:2.1.0"
     exon            524..596
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /inference="alignment:Splign:2.1.0"
     exon            597..662
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /inference="alignment:Splign:2.1.0"
     exon            663..709
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /inference="alignment:Splign:2.1.0"
     exon            710..777
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /inference="alignment:Splign:2.1.0"
     exon            778..842
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /inference="alignment:Splign:2.1.0"
     exon            843..2369
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      991..996
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /note="hexamer: TATAAA"
     polyA_site      1009
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /note="major polyA site"
     regulatory      1507..1512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /note="hexamer: ATTAAA"
     polyA_site      1531
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
     regulatory      2340..2345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /note="hexamer: AATAAA"
     polyA_site      2369
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /note="major polyA site"
ORIGIN      
        1 aagaggaaag gctattggtg gagagcgcag ccaatgggcg agcctgttac tagcctgcgc
       61 cgtgtgcggc gtaggagcgg cgcttgaggc ctggaagcgt tccgcggcct gccgggtcag
      121 caccatgagc tccatcggca ctgggtatga cttgtcagcc tctacgttct ctcctgatgg
      181 aagagttttc caagttgaat atgccatgaa ggctgtggaa aacagtagct attgggatca
      241 gatgtaaaga tggtgttgtg tttggggtag aaaaactagt cctttctaaa ctttatgaag
      301 aaggctccaa taaacgtctt tttaatgttg atcgacatgt tggaatggca gttgcaggtt
      361 tgctggcaga tgctcgttca ttagcagaca tagcgagaga agaagcatcc aactttaggt
      421 ccaacttcgg ctataacatt cctctaaaac atcttgcaga cagagtggcc atgtatgtac
      481 acgcctatac actctacagc gctgttagac cttttggctg cagtttcatg ttggggtctt
      541 acagtgcgaa tgatggtgca cagctctata tgatcgaccc atcaggtgtt tcatatggtt
      601 actggggctg tgcgattggc aaagccaggc aggctgcaaa gacagagata gaaaagcttc
      661 agatgaagga aatgacttgc cgtgatgtag ttaaagaagt tgcaaaaata atttacatag
      721 tacacgatga agttaaggat aaagcttttg aactggagct cagctgggtt ggtgaattaa
      781 ctaaaggaag acatgaaatt gttcccaaag acataagaga ggaagcagag aaatatgcca
      841 aggaatcttt gaaggaagaa gatgaatcag atgatgacaa tatgtaatat tttcttcccc
      901 atccgctggt ttacatttct gtaacagttg catatggcta gcaccatgga ctatatatac
      961 ccactgaccg attttcatta aattttgtct tataaacatt gttgggtaat tgaagctatc
     1021 tgtgtaatat taaaatatag attgatgttt gattaaaaat tcttagaact gggcctggag
     1081 agatggctca gcagttaaga gctgctcttc caggggacat aggttcaatt cccagcacct
     1141 acaatggcag ctcacacctg tctgtaactc cagttccagg cttctgacac ctacaaactg
     1201 aggtacatgc aggcaaaaca ccaatgaata taaaataaaa ataaatgata tctacttaca
     1261 catataataa atgcaaaaat acaaatatgt atatatacag acacacatgt gtatatacat
     1321 ttaaattctt ggtgctattc tcgtgtggta gtacatgcct ttaatcctag tactcagagg
     1381 caggtggacc tcttgagttc aaggctagta ttcaaaaaaa aaaaaaaaaa aaaaaaaagc
     1441 agtgcccaga gttaaggccg aaagattgag cccacaagtt aatttatcca ttttgtttta
     1501 actagaatta aaataataat ttttagattt atttttgtgg gttttttttt tttttttttt
     1561 gcatgtttat attacaatgt ccatgcctgg tatccacgaa ggtcagaaga gctttaatct
     1621 agaactaaag ttatggatgg ctgtgaatca tgggtgctcg gaactgaacc caggtcttgt
     1681 gcaagagcaa catgtcctct taaccactga gccgtctctc cagccttctt taactagaat
     1741 gatcatatta ttctgtggtt cttgtaataa tgttgtgttt aatgtaggga cattctgtaa
     1801 ccactactga gaacagcgag ctttttgtgg aaaatgtgac agcatttatt tttcagattg
     1861 catagatatc ttatgactgg aaattatcac ctgtcttagt cagggtttct attcctgcac
     1921 aatcatcatg accaagaagc aagctgggga ggaaagggtt tattcagctt acactttcca
     1981 ttctgctgtt catcaccaaa ggaagtcagg actggaactc aaacaggtca gaaagcagga
     2041 actgatgcag aggccatgga gggatgttct ttactggctc gcttcccctg gcttgctcag
     2101 cttactttct tacagaaccc aggactacta gtccaggggt ggcaccgccc acaagggacc
     2161 ctccccactt gatcactaat tgagaaaatg ctttacagtt gggtctcaat ggaggccctt
     2221 ccctaactaa gctcctcctc tgtgataact ccagctgtgt caagttaata cacaaaccat
     2281 ccagtacagc acttgaaaca aaaactttaa ggtatcaaat tgagcttaaa tattcatgta
     2341 ataaaatgtt tatagtactt ctctgataa
//
