LOCUS       NM_011965               1255 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus proteasome subunit alpha 1 (Psma1), mRNA.
ACCESSION   NM_011965
VERSION     NM_011965.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1255)
  AUTHORS   Choi,J.H., Jo,H.S., Lim,S., Kim,H.T., Lee,K.W., Moon,K.H., Ha,T.,
            Kwak,S.S., Kim,Y., Lee,E.J., Joe,C.O. and Kim,J.W.
  TITLE     mTORC1 accelerates retinal development via the immunoproteasome
  JOURNAL   Nat Commun 9 (1), 2502 (2018)
   PUBMED   29950673
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1255)
  AUTHORS   Hamazaki,J., Hirayama,S. and Murata,S.
  TITLE     Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated
            Proteins and Cellular Homeostasis
  JOURNAL   PLoS Genet 11 (7), e1005401 (2015)
   PUBMED   26222436
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1255)
  AUTHORS   Sasaki,K., Hamazaki,J., Koike,M., Hirano,Y., Komatsu,M.,
            Uchiyama,Y., Tanaka,K. and Murata,S.
  TITLE     PAC1 gene knockout reveals an essential role of chaperone-mediated
            20S proteasome biogenesis and latent 20S proteasomes in cellular
            homeostasis
  JOURNAL   Mol Cell Biol 30 (15), 3864-3874 (2010)
   PUBMED   20498273
REFERENCE   4  (bases 1 to 1255)
  AUTHORS   Martinez-Solano,L., Reales-Calderon,J.A., Nombela,C., Molero,G. and
            Gil,C.
  TITLE     Proteomics of RAW 264.7 macrophages upon interaction with
            heat-inactivated Candida albicans cells unravel an
            anti-inflammatory response
  JOURNAL   Proteomics 9 (11), 2995-3010 (2009)
   PUBMED   19526544
REFERENCE   5  (bases 1 to 1255)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   6  (bases 1 to 1255)
  AUTHORS   Gomes,A.V., Zong,C., Edmondson,R.D., Li,X., Stefani,E., Zhang,J.,
            Jones,R.C., Thyparambil,S., Wang,G.W., Qiao,X., Bardag-Gorce,F. and
            Ping,P.
  TITLE     Mapping the murine cardiac 26S proteasome complexes
  JOURNAL   Circ Res 99 (4), 362-371 (2006)
   PUBMED   16857966
REFERENCE   7  (bases 1 to 1255)
  AUTHORS   Qureshi,N., Perera,P.Y., Shen,J., Zhang,G., Lenschat,A.,
            Splitter,G., Morrison,D.C. and Vogel,S.N.
  TITLE     The proteasome as a lipopolysaccharide-binding protein in
            macrophages: differential effects of proteasome inhibition on
            lipopolysaccharide-induced signaling events
  JOURNAL   J Immunol 171 (3), 1515-1525 (2003)
   PUBMED   12874245
REFERENCE   8  (bases 1 to 1255)
  AUTHORS   De Conto,F., Pilotti,E., Razin,S.V., Ferraglia,F., Geraud,G.,
            Arcangeletti,C. and Scherrer,K.
  TITLE     In mouse myoblasts nuclear prosomes are associated with the nuclear
            matrix and accumulate preferentially in the perinucleolar areas
  JOURNAL   J Cell Sci 113 (Pt 13), 2399-2407 (2000)
   PUBMED   10852819
REFERENCE   9  (bases 1 to 1255)
  AUTHORS   Hopitzan,A., Himmelbauer,H., Spevak,W. and Castanon,M.J.
  TITLE     The mouse Psma1 gene coding for the alpha-type C2 proteasome
            subunit: structural and functional analysis, mapping, and
            colocalization with Pde3b on mouse chromosome 7
  JOURNAL   Genomics 66 (3), 313-323 (2000)
   PUBMED   10873386
REFERENCE   10 (bases 1 to 1255)
  AUTHORS   Elenich,L.A., Nandi,D., Kent,A.E., McCluskey,T.S., Cruz,M.,
            Iyer,M.N., Woodward,E.C., Conn,C.W., Ochoa,A.L., Ginsburg,D.B. and
            Monaco,J.J.
  TITLE     The complete primary structure of mouse 20S proteasomes
  JOURNAL   Immunogenetics 49 (10), 835-842 (1999)
   PUBMED   10436176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY108158.1, AK162277.1 and BY425950.1.
