LOCUS       NM_173432               3317 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus protein serine kinase H1 (Pskh1), mRNA.
ACCESSION   NM_173432
VERSION     NM_173432.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3317)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3317)
  AUTHORS   Potter,P.K., Bowl,M.R., Jeyarajan,P., Wisby,L., Blease,A.,
            Goldsworthy,M.E., Simon,M.M., Greenaway,S., Michel,V., Barnard,A.,
            Aguilar,C., Agnew,T., Banks,G., Blake,A., Chessum,L., Dorning,J.,
            Falcone,S., Goosey,L., Harris,S., Haynes,A., Heise,I., Hillier,R.,
            Hough,T., Hoslin,A., Hutchison,M., King,R., Kumar,S., Lad,H.V.,
            Law,G., MacLaren,R.E., Morse,S., Nicol,T., Parker,A., Pickford,K.,
            Sethi,S., Starbuck,B., Stelma,F., Cheeseman,M., Cross,S.H.,
            Foster,R.G., Jackson,I.J., Peirson,S.N., Thakker,R.V., Vincent,T.,
            Scudamore,C., Wells,S., El-Amraoui,A., Petit,C.,
            Acevedo-Arozena,A., Nolan,P.M., Cox,R., Mallon,A.M. and Brown,S.D.
  TITLE     Novel gene function revealed by mouse mutagenesis screens for
            models of age-related disease
  JOURNAL   Nat Commun 7, 12444 (2016)
   PUBMED   27534441
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3317)
  AUTHORS   Burnicka-Turek,O., Steimle,J.D., Huang,W., Felker,L., Kamp,A.,
            Kweon,J., Peterson,M., Reeves,R.H., Maslen,C.L., Gruber,P.J.,
            Yang,X.H., Shendure,J. and Moskowitz,I.P.
  TITLE     Cilia gene mutations cause atrioventricular septal defects by
            multiple mechanisms
  JOURNAL   Hum Mol Genet 25 (14), 3011-3028 (2016)
   PUBMED   27340223
REFERENCE   4  (bases 1 to 3317)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   5  (bases 1 to 3317)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 3317)
  AUTHORS   Keegan,C.E., Hutz,J.E., Else,T., Adamska,M., Shah,S.P., Kent,A.E.,
            Howes,J.M., Beamer,W.G. and Hammer,G.D.
  TITLE     Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd)
            mice is caused by a splicing mutation in a novel telomeric
            regulator
  JOURNAL   Hum Mol Genet 14 (1), 113-123 (2005)
   PUBMED   15537664
REFERENCE   7  (bases 1 to 3317)
  AUTHORS   Paronetto,M.P., Giorda,E., Carsetti,R., Rossi,P., Geremia,R. and
            Sette,C.
  TITLE     Functional interaction between p90Rsk2 and Emi1 contributes to the
            metaphase arrest of mouse oocytes
  JOURNAL   EMBO J 23 (23), 4649-4659 (2004)
   PUBMED   15526037
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC050128.1.
            
            On Jun 19, 2003 this sequence version replaced NM_173432.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050128.1, AK166338.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3317
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.06 cM"
     gene            1..3317
                     /gene="Pskh1"
                     /gene_synonym="b2b1230Clo; E130013P03Rik"
                     /note="protein serine kinase H1"
                     /db_xref="GeneID:244631"
                     /db_xref="MGI:MGI:3528383"
     exon            1..67
                     /gene="Pskh1"
                     /gene_synonym="b2b1230Clo; E130013P03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            68..1094
                     /gene="Pskh1"
                     /gene_synonym="b2b1230Clo; E130013P03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1412
                     /gene="Pskh1"
                     /gene_synonym="b2b1230Clo; E130013P03Rik"
                     /EC_number="2.7.11.1"
                     /note="PSK-H1; Mutant line 1230"
                     /codon_start=1
                     /product="serine/threonine-protein kinase H1"
                     /protein_id="NP_775608.1"
                     /db_xref="CCDS:CCDS22619.1"
                     /db_xref="GeneID:244631"
                     /db_xref="MGI:MGI:3528383"
                     /translation="MGCGTSKVLPEPPKDVQLDLVKKVEPFSGTKNDVYKHFITEVDS
                     VGPLKAGFPATSQYAPPCPGVPNTGHTAPPSEPPRRARVAKYRAKFDPRVTAKYDIKA
                     LIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVE
                     VFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRD
                     LKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTN
                     SVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYLGEPWPSVSNLAKDFIDR
