LOCUS       NM_008944                963 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus proteasome subunit alpha 2 (Psma2), mRNA.
ACCESSION   NM_008944
VERSION     NM_008944.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 963)
  AUTHORS   Xing,L., Simon,J.M., Ptacek,T.S., Yi,J.J., Loo,L., Mao,H.,
            Wolter,J.M., McCoy,E.S., Paranjape,S.R., Taylor-Blake,B. and
            Zylka,M.J.
  TITLE     Autism-linked UBE3A gain-of-function mutation causes interneuron
            and behavioral phenotypes when inherited maternally or paternally
            in mice
  JOURNAL   Cell Rep 42 (7), 112706 (2023)
   PUBMED   37389991
REFERENCE   2  (bases 1 to 963)
  AUTHORS   Lukic,Z., Hausmann,S., Sebastian,S., Rucci,J., Sastri,J.,
            Robia,S.L., Luban,J. and Campbell,E.M.
  TITLE     TRIM5alpha associates with proteasomal subunits in cells while in
            complex with HIV-1 virions
  JOURNAL   Retrovirology 8, 93 (2011)
   PUBMED   22078707
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 963)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   4  (bases 1 to 963)
  AUTHORS   Qiu,X.B., Ouyang,S.Y., Li,C.J., Miao,S., Wang,L. and Goldberg,A.L.
  TITLE     hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the
            deubiquitinating enzyme, UCH37
  JOURNAL   EMBO J 25 (24), 5742-5753 (2006)
   PUBMED   17139257
REFERENCE   5  (bases 1 to 963)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   6  (bases 1 to 963)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 963)
  AUTHORS   Bommel,H., Xie,G., Rossoll,W., Wiese,S., Jablonka,S., Boehm,T. and
            Sendtner,M.
  TITLE     Missense mutation in the tubulin-specific chaperone E (Tbce) gene
            in the mouse mutant progressive motor neuronopathy, a model of
            human motoneuron disease
  JOURNAL   J Cell Biol 159 (4), 563-569 (2002)
   PUBMED   12446740
REFERENCE   8  (bases 1 to 963)
  AUTHORS   Neidhardt,L., Gasca,S., Wertz,K., Obermayr,F., Worpenberg,S.,
            Lehrach,H. and Herrmann,B.G.
  TITLE     Large-scale screen for genes controlling mammalian embryogenesis,
            using high-throughput gene expression analysis in mouse embryos
  JOURNAL   Mech Dev 98 (1-2), 77-94 (2000)
   PUBMED   11044609
REFERENCE   9  (bases 1 to 963)
  AUTHORS   Elenich,L.A., Nandi,D., Kent,A.E., McCluskey,T.S., Cruz,M.,
            Iyer,M.N., Woodward,E.C., Conn,C.W., Ochoa,A.L., Ginsburg,D.B. and
            Monaco,J.J.
  TITLE     The complete primary structure of mouse 20S proteasomes
  JOURNAL   Immunogenetics 49 (10), 835-842 (1999)
   PUBMED   10436176
REFERENCE   10 (bases 1 to 963)
  AUTHORS   Seelig,A., Boes,B. and Kloetzel,P.M.
  TITLE     Characterization of mouse proteasome subunit MC3 and identification
            of proteasome subtypes with different cleavage characteristics.
            Proteasome subunits, proteasome subpopulations
  JOURNAL   Enzyme Protein 47 (4-6), 330-342 (1993)
   PUBMED   7697131
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ052982.1, AK152862.1 and BU755659.1.