            
            On Feb 2, 2007 this sequence version replaced NM_011965.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088673.1, AJ272019.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                BY108158.1         1-54
            55-1197             AK162277.1         2-1144
            1198-1255           BY425950.1         254-311
FEATURES             Location/Qualifiers
     source          1..1255
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 59.32 cM"
     gene            1..1255
                     /gene="Psma1"
                     /gene_synonym="alpha-type; C2; HC2; Pros-30"
                     /note="proteasome subunit alpha 1"
                     /db_xref="GeneID:26440"
                     /db_xref="MGI:MGI:1347005"
     exon            1..116
                     /gene="Psma1"
                     /gene_synonym="alpha-type; C2; HC2; Pros-30"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..905
                     /gene="Psma1"
                     /gene_synonym="alpha-type; C2; HC2; Pros-30"
                     /EC_number="3.4.25.1"
                     /note="proteasome (prosome, macropain) subunit, alpha type
                     1; 20S proteasome subunit C2; multicatalytic endopeptidase
                     complex subunit C2; proteasome nu chain; macropain subunit
                     C2; proteasome component C2; alpha-6; proteasome subunit
                     alpha-6"
                     /codon_start=1
                     /product="proteasome subunit alpha type-1"
                     /protein_id="NP_036095.1"
                     /db_xref="CCDS:CCDS40094.1"
                     /db_xref="GeneID:26440"
                     /db_xref="MGI:MGI:1347005"
                     /translation="MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHA
                     VLVALKRAQSELAAHQKKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRP
                     LPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMS
                     IGARSQSARTYLERHMSEFMECNLDELVKHGLRALRETLPAEQDLTTKNVSIGIVGKD
                     LEFTIYDDDDVSPFLDGLEERPQRKAQPSQAAEEPAEKADEPMEH"
     exon            117..161
                     /gene="Psma1"
                     /gene_synonym="alpha-type; C2; HC2; Pros-30"
                     /inference="alignment:Splign:2.1.0"
     exon            162..263
                     /gene="Psma1"
                     /gene_synonym="alpha-type; C2; HC2; Pros-30"
                     /inference="alignment:Splign:2.1.0"
     exon            264..367
                     /gene="Psma1"
                     /gene_synonym="alpha-type; C2; HC2; Pros-30"
                     /inference="alignment:Splign:2.1.0"
     exon            368..456
                     /gene="Psma1"
                     /gene_synonym="alpha-type; C2; HC2; Pros-30"
                     /inference="alignment:Splign:2.1.0"
     exon            457..527
                     /gene="Psma1"
                     /gene_synonym="alpha-type; C2; HC2; Pros-30"
                     /inference="alignment:Splign:2.1.0"
     exon            528..657
                     /gene="Psma1"
                     /gene_synonym="alpha-type; C2; HC2; Pros-30"
                     /inference="alignment:Splign:2.1.0"
     exon            658..737
                     /gene="Psma1"
                     /gene_synonym="alpha-type; C2; HC2; Pros-30"
                     /inference="alignment:Splign:2.1.0"
     exon            738..848
                     /gene="Psma1"
                     /gene_synonym="alpha-type; C2; HC2; Pros-30"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1255
                     /gene="Psma1"
                     /gene_synonym="alpha-type; C2; HC2; Pros-30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1178..1183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Psma1"
                     /gene_synonym="alpha-type; C2; HC2; Pros-30"
                     /note="hexamer: AATAAA"
     polyA_site      1197
                     /gene="Psma1"
                     /gene_synonym="alpha-type; C2; HC2; Pros-30"
                     /note="major polyA site"
ORIGIN      
        1 ttcctgcgtc gccgccgtca agactccgca ggcttctttg acgatcaccg aaccgtagtt
       61 ggggccgtgt tcctgtgtcc gctgctgggt caggttgtcg ctgcgccgga gctatgtttc
      121 gaaaccagta tgacaatgat gtcactgttt ggagccctca gggcaggatt catcaaattg
      181 aatatgcaat ggaagctgtt aagcaaggtt cagcaacagt tggtctaaaa tcaaaaacgc
      241 acgcagtgct ggttgcactg aagagagcac agtcagagct tgccgctcac cagaagaaaa
      301 ttctccatgt tgacaaccat attggtatct caattgcggg tctaactgct gatgccagac
      361 tgttatgcaa ctttatgcgc caggagtgtt tggattccag atttgtgttt gacagaccac
      421 ttcctgtgtc tcgtcttgtg tctctaattg gaagcaaaac ccagatccca acacagcgat
      481 atggccggag gccgtatggt gttgggctgc tcattgctgg ttatgatgat atgggccctc
      541 atattttcca aacctgtcca tctgctaact attttgactg cagagctatg tctattggag
      601 cccgttctca atcagctcgt acttacctgg agagacatat gtctgaattt atggagtgca
      661 atttggatga actggttaaa catggtctgc gtgccttaag agaaacactc cctgcagagc
      721 aggacctgac cacaaagaat gtttccattg gaatcgttgg taaagacttg gaatttacaa
      781 tctacgatga tgatgatgta tctccattcc tggatggtct tgaagaaaga ccacagagaa
      841 aagcacagcc ttcacaggct gctgaggaac ctgcagaaaa agccgatgaa ccaatggaac
      901 attaagtgat aaaggttaca aggacataag aatgcaggga catacactgg cgacaataat
      961 ctgtatttta aaccaacagc tgcagtgtat tgggtggtat gttttagaaa tcagtccaga
     1021 tgtaagtttt ctctaagcaa cttcacagaa accatataat ggggtgcatt ttctttgaaa
     1081 gggtatacat aatcattttc taggaagtat aggtatctat accaatgttt ttatatgaag
     1141 aaaataagtg tctttgcagt tttaaagaca actgtgaaat aaaattgttt caccacctat
     1201 tgtgtcaagt ttttgttttt aagtagtttc aactgtacat ggaagctaat attac
//