                     LLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSRCQSTKSSQST
                     RSSRSTRSNKSRRVRERELRELNLRYQQQYNG"
     exon            1095..3246
                     /gene="Pskh1"
                     /gene_synonym="b2b1230Clo; E130013P03Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtggcctgg gctgggagac ggtgggctga gccgccgaga ctccggagag cccgccgccc
       61 gcgcgaggtg tagtcggggc actgcctaca gagcaggtcc tgccagcctc gctggagagg
      121 atgcccccgt gtcagtgatg ggctgtggga caagcaaggt ccttcctgag ccacccaagg
      181 atgtccagct ggatctggtc aagaaagtgg agcccttcag tggcactaag aatgatgtat
      241 acaagcactt catcacagag gtggacagtg ttggccctct caaagctggc ttcccagcta
      301 ctagtcagta tgcacctccc tgccctggtg ttcccaatac tggccacaca gcgcctcctt
      361 cagaaccacc acgaagggcc agggtggcaa agtacagggc caaatttgac ccacgagtga
      421 cagctaagta tgatataaag gccctaattg ggcgaggcag ctttagccga gtggtacgtg
      481 tggagcaccg ggcaacccga cagccatatg ctatcaagat gatagagacc aagtaccgag
      541 aagggcggga ggtgtgtgag tccgagctcc gagtgctgcg ccgggtgcgc cacgccaaca
      601 tcatccagct ggtagaagtg tttgagacac aggagcgtgt atatatggtg atggagctgg
      661 ccactggcgg tgagctcttt gaccggatta ttgccaaggg ttctttcact gaacgagatg
      721 ccacaagagt gcttcaaatg gtactggatg gtgtccggta tcttcatgcc cttggcatta
      781 cacaccgaga cctcaagcct gagaatctcc tttactacca cccaggcact gactccaaga
      841 tcatcatcac tgactttggc ttggccagtg cccggaagaa aggtgacgac tgcctgatga
      901 agaccacgtg cggcacacct gagtacattg ctcctgaggt tctggtgcga aaaccctaca
      961 ccaattccgt ggatatgtgg gcactgggtg tcattgccta catcctgctc agcggcacca
     1021 tgccctttga ggatgacaac cgcacccggc tataccggca gatcctcagg ggcaaataca
     1081 gttatctggg ggagccctgg cctagtgtat ctaatctggc caaggacttc attgaccgcc
     1141 tgctgaccgt ggaccctgga gcccggatga ctgcactgca ggccctaaga cacccatggg
     1201 tagtaagcat ggcagcctct tcatccatga agaatctgca ccgatccatc tcccagaatc
     1261 tcctcaagcg ggcttcctct cgttgccaga gcaccaagtc ttcccagtcc acgcgttcca
     1321 gccgctccac tcgttccaac aagtcacgcc gtgttcggga gcgcgaactg cgggagctta
     1381 acctgcgcta tcaacagcag tataacggct gagccaccag ctatgacatg gacacactag
     1441 tgtctcatct ggacactttc tgccatgtca cctgggccta ataccttctc tatagctaga
     1501 cctcatgccc agcagtatgt agggtatgtc tggacccagc tcctctctgt acctttagta
     1561 gcccctacct cctatcacag gcctggcctg ttaggatgga atggtggcag gactgagtct
     1621 ccactgatct ctttaatttt tgccactttc ttggaccaag cggggctact gtgttgggta
     1681 gaagggtcct atggctcagg actctttacc cattcctttt ataaccccct tccctccaca
     1741 gagctttgtc tagctcccac atcctctgcc atgccaatcc ttaagattat gctccagtgg
     1801 gaggtctggc ttgtgccgta gctaactcgc ctcattagtc ctttagtcct ttagctccag
     1861 ttagtctcca gcaaccctct ctcccccagc caagatctgt ctgtcttcat ggtgccaccg
     1921 gggacacctt ctagtcccca gacttgccag gacctctggc tgtagagact gtggcatggc
     1981 ccttgacctc aggctccagc ctctctatga gaggaatcct gtctgtcacc ctccgtgcct
     2041 ttgcagagcc cactgtcgcc tgtctctcca ccaggaggac gccatttcat tccccagctg
     2101 cctccttccc aacagtgagg ggttaaggga gctccgtgct gctacctggg ggtggatgtg
     2161 cctgaggaag gtcctcctca gaacctcctc atcaaccttt gttctgtcct ttgctgtact
     2221 gccctttgct gcttccttct ggagctgcct ggccctcctt tatagctcca ttgcgccacc
     2281 tcgtgtctgg tctgggtata ggtggccagg ggagggggtg gtgacggatg cacaaccttg
     2341 caaacccaca gccctctaaa cggactagga aagaaaggcg ttgctgaatt gggggagagt
     2401 cctgggctgc tcaactcctc ttctgctcag tttctccaaa cctcaccctg gaacttagcc
     2461 gtactgtgtt acctgcctct gaaccctggg tgccttgggt gctgaccttg ctgtaagagc
     2521 tggccttgcc ctatttgccc tgtgcccgtt tcttttcata gcattaactt tccaggctgg
     2581 ccccaccgag tctcaggctg ggaggtaggg tagggttaca ggggcagctt tcccaaggga
     2641 ctgagccaca acagtcccta tagctgtcgt gggctctcta ccactgttag gctggaatgc
     2701 aacctccctc catctgtagc tgctctcagt gggtaggaag gggccaggca gagcctagct
     2761 tgggccttgg ctagattaag agcctgtcag caggaagagt ctagctccac tcagctcctc
     2821 tcaggaggca gccttgggcg aggcgctctt ttctacatat gccacctcca ctgggaaact
     2881 aaaccaaaga gaccactctg tgccaagtca actgtgcctt ctatatgctc tcttcacaca
     2941 cccctccccc tgggtaggag gcagtggaga gccaaagcct cagagttccc ccacctacca
     3001 gttccccagg aatccctggg ggtgtgaacc aatggggatt tattttttct cttgcccaaa
     3061 gtaggtctgg ttgtgaggat aagacagagg gagtttagtg tccgggcctt tgataggtcc
     3121 accaggcctt catgccatgg accatggatg gagactgcag ttatttattt gtgtactctg
     3181 taaatgtatc ttctgtatcc aataaacagg ctgccctccc tcagggaagg ctgccatttt
     3241 ttctgaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3301 aaaaaaaaaa aaaaaaa
//