            
            On Mar 23, 2007 this sequence version replaced NM_008944.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136115.1, AK035578.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                CJ052982.1         3-12
            11-860              AK152862.1         2-851
            861-866             BU755659.1         99-104              c
            867-963             BU755659.1         1-97                c
FEATURES             Location/Qualifiers
     source          1..963
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 5.36 cM"
     gene            1..963
                     /gene="Psma2"
                     /gene_synonym="Lmpc3"
                     /note="proteasome subunit alpha 2"
                     /db_xref="GeneID:19166"
                     /db_xref="MGI:MGI:104885"
     exon            1..74
                     /gene="Psma2"
                     /gene_synonym="Lmpc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..738
                     /gene="Psma2"
                     /gene_synonym="Lmpc3"
                     /EC_number="3.4.25.1"
                     /note="macropain subunit C3; proteasome component C3;
                     multicatalytic endopeptidase complex subunit C3; alpha-2;
                     proteasome (prosome, macropain) subunit, alpha type 2"
                     /codon_start=1
                     /product="proteasome subunit alpha type-2"
                     /protein_id="NP_032970.2"
                     /db_xref="CCDS:CCDS36602.1"
                     /db_xref="GeneID:19166"
                     /db_xref="MGI:MGI:104885"
                     /translation="MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGV
                     VLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQ
                     EPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKA
                     TAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGF
                     RRLTPTEVRDYLAAIA"
     exon            75..151
                     /gene="Psma2"
                     /gene_synonym="Lmpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            152..284
                     /gene="Psma2"
                     /gene_synonym="Lmpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            285..407
                     /gene="Psma2"
                     /gene_synonym="Lmpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            408..489
                     /gene="Psma2"
                     /gene_synonym="Lmpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            490..563
                     /gene="Psma2"
                     /gene_synonym="Lmpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            564..621
                     /gene="Psma2"
                     /gene_synonym="Lmpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            622..946
                     /gene="Psma2"
                     /gene_synonym="Lmpc3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      844..849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psma2"
                     /gene_synonym="Lmpc3"
                     /note="hexamer: AATAAA"
     polyA_site      882
                     /gene="Psma2"
                     /gene_synonym="Lmpc3"
                     /note="major polyA site"
     regulatory      929..934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psma2"
                     /gene_synonym="Lmpc3"
                     /note="hexamer: ATTAAA"
     polyA_site      946
                     /gene="Psma2"
                     /gene_synonym="Lmpc3"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgtggct gtgttccgac tttccgggta aagatggcag agcgcggtta cagcttctcg
       61 ctgactacat tcagcccatc tggtaagctt gtccagattg aatatgcctt ggctgcggta
      121 gctggagggg ccccgtcagt ggggattaaa gctgcaaatg gcgtagtatt agcaaccgag
      181 aaaaagcaga aatccatcct gtatgatgaa aggagtgttc acaaggtgga gcccattacc
      241 aagcacatcg gtttggtgta cagtggcatg ggccccgatt acagagtact tgtacacaga
      301 gctcggaaac ttgctcagca atactacctt gtttaccaag aacccattcc cacagcccag
      361 ctggtacaga gagtagcctc tgtgatgcag gagtacacgc agtcaggtgg tgttcgtcca
      421 tttggtgttt ctttactcat ttgtgggtgg aatgagggac gaccatattt atttcagtca
      481 gatccatctg gagcttactt tgcctggaag gccacagcaa tgggaaagaa ctatgtgaac
      541 gggaaaactt tccttgagaa aagatataat gaagacctag aactggagga tgccattcat
      601 acagccatct taaccctaaa ggaaagcttt gaagggcaga tgacagaaga taacatagaa
      661 gttgggatct gcaatgaggc tggctttagg aggctcactc caactgaagt gagggattac
      721 ctggctgcca tagcgtgatg aagatgtgct cacacactcg actttttcat gtttaaagta
      781 tgttttgttt gtgcagactt atttctacat ggtttagtgg attcacattt taaaaataat
      841 cataataaac tgttaaaacc aattttagtt tttaagagta aagtttgcat atacttcttt
      901 cttgctttct catagttgac ttttggaaat taaatggtaa aatcacaaaa aaaaaaaaaa
      961 aaa
//
