LOCUS       NM_001310595            2398 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus proteasome subunit alpha 3 (Psma3), transcript variant
            2, mRNA.
ACCESSION   NM_001310595 XM_006515606
VERSION     NM_001310595.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2398)
  AUTHORS   Shin,S.W., Vogt,E.J., Jimenez-Movilla,M., Baibakov,B. and Dean,J.
  TITLE     Cytoplasmic cleavage of DPPA3 is required for intracellular
            trafficking and cleavage-stage development in mice
  JOURNAL   Nat Commun 8 (1), 1643 (2017)
   PUBMED   29158485
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2398)
  AUTHORS   Geng,S., White,S.N., Paine,M.L. and Snead,M.L.
  TITLE     Protein Interaction between Ameloblastin and Proteasome Subunit
            alpha Type 3 Can Facilitate Redistribution of Ameloblastin Domains
            within Forming Enamel
  JOURNAL   J Biol Chem 290 (34), 20661-20673 (2015)
   PUBMED   26070558
  REMARK    GeneRIF: Protein interaction between Ambn and Psma3 can facilitate
            redistribution of ameloblastin domains within forming enamel.
REFERENCE   3  (bases 1 to 2398)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   4  (bases 1 to 2398)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   5  (bases 1 to 2398)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 2398)
  AUTHORS   Tanida,I., Tanida-Miyake,E., Nishitani,T., Komatsu,M., Yamazaki,H.,
            Ueno,T. and Kominami,E.
  TITLE     Murine Apg12p has a substrate preference for murine Apg7p over
            three Apg8p homologs
  JOURNAL   Biochem Biophys Res Commun 292 (1), 256-262 (2002)
   PUBMED   11890701
REFERENCE   7  (bases 1 to 2398)
  AUTHORS   Gao,Y., Lecker,S., Post,M.J., Hietaranta,A.J., Li,J., Volk,R.,
            Li,M., Sato,K., Saluja,A.K., Steer,M.L., Goldberg,A.L. and
            Simons,M.
  TITLE     Inhibition of ubiquitin-proteasome pathway-mediated I kappa B alpha
            degradation by a naturally occurring antibacterial peptide
  JOURNAL   J Clin Invest 106 (3), 439-448 (2000)
   PUBMED   10930447
REFERENCE   8  (bases 1 to 2398)
  AUTHORS   Elenich,L.A., Nandi,D., Kent,A.E., McCluskey,T.S., Cruz,M.,
            Iyer,M.N., Woodward,E.C., Conn,C.W., Ochoa,A.L., Ginsburg,D.B. and
            Monaco,J.J.
  TITLE     The complete primary structure of mouse 20S proteasomes
  JOURNAL   Immunogenetics 49 (10), 835-842 (1999)
   PUBMED   10436176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY159585.1, AI303320.1, AK169577.1 and AC132325.4.
            
            On Jul 16, 2015 this sequence version replaced XM_006515606.2.
            
            Transcript Variant: This variant (2) differs in the 5' structure,
            lacks a portion of the 5' coding region, and initiates translation
            at a downstream start site, compared to variant 1. The encoded
            isoform (b) has a shorter N-terminus compared to isoform a.
            Variants 2 and 3 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169577.1, CA321730.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BY159585.1         1-11
            12-98               AI303320.1         11-97
            99-875              AK169577.1         2-778
            876-876             AC132325.4         116619-116619
            877-1036            AK169577.1         780-939
            1037-2398           AC132325.4         116780-118141
FEATURES             Location/Qualifiers
     source          1..2398
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 29.39 cM"
     gene            1..2398
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /note="proteasome subunit alpha 3"
                     /db_xref="GeneID:19167"
                     /db_xref="MGI:MGI:104883"
     exon            1..145
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /inference="alignment:Splign:2.1.0"
     exon            146..252
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /inference="alignment:Splign:2.1.0"
     exon            253..376
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /inference="alignment:Splign:2.1.0"
     CDS             374..916
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /EC_number="3.4.25.1"
                     /note="isoform b is encoded by transcript variant 2;
                     proteasome subunit alpha type-3; macropain subunit C8;
                     proteasome (prosome, macropain) subunit, alpha type 3;
                     proteasome subunit K; proteasome component C8;
                     multicatalytic endopeptidase complex subunit C8; alpha-7;
                     proteasome subunit alpha-7"
                     /codon_start=1
                     /product="proteasome subunit alpha type-3 isoform b"
                     /protein_id="NP_001297524.1"
                     /db_xref="CCDS:CCDS79119.1"
                     /db_xref="GeneID:19167"
                     /db_xref="MGI:MGI:104883"
                     /translation="MAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMY
                     VHAYTLYSAVRPFGCSFMLGSYSANDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEI
                     EKLQMKEMTCRDVVKEVAKIIYIVHDEVKDKAFELELSWVGELTKGRHEIVPKDIREE
                     AEKYAKESLKEEDESDDDNM"
     exon            377..478
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /inference="alignment:Splign:2.1.0"
     exon            479..552
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /inference="alignment:Splign:2.1.0"
     exon            553..625
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /inference="alignment:Splign:2.1.0"
     exon            626..691
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /inference="alignment:Splign:2.1.0"
     exon            692..738
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /inference="alignment:Splign:2.1.0"
     exon            739..806
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /inference="alignment:Splign:2.1.0"
     exon            807..871
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /inference="alignment:Splign:2.1.0"
     exon            872..2398
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1020..1025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /note="hexamer: TATAAA"
     polyA_site      1038
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /note="major polyA site"
     regulatory      1536..1541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /note="hexamer: ATTAAA"
     polyA_site      1560
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
     regulatory      2369..2374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /note="hexamer: AATAAA"
     polyA_site      2398
                     /gene="Psma3"
                     /gene_synonym="Lmpc8"
                     /note="major polyA site"
ORIGIN      
        1 aagaggaaag gctattggtg gagagcgcag ccaatgggcg agcctgttac tagcctgcgc
       61 cgtgtgcggc gtaggagcgg cgcttgaggc ctggaagcgt tccgcggcct gccgggtcag
      121 caccatgagc tccatcggca ctgggtatga cttgtcagcc tctacgttct ctcctgatgg
      181 aagagttttc caagttgaat atgccatgaa ggctgtggaa aacagtaggt aagaagccct
      241 gtttgatttg aatacagcta ttgggatcag atgtaaagat ggtgttgtgt ttggggtaga
      301 aaaactagtc ctttctaaac tttatgaaga aggctccaat aaacgtcttt ttaatgttga
      361 tcgacatgtt ggaatggcag ttgcaggttt gctggcagat gctcgttcat tagcagacat
      421 agcgagagaa gaagcatcca actttaggtc caacttcggc tataacattc ctctaaaaca
      481 tcttgcagac agagtggcca tgtatgtaca cgcctataca ctctacagcg ctgttagacc
      541 ttttggctgc agtttcatgt tggggtctta cagtgcgaat gatggtgcac agctctatat
      601 gatcgaccca tcaggtgttt catatggtta ctggggctgt gcgattggca aagccaggca
      661 ggctgcaaag acagagatag aaaagcttca gatgaaggaa atgacttgcc gtgatgtagt
      721 taaagaagtt gcaaaaataa tttacatagt acacgatgaa gttaaggata aagcttttga
      781 actggagctc agctgggttg gtgaattaac taaaggaaga catgaaattg ttcccaaaga
      841 cataagagag gaagcagaga aatatgccaa ggaatctttg aaggaagaag atgaatcaga
      901 tgatgacaat atgtaatatt ttcttcccca tccgctggtt tacatttctg taacagttgc
      961 atatggctag caccatggac tatatatacc cactgaccga ttttcattaa attttgtctt
     1021 ataaacattg ttgggtaatt gaagctatct gtgtaatatt aaaatataga ttgatgtttg
     1081 attaaaaatt cttagaactg ggcctggaga gatggctcag cagttaagag ctgctcttcc
     1141 aggggacata ggttcaattc ccagcaccta caatggcagc tcacacctgt ctgtaactcc
     1201 agttccaggc ttctgacacc tacaaactga ggtacatgca ggcaaaacac caatgaatat
     1261 aaaataaaaa taaatgatat ctacttacac atataataaa tgcaaaaata caaatatgta
     1321 tatatacaga cacacatgtg tatatacatt taaattcttg gtgctattct cgtgtggtag
     1381 tacatgcctt taatcctagt actcagaggc aggtggacct cttgagttca aggctagtat
     1441 tcaaaaaaaa aaaaaaaaaa aaaaaaagca gtgcccagag ttaaggccga aagattgagc
     1501 ccacaagtta atttatccat tttgttttaa ctagaattaa aataataatt tttagattta
     1561 tttttgtggg tttttttttt tttttttttg catgtttata ttacaatgtc catgcctggt
     1621 atccacgaag gtcagaagag ctttaatcta gaactaaagt tatggatggc tgtgaatcat
     1681 gggtgctcgg aactgaaccc aggtcttgtg caagagcaac atgtcctctt aaccactgag
     1741 ccgtctctcc agccttcttt aactagaatg atcatattat tctgtggttc ttgtaataat
     1801 gttgtgttta atgtagggac attctgtaac cactactgag aacagcgagc tttttgtgga
     1861 aaatgtgaca gcatttattt ttcagattgc atagatatct tatgactgga aattatcacc
     1921 tgtcttagtc agggtttcta ttcctgcaca atcatcatga ccaagaagca agctggggag
     1981 gaaagggttt attcagctta cactttccat tctgctgttc atcaccaaag gaagtcagga
     2041 ctggaactca aacaggtcag aaagcaggaa ctgatgcaga ggccatggag ggatgttctt
     2101 tactggctcg cttcccctgg cttgctcagc ttactttctt acagaaccca ggactactag
     2161 tccaggggtg gcaccgccca caagggaccc tccccacttg atcactaatt gagaaaatgc
     2221 tttacagttg ggtctcaatg gaggcccttc cctaactaag ctcctcctct gtgataactc
     2281 cagctgtgtc aagttaatac acaaaccatc cagtacagca cttgaaacaa aaactttaag
     2341 gtatcaaatt gagcttaaat attcatgtaa taaaatgttt atagtacttc tctgataa
//
